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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERBB2-CNIH4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERBB2-CNIH4
	FusionPDB ID: 27144
	FusionGDB2.0 ID: 27144
		Hgene	Tgene
	Gene symbol	ERBB2	CNIH4
	Gene ID	2064	29097
	Gene name	erb-b2 receptor tyrosine kinase 2	cornichon family AMPA receptor auxiliary protein 4
	Synonyms	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1	CNIH-4\|CNIH2\|HSPC163
	Cytomap	17q12	1q42.11
	Type of gene	protein-coding	protein-coding
	Description	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2	protein cornichon homolog 4cornichon homolog 4
	Modification date	20200329	20200313
	UniProtAcc	P04626	Q9P003
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269571, ENST00000406381, ENST00000540042, ENST00000540147, ENST00000541774, ENST00000578199, ENST00000584450, ENST00000584601, ENST00000445658, ENST00000584888,	ENST00000366856, ENST00000468318, ENST00000366857, ENST00000366858, ENST00000465271,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	50 X 44 X 14=30800	10 X 7 X 8=560
	# samples	73	13
	** MAII score	log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/560*10)=-2.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERBB2 [Title/Abstract] AND CNIH4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2(37866734)-CNIH4(224553581), # samples:2
Anticipated loss of major functional domain due to fusion event.	ERBB2-CNIH4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-CNIH4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-CNIH4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERBB2-CNIH4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ERBB2-CNIH4 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ERBB2-CNIH4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERBB2	GO:0007165	signal transduction	10572067
Hgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Hgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Hgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Hgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Hgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Hgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Hgene	ERBB2	GO:0042060	wound healing	12646923
Hgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Hgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Hgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Hgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Fusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CNIH4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-D1-A3JP-01A	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+
ChimerDB4	UCEC	TCGA-D1-A3JP-01A	ERBB2	chr17	37866134	+	CNIH4	chr1	224553581	+
ChimerDB4	UCEC	TCGA-D1-A3JP-01A	ERBB2	chr17	37866734	+	CNIH4	chr1	224553581	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000584601	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4844	932	752	1213	153
ENST00000584601	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	1429	932	703	1050	115
ENST00000584601	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	4703	932	703	1068	121
ENST00000406381	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4557	645	510	926	138
ENST00000406381	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	1142	645	467	763	98
ENST00000406381	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	4416	645	467	781	104
ENST00000541774	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4092	180	0	461	153
ENST00000541774	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	677	180	0	314	104
ENST00000541774	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	3951	180	0	320	106
ENST00000540147	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4375	463	25	744	239
ENST00000540147	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	960	463	25	597	190
ENST00000540147	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	4234	463	25	603	192
ENST00000584450	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4352	440	2	721	239
ENST00000584450	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	937	440	2	574	190
ENST00000584450	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	4211	440	2	580	192
ENST00000269571	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4296	384	57	665	202
ENST00000269571	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	881	384	57	518	153
ENST00000269571	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	4155	384	57	524	155
ENST00000578199	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4588	676	541	957	138
ENST00000578199	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	1173	676	498	794	98
ENST00000578199	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	4447	676	498	812	104
ENST00000540042	ERBB2	chr17	37863394	+	ENST00000465271	CNIH4	chr1	224553581	+	4213	301	166	582	138
ENST00000540042	ERBB2	chr17	37863394	+	ENST00000366858	CNIH4	chr1	224553581	+	798	301	144	419	91
ENST00000540042	ERBB2	chr17	37863394	+	ENST00000366857	CNIH4	chr1	224553581	+	4072	301	144	437	97

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000584601	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.057834342	0.9421657
ENST00000584601	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.13345093	0.866549
ENST00000584601	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.26847076	0.73152924
ENST00000406381	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.060717426	0.9392826
ENST00000406381	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.17339388	0.8266061
ENST00000406381	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.28449595	0.71550405
ENST00000541774	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.05642887	0.94357115
ENST00000541774	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.12919718	0.8708028
ENST00000541774	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.27613685	0.7238631
ENST00000540147	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.018296866	0.9817031
ENST00000540147	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.15582278	0.84417725
ENST00000540147	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.094604954	0.90539503
ENST00000584450	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.018018335	0.9819817
ENST00000584450	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.13191701	0.868083
ENST00000584450	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.09332618	0.90667385
ENST00000269571	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.017273726	0.9827262
ENST00000269571	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.08023406	0.9197659
ENST00000269571	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.09075072	0.90924925
ENST00000578199	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.060766924	0.93923306
ENST00000578199	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.28703627	0.71296376
ENST00000578199	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.29321608	0.70678395
ENST00000540042	ENST00000465271	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.064463556	0.93553644
ENST00000540042	ENST00000366858	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.22571121	0.77428883
ENST00000540042	ENST00000366857	ERBB2	chr17	37863394	+	CNIH4	chr1	224553581	+	0.32422227	0.67577773

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27144_27144_1_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000269571_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=155AA_BP=107
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV

--------------------------------------------------------------

>27144_27144_2_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000269571_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=153AA_BP=107
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV

--------------------------------------------------------------

>27144_27144_3_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000269571_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=202AA_BP=107
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIK

--------------------------------------------------------------

>27144_27144_4_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000406381_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=104AA_BP=58
MLWTCTKVSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHCITAHVIALVHLPSQLTC

--------------------------------------------------------------

>27144_27144_5_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000406381_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=98AA_BP=58
MLWTCTKVSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHCITAHVIALVHLPSQLTC

--------------------------------------------------------------

>27144_27144_6_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000406381_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=138AA_BP=43
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSG

--------------------------------------------------------------

>27144_27144_7_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000540042_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=97AA_BP=51
MSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHCITAHVIALVHLPSQLTCCHLEYIS

--------------------------------------------------------------

>27144_27144_8_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000540042_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=91AA_BP=51
MSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHCITAHVIALVHLPSQLTCCHLEYIS

--------------------------------------------------------------

>27144_27144_9_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000540042_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=138AA_BP=43
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSG

--------------------------------------------------------------

>27144_27144_10_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000540147_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=192AA_BP=144
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATW

--------------------------------------------------------------

>27144_27144_11_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000540147_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=190AA_BP=144
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATW

--------------------------------------------------------------

>27144_27144_12_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000540147_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=239AA_BP=144
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATW

--------------------------------------------------------------

>27144_27144_13_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000541774_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=106AA_BP=58
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLP

--------------------------------------------------------------

>27144_27144_14_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000541774_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=104AA_BP=58
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLP

--------------------------------------------------------------

>27144_27144_15_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000541774_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=153AA_BP=58
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLP

--------------------------------------------------------------

>27144_27144_16_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000578199_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=104AA_BP=58
MLWTCTKVSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHCITAHVIALVHLPSQLTC

--------------------------------------------------------------

>27144_27144_17_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000578199_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=98AA_BP=58
MLWTCTKVSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHCITAHVIALVHLPSQLTC

--------------------------------------------------------------

>27144_27144_18_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000578199_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=138AA_BP=43
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATWNIYRYIMVPSG

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>27144_27144_19_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000584450_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=192AA_BP=144
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATW

--------------------------------------------------------------

>27144_27144_20_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000584450_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=190AA_BP=144
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATW

--------------------------------------------------------------

>27144_27144_21_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000584450_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=239AA_BP=144
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLPVATW

--------------------------------------------------------------

>27144_27144_22_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000584601_CNIH4_chr1_224553581_ENST00000366857_length(amino acids)=121AA_BP=75
MLWTCTKVRYFKDSRRYAPGVLEATSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHC

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>27144_27144_23_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000584601_CNIH4_chr1_224553581_ENST00000366858_length(amino acids)=115AA_BP=75
MLWTCTKVRYFKDSRRYAPGVLEATSVHRHRHEAAAPCQSRDPPGHAPPPLPGLPGGAGKPGTHLPAHQCQPVLPAVGNSRIDWPYHCHC

--------------------------------------------------------------

>27144_27144_24_ERBB2-CNIH4_ERBB2_chr17_37863394_ENST00000584601_CNIH4_chr1_224553581_ENST00000465271_length(amino acids)=153AA_BP=58
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQWVIPELIGHTIVTVLLLMSLHWFIFLLNLP

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37866734/chr1:224553581)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2 P04626	CNIH4 Q9P003
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.	FUNCTION: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750). {ECO:0000269\|PubMed:24405750}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CNIH4

chr17:37863394

chr1:224553581

ENST00000366857

118_138

46.0

93.0

Transmembrane

Helical

Tgene

CNIH4

chr17:37863394

chr1:224553581

ENST00000366857

57_77

46.0

93.0

Transmembrane

Helical

Tgene

CNIH4

chr17:37863394

chr1:224553581

ENST00000465271

118_138

46.0

140.0

Transmembrane

Helical

Tgene

CNIH4

chr17:37863394

chr1:224553581

ENST00000465271

57_77

46.0

140.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000269571

720_987

75.0

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000541774

720_987

60.0

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000269571

676_689

75.0

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000541774

676_689

60.0

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000269571

726_734

75.0

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000541774

726_734

60.0

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000269571

23_652

75.0

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000269571

676_1255

75.0

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000541774

23_652

60.0

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000541774

676_1255

60.0

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000269571

653_675

75.0

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37863394

chr1:224553581

ENST00000541774

653_675

60.0

1241.0

Transmembrane

Helical

Tgene

CNIH4

chr17:37863394

chr1:224553581

ENST00000366857

5_25

46.0

93.0

Transmembrane

Helical

Tgene

CNIH4

chr17:37863394

chr1:224553581

ENST00000465271

5_25

46.0

140.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERBB2
CNIH4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ERBB2	chr17:37863394	chr1:224553581	ENST00000269571	+	2	27	1195_1197	75.0	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37863394	chr1:224553581	ENST00000541774	+	2	27	1195_1197	60.0	1241.0	PIK3C2B

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Related Drugs to ERBB2-CNIH4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ERBB2-CNIH4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source