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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERBB2-CDK12

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERBB2-CDK12
FusionPDB ID: 27142
FusionGDB2.0 ID: 27142
HgeneTgene
Gene symbol

ERBB2

CDK12

Gene ID

2064

51755

Gene nameerb-b2 receptor tyrosine kinase 2cyclin dependent kinase 12
SynonymsCD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1CRK7|CRKR|CRKRS
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2020032920200313
UniProtAcc

P04626

Q9NYV4

Ensembl transtripts involved in fusion geneENST idsENST00000269571, ENST00000406381, 
ENST00000445658, ENST00000540042, 
ENST00000540147, ENST00000541774, 
ENST00000578199, ENST00000584450, 
ENST00000584601, ENST00000584888, 
ENST00000559545, ENST00000430627, 
ENST00000447079, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score50 X 44 X 14=3080036 X 30 X 14=15120
# samples 7355
** MAII scorelog2(73/30800*10)=-5.39889007670225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/15120*10)=-4.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERBB2 [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases (pmid: 29996110)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERBB2(37868701)-CDK12(37680927), # samples:2
CDK12(37657692)-ERBB2(37851240), # samples:1
CDK12(37657692)-ERBB2(37851241), # samples:1
Anticipated loss of major functional domain due to fusion event.ERBB2-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERBB2-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERBB2-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERBB2-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB2

GO:0007165

signal transduction

10572067

HgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

HgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

HgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

HgeneERBB2

GO:0018108

peptidyl-tyrosine phosphorylation

12000754

HgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

HgeneERBB2

GO:0035556

intracellular signal transduction

19372587

HgeneERBB2

GO:0042060

wound healing

12646923

HgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

HgeneERBB2

GO:0046777

protein autophosphorylation

7556068

HgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

HgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870

TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDK12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A204-01AERBB2chr17

37868701

-CDK12chr17

37680927

+
ChimerDB4BRCATCGA-BH-A204-01AERBB2chr17

37868701

+CDK12chr17

37680927

+
ChimerDB4BRCATCGA-BH-A204ERBB2chr17

37868701

+CDK12chr17

37680926

+
ChimerDB4BRCATCGA-E2-A1LE-01AERBB2chr17

37866734

+CDK12chr17

37712539

+
ChimerDB4STADTCGA-BR-8289-01AERBB2chr17

37886762

+CDK12chr17

37667831

+
ChimerDB4UCECTCGA-EO-A2CG-01AERBB2chr17

37873733

+CDK12chr17

37721013

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000584601ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+436718557523205817
ENST00000584601ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+706318557523232826
ENST00000406381ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+408015685102918802
ENST00000406381ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+677615685102945811
ENST00000541774ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+3615110302453817
ENST00000541774ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+6311110302480826
ENST00000445658ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+3095583501933627
ENST00000445658ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+5791583501960636
ENST00000540147ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+38981386252736903
ENST00000540147ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+65941386252763912
ENST00000584450ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+3875136322713903
ENST00000584450ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+6571136322740912
ENST00000269571ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+38191307572657866
ENST00000269571ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+65151307572684875
ENST00000578199ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+411115995412949802
ENST00000578199ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+680715995412976811
ENST00000540042ERBB2chr1737868701+ENST00000430627CDK12chr1737680926+373612241662574802
ENST00000540042ERBB2chr1737868701+ENST00000447079CDK12chr1737680926+643212241662601811
ENST00000584601ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+436718557523205817
ENST00000584601ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+706318557523232826
ENST00000406381ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+408015685102918802
ENST00000406381ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+677615685102945811
ENST00000541774ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+3615110302453817
ENST00000541774ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+6311110302480826
ENST00000445658ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+3095583501933627
ENST00000445658ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+5791583501960636
ENST00000540147ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+38981386252736903
ENST00000540147ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+65941386252763912
ENST00000584450ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+3875136322713903
ENST00000584450ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+6571136322740912
ENST00000269571ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+38191307572657866
ENST00000269571ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+65151307572684875
ENST00000578199ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+411115995412949802
ENST00000578199ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+680715995412976811
ENST00000540042ERBB2chr1737868701+ENST00000430627CDK12chr1737680927+373612241662574802
ENST00000540042ERBB2chr1737868701+ENST00000447079CDK12chr1737680927+643212241662601811

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000584601ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0067058230.99329424
ENST00000584601ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0012931160.99870694
ENST00000406381ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0060656350.99393433
ENST00000406381ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0006674660.9993325
ENST00000541774ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0075486480.99245137
ENST00000541774ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0012131670.99878687
ENST00000445658ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0096121490.99038786
ENST00000445658ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0005799460.99942005
ENST00000540147ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0090884720.99091154
ENST00000540147ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0014091220.9985909
ENST00000584450ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0092315570.9907685
ENST00000584450ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0014158980.99858415
ENST00000269571ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0091416570.9908584
ENST00000269571ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0014107080.9985892
ENST00000578199ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0053414820.9946585
ENST00000578199ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0006099030.9993901
ENST00000540042ENST00000430627ERBB2chr1737868701+CDK12chr1737680926+0.0060510690.99394894
ENST00000540042ENST00000447079ERBB2chr1737868701+CDK12chr1737680926+0.0005800310.99942005
ENST00000584601ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0067058230.99329424
ENST00000584601ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0012931160.99870694
ENST00000406381ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0060656350.99393433
ENST00000406381ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0006674660.9993325
ENST00000541774ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0075486480.99245137
ENST00000541774ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0012131670.99878687
ENST00000445658ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0096121490.99038786
ENST00000445658ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0005799460.99942005
ENST00000540147ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0090884720.99091154
ENST00000540147ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0014091220.9985909
ENST00000584450ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0092315570.9907685
ENST00000584450ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0014158980.99858415
ENST00000269571ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0091416570.9908584
ENST00000269571ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0014107080.9985892
ENST00000578199ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0053414820.9946585
ENST00000578199ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0006099030.9993901
ENST00000540042ENST00000430627ERBB2chr1737868701+CDK12chr1737680927+0.0060510690.99394894
ENST00000540042ENST00000447079ERBB2chr1737868701+CDK12chr1737680927+0.0005800310.99942005

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27142_27142_1_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000269571_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=866AA_BP=413
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKT
SRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQ
SISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTP
TMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGP
ETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAE

--------------------------------------------------------------

>27142_27142_2_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000269571_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=875AA_BP=413
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKT
SRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQ
SISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTP
TMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPN
RTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEG

--------------------------------------------------------------

>27142_27142_3_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000269571_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=866AA_BP=413
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKT
SRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQ
SISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTP
TMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGP
ETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAE

--------------------------------------------------------------

>27142_27142_4_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000269571_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=875AA_BP=413
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKT
SRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQ
SISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTP
TMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPN
RTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEG

--------------------------------------------------------------

>27142_27142_5_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000406381_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=802AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPH
EHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARV

--------------------------------------------------------------

>27142_27142_6_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000406381_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=811AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPE
AEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPG
DQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVP

--------------------------------------------------------------

>27142_27142_7_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000406381_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=802AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPH
EHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARV

--------------------------------------------------------------

>27142_27142_8_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000406381_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=811AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPE
AEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPG
DQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVP

--------------------------------------------------------------

>27142_27142_9_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000445658_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=627AA_BP=174
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLP
HWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQ
SQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLL
SQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPP
GHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDL

--------------------------------------------------------------

>27142_27142_10_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000445658_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=636AA_BP=174
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLP
HWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQ
SQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLL
SQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQL
LSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGS
VQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGR

--------------------------------------------------------------

>27142_27142_11_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000445658_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=627AA_BP=174
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLP
HWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQ
SQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLL
SQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPP
GHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDL

--------------------------------------------------------------

>27142_27142_12_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000445658_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=636AA_BP=174
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLP
HWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQ
SQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLL
SQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQL
LSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGS
VQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGR

--------------------------------------------------------------

>27142_27142_13_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540042_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=802AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPH
EHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARV

--------------------------------------------------------------

>27142_27142_14_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540042_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=811AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPE
AEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPG
DQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVP

--------------------------------------------------------------

>27142_27142_15_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540042_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=802AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPH
EHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARV

--------------------------------------------------------------

>27142_27142_16_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540042_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=811AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPE
AEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPG
DQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVP

--------------------------------------------------------------

>27142_27142_17_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540147_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=903AA_BP=450
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQ
PEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQF
PGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRG

--------------------------------------------------------------

>27142_27142_18_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540147_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=912AA_BP=450
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVT
AALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSS
YQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRV

--------------------------------------------------------------

>27142_27142_19_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540147_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=903AA_BP=450
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQ
PEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQF
PGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRG

--------------------------------------------------------------

>27142_27142_20_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000540147_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=912AA_BP=450
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVT
AALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSS
YQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRV

--------------------------------------------------------------

>27142_27142_21_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000541774_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=817AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQ
LLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTG
SVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGG

--------------------------------------------------------------

>27142_27142_22_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000541774_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=826AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELN
PAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLG
ESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRG

--------------------------------------------------------------

>27142_27142_23_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000541774_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=817AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQ
LLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTG
SVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGG

--------------------------------------------------------------

>27142_27142_24_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000541774_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=826AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELN
PAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLG
ESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRG

--------------------------------------------------------------

>27142_27142_25_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000578199_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=802AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPH
EHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARV

--------------------------------------------------------------

>27142_27142_26_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000578199_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=811AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPE
AEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPG
DQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVP

--------------------------------------------------------------

>27142_27142_27_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000578199_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=802AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPH
EHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARV

--------------------------------------------------------------

>27142_27142_28_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000578199_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=811AA_BP=349
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPE
AEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPG
DQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVP

--------------------------------------------------------------

>27142_27142_29_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584450_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=903AA_BP=450
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQ
PEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQF
PGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRG

--------------------------------------------------------------

>27142_27142_30_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584450_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=912AA_BP=450
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVT
AALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSS
YQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRV

--------------------------------------------------------------

>27142_27142_31_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584450_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=903AA_BP=450
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQ
PEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQF
PGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRG

--------------------------------------------------------------

>27142_27142_32_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584450_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=912AA_BP=450
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAV
LLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQN
ILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVT
AALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSS
YQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRV

--------------------------------------------------------------

>27142_27142_33_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584601_CDK12_chr17_37680926_ENST00000430627_length(amino acids)=817AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQ
LLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTG
SVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGG

--------------------------------------------------------------

>27142_27142_34_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584601_CDK12_chr17_37680926_ENST00000447079_length(amino acids)=826AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELN
PAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLG
ESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRG

--------------------------------------------------------------

>27142_27142_35_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584601_CDK12_chr17_37680927_ENST00000430627_length(amino acids)=817AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQ
LLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTG
SVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGG

--------------------------------------------------------------

>27142_27142_36_ERBB2-CDK12_ERBB2_chr17_37868701_ENST00000584601_CDK12_chr17_37680927_ENST00000447079_length(amino acids)=826AA_BP=364
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQS
ELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELN
PAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLG
ESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37868701/chr17:37680927)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB2

P04626

CDK12

Q9NYV4

FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDK12chr17:37868701chr17:37680926ENST0000043062710141266_12801031.66666666666671482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:37868701chr17:37680926ENST0000044707910141266_12801031.66666666666671491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:37868701chr17:37680927ENST0000043062710141266_12801031.66666666666671482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:37868701chr17:37680927ENST0000044707910141266_12801031.66666666666671491.0Compositional biasNote=Poly-Pro

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB2chr17:37868701chr17:37680926ENST00000269571+927720_987382.66666666666671256.0DomainProtein kinase
HgeneERBB2chr17:37868701chr17:37680926ENST00000541774+927720_987367.66666666666671241.0DomainProtein kinase
HgeneERBB2chr17:37868701chr17:37680927ENST00000269571+927720_987382.66666666666671256.0DomainProtein kinase
HgeneERBB2chr17:37868701chr17:37680927ENST00000541774+927720_987367.66666666666671241.0DomainProtein kinase
HgeneERBB2chr17:37868701chr17:37680926ENST00000269571+927676_689382.66666666666671256.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37868701chr17:37680926ENST00000541774+927676_689367.66666666666671241.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37868701chr17:37680927ENST00000269571+927676_689382.66666666666671256.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37868701chr17:37680927ENST00000541774+927676_689367.66666666666671241.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37868701chr17:37680926ENST00000269571+927726_734382.66666666666671256.0Nucleotide bindingATP
HgeneERBB2chr17:37868701chr17:37680926ENST00000541774+927726_734367.66666666666671241.0Nucleotide bindingATP
HgeneERBB2chr17:37868701chr17:37680927ENST00000269571+927726_734382.66666666666671256.0Nucleotide bindingATP
HgeneERBB2chr17:37868701chr17:37680927ENST00000541774+927726_734367.66666666666671241.0Nucleotide bindingATP
HgeneERBB2chr17:37868701chr17:37680926ENST00000269571+92723_652382.66666666666671256.0Topological domainExtracellular
HgeneERBB2chr17:37868701chr17:37680926ENST00000269571+927676_1255382.66666666666671256.0Topological domainCytoplasmic
HgeneERBB2chr17:37868701chr17:37680926ENST00000541774+92723_652367.66666666666671241.0Topological domainExtracellular
HgeneERBB2chr17:37868701chr17:37680926ENST00000541774+927676_1255367.66666666666671241.0Topological domainCytoplasmic
HgeneERBB2chr17:37868701chr17:37680927ENST00000269571+92723_652382.66666666666671256.0Topological domainExtracellular
HgeneERBB2chr17:37868701chr17:37680927ENST00000269571+927676_1255382.66666666666671256.0Topological domainCytoplasmic
HgeneERBB2chr17:37868701chr17:37680927ENST00000541774+92723_652367.66666666666671241.0Topological domainExtracellular
HgeneERBB2chr17:37868701chr17:37680927ENST00000541774+927676_1255367.66666666666671241.0Topological domainCytoplasmic
HgeneERBB2chr17:37868701chr17:37680926ENST00000269571+927653_675382.66666666666671256.0TransmembraneHelical
HgeneERBB2chr17:37868701chr17:37680926ENST00000541774+927653_675367.66666666666671241.0TransmembraneHelical
HgeneERBB2chr17:37868701chr17:37680927ENST00000269571+927653_675382.66666666666671256.0TransmembraneHelical
HgeneERBB2chr17:37868701chr17:37680927ENST00000541774+927653_675367.66666666666671241.0TransmembraneHelical
TgeneCDK12chr17:37868701chr17:37680926ENST000004306271014407_4131031.66666666666671482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:37868701chr17:37680926ENST000004306271014535_5401031.66666666666671482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:37868701chr17:37680926ENST000004470791014407_4131031.66666666666671491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:37868701chr17:37680926ENST000004470791014535_5401031.66666666666671491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:37868701chr17:37680927ENST000004306271014407_4131031.66666666666671482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:37868701chr17:37680927ENST000004306271014535_5401031.66666666666671482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:37868701chr17:37680927ENST000004470791014407_4131031.66666666666671491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:37868701chr17:37680927ENST000004470791014535_5401031.66666666666671491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:37868701chr17:37680926ENST000004306271014727_10201031.66666666666671482.0DomainProtein kinase
TgeneCDK12chr17:37868701chr17:37680926ENST000004470791014727_10201031.66666666666671491.0DomainProtein kinase
TgeneCDK12chr17:37868701chr17:37680927ENST000004306271014727_10201031.66666666666671482.0DomainProtein kinase
TgeneCDK12chr17:37868701chr17:37680927ENST000004470791014727_10201031.66666666666671491.0DomainProtein kinase
TgeneCDK12chr17:37868701chr17:37680926ENST000004306271014733_7411031.66666666666671482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:37868701chr17:37680926ENST000004306271014814_8191031.66666666666671482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:37868701chr17:37680926ENST000004470791014733_7411031.66666666666671491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:37868701chr17:37680926ENST000004470791014814_8191031.66666666666671491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:37868701chr17:37680927ENST000004306271014733_7411031.66666666666671482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:37868701chr17:37680927ENST000004306271014814_8191031.66666666666671482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:37868701chr17:37680927ENST000004470791014733_7411031.66666666666671491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:37868701chr17:37680927ENST000004470791014814_8191031.66666666666671491.0Nucleotide bindingNote=ATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERBB2
CDK12


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneERBB2chr17:37868701chr17:37680926ENST00000269571+9271195_1197382.66666666666671256.0PIK3C2B
HgeneERBB2chr17:37868701chr17:37680926ENST00000541774+9271195_1197367.66666666666671241.0PIK3C2B
HgeneERBB2chr17:37868701chr17:37680927ENST00000269571+9271195_1197382.66666666666671256.0PIK3C2B
HgeneERBB2chr17:37868701chr17:37680927ENST00000541774+9271195_1197367.66666666666671241.0PIK3C2B


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Related Drugs to ERBB2-CDK12


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERBB2-CDK12


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource