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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EPS15L1-CPAMD8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EPS15L1-CPAMD8
FusionPDB ID: 27070
FusionGDB2.0 ID: 27070
HgeneTgene
Gene symbol

EPS15L1

CPAMD8

Gene ID

58513

27151

Gene nameepidermal growth factor receptor pathway substrate 15 like 1C3 and PZP like alpha-2-macroglobulin domain containing 8
SynonymsEPS15RASGD8|K-CAP|VIP
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related proteinC3 and PZP-like alpha-2-macroglobulin domain-containing protein 8alpha-2 macroglobulin family protein VIP
Modification date2020031320200313
UniProtAcc

Q9UBC2

Q8IZJ3

Ensembl transtripts involved in fusion geneENST idsENST00000248070, ENST00000455140, 
ENST00000535753, ENST00000594975, 
ENST00000597937, ENST00000602009, 
ENST00000388925, ENST00000597335, 
ENST00000443236, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 17 X 14=54744 X 4 X 4=64
# samples 346
** MAII scorelog2(34/5474*10)=-4.00898878322726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EPS15L1 [Title/Abstract] AND CPAMD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EPS15L1(16582724)-CPAMD8(17049256), # samples:3
Anticipated loss of major functional domain due to fusion event.EPS15L1-CPAMD8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPS15L1-CPAMD8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPS15L1-CPAMD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPS15L1-CPAMD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EPS15L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CPAMD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YJ-A8SW-01AEPS15L1chr19

16582724

-CPAMD8chr19

17049256

-
ChimerDB4PRADTCGA-YJ-A8SWEPS15L1chr19

16582723

-CPAMD8chr19

17049256

-
ChimerDB4PRADTCGA-YJ-A8SWEPS15L1chr19

16582724

-CPAMD8chr19

17049256

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455140EPS15L1chr1916582724-ENST00000443236CPAMD8chr1917049256-3126100672964965
ENST00000248070EPS15L1chr1916582724-ENST00000443236CPAMD8chr1917049256-3199173230371011
ENST00000535753EPS15L1chr1916582724-ENST00000443236CPAMD8chr1917049256-309064312928965
ENST00000594975EPS15L1chr1916582724-ENST00000443236CPAMD8chr1917049256-3199173230371011
ENST00000597937EPS15L1chr1916582724-ENST00000443236CPAMD8chr1917049256-30643852902965
ENST00000455140EPS15L1chr1916582723-ENST00000443236CPAMD8chr1917049256-3126100672964965
ENST00000248070EPS15L1chr1916582723-ENST00000443236CPAMD8chr1917049256-3199173230371011
ENST00000535753EPS15L1chr1916582723-ENST00000443236CPAMD8chr1917049256-309064312928965
ENST00000594975EPS15L1chr1916582723-ENST00000443236CPAMD8chr1917049256-3199173230371011
ENST00000597937EPS15L1chr1916582723-ENST00000443236CPAMD8chr1917049256-30643852902965

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455140ENST00000443236EPS15L1chr1916582724-CPAMD8chr1917049256-0.0035805070.99641955
ENST00000248070ENST00000443236EPS15L1chr1916582724-CPAMD8chr1917049256-0.0028149490.99718505
ENST00000535753ENST00000443236EPS15L1chr1916582724-CPAMD8chr1917049256-0.0035138670.9964862
ENST00000594975ENST00000443236EPS15L1chr1916582724-CPAMD8chr1917049256-0.0028149490.99718505
ENST00000597937ENST00000443236EPS15L1chr1916582724-CPAMD8chr1917049256-0.0035723130.9964277
ENST00000455140ENST00000443236EPS15L1chr1916582723-CPAMD8chr1917049256-0.0035805070.99641955
ENST00000248070ENST00000443236EPS15L1chr1916582723-CPAMD8chr1917049256-0.0028149490.99718505
ENST00000535753ENST00000443236EPS15L1chr1916582723-CPAMD8chr1917049256-0.0035138670.9964862
ENST00000594975ENST00000443236EPS15L1chr1916582723-CPAMD8chr1917049256-0.0028149490.99718505
ENST00000597937ENST00000443236EPS15L1chr1916582723-CPAMD8chr1917049256-0.0035723130.9964277

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27070_27070_1_EPS15L1-CPAMD8_EPS15L1_chr19_16582723_ENST00000248070_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=1011AA_BP=32
MRGPVYGPALSRDRRPAHRPPVVPVRTRGCSPAPVPPALGARVRGKMAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYV
QRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPE
PSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGC
GEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELA
AAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLR
SPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFS
STQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKP
AFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLL
DKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAP
ARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDL
ASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVY

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>27070_27070_2_EPS15L1-CPAMD8_EPS15L1_chr19_16582723_ENST00000455140_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=965AA_BP=10
MAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRS
WISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYS
EAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTY
KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALL
ETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQ
SVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRT
NQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHH
QEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSA
LPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVV
YASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSS

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>27070_27070_3_EPS15L1-CPAMD8_EPS15L1_chr19_16582723_ENST00000535753_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=965AA_BP=10
MAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRS
WISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYS
EAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTY
KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALL
ETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQ
SVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRT
NQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHH
QEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSA
LPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVV
YASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSS

--------------------------------------------------------------

>27070_27070_4_EPS15L1-CPAMD8_EPS15L1_chr19_16582723_ENST00000594975_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=1011AA_BP=32
MRGPVYGPALSRDRRPAHRPPVVPVRTRGCSPAPVPPALGARVRGKMAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYV
QRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPE
PSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGC
GEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELA
AAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLR
SPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFS
STQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKP
AFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLL
DKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAP
ARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDL
ASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVY

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>27070_27070_5_EPS15L1-CPAMD8_EPS15L1_chr19_16582723_ENST00000597937_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=965AA_BP=10
MAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRS
WISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYS
EAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTY
KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALL
ETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQ
SVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRT
NQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHH
QEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSA
LPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVV
YASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSS

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>27070_27070_6_EPS15L1-CPAMD8_EPS15L1_chr19_16582724_ENST00000248070_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=1011AA_BP=32
MRGPVYGPALSRDRRPAHRPPVVPVRTRGCSPAPVPPALGARVRGKMAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYV
QRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPE
PSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGC
GEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELA
AAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLR
SPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFS
STQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKP
AFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLL
DKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAP
ARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDL
ASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVY

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>27070_27070_7_EPS15L1-CPAMD8_EPS15L1_chr19_16582724_ENST00000455140_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=965AA_BP=10
MAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRS
WISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYS
EAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTY
KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALL
ETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQ
SVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRT
NQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHH
QEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSA
LPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVV
YASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSS

--------------------------------------------------------------

>27070_27070_8_EPS15L1-CPAMD8_EPS15L1_chr19_16582724_ENST00000535753_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=965AA_BP=10
MAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRS
WISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYS
EAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTY
KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALL
ETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQ
SVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRT
NQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHH
QEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSA
LPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVV
YASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSS

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>27070_27070_9_EPS15L1-CPAMD8_EPS15L1_chr19_16582724_ENST00000594975_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=1011AA_BP=32
MRGPVYGPALSRDRRPAHRPPVVPVRTRGCSPAPVPPALGARVRGKMAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYV
QRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPE
PSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGC
GEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELA
AAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLR
SPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFS
STQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKP
AFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLL
DKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAP
ARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDL
ASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVY

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>27070_27070_10_EPS15L1-CPAMD8_EPS15L1_chr19_16582724_ENST00000597937_CPAMD8_chr19_17049256_ENST00000443236_length(amino acids)=965AA_BP=10
MAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRS
WISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYS
EAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTY
KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALL
ETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQ
SVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRT
NQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHH
QEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSA
LPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVV
YASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16582724/chr19:17049256)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPS15L1

Q9UBC2

CPAMD8

Q8IZJ3

FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCPAMD8chr19:16582723chr19:17049256ENST0000044323621421242_1245978.01933.0Compositional biasNote=Poly-Gln
TgeneCPAMD8chr19:16582723chr19:17049256ENST0000044323621421540_1543978.01933.0Compositional biasNote=Poly-Asp
TgeneCPAMD8chr19:16582723chr19:17049256ENST0000044323621421765_1768978.01933.0Compositional biasNote=Poly-Ser
TgeneCPAMD8chr19:16582724chr19:17049256ENST0000044323621421242_1245978.01933.0Compositional biasNote=Poly-Gln
TgeneCPAMD8chr19:16582724chr19:17049256ENST0000044323621421540_1543978.01933.0Compositional biasNote=Poly-Asp
TgeneCPAMD8chr19:16582724chr19:17049256ENST0000044323621421765_1768978.01933.0Compositional biasNote=Poly-Ser
TgeneCPAMD8chr19:16582723chr19:17049256ENST0000044323621421706_1757978.01933.0DomainKazal-like
TgeneCPAMD8chr19:16582724chr19:17049256ENST0000044323621421706_1757978.01933.0DomainKazal-like

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123172_18411.0865.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124172_18411.0911.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122172_18411.0755.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116172_18411.0602.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123172_18411.0865.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124172_18411.0911.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122172_18411.0755.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116172_18411.0602.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123386_55311.0865.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124386_55311.0911.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122386_55311.0755.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116386_55311.0602.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123386_55311.0865.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124386_55311.0911.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122386_55311.0755.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116386_55311.0602.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123750_81611.0865.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124750_81611.0911.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122750_81611.0755.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116750_81611.0602.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123750_81611.0865.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124750_81611.0911.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122750_81611.0755.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116750_81611.0602.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123127_21511.0865.0DomainEH 2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123159_19411.0865.0DomainEF-hand
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-12315_10411.0865.0DomainEH 1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123275_36511.0865.0DomainEH 3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124127_21511.0911.0DomainEH 2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124159_19411.0911.0DomainEF-hand
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-12415_10411.0911.0DomainEH 1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124275_36511.0911.0DomainEH 3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122127_21511.0755.0DomainEH 2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122159_19411.0755.0DomainEF-hand
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-12215_10411.0755.0DomainEH 1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122275_36511.0755.0DomainEH 3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116127_21511.0602.0DomainEH 2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116159_19411.0602.0DomainEF-hand
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-11615_10411.0602.0DomainEH 1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116275_36511.0602.0DomainEH 3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123127_21511.0865.0DomainEH 2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123159_19411.0865.0DomainEF-hand
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-12315_10411.0865.0DomainEH 1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123275_36511.0865.0DomainEH 3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124127_21511.0911.0DomainEH 2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124159_19411.0911.0DomainEF-hand
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-12415_10411.0911.0DomainEH 1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124275_36511.0911.0DomainEH 3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122127_21511.0755.0DomainEH 2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122159_19411.0755.0DomainEF-hand
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-12215_10411.0755.0DomainEH 1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122275_36511.0755.0DomainEH 3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116127_21511.0602.0DomainEH 2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116159_19411.0602.0DomainEF-hand
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-11615_10411.0602.0DomainEH 1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116275_36511.0602.0DomainEH 3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123618_83511.0865.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124618_83511.0911.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122618_83511.0755.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116618_83511.0602.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123618_83511.0865.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124618_83511.0911.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122618_83511.0755.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116618_83511.0602.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123618_62011.0865.0RepeatNote=1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123640_64211.0865.0RepeatNote=2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123645_64711.0865.0RepeatNote=3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123650_65211.0865.0RepeatNote=4
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123656_65811.0865.0RepeatNote=5
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123661_66311.0865.0RepeatNote=6
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123667_66911.0865.0RepeatNote=7
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123685_68711.0865.0RepeatNote=8
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123690_69211.0865.0RepeatNote=9
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123709_71111.0865.0RepeatNote=10
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123728_73011.0865.0RepeatNote=11
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123754_75611.0865.0RepeatNote=12
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123806_80811.0865.0RepeatNote=13
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123812_81411.0865.0RepeatNote=14
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-123833_83511.0865.0RepeatNote=15
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124618_62011.0911.0RepeatNote=1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124640_64211.0911.0RepeatNote=2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124645_64711.0911.0RepeatNote=3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124650_65211.0911.0RepeatNote=4
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124656_65811.0911.0RepeatNote=5
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124661_66311.0911.0RepeatNote=6
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124667_66911.0911.0RepeatNote=7
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124685_68711.0911.0RepeatNote=8
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124690_69211.0911.0RepeatNote=9
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124709_71111.0911.0RepeatNote=10
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124728_73011.0911.0RepeatNote=11
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124754_75611.0911.0RepeatNote=12
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124806_80811.0911.0RepeatNote=13
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124812_81411.0911.0RepeatNote=14
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-124833_83511.0911.0RepeatNote=15
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122618_62011.0755.0RepeatNote=1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122640_64211.0755.0RepeatNote=2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122645_64711.0755.0RepeatNote=3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122650_65211.0755.0RepeatNote=4
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122656_65811.0755.0RepeatNote=5
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122661_66311.0755.0RepeatNote=6
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122667_66911.0755.0RepeatNote=7
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122685_68711.0755.0RepeatNote=8
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122690_69211.0755.0RepeatNote=9
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122709_71111.0755.0RepeatNote=10
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122728_73011.0755.0RepeatNote=11
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122754_75611.0755.0RepeatNote=12
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122806_80811.0755.0RepeatNote=13
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122812_81411.0755.0RepeatNote=14
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-122833_83511.0755.0RepeatNote=15
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116618_62011.0602.0RepeatNote=1
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116640_64211.0602.0RepeatNote=2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116645_64711.0602.0RepeatNote=3
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116650_65211.0602.0RepeatNote=4
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116656_65811.0602.0RepeatNote=5
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116661_66311.0602.0RepeatNote=6
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116667_66911.0602.0RepeatNote=7
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116685_68711.0602.0RepeatNote=8
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116690_69211.0602.0RepeatNote=9
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116709_71111.0602.0RepeatNote=10
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116728_73011.0602.0RepeatNote=11
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116754_75611.0602.0RepeatNote=12
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116806_80811.0602.0RepeatNote=13
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116812_81411.0602.0RepeatNote=14
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-116833_83511.0602.0RepeatNote=15
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123618_62011.0865.0RepeatNote=1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123640_64211.0865.0RepeatNote=2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123645_64711.0865.0RepeatNote=3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123650_65211.0865.0RepeatNote=4
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123656_65811.0865.0RepeatNote=5
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123661_66311.0865.0RepeatNote=6
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123667_66911.0865.0RepeatNote=7
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123685_68711.0865.0RepeatNote=8
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123690_69211.0865.0RepeatNote=9
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123709_71111.0865.0RepeatNote=10
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123728_73011.0865.0RepeatNote=11
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123754_75611.0865.0RepeatNote=12
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123806_80811.0865.0RepeatNote=13
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123812_81411.0865.0RepeatNote=14
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-123833_83511.0865.0RepeatNote=15
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124618_62011.0911.0RepeatNote=1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124640_64211.0911.0RepeatNote=2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124645_64711.0911.0RepeatNote=3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124650_65211.0911.0RepeatNote=4
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124656_65811.0911.0RepeatNote=5
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124661_66311.0911.0RepeatNote=6
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124667_66911.0911.0RepeatNote=7
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124685_68711.0911.0RepeatNote=8
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124690_69211.0911.0RepeatNote=9
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124709_71111.0911.0RepeatNote=10
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124728_73011.0911.0RepeatNote=11
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124754_75611.0911.0RepeatNote=12
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124806_80811.0911.0RepeatNote=13
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124812_81411.0911.0RepeatNote=14
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-124833_83511.0911.0RepeatNote=15
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122618_62011.0755.0RepeatNote=1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122640_64211.0755.0RepeatNote=2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122645_64711.0755.0RepeatNote=3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122650_65211.0755.0RepeatNote=4
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122656_65811.0755.0RepeatNote=5
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122661_66311.0755.0RepeatNote=6
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122667_66911.0755.0RepeatNote=7
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122685_68711.0755.0RepeatNote=8
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122690_69211.0755.0RepeatNote=9
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122709_71111.0755.0RepeatNote=10
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122728_73011.0755.0RepeatNote=11
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122754_75611.0755.0RepeatNote=12
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122806_80811.0755.0RepeatNote=13
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122812_81411.0755.0RepeatNote=14
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-122833_83511.0755.0RepeatNote=15
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116618_62011.0602.0RepeatNote=1
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116640_64211.0602.0RepeatNote=2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116645_64711.0602.0RepeatNote=3
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116650_65211.0602.0RepeatNote=4
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116656_65811.0602.0RepeatNote=5
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116661_66311.0602.0RepeatNote=6
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116667_66911.0602.0RepeatNote=7
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116685_68711.0602.0RepeatNote=8
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116690_69211.0602.0RepeatNote=9
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116709_71111.0602.0RepeatNote=10
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116728_73011.0602.0RepeatNote=11
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116754_75611.0602.0RepeatNote=12
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116806_80811.0602.0RepeatNote=13
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116812_81411.0602.0RepeatNote=14
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-116833_83511.0602.0RepeatNote=15
TgeneCPAMD8chr19:16582723chr19:17049256ENST000004432362142668_671978.01933.0Compositional biasNote=Poly-Arg
TgeneCPAMD8chr19:16582724chr19:17049256ENST000004432362142668_671978.01933.0Compositional biasNote=Poly-Arg


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1792_EPS15L1_16582724_CPAMD8_17049256_ranked_0.pdbEPS15L11658272316582724ENST00000443236CPAMD8chr1917049256-
MRGPVYGPALSRDRRPAHRPPVVPVRTRGCSPAPVPPALGARVRGKMAAPLIPLSQQAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYV
QRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPE
PSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGC
GEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELA
AAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLR
SPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFS
STQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKP
AFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLL
DKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAP
ARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDL
ASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVY
1011


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EPS15L1_pLDDT.png
all structure
all structure
CPAMD8_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EPS15L1
CPAMD8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000248070-12315_36811.0865.0DAB2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000455140-12415_36811.0911.0DAB2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000535753-12215_36811.0755.0DAB2
HgeneEPS15L1chr19:16582723chr19:17049256ENST00000597937-11615_36811.0602.0DAB2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000248070-12315_36811.0865.0DAB2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000455140-12415_36811.0911.0DAB2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000535753-12215_36811.0755.0DAB2
HgeneEPS15L1chr19:16582724chr19:17049256ENST00000597937-11615_36811.0602.0DAB2


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Related Drugs to EPS15L1-CPAMD8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EPS15L1-CPAMD8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource