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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AFF3-HDAC5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AFF3-HDAC5
FusionPDB ID: 2685
FusionGDB2.0 ID: 2685
HgeneTgene
Gene symbol

AFF3

HDAC5

Gene ID

3899

10014

Gene nameAF4/FMR2 family member 3histone deacetylase 5
SynonymsLAF4|MLLT2-likeHD5|NY-CO-9
Cytomap

2q11.2

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4histone deacetylase 5antigen NY-CO-9
Modification date2020031320200313
UniProtAcc

P51826

Q9UQL6

Ensembl transtripts involved in fusion geneENST idsENST00000317233, ENST00000356421, 
ENST00000409236, ENST00000409579, 
ENST00000483600, 		ENST00000225983, 
ENST00000336057, ENST00000393622, 
ENST00000586802, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 13 X 7=154713 X 11 X 8=1144
# samples 1714
** MAII scorelog2(17/1547*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1144*10)=-3.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AFF3 [Title/Abstract] AND HDAC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AFF3(100623094)-HDAC5(42195072), # samples:1
AFF3(100623094)-HDAC5(42171202), # samples:1
Anticipated loss of major functional domain due to fusion event.AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHDAC5

GO:0000122

negative regulation of transcription by RNA polymerase II

16236793

TgeneHDAC5

GO:0016575

histone deacetylation

10869435


check buttonFusion gene breakpoints across AFF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HDAC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8HO-01AAFF3chr2

100623094

-HDAC5chr17

42171202

-
ChimerDB4PRADTCGA-YL-A8HO-01AAFF3chr2

100623094

-HDAC5chr17

42195072

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409236AFF3chr2100623094-ENST00000225983HDAC5chr1742171202-589198689242601122
ENST00000409236AFF3chr2100623094-ENST00000393622HDAC5chr1742171202-588498689242601122
ENST00000409236AFF3chr2100623094-ENST00000336057HDAC5chr1742171202-562898689240051037
ENST00000409236AFF3chr2100623094-ENST00000586802HDAC5chr1742171202-434398689242601122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409236ENST00000225983AFF3chr2100623094-HDAC5chr1742171202-0.0121211750.98787886
ENST00000409236ENST00000393622AFF3chr2100623094-HDAC5chr1742171202-0.0122917990.9877082
ENST00000409236ENST00000336057AFF3chr2100623094-HDAC5chr1742171202-0.0153475480.98465246
ENST00000409236ENST00000586802AFF3chr2100623094-HDAC5chr1742171202-0.0236526320.9763474

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2685_2685_1_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000225983_length(amino acids)=1122AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLE
LAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL
MTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET

--------------------------------------------------------------

>2685_2685_2_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000336057_length(amino acids)=1037AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAV
GCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRY
DNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGH
LTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREA

--------------------------------------------------------------

>2685_2685_3_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000393622_length(amino acids)=1122AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLE
LAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL
MTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET

--------------------------------------------------------------

>2685_2685_4_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000586802_length(amino acids)=1122AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLE
LAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL
MTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:100623094/chr17:42195072)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF3

P51826

HDAC5

Q9UQL6

FUNCTION: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHDAC5chr2:100623094chr17:42171202ENST000002259832271099_110432.3333333333333361124.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000022598322747_5232.3333333333333361124.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000225983227596_59932.3333333333333361124.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000022598322785_9232.3333333333333361124.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000003360572251099_110431.3333333333333321038.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000033605722547_5231.3333333333333321038.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000336057225596_59931.3333333333333321038.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000033605722585_9231.3333333333333321038.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000003936222271099_110431.3333333333333321123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000039362222747_5231.3333333333333321123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000393622227596_59931.3333333333333321123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000039362222785_9231.3333333333333321123.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000005868022271099_110431.3333333333333321123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000058680222747_5231.3333333333333321123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000586802227596_59931.3333333333333321123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000058680222785_9231.3333333333333321123.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000002259832271081_112232.3333333333333361124.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST000003360572251081_112231.3333333333333321038.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST000003936222271081_112231.3333333333333321123.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST000005868022271081_112231.3333333333333321123.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST00000225983227684_102832.3333333333333361124.0RegionNote=Histone deacetylase
TgeneHDAC5chr2:100623094chr17:42171202ENST00000336057225684_102831.3333333333333321038.0RegionNote=Histone deacetylase
TgeneHDAC5chr2:100623094chr17:42171202ENST00000393622227684_102831.3333333333333321123.0RegionNote=Histone deacetylase
TgeneHDAC5chr2:100623094chr17:42171202ENST00000586802227684_102831.3333333333333321123.0RegionNote=Histone deacetylase

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624413_419291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624422_432291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624440_445291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624670_679291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624413_419316.01252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624422_432316.01252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624440_445316.01252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624670_679316.01252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523413_419291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523422_432291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523440_445291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523670_679291.01227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725413_419316.01252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725422_432316.01252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725440_445316.01252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725670_679316.01252.0Compositional biasNote=Poly-Ser


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AFF3all structure
HDAC5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AFF3-HDAC5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AFF3-HDAC5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAFF3C0003873Rheumatoid Arthritis2CTD_human
HgeneAFF3C0013146Drug abuse1CTD_human
HgeneAFF3C0013170Drug habituation1CTD_human
HgeneAFF3C0013222Drug Use Disorders1CTD_human
HgeneAFF3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneAFF3C0036572Seizures1GENOMICS_ENGLAND
HgeneAFF3C0038580Substance Dependence1CTD_human
HgeneAFF3C0038586Substance Use Disorders1CTD_human
HgeneAFF3C0236969Substance-Related Disorders1CTD_human
HgeneAFF3C0740858Substance abuse problem1CTD_human
HgeneAFF3C1510472Drug Dependence1CTD_human
HgeneAFF3C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneAFF3C4316881Prescription Drug Abuse1CTD_human