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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EPB41-YTHDF2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EPB41-YTHDF2
FusionPDB ID: 26880
FusionGDB2.0 ID: 26880
HgeneTgene
Gene symbol

EPB41

YTHDF2

Gene ID

2035

51441

Gene nameerythrocyte membrane protein band 4.1YTH N6-methyladenosine RNA binding protein 2
Synonyms4.1R|EL1|HECAHL|HGRG8|NY-REN-2
Cytomap

1p35.3

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionprotein 4.1EPB4.1P4.1band 4.1elliptocytosis 1, RH-linkederythrocyte surface protein band 4.1YTH domain-containing family protein 29430020E02RikCLL-associated antigen KW-14YTH N(6)-methyladenosine RNA binding protein 2YTH domain family, member 2high-glucose-regulated protein 8renal carcinoma antigen NY-REN-2
Modification date2020032020200313
UniProtAcc

Q9HCM4

.
Ensembl transtripts involved in fusion geneENST idsENST00000343067, ENST00000347529, 
ENST00000349460, ENST00000356093, 
ENST00000373797, ENST00000373798, 
ENST00000373800, ENST00000398863, 
ENST00000460378, 		ENST00000478283, 
ENST00000541996, ENST00000373812, 
ENST00000542507, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 16 X 9=259210 X 8 X 8=640
# samples 2014
** MAII scorelog2(20/2592*10)=-3.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/640*10)=-2.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EPB41 [Title/Abstract] AND YTHDF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EPB41(29365938)-YTHDF2(29095441), # samples:1
EPB41(29213722)-YTHDF2(29068940), # samples:1
EPB41(29320054)-YTHDF2(29068915), # samples:1
EPB41(29220349)-YTHDF2(29068915), # samples:1
Anticipated loss of major functional domain due to fusion event.EPB41-YTHDF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41-YTHDF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41-YTHDF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41-YTHDF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41-YTHDF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EPB41-YTHDF2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EPB41-YTHDF2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
EPB41-YTHDF2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPB41

GO:0032092

positive regulation of protein binding

3693401

TgeneYTHDF2

GO:0006402

mRNA catabolic process

27558897|30559377|30930054

TgeneYTHDF2

GO:0061157

mRNA destabilization

27558897|30559377|30930054

TgeneYTHDF2

GO:1903679

positive regulation of cap-independent translational initiation

26458103


check buttonFusion gene breakpoints across EPB41 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YTHDF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A3KG-01AEPB41chr1

29365938

+YTHDF2chr1

29095441

+
ChimerDB4PCPGTCGA-QR-A70V-01AEPB41chr1

29213722

+YTHDF2chr1

29068940

+
ChimerDB4PCPGTCGA-QR-A70V-01AEPB41chr1

29220349

-YTHDF2chr1

29068915

+
ChimerDB4UCSTCGA-N8-A4PI-01AEPB41chr1

29320054

-YTHDF2chr1

29068915

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356093EPB41chr129320054-ENST00000542507YTHDF2chr129068915+323880872415802
ENST00000356093EPB41chr129320054-ENST00000373812YTHDF2chr129068915+323980872415802
ENST00000398863EPB41chr129320054-ENST00000542507YTHDF2chr129068915+323880872415802
ENST00000398863EPB41chr129320054-ENST00000373812YTHDF2chr129068915+323980872415802
ENST00000343067EPB41chr129320054-ENST00000542507YTHDF2chr129068915+323880872415802
ENST00000343067EPB41chr129320054-ENST00000373812YTHDF2chr129068915+323980872415802
ENST00000349460EPB41chr129320054-ENST00000542507YTHDF2chr129068915+32858556062462618
ENST00000349460EPB41chr129320054-ENST00000373812YTHDF2chr129068915+32868556062462618
ENST00000373800EPB41chr129320054-ENST00000542507YTHDF2chr129068915+32688385892445618
ENST00000373800EPB41chr129320054-ENST00000373812YTHDF2chr129068915+32698385892445618
ENST00000347529EPB41chr129320054-ENST00000542507YTHDF2chr129068915+3157727462334762
ENST00000347529EPB41chr129320054-ENST00000373812YTHDF2chr129068915+3158727462334762
ENST00000373798EPB41chr129320054-ENST00000542507YTHDF2chr129068915+32157851042392762
ENST00000373798EPB41chr129320054-ENST00000373812YTHDF2chr129068915+32167851042392762
ENST00000373797EPB41chr129320054-ENST00000542507YTHDF2chr129068915+3308878442485813
ENST00000373797EPB41chr129320054-ENST00000373812YTHDF2chr129068915+3309878442485813

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356093ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0003209560.9996791
ENST00000356093ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0003243740.99967563
ENST00000398863ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0003209560.9996791
ENST00000398863ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0003243740.99967563
ENST00000343067ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0003209560.9996791
ENST00000343067ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0003243740.99967563
ENST00000349460ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0005103090.99948967
ENST00000349460ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0005152450.9994848
ENST00000373800ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0004747260.9995253
ENST00000373800ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0004794510.99952054
ENST00000347529ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0003078470.9996922
ENST00000347529ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0003112150.99968886
ENST00000373798ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0003115110.9996885
ENST00000373798ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0003145860.9996854
ENST00000373797ENST00000542507EPB41chr129320054-YTHDF2chr129068915+0.0003795750.99962044
ENST00000373797ENST00000373812EPB41chr129320054-YTHDF2chr129068915+0.0003841720.9996158

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26880_26880_1_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000343067_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=802AA_BP=267
MSVQVEAPAGQSGRNLLKGESGAEPERGRPGPRRTQPSNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCE
QKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELK
TDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNA
YTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNN
SSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLP
PATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPV
AQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNL
KHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDV

--------------------------------------------------------------

>26880_26880_2_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000343067_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=802AA_BP=267
MSVQVEAPAGQSGRNLLKGESGAEPERGRPGPRRTQPSNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCE
QKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELK
TDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNA
YTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNN
SSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLP
PATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPV
AQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNL
KHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDV

--------------------------------------------------------------

>26880_26880_3_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000347529_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=762AA_BP=227
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRP
KSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS
KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLT
SYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLN
KAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPP
PIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNR
GSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYR
SMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKA

--------------------------------------------------------------

>26880_26880_4_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000347529_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=762AA_BP=227
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRP
KSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS
KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLT
SYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLN
KAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPP
PIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNR
GSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYR
SMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKA

--------------------------------------------------------------

>26880_26880_5_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000349460_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=618AA_BP=83
MKHVNIICIVKSPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAM
SDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQG
QSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATI
APPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQAS
VGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGR
VFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIF

--------------------------------------------------------------

>26880_26880_6_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000349460_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=618AA_BP=83
MKHVNIICIVKSPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAM
SDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQG
QSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATI
APPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQAS
VGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGR
VFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIF

--------------------------------------------------------------

>26880_26880_7_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000356093_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=802AA_BP=267
MSVQVEAPAGQSGRNLLKGESGAEPERGRPGPRRTQPSNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCE
QKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELK
TDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNA
YTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNN
SSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLP
PATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPV
AQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNL
KHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDV

--------------------------------------------------------------

>26880_26880_8_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000356093_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=802AA_BP=267
MSVQVEAPAGQSGRNLLKGESGAEPERGRPGPRRTQPSNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCE
QKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELK
TDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNA
YTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNN
SSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLP
PATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPV
AQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNL
KHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDV

--------------------------------------------------------------

>26880_26880_9_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000373797_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=813AA_BP=278
MVRLVSQPAAAGGPASRRGPEPRTPAPPPAIVRRAAAVAGAGARPRSHRNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESC
QTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILK
APIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDD
TVYECVVENNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFP
SGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSI
TSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQP
VGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSIN
NYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVW
SQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQG

--------------------------------------------------------------

>26880_26880_10_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000373797_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=813AA_BP=278
MVRLVSQPAAAGGPASRRGPEPRTPAPPPAIVRRAAAVAGAGARPRSHRNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESC
QTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILK
APIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDD
TVYECVVENNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFP
SGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSI
TSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQP
VGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSIN
NYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVW
SQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQG

--------------------------------------------------------------

>26880_26880_11_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000373798_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=762AA_BP=227
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRP
KSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS
KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLT
SYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLN
KAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPP
PIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNR
GSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYR
SMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKA

--------------------------------------------------------------

>26880_26880_12_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000373798_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=762AA_BP=227
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRP
KSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS
KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLT
SYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLN
KAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPP
PIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNR
GSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYR
SMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKA

--------------------------------------------------------------

>26880_26880_13_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000373800_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=618AA_BP=83
MKHVNIICIVKSPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAM
SDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQG
QSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATI
APPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQAS
VGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGR
VFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIF

--------------------------------------------------------------

>26880_26880_14_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000373800_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=618AA_BP=83
MKHVNIICIVKSPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNAYTAM
SDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQG
QSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLPPATI
APPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQAS
VGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGR
VFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIF

--------------------------------------------------------------

>26880_26880_15_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000398863_YTHDF2_chr1_29068915_ENST00000373812_length(amino acids)=802AA_BP=267
MSVQVEAPAGQSGRNLLKGESGAEPERGRPGPRRTQPSNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCE
QKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELK
TDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNA
YTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNN
SSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLP
PATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPV
AQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNL
KHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDV

--------------------------------------------------------------

>26880_26880_16_EPB41-YTHDF2_EPB41_chr1_29320054_ENST00000398863_YTHDF2_chr1_29068915_ENST00000542507_length(amino acids)=802AA_BP=267
MSVQVEAPAGQSGRNLLKGESGAEPERGRPGPRRTQPSNIMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCE
QKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELK
TDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVENNA
YTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNN
SSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASNVPKVVGSAVGSGSITSNIVASNSLP
PATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPV
AQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNL
KHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:29365938/chr1:29095441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPB41

Q9HCM4

.
FUNCTION: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000037381225410_54444.0580.0DomainYTH
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054199614410_5440530.0DomainYTH
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054250736410_54444.0580.0DomainYTH
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000037381225230_38744.0580.0RegionDisordered
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000037381225416_41844.0580.0RegionN6-methyladenosine binding
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000037381225432_43344.0580.0RegionN6-methyladenosine binding
TgeneYTHDF2chr1:29320054chr1:29068915ENST00000541996141_460530.0RegionDisordered
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054199614230_3870530.0RegionDisordered
TgeneYTHDF2chr1:29320054chr1:29068915ENST00000541996142_3840530.0RegionLocalization to mRNA processing bodies (P-bodies)
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054199614416_4180530.0RegionN6-methyladenosine binding
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054199614432_4330530.0RegionN6-methyladenosine binding
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054250736230_38744.0580.0RegionDisordered
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054250736416_41844.0580.0RegionN6-methyladenosine binding
TgeneYTHDF2chr1:29320054chr1:29068915ENST0000054250736432_43344.0580.0RegionN6-methyladenosine binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPB41chr1:29320054chr1:29068915ENST00000343067-321210_491227.01892.3333333333333DomainFERM
HgeneEPB41chr1:29320054chr1:29068915ENST00000347529-317210_491227.0861.6666666666666DomainFERM
HgeneEPB41chr1:29320054chr1:29068915ENST00000349460-421210_49118.0711.6666666666666DomainFERM
HgeneEPB41chr1:29320054chr1:29068915ENST00000356093-319210_491227.01859.3333333333333DomainFERM
HgeneEPB41chr1:29320054chr1:29068915ENST00000373797-315210_491227.0721.0DomainFERM
HgeneEPB41chr1:29320054chr1:29068915ENST00000373798-321210_491227.01907.0DomainFERM
HgeneEPB41chr1:29320054chr1:29068915ENST00000373800-419210_49118.0658.6666666666666DomainFERM
HgeneEPB41chr1:29320054chr1:29068915ENST00000343067-321494_614227.01892.3333333333333RegionNote=Hydrophilic
HgeneEPB41chr1:29320054chr1:29068915ENST00000343067-321615_713227.01892.3333333333333RegionNote=Spectrin--actin-binding
HgeneEPB41chr1:29320054chr1:29068915ENST00000343067-321714_864227.01892.3333333333333RegionNote=C-terminal (CTD)
HgeneEPB41chr1:29320054chr1:29068915ENST00000347529-317494_614227.0861.6666666666666RegionNote=Hydrophilic
HgeneEPB41chr1:29320054chr1:29068915ENST00000347529-317615_713227.0861.6666666666666RegionNote=Spectrin--actin-binding
HgeneEPB41chr1:29320054chr1:29068915ENST00000347529-317714_864227.0861.6666666666666RegionNote=C-terminal (CTD)
HgeneEPB41chr1:29320054chr1:29068915ENST00000349460-421494_61418.0711.6666666666666RegionNote=Hydrophilic
HgeneEPB41chr1:29320054chr1:29068915ENST00000349460-421615_71318.0711.6666666666666RegionNote=Spectrin--actin-binding
HgeneEPB41chr1:29320054chr1:29068915ENST00000349460-421714_86418.0711.6666666666666RegionNote=C-terminal (CTD)
HgeneEPB41chr1:29320054chr1:29068915ENST00000356093-319494_614227.01859.3333333333333RegionNote=Hydrophilic
HgeneEPB41chr1:29320054chr1:29068915ENST00000356093-319615_713227.01859.3333333333333RegionNote=Spectrin--actin-binding
HgeneEPB41chr1:29320054chr1:29068915ENST00000356093-319714_864227.01859.3333333333333RegionNote=C-terminal (CTD)
HgeneEPB41chr1:29320054chr1:29068915ENST00000373797-315494_614227.0721.0RegionNote=Hydrophilic
HgeneEPB41chr1:29320054chr1:29068915ENST00000373797-315615_713227.0721.0RegionNote=Spectrin--actin-binding
HgeneEPB41chr1:29320054chr1:29068915ENST00000373797-315714_864227.0721.0RegionNote=C-terminal (CTD)
HgeneEPB41chr1:29320054chr1:29068915ENST00000373798-321494_614227.01907.0RegionNote=Hydrophilic
HgeneEPB41chr1:29320054chr1:29068915ENST00000373798-321615_713227.01907.0RegionNote=Spectrin--actin-binding
HgeneEPB41chr1:29320054chr1:29068915ENST00000373798-321714_864227.01907.0RegionNote=C-terminal (CTD)
HgeneEPB41chr1:29320054chr1:29068915ENST00000373800-419494_61418.0658.6666666666666RegionNote=Hydrophilic
HgeneEPB41chr1:29320054chr1:29068915ENST00000373800-419615_71318.0658.6666666666666RegionNote=Spectrin--actin-binding
HgeneEPB41chr1:29320054chr1:29068915ENST00000373800-419714_86418.0658.6666666666666RegionNote=C-terminal (CTD)
TgeneYTHDF2chr1:29320054chr1:29068915ENST00000373812251_4644.0580.0RegionDisordered
TgeneYTHDF2chr1:29320054chr1:29068915ENST00000373812252_38444.0580.0RegionLocalization to mRNA processing bodies (P-bodies)
TgeneYTHDF2chr1:29320054chr1:29068915ENST00000542507361_4644.0580.0RegionDisordered
TgeneYTHDF2chr1:29320054chr1:29068915ENST00000542507362_38444.0580.0RegionLocalization to mRNA processing bodies (P-bodies)


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EPB41
YTHDF2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EPB41-YTHDF2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EPB41-YTHDF2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource