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Fusion Protein:EPHA7-PTPRK |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: EPHA7-PTPRK | FusionPDB ID: 26982 | FusionGDB2.0 ID: 26982 | Hgene | Tgene | Gene symbol | EPHA7 | PTPRK | Gene ID | 2045 | 5796 |
| Gene name | EPH receptor A7 | protein tyrosine phosphatase receptor type K | |
| Synonyms | EHK-3|EHK3|EK11|HEK11 | R-PTP-kappa | |
| Cytomap | 6q16.1 | 6q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ephrin type-A receptor 7EPH homology kinase 3EPH-like kinase 11Eph homology kinase-3receptor protein-tyrosine kinase HEK11tyrosine-protein kinase receptor EHK-3 | receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha | |
| Modification date | 20200313 | 20200322 | |
| UniProtAcc | Q15375 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000369303, ENST00000369297, | ENST00000524481, ENST00000525459, ENST00000368207, ENST00000368210, ENST00000368213, ENST00000368215, ENST00000368226, ENST00000368227, ENST00000532331, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 5 X 4=120 | 17 X 12 X 9=1836 |
| # samples | 6 | 21 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/1836*10)=-3.12810482574769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: EPHA7 [Title/Abstract] AND PTPRK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | EPHA7(94066435)-PTPRK(128718833), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | EPHA7-PTPRK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPHA7-PTPRK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPHA7-PTPRK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EPHA7-PTPRK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EPHA7 | GO:0048013 | ephrin receptor signaling pathway | 17726105 |
| Hgene | EPHA7 | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 17726105 |
| Hgene | EPHA7 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 17726105 |
| Tgene | PTPRK | GO:0006470 | protein dephosphorylation | 16263724 |
| Tgene | PTPRK | GO:0007165 | signal transduction | 16849327 |
| Tgene | PTPRK | GO:0007179 | transforming growth factor beta receptor signaling pathway | 15899872 |
| Tgene | PTPRK | GO:0008285 | negative regulation of cell proliferation | 15899872|18276111 |
| Tgene | PTPRK | GO:0010839 | negative regulation of keratinocyte proliferation | 16263724 |
| Tgene | PTPRK | GO:0030336 | negative regulation of cell migration | 18276111 |
| Tgene | PTPRK | GO:0034394 | protein localization to cell surface | 18276111 |
| Tgene | PTPRK | GO:0034614 | cellular response to reactive oxygen species | 16849327 |
| Tgene | PTPRK | GO:0034644 | cellular response to UV | 16849327 |
| Tgene | PTPRK | GO:0045786 | negative regulation of cell cycle | 15899872 |
| Tgene | PTPRK | GO:0045892 | negative regulation of transcription, DNA-templated | 18276111 |
| Fusion gene breakpoints across EPHA7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PTPRK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A7-A3IZ-01A | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000369303 | EPHA7 | chr6 | 94066435 | - | ENST00000368226 | PTPRK | chr6 | 128718833 | - | 7180 | 1509 | 185 | 5731 | 1848 |
| ENST00000369303 | EPHA7 | chr6 | 94066435 | - | ENST00000368227 | PTPRK | chr6 | 128718833 | - | 7230 | 1509 | 185 | 5782 | 1865 |
| ENST00000369303 | EPHA7 | chr6 | 94066435 | - | ENST00000532331 | PTPRK | chr6 | 128718833 | - | 7048 | 1509 | 185 | 5797 | 1870 |
| ENST00000369303 | EPHA7 | chr6 | 94066435 | - | ENST00000368213 | PTPRK | chr6 | 128718833 | - | 7000 | 1509 | 185 | 5749 | 1854 |
| ENST00000369303 | EPHA7 | chr6 | 94066435 | - | ENST00000368210 | PTPRK | chr6 | 128718833 | - | 6176 | 1509 | 185 | 5785 | 1866 |
| ENST00000369303 | EPHA7 | chr6 | 94066435 | - | ENST00000368215 | PTPRK | chr6 | 128718833 | - | 6060 | 1509 | 185 | 5728 | 1847 |
| ENST00000369303 | EPHA7 | chr6 | 94066435 | - | ENST00000368207 | PTPRK | chr6 | 128718833 | - | 5942 | 1509 | 185 | 5827 | 1880 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000369303 | ENST00000368226 | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - | 0.000255881 | 0.9997441 |
| ENST00000369303 | ENST00000368227 | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - | 0.000572509 | 0.99942756 |
| ENST00000369303 | ENST00000532331 | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - | 0.000570296 | 0.99942964 |
| ENST00000369303 | ENST00000368213 | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - | 0.000431122 | 0.9995689 |
| ENST00000369303 | ENST00000368210 | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - | 0.000924972 | 0.99907506 |
| ENST00000369303 | ENST00000368215 | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - | 0.00056621 | 0.9994338 |
| ENST00000369303 | ENST00000368207 | EPHA7 | chr6 | 94066435 | - | PTPRK | chr6 | 128718833 | - | 0.00086715 | 0.99913293 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >26982_26982_1_EPHA7-PTPRK_EPHA7_chr6_94066435_ENST00000369303_PTPRK_chr6_128718833_ENST00000368207_length(amino acids)=1880AA_BP=441 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWI SKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQ QKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAGGCTFDDGP GACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKG PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRD AVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQL NANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQ ARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGP VPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA TAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAA ELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGIL VFILLLLVVILIVKKRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAV LVPITDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNR YGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYW PDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRT GCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQT LNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS IVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVE -------------------------------------------------------------- >26982_26982_2_EPHA7-PTPRK_EPHA7_chr6_94066435_ENST00000369303_PTPRK_chr6_128718833_ENST00000368210_length(amino acids)=1866AA_BP=441 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWI SKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQ QKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAGGCTFDDGP GACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKG PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRD AVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQL NANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQ ARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGP VPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA TAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAA ELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGIL VFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATAE SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL QPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCP QYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI -------------------------------------------------------------- >26982_26982_3_EPHA7-PTPRK_EPHA7_chr6_94066435_ENST00000369303_PTPRK_chr6_128718833_ENST00000368213_length(amino acids)=1854AA_BP=441 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWI SKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQ QKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAGGCTFDDGP GACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKG PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRD AVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQL NANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQ ARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGP VPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA TAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAA ELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGIL VFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLC EGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYI NANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVR TFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVK ALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNR FMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYG PIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGM -------------------------------------------------------------- >26982_26982_4_EPHA7-PTPRK_EPHA7_chr6_94066435_ENST00000369303_PTPRK_chr6_128718833_ENST00000368215_length(amino acids)=1847AA_BP=441 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWI SKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQ QKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAGGCTFDDGP GACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKG PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRD AVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQL NANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQ ARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGP VPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA TAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAA ELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILV FILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCE GTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYIN ANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERR GYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRI NMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPP DRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECM SCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV -------------------------------------------------------------- >26982_26982_5_EPHA7-PTPRK_EPHA7_chr6_94066435_ENST00000369303_PTPRK_chr6_128718833_ENST00000368226_length(amino acids)=1848AA_BP=441 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWI SKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQ QKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAGGCTFDDGP GACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKG PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRD AVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQL NANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQ ARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGP VPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA TAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAA ELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGIL VFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLC EGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYI NANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLER RGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRR INMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLP PDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVEC MSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGI -------------------------------------------------------------- >26982_26982_6_EPHA7-PTPRK_EPHA7_chr6_94066435_ENST00000369303_PTPRK_chr6_128718833_ENST00000368227_length(amino acids)=1865AA_BP=441 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWI SKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQ QKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAGGCTFDDGP GACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKG PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRD AVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQL NANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQ ARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGP VPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA TAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAA ELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGIL VFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATAE SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL QPVEDDPSSDYINANYIDVSIFIGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCV EMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAER EGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSI ACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQ YWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTII -------------------------------------------------------------- >26982_26982_7_EPHA7-PTPRK_EPHA7_chr6_94066435_ENST00000369303_PTPRK_chr6_128718833_ENST00000532331_length(amino acids)=1870AA_BP=441 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWI SKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQ QKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAGGCTFDDGP GACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKG PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRD AVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQL NANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQ ARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGP VPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA TAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAA ELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGIL VFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHS ATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHS RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDF KVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIML DMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQA EDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS QGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:94066435/chr6:128718833) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPHA7 | . |
| FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 192_328 | 441.3333333333333 | 999.0 | Compositional bias | Note=Cys-rich |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 32_210 | 441.3333333333333 | 999.0 | Domain | Eph LBD |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 331_441 | 441.3333333333333 | 999.0 | Domain | Fibronectin type-III 1 |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 1173_1435 | 33.333333333333336 | 1447.0 | Domain | Tyrosine-protein phosphatase 2 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 196_281 | 33.333333333333336 | 1447.0 | Domain | Note=Ig-like C2-type | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 294_389 | 33.333333333333336 | 1447.0 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 31_194 | 33.333333333333336 | 1447.0 | Domain | MAM | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 392_488 | 33.333333333333336 | 1447.0 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 491_595 | 33.333333333333336 | 1447.0 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 597_680 | 33.333333333333336 | 1447.0 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 887_1141 | 33.333333333333336 | 1447.0 | Domain | Tyrosine-protein phosphatase 1 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 1173_1435 | 33.333333333333336 | 1440.0 | Domain | Tyrosine-protein phosphatase 2 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 196_281 | 33.333333333333336 | 1440.0 | Domain | Note=Ig-like C2-type | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 294_389 | 33.333333333333336 | 1440.0 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 31_194 | 33.333333333333336 | 1440.0 | Domain | MAM | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 392_488 | 33.333333333333336 | 1440.0 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 491_595 | 33.333333333333336 | 1440.0 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 597_680 | 33.333333333333336 | 1440.0 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 887_1141 | 33.333333333333336 | 1440.0 | Domain | Tyrosine-protein phosphatase 1 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 1173_1435 | 33.333333333333336 | 1441.0 | Domain | Tyrosine-protein phosphatase 2 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 196_281 | 33.333333333333336 | 1441.0 | Domain | Note=Ig-like C2-type | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 294_389 | 33.333333333333336 | 1441.0 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 31_194 | 33.333333333333336 | 1441.0 | Domain | MAM | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 392_488 | 33.333333333333336 | 1441.0 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 491_595 | 33.333333333333336 | 1441.0 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 597_680 | 33.333333333333336 | 1441.0 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 887_1141 | 33.333333333333336 | 1441.0 | Domain | Tyrosine-protein phosphatase 1 | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 1082_1088 | 33.333333333333336 | 1447.0 | Region | Substrate binding | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 1082_1088 | 33.333333333333336 | 1440.0 | Region | Substrate binding | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 1082_1088 | 33.333333333333336 | 1441.0 | Region | Substrate binding | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 775_1439 | 33.333333333333336 | 1447.0 | Topological domain | Cytoplasmic | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 775_1439 | 33.333333333333336 | 1440.0 | Topological domain | Cytoplasmic | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 775_1439 | 33.333333333333336 | 1441.0 | Topological domain | Cytoplasmic | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 753_774 | 33.333333333333336 | 1447.0 | Transmembrane | Helical | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 753_774 | 33.333333333333336 | 1440.0 | Transmembrane | Helical | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 753_774 | 33.333333333333336 | 1441.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 192_328 | 0 | 280.0 | Compositional bias | Note=Cys-rich |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 32_210 | 0 | 280.0 | Domain | Eph LBD |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 331_441 | 0 | 280.0 | Domain | Fibronectin type-III 1 |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 442_537 | 0 | 280.0 | Domain | Fibronectin type-III 2 |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 633_894 | 0 | 280.0 | Domain | Protein kinase |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 923_987 | 0 | 280.0 | Domain | SAM |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 442_537 | 441.3333333333333 | 999.0 | Domain | Fibronectin type-III 2 |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 633_894 | 441.3333333333333 | 999.0 | Domain | Protein kinase |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 923_987 | 441.3333333333333 | 999.0 | Domain | SAM |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 996_998 | 0 | 280.0 | Motif | PDZ-binding |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 996_998 | 441.3333333333333 | 999.0 | Motif | PDZ-binding |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 639_647 | 0 | 280.0 | Nucleotide binding | ATP |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 639_647 | 441.3333333333333 | 999.0 | Nucleotide binding | ATP |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 28_555 | 0 | 280.0 | Topological domain | Extracellular |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 577_998 | 0 | 280.0 | Topological domain | Cytoplasmic |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 28_555 | 441.3333333333333 | 999.0 | Topological domain | Extracellular |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 577_998 | 441.3333333333333 | 999.0 | Topological domain | Cytoplasmic |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369297 | - | 1 | 3 | 556_576 | 0 | 280.0 | Transmembrane | Helical |
| Hgene | EPHA7 | chr6:94066435 | chr6:128718833 | ENST00000369303 | - | 5 | 17 | 556_576 | 441.3333333333333 | 999.0 | Transmembrane | Helical |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368213 | 0 | 31 | 27_752 | 33.333333333333336 | 1447.0 | Topological domain | Extracellular | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368215 | 0 | 30 | 27_752 | 33.333333333333336 | 1440.0 | Topological domain | Extracellular | |
| Tgene | PTPRK | chr6:94066435 | chr6:128718833 | ENST00000368226 | 0 | 30 | 27_752 | 33.333333333333336 | 1441.0 | Topological domain | Extracellular |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| EPHA7 | |
| PTPRK |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to EPHA7-PTPRK |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to EPHA7-PTPRK |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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