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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERBB2-SLC29A3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERBB2-SLC29A3
	FusionPDB ID: 27191
	FusionGDB2.0 ID: 27191
		Hgene	Tgene
	Gene symbol	ERBB2	SLC29A3
	Gene ID	2064	55315
	Gene name	erb-b2 receptor tyrosine kinase 2	solute carrier family 29 member 3
	Synonyms	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1	ENT3\|HCLAP\|HJCD\|PHID
	Cytomap	17q12	10q22.1
	Type of gene	protein-coding	protein-coding
	Description	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2	equilibrative nucleoside transporter 3solute carrier family 29 (equilibrative nucleoside transporter), member 3solute carrier family 29 (nucleoside transporters), member 3
	Modification date	20200329	20200329
	UniProtAcc	P04626	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269571, ENST00000406381, ENST00000445658, ENST00000540147, ENST00000541774, ENST00000584450, ENST00000584601, ENST00000540042, ENST00000578199, ENST00000584888,	ENST00000469204, ENST00000373189,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	50 X 44 X 14=30800	3 X 3 X 3=27
	# samples	73	5
	** MAII score	log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/27*10)=0.888968687611256 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERBB2 [Title/Abstract] AND SLC29A3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2(37883256)-SLC29A3(73121711), # samples:3
Anticipated loss of major functional domain due to fusion event.	ERBB2-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-SLC29A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERBB2	GO:0007165	signal transduction	10572067
Hgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Hgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Hgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Hgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Hgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Hgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Hgene	ERBB2	GO:0042060	wound healing	12646923
Hgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Hgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Hgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Hgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Fusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC29A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A254-01A	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+
ChimerDB4	BRCA	TCGA-AR-A254-01A	ERBB2	chr17	37883256	-	SLC29A3	chr10	73121711	+
ChimerDB4	BRCA	TCGA-AR-A254-01A	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+
ChimerDB4	BRCA	TCGA-AR-A254	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000584601	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121711	+	5298	3866	752	3910	1052
ENST00000406381	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121711	+	5011	3579	510	3623	1037
ENST00000541774	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121711	+	4546	3114	0	3158	1052
ENST00000445658	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121711	+	4026	2594	50	2638	862
ENST00000540147	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121711	+	4829	3397	25	3441	1138
ENST00000584450	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121711	+	4806	3374	2	3418	1138
ENST00000269571	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121711	+	4750	3318	57	3362	1101
ENST00000584601	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121710	+	5298	3866	752	3910	1052
ENST00000406381	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121710	+	5011	3579	510	3623	1037
ENST00000541774	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121710	+	4546	3114	0	3158	1052
ENST00000445658	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121710	+	4026	2594	50	2638	862
ENST00000540147	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121710	+	4829	3397	25	3441	1138
ENST00000584450	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121710	+	4806	3374	2	3418	1138
ENST00000269571	ERBB2	chr17	37883256	+	ENST00000373189	SLC29A3	chr10	73121710	+	4750	3318	57	3362	1101
ENST00000584601	ERBB2	chr17	37883255	+	ENST00000373189	SLC29A3	chr10	73121710	+	5298	3866	752	3910	1052
ENST00000406381	ERBB2	chr17	37883255	+	ENST00000373189	SLC29A3	chr10	73121710	+	5011	3579	510	3623	1037
ENST00000541774	ERBB2	chr17	37883255	+	ENST00000373189	SLC29A3	chr10	73121710	+	4546	3114	0	3158	1052
ENST00000445658	ERBB2	chr17	37883255	+	ENST00000373189	SLC29A3	chr10	73121710	+	4026	2594	50	2638	862
ENST00000540147	ERBB2	chr17	37883255	+	ENST00000373189	SLC29A3	chr10	73121710	+	4829	3397	25	3441	1138
ENST00000584450	ERBB2	chr17	37883255	+	ENST00000373189	SLC29A3	chr10	73121710	+	4806	3374	2	3418	1138
ENST00000269571	ERBB2	chr17	37883255	+	ENST00000373189	SLC29A3	chr10	73121710	+	4750	3318	57	3362	1101

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000584601	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+	0.002471897	0.99752814
ENST00000406381	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+	0.001926238	0.9980737
ENST00000541774	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+	0.001173401	0.99882656
ENST00000445658	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+	0.004988879	0.9950111
ENST00000540147	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+	0.001691971	0.99830806
ENST00000584450	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+	0.00170476	0.99829525
ENST00000269571	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121711	+	0.0016029	0.99839705
ENST00000584601	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+	0.002471897	0.99752814
ENST00000406381	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+	0.001926238	0.9980737
ENST00000541774	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+	0.001173401	0.99882656
ENST00000445658	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+	0.004988879	0.9950111
ENST00000540147	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+	0.001691971	0.99830806
ENST00000584450	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+	0.00170476	0.99829525
ENST00000269571	ENST00000373189	ERBB2	chr17	37883256	+	SLC29A3	chr10	73121710	+	0.0016029	0.99839705
ENST00000584601	ENST00000373189	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+	0.002471897	0.99752814
ENST00000406381	ENST00000373189	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+	0.001926238	0.9980737
ENST00000541774	ENST00000373189	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+	0.001173401	0.99882656
ENST00000445658	ENST00000373189	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+	0.004988879	0.9950111
ENST00000540147	ENST00000373189	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+	0.001691971	0.99830806
ENST00000584450	ENST00000373189	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+	0.00170476	0.99829525
ENST00000269571	ENST00000373189	ERBB2	chr17	37883255	+	SLC29A3	chr10	73121710	+	0.0016029	0.99839705

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27191_27191_1_ERBB2-SLC29A3_ERBB2_chr17_37883255_ENST00000269571_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1101AA_BP=1083
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVG
EGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFC
VARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYT
MRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAG
VGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGL
ARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV
KCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHR

--------------------------------------------------------------

>27191_27191_2_ERBB2-SLC29A3_ERBB2_chr17_37883255_ENST00000406381_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1037AA_BP=1019
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ
NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE
IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA

--------------------------------------------------------------

>27191_27191_3_ERBB2-SLC29A3_ERBB2_chr17_37883255_ENST00000445658_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=862AA_BP=844
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHP
ECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSII
SAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGEN
VKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSY
LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDG
IPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMG

--------------------------------------------------------------

>27191_27191_4_ERBB2-SLC29A3_ERBB2_chr17_37883255_ENST00000540147_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1138AA_BP=1120
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARH
CLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRAS
PLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW
IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQI
AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL

--------------------------------------------------------------

>27191_27191_5_ERBB2-SLC29A3_ERBB2_chr17_37883255_ENST00000541774_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1052AA_BP=1034
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

>27191_27191_6_ERBB2-SLC29A3_ERBB2_chr17_37883255_ENST00000584450_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1138AA_BP=1120
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARH
CLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRAS
PLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW
IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQI
AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL

--------------------------------------------------------------

>27191_27191_7_ERBB2-SLC29A3_ERBB2_chr17_37883255_ENST00000584601_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1052AA_BP=1034
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

>27191_27191_8_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000269571_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1101AA_BP=1083
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVG
EGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFC
VARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYT
MRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAG
VGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGL
ARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV
KCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHR

--------------------------------------------------------------

>27191_27191_9_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000269571_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=1101AA_BP=1083
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWP
DSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVG
EGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFC
VARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYT
MRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAG
VGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGL
ARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV
KCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHR

--------------------------------------------------------------

>27191_27191_10_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000406381_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1037AA_BP=1019
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ
NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE
IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA

--------------------------------------------------------------

>27191_27191_11_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000406381_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=1037AA_BP=1019
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ
NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE
IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA

--------------------------------------------------------------

>27191_27191_12_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000445658_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=862AA_BP=844
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHP
ECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSII
SAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGEN
VKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSY
LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDG
IPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMG

--------------------------------------------------------------

>27191_27191_13_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000445658_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=862AA_BP=844
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDP
ASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC
FVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHP
ECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSII
SAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGEN
VKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSY
LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDG
IPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMG

--------------------------------------------------------------

>27191_27191_14_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000540147_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1138AA_BP=1120
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARH
CLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRAS
PLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW
IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQI
AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL

--------------------------------------------------------------

>27191_27191_15_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000540147_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=1138AA_BP=1120
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARH
CLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRAS
PLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW
IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQI
AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL

--------------------------------------------------------------

>27191_27191_16_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000541774_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1052AA_BP=1034
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

>27191_27191_17_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000541774_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=1052AA_BP=1034
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

>27191_27191_18_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000584450_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1138AA_BP=1120
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARH
CLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRAS
PLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW
IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQI
AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL

--------------------------------------------------------------

>27191_27191_19_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000584450_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=1138AA_BP=1120
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIH
HNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARH
CLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRAS
PLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW
IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQI
AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL

--------------------------------------------------------------

>27191_27191_20_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000584601_SLC29A3_chr10_73121710_ENST00000373189_length(amino acids)=1052AA_BP=1034
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

>27191_27191_21_ERBB2-SLC29A3_ERBB2_chr17_37883256_ENST00000584601_SLC29A3_chr10_73121711_ENST00000373189_length(amino acids)=1052AA_BP=1034
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37883256/chr10:73121711)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2 P04626	.
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000269571

720_987

1053.0

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000541774

720_987

1038.0

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000269571

720_987

1053.0

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000541774

720_987

1038.0

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000269571

720_987

1053.0

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000541774

720_987

1038.0

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000269571

676_689

1053.0

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000541774

676_689

1038.0

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000269571

676_689

1053.0

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000541774

676_689

1038.0

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000269571

676_689

1053.0

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000541774

676_689

1038.0

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000269571

726_734

1053.0

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000541774

726_734

1038.0

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000269571

726_734

1053.0

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000541774

726_734

1038.0

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000269571

726_734

1053.0

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000541774

726_734

1038.0

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000269571

23_652

1053.0

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000541774

23_652

1038.0

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000269571

23_652

1053.0

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000541774

23_652

1038.0

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000269571

23_652

1053.0

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000541774

23_652

1038.0

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000269571

653_675

1053.0

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000541774

653_675

1038.0

1241.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000269571

653_675

1053.0

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000541774

653_675

1038.0

1241.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000269571

653_675

1053.0

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000541774

653_675

1038.0

1241.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

327_337

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

359_377

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

399_415

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

437_454

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

327_337

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

359_377

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

399_415

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

437_454

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

327_337

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

359_377

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

399_415

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

437_454

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

306_326

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

338_358

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

378_398

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

416_436

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

455_475

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

306_326

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

338_358

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

378_398

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

416_436

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

455_475

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

306_326

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

338_358

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

378_398

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

416_436

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

455_475

257.6666666666667

476.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000269571

676_1255

1053.0

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37883255

chr10:73121710

ENST00000541774

676_1255

1038.0

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000269571

676_1255

1053.0

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37883256

chr10:73121710

ENST00000541774

676_1255

1038.0

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000269571

676_1255

1053.0

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37883256

chr10:73121711

ENST00000541774

676_1255

1038.0

1241.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

127_134

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

156_162

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

184_199

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

1_53

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

221_230

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

252_305

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

75_105

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

127_134

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

156_162

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

184_199

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

1_53

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

221_230

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

252_305

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

75_105

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

127_134

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

156_162

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

184_199

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

1_53

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

221_230

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

252_305

257.6666666666667

476.0

Topological domain

Cytoplasmic

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

75_105

257.6666666666667

476.0

Topological domain

Extracellular

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

106_126

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

135_155

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

163_183

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

200_220

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

231_251

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883255

chr10:73121710

ENST00000373189

54_74

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

106_126

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

135_155

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

163_183

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

200_220

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

231_251

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121710

ENST00000373189

54_74

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

106_126

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

135_155

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

163_183

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

200_220

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

231_251

257.6666666666667

476.0

Transmembrane

Helical

Tgene

SLC29A3

chr17:37883256

chr10:73121711

ENST00000373189

54_74

257.6666666666667

476.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERBB2
SLC29A3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ERBB2	chr17:37883255	chr10:73121710	ENST00000269571	+	25	27	1195_1197	1053.0	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37883255	chr10:73121710	ENST00000541774	+	25	27	1195_1197	1038.0	1241.0	PIK3C2B
Hgene	ERBB2	chr17:37883256	chr10:73121710	ENST00000269571	+	25	27	1195_1197	1053.0	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37883256	chr10:73121710	ENST00000541774	+	25	27	1195_1197	1038.0	1241.0	PIK3C2B
Hgene	ERBB2	chr17:37883256	chr10:73121711	ENST00000269571	+	25	27	1195_1197	1053.0	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37883256	chr10:73121711	ENST00000541774	+	25	27	1195_1197	1038.0	1241.0	PIK3C2B

Top

Related Drugs to ERBB2-SLC29A3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ERBB2-SLC29A3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source