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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERBB2-GUK1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERBB2-GUK1
	FusionPDB ID: 27149
	FusionGDB2.0 ID: 27149
		Hgene	Tgene
	Gene symbol	ERBB2	GUK1
	Gene ID	2064	2987
	Gene name	erb-b2 receptor tyrosine kinase 2	guanylate kinase 1
	Synonyms	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1	GMK
	Cytomap	17q12	1q42.13
	Type of gene	protein-coding	protein-coding
	Description	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2	guanylate kinaseATP:GMP phosphotransferaseGMP kinase
	Modification date	20200329	20200320
	UniProtAcc	P04626	Q16774
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269571, ENST00000406381, ENST00000445658, ENST00000540042, ENST00000540147, ENST00000541774, ENST00000578199, ENST00000584450, ENST00000584601, ENST00000584888,	ENST00000366716, ENST00000470040, ENST00000366721, ENST00000312726, ENST00000366718, ENST00000366722, ENST00000366723, ENST00000366726, ENST00000366728, ENST00000366730, ENST00000391865,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	50 X 44 X 14=30800	9 X 8 X 3=216
	# samples	73	10
	** MAII score	log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/216*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERBB2 [Title/Abstract] AND GUK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2(37872192)-GUK1(228333727), # samples:1
Anticipated loss of major functional domain due to fusion event.	ERBB2-GUK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-GUK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-GUK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERBB2-GUK1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ERBB2-GUK1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ERBB2-GUK1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ERBB2-GUK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERBB2	GO:0007165	signal transduction	10572067
Hgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Hgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Hgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Hgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Hgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Hgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Hgene	ERBB2	GO:0042060	wound healing	12646923
Hgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Hgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Hgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Hgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870
Tgene	GUK1	GO:0006163	purine nucleotide metabolic process	8663313
Tgene	GUK1	GO:0006805	xenobiotic metabolic process	6306664

Fusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GUK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-FP-8210-01A	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2845	2220	752	2701	649
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2960	2220	752	2701	649
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2885	2220	752	2701	649
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2951	2220	752	2701	649
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2874	2220	752	2770	672
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2888	2220	752	2701	649
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2890	2220	752	2836	694
ENST00000584601	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2956	2220	752	2701	649
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2558	1933	510	2414	634
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2673	1933	510	2414	634
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2598	1933	510	2414	634
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2664	1933	510	2414	634
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2587	1933	510	2483	657
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2601	1933	510	2414	634
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2603	1933	510	2549	679
ENST00000406381	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2669	1933	510	2414	634
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2093	1468	0	1949	649
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2208	1468	0	1949	649
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2133	1468	0	1949	649
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2199	1468	0	1949	649
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2122	1468	0	2018	672
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2136	1468	0	1949	649
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2138	1468	0	2084	694
ENST00000541774	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2204	1468	0	1949	649
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	1573	948	50	1429	459
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	1688	948	50	1429	459
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	1613	948	50	1429	459
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	1679	948	50	1429	459
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	1602	948	50	1498	482
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	1616	948	50	1429	459
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	1618	948	50	1564	504
ENST00000445658	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	1684	948	50	1429	459
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2376	1751	25	2232	735
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2491	1751	25	2232	735
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2416	1751	25	2232	735
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2482	1751	25	2232	735
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2405	1751	25	2301	758
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2419	1751	25	2232	735
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2421	1751	25	2367	780
ENST00000540147	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2487	1751	25	2232	735
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2353	1728	2	2209	735
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2468	1728	2	2209	735
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2393	1728	2	2209	735
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2459	1728	2	2209	735
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2382	1728	2	2278	758
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2396	1728	2	2209	735
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2398	1728	2	2344	780
ENST00000584450	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2464	1728	2	2209	735
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2297	1672	57	2153	698
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2412	1672	57	2153	698
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2337	1672	57	2153	698
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2403	1672	57	2153	698
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2326	1672	57	2222	721
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2340	1672	57	2153	698
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2342	1672	57	2288	743
ENST00000269571	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2408	1672	57	2153	698
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2589	1964	541	2445	634
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2704	1964	541	2445	634
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2629	1964	541	2445	634
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2695	1964	541	2445	634
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2618	1964	541	2514	657
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2632	1964	541	2445	634
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2634	1964	541	2580	679
ENST00000578199	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2700	1964	541	2445	634
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000366730	GUK1	chr1	228333727	+	2214	1589	166	2070	634
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000391865	GUK1	chr1	228333727	+	2329	1589	166	2070	634
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000366726	GUK1	chr1	228333727	+	2254	1589	166	2070	634
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000312726	GUK1	chr1	228333727	+	2320	1589	166	2070	634
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000366728	GUK1	chr1	228333727	+	2243	1589	166	2139	657
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000366723	GUK1	chr1	228333727	+	2257	1589	166	2070	634
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000366722	GUK1	chr1	228333727	+	2259	1589	166	2205	679
ENST00000540042	ERBB2	chr17	37872192	+	ENST00000366718	GUK1	chr1	228333727	+	2325	1589	166	2070	634

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000584601	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.030775877	0.96922415
ENST00000584601	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.025388485	0.9746115
ENST00000584601	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.02944107	0.97055894
ENST00000584601	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.025650535	0.97434944
ENST00000584601	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.039184414	0.9608156
ENST00000584601	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.049394764	0.9506052
ENST00000584601	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.034520615	0.9654794
ENST00000584601	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.025984641	0.97401536
ENST00000406381	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.023107167	0.9768928
ENST00000406381	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.019173771	0.98082626
ENST00000406381	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.022329379	0.97767067
ENST00000406381	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.019334009	0.980666
ENST00000406381	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.036578868	0.9634211
ENST00000406381	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.04305613	0.95694387
ENST00000406381	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.03139652	0.9686035
ENST00000406381	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.01969098	0.980309
ENST00000541774	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.045829844	0.95417017
ENST00000541774	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.037691712	0.9623083
ENST00000541774	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.044600073	0.95539993
ENST00000541774	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.038056772	0.96194327
ENST00000541774	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.059050698	0.94094926
ENST00000541774	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.07180451	0.92819554
ENST00000541774	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.050787296	0.9492127
ENST00000541774	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.038725153	0.9612748
ENST00000445658	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.011065762	0.9889342
ENST00000445658	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.01288497	0.987115
ENST00000445658	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.012327105	0.98767287
ENST00000445658	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.012935418	0.9870646
ENST00000445658	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.08365359	0.91634643
ENST00000445658	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.050714754	0.94928527
ENST00000445658	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.037346758	0.9626533
ENST00000445658	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.012953916	0.9870461
ENST00000540147	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.048206355	0.9517937
ENST00000540147	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.03888535	0.9611147
ENST00000540147	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.045605842	0.9543941
ENST00000540147	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.03929395	0.9607061
ENST00000540147	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.057920367	0.94207966
ENST00000540147	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.07169287	0.9283071
ENST00000540147	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.05016497	0.94983506
ENST00000540147	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.03986113	0.9601389
ENST00000584450	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.050289407	0.94971055
ENST00000584450	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.041087683	0.9589123
ENST00000584450	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.047879677	0.95212024
ENST00000584450	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.04144543	0.95855457
ENST00000584450	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.061263394	0.9387367
ENST00000584450	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.07509346	0.9249065
ENST00000584450	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.052941665	0.9470583
ENST00000584450	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.041953556	0.9580465
ENST00000269571	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.051069632	0.9489304
ENST00000269571	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.041884247	0.95811576
ENST00000269571	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.048835427	0.9511646
ENST00000269571	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.042296167	0.95770377
ENST00000269571	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.06268423	0.9373158
ENST00000269571	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.07688639	0.9231136
ENST00000269571	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.05446967	0.94553035
ENST00000269571	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.042747717	0.9572523
ENST00000578199	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.019045908	0.98095405
ENST00000578199	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.015936805	0.98406315
ENST00000578199	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.018374188	0.9816258
ENST00000578199	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.016059643	0.98394036
ENST00000578199	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.030464513	0.96953547
ENST00000578199	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.036325186	0.9636748
ENST00000578199	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.026316458	0.97368354
ENST00000578199	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.016385349	0.9836146
ENST00000540042	ENST00000366730	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.026399145	0.9736008
ENST00000540042	ENST00000391865	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.020295363	0.9797046
ENST00000540042	ENST00000366726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.024630453	0.9753695
ENST00000540042	ENST00000312726	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.020556102	0.9794439
ENST00000540042	ENST00000366728	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.039557807	0.96044225
ENST00000540042	ENST00000366723	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.047657426	0.9523426
ENST00000540042	ENST00000366722	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.034621928	0.96537805
ENST00000540042	ENST00000366718	ERBB2	chr17	37872192	+	GUK1	chr1	228333727	+	0.020936688	0.97906333

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27149_27149_1_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=698AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV

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>27149_27149_2_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=698AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV

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>27149_27149_3_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=743AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV
LRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEVGPSLCLPGQGPRGGLGARPLLSMRPLRKSRKLK

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>27149_27149_4_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=698AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV

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>27149_27149_5_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=698AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV

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>27149_27149_6_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=721AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV
LEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPGPIQDQGSSIEPPPWQAIRQLCALGQHVEWRRCCPCGWNIL

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>27149_27149_7_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=698AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV

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>27149_27149_8_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000269571_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=698AA_BP=538
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDT
TRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHV

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>27149_27149_9_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

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>27149_27149_10_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

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>27149_27149_11_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=679AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEVGPSLCLP

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>27149_27149_12_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQSPACLMWSSLTTAWTR

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>27149_27149_13_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_14_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=657AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPGPIQDQGSSIEPPPW

--------------------------------------------------------------

>27149_27149_15_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_16_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000406381_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_17_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=459AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEE

--------------------------------------------------------------

>27149_27149_18_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=459AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEE

--------------------------------------------------------------

>27149_27149_19_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=504AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEVGP

--------------------------------------------------------------

>27149_27149_20_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=459AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQSPACLMWSSLT

--------------------------------------------------------------

>27149_27149_21_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=459AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEE

--------------------------------------------------------------

>27149_27149_22_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=482AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPGPIQDQGSSI

--------------------------------------------------------------

>27149_27149_23_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=459AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEE

--------------------------------------------------------------

>27149_27149_24_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000445658_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=459AA_BP=299
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRIC
VLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEE

--------------------------------------------------------------

>27149_27149_25_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_26_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_27_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=679AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEVGPSLCLP

--------------------------------------------------------------

>27149_27149_28_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQSPACLMWSSLTTAWTR

--------------------------------------------------------------

>27149_27149_29_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_30_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=657AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPGPIQDQGSSIEPPPW

--------------------------------------------------------------

>27149_27149_31_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_32_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540042_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_33_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=735AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_34_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=735AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_35_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=780AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA

--------------------------------------------------------------

>27149_27149_36_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=735AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQSPACL

--------------------------------------------------------------

>27149_27149_37_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=735AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_38_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=758AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPGPIQ

--------------------------------------------------------------

>27149_27149_39_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=735AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_40_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000540147_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=735AA_BP=575
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_41_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_42_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_43_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=694AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE

--------------------------------------------------------------

>27149_27149_44_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQS

--------------------------------------------------------------

>27149_27149_45_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_46_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=672AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHP

--------------------------------------------------------------

>27149_27149_47_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_48_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000541774_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_49_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_50_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_51_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=679AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEVGPSLCLP

--------------------------------------------------------------

>27149_27149_52_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQSPACLMWSSLTTAWTR

--------------------------------------------------------------

>27149_27149_53_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_54_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=657AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPGPIQDQGSSIEPPPW

--------------------------------------------------------------

>27149_27149_55_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_56_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000578199_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=634AA_BP=474
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVD
LQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQ

--------------------------------------------------------------

>27149_27149_57_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=735AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_58_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=735AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_59_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=780AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA

--------------------------------------------------------------

>27149_27149_60_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=735AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQSPACL

--------------------------------------------------------------

>27149_27149_61_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=735AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_62_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=758AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPGPIQ

--------------------------------------------------------------

>27149_27149_63_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=735AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_64_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584450_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=735AA_BP=575
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQ
AMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK

--------------------------------------------------------------

>27149_27149_65_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000312726_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_66_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000366718_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_67_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000366722_length(amino acids)=694AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE

--------------------------------------------------------------

>27149_27149_68_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000366723_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSPAGLESCPTAAVRTAAGQS

--------------------------------------------------------------

>27149_27149_69_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000366726_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_70_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000366728_length(amino acids)=672AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHP

--------------------------------------------------------------

>27149_27149_71_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000366730_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

>27149_27149_72_ERBB2-GUK1_ERBB2_chr17_37872192_ENST00000584601_GUK1_chr1_228333727_ENST00000391865_length(amino acids)=649AA_BP=489
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECDTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV
QAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAY

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37872192/chr1:228333727)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2 P04626	GUK1 Q16774
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.	FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250\|UniProtKB:P46195, ECO:0000269\|PubMed:197968, ECO:0000269\|PubMed:31201273, ECO:0000269\|PubMed:6248551, ECO:0000269\|PubMed:6306664}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000312726

171_172

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000312726

37_51

37.333333333333336

198.0

Nucleotide binding

Substrate binding

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366716

171_172

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366716

37_51

37.333333333333336

198.0

Nucleotide binding

Substrate binding

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366718

171_172

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366718

37_51

37.333333333333336

198.0

Nucleotide binding

Substrate binding

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366726

171_172

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366726

37_51

37.333333333333336

198.0

Nucleotide binding

Substrate binding

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366728

171_172

58.333333333333336

242.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366730

171_172

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366730

37_51

37.333333333333336

198.0

Nucleotide binding

Substrate binding

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000391865

171_172

58.333333333333336

219.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000269571

720_987

504.3333333333333

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000541774

720_987

489.3333333333333

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000269571

676_689

504.3333333333333

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000541774

676_689

489.3333333333333

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000269571

726_734

504.3333333333333

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000541774

726_734

489.3333333333333

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000269571

23_652

504.3333333333333

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000269571

676_1255

504.3333333333333

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000541774

23_652

489.3333333333333

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000541774

676_1255

489.3333333333333

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000269571

653_675

504.3333333333333

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37872192

chr1:228333727

ENST00000541774

653_675

489.3333333333333

1241.0

Transmembrane

Helical

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000312726

4_186

37.333333333333336

198.0

Domain

Guanylate kinase-like

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366716

4_186

37.333333333333336

198.0

Domain

Guanylate kinase-like

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366718

4_186

37.333333333333336

198.0

Domain

Guanylate kinase-like

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366726

4_186

37.333333333333336

198.0

Domain

Guanylate kinase-like

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366728

4_186

58.333333333333336

242.0

Domain

Guanylate kinase-like

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366730

4_186

37.333333333333336

198.0

Domain

Guanylate kinase-like

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000391865

4_186

58.333333333333336

219.0

Domain

Guanylate kinase-like

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000312726

14_19

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366716

14_19

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366718

14_19

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366726

14_19

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366728

14_19

58.333333333333336

242.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366728

37_51

58.333333333333336

242.0

Nucleotide binding

Substrate binding

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000366730

14_19

37.333333333333336

198.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000391865

14_19

58.333333333333336

219.0

Nucleotide binding

ATP

Tgene

GUK1

chr17:37872192

chr1:228333727

ENST00000391865

37_51

58.333333333333336

219.0

Nucleotide binding

Substrate binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERBB2
GUK1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ERBB2	chr17:37872192	chr1:228333727	ENST00000269571	+	12	27	1195_1197	504.3333333333333	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37872192	chr1:228333727	ENST00000541774	+	12	27	1195_1197	489.3333333333333	1241.0	PIK3C2B

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Related Drugs to ERBB2-GUK1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ERBB2-GUK1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source