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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERBB2-NARS2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERBB2-NARS2
	FusionPDB ID: 27176
	FusionGDB2.0 ID: 27176
		Hgene	Tgene
	Gene symbol	ERBB2	NARS2
	Gene ID	2064	79731
	Gene name	erb-b2 receptor tyrosine kinase 2	asparaginyl-tRNA synthetase 2, mitochondrial
	Synonyms	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1	DFNB94\|SLM5\|asnRS
	Cytomap	17q12	11q14.1
	Type of gene	protein-coding	protein-coding
	Description	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2	probable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrial
	Modification date	20200329	20200313
	UniProtAcc	P04626	Q96I59
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269571, ENST00000406381, ENST00000540042, ENST00000540147, ENST00000541774, ENST00000578199, ENST00000584450, ENST00000584601, ENST00000445658, ENST00000584888,	ENST00000528850, ENST00000281038,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	50 X 44 X 14=30800	29 X 15 X 11=4785
	# samples	73	37
	** MAII score	log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(37/4785*10)=-3.69292174885708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERBB2 [Title/Abstract] AND NARS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2(37866734)-NARS2(78147860), # samples:2 ERBB2(37866134)-NARS2(78147860), # samples:2
Anticipated loss of major functional domain due to fusion event.	ERBB2-NARS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-NARS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-NARS2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERBB2-NARS2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ERBB2-NARS2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ERBB2-NARS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERBB2	GO:0007165	signal transduction	10572067
Hgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Hgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Hgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Hgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Hgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Hgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Hgene	ERBB2	GO:0042060	wound healing	12646923
Hgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Hgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Hgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Hgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Fusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A1EN-01A	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-
ChimerDB4	BRCA	TCGA-BH-A1EN-01A	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-
ChimerDB4	BRCA	TCGA-BH-A1EN-01A	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-
ChimerDB4	BRCA	TCGA-BH-A1EN	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-
ChimerDB4	BRCA	TCGA-BH-A1EN	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000584601	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	2462	1608	752	1768	338
ENST00000406381	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	2175	1321	510	1481	323
ENST00000541774	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	1710	856	0	1016	338
ENST00000540147	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	1993	1139	25	1299	424
ENST00000584450	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	1970	1116	2	1276	424
ENST00000269571	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	1914	1060	57	1220	387
ENST00000578199	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	2206	1352	541	1512	323
ENST00000540042	ERBB2	chr17	37866734	+	ENST00000281038	NARS2	chr11	78147860	-	1831	977	166	1137	323
ENST00000584601	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	2204	1350	752	1510	252
ENST00000406381	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	1917	1063	510	1223	237
ENST00000541774	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	1452	598	0	758	252
ENST00000540147	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	1735	881	25	1041	338
ENST00000584450	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	1712	858	2	1018	338
ENST00000269571	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	1656	802	57	962	301
ENST00000578199	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	1948	1094	541	1254	237
ENST00000540042	ERBB2	chr17	37866134	+	ENST00000281038	NARS2	chr11	78147860	-	1573	719	166	879	237
ENST00000584601	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	2462	1608	752	1768	338
ENST00000406381	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	2175	1321	510	1481	323
ENST00000541774	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	1710	856	0	1016	338
ENST00000540147	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	1993	1139	25	1299	424
ENST00000584450	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	1970	1116	2	1276	424
ENST00000269571	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	1914	1060	57	1220	387
ENST00000578199	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	2206	1352	541	1512	323
ENST00000540042	ERBB2	chr17	37866733	+	ENST00000281038	NARS2	chr11	78147859	-	1831	977	166	1137	323

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000584601	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.024487212	0.9755128
ENST00000406381	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.016759219	0.9832408
ENST00000541774	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.02032381	0.97967625
ENST00000540147	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.02266574	0.9773343
ENST00000584450	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.023504287	0.97649574
ENST00000269571	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.022160532	0.97783947
ENST00000578199	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.013040949	0.98695904
ENST00000540042	ENST00000281038	ERBB2	chr17	37866734	+	NARS2	chr11	78147860	-	0.014448029	0.98555195
ENST00000584601	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.051640864	0.9483591
ENST00000406381	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.014961098	0.9850389
ENST00000541774	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.045729566	0.9542705
ENST00000540147	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.020559363	0.97944057
ENST00000584450	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.018965611	0.98103434
ENST00000269571	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.017029345	0.9829707
ENST00000578199	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.010900661	0.9890994
ENST00000540042	ENST00000281038	ERBB2	chr17	37866134	+	NARS2	chr11	78147860	-	0.011152435	0.9888475
ENST00000584601	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.024487212	0.9755128
ENST00000406381	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.016759219	0.9832408
ENST00000541774	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.02032381	0.97967625
ENST00000540147	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.02266574	0.9773343
ENST00000584450	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.023504287	0.97649574
ENST00000269571	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.022160532	0.97783947
ENST00000578199	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.013040949	0.98695904
ENST00000540042	ENST00000281038	ERBB2	chr17	37866733	+	NARS2	chr11	78147859	-	0.014448029	0.98555195

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27176_27176_1_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000269571_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=301AA_BP=249
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSRIWTFVDLDLCHMEVLGWDLNA

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>27176_27176_2_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000406381_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=237AA_BP=185
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE

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>27176_27176_3_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000540042_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=237AA_BP=185
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE

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>27176_27176_4_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000540147_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=338AA_BP=286
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC

--------------------------------------------------------------

>27176_27176_5_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000541774_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=252AA_BP=200
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC

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>27176_27176_6_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000578199_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=237AA_BP=185
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE

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>27176_27176_7_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000584450_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=338AA_BP=286
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC

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>27176_27176_8_ERBB2-NARS2_ERBB2_chr17_37866134_ENST00000584601_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=252AA_BP=200
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC

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>27176_27176_9_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000269571_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=387AA_BP=335
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPCIWTFVDLDLCHMEVLGWDLNATCSA

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>27176_27176_10_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000406381_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=323AA_BP=271
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP

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>27176_27176_11_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000540042_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=323AA_BP=271
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP

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>27176_27176_12_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000540147_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=424AA_BP=372
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY

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>27176_27176_13_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000541774_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=338AA_BP=286
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP

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>27176_27176_14_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000578199_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=323AA_BP=271
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP

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>27176_27176_15_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000584450_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=424AA_BP=372
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY

--------------------------------------------------------------

>27176_27176_16_ERBB2-NARS2_ERBB2_chr17_37866733_ENST00000584601_NARS2_chr11_78147859_ENST00000281038_length(amino acids)=338AA_BP=286
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP

--------------------------------------------------------------

>27176_27176_17_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000269571_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=387AA_BP=335
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPCIWTFVDLDLCHMEVLGWDLNATCSA

--------------------------------------------------------------

>27176_27176_18_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000406381_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=323AA_BP=271
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP

--------------------------------------------------------------

>27176_27176_19_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000540042_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=323AA_BP=271
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP

--------------------------------------------------------------

>27176_27176_20_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000540147_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=424AA_BP=372
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY

--------------------------------------------------------------

>27176_27176_21_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000541774_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=338AA_BP=286
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP

--------------------------------------------------------------

>27176_27176_22_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000578199_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=323AA_BP=271
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP

--------------------------------------------------------------

>27176_27176_23_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000584450_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=424AA_BP=372
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY

--------------------------------------------------------------

>27176_27176_24_ERBB2-NARS2_ERBB2_chr17_37866734_ENST00000584601_NARS2_chr11_78147860_ENST00000281038_length(amino acids)=338AA_BP=286
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37866734/chr11:78147860)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2 P04626	NARS2 Q96I59
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000269571

720_987

214.33333333333334

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000541774

720_987

199.33333333333334

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000269571

720_987

300.3333333333333

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000541774

720_987

285.3333333333333

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000269571

720_987

300.3333333333333

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000541774

720_987

285.3333333333333

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000269571

676_689

214.33333333333334

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000541774

676_689

199.33333333333334

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000269571

676_689

300.3333333333333

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000541774

676_689

285.3333333333333

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000269571

676_689

300.3333333333333

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000541774

676_689

285.3333333333333

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000269571

726_734

214.33333333333334

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000541774

726_734

199.33333333333334

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000269571

726_734

300.3333333333333

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000541774

726_734

285.3333333333333

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000269571

726_734

300.3333333333333

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000541774

726_734

285.3333333333333

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000269571

23_652

214.33333333333334

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000269571

676_1255

214.33333333333334

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000541774

23_652

199.33333333333334

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000541774

676_1255

199.33333333333334

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000269571

23_652

300.3333333333333

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000269571

676_1255

300.3333333333333

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000541774

23_652

285.3333333333333

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000541774

676_1255

285.3333333333333

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000269571

23_652

300.3333333333333

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000269571

676_1255

300.3333333333333

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000541774

23_652

285.3333333333333

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000541774

676_1255

285.3333333333333

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000269571

653_675

214.33333333333334

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37866134

chr11:78147860

ENST00000541774

653_675

199.33333333333334

1241.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000269571

653_675

300.3333333333333

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37866733

chr11:78147859

ENST00000541774

653_675

285.3333333333333

1241.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000269571

653_675

300.3333333333333

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37866734

chr11:78147860

ENST00000541774

653_675

285.3333333333333

1241.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>883_ERBB2_37866734_NARS2_78147860_883_ERBB2_37866734_NARS2_78147860_ranked_0.pdb	ERBB2	37866733	37866734	ENST00000281038	NARS2	chr11	78147860	-	MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY	424

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ERBB2_pLDDT.png

NARS2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERBB2
NARS2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ERBB2	chr17:37866134	chr11:78147860	ENST00000269571	+	5	27	1195_1197	214.33333333333334	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37866134	chr11:78147860	ENST00000541774	+	5	27	1195_1197	199.33333333333334	1241.0	PIK3C2B
Hgene	ERBB2	chr17:37866733	chr11:78147859	ENST00000269571	+	7	27	1195_1197	300.3333333333333	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37866733	chr11:78147859	ENST00000541774	+	7	27	1195_1197	285.3333333333333	1241.0	PIK3C2B
Hgene	ERBB2	chr17:37866734	chr11:78147860	ENST00000269571	+	7	27	1195_1197	300.3333333333333	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37866734	chr11:78147860	ENST00000541774	+	7	27	1195_1197	285.3333333333333	1241.0	PIK3C2B

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Related Drugs to ERBB2-NARS2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ERBB2-NARS2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source