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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERBB4-IKZF2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERBB4-IKZF2
FusionPDB ID: 27228
FusionGDB2.0 ID: 27228
HgeneTgene
Gene symbol

ERBB4

IKZF2

Gene ID

2066

22807

Gene nameerb-b2 receptor tyrosine kinase 4IKAROS family zinc finger 2
SynonymsALS19|HER4|p180erbB4ANF1A2|HELIOS|ZNF1A2|ZNFN1A2
Cytomap

2q34

2q34

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-4avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4human epidermal growth factor receptor 4proto-oncogene-like protein c-ErbB-4tyrosine kinase-type cell surface receptor HER4v-erb-a erythroblastic zinc finger protein Heliosikaros family zinc finger protein 2zinc finger DNA binding protein Helioszinc finger protein, subfamily 1A, 2 (Helios)
Modification date2020032720200313
UniProtAcc

Q15303

Q9UKS7

Ensembl transtripts involved in fusion geneENST idsENST00000342788, ENST00000402597, 
ENST00000436443, ENST00000484474, 
ENST00000374327, ENST00000413091, 
ENST00000421754, ENST00000442445, 
ENST00000451136, ENST00000342002, 
ENST00000374319, ENST00000434687, 
ENST00000457361, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 15 X 4=11402 X 2 X 2=8
# samples 212
** MAII scorelog2(21/1140*10)=-2.44057259138598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERBB4 [Title/Abstract] AND IKZF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERBB4(212812154)-IKZF2(213921823), # samples:1
Anticipated loss of major functional domain due to fusion event.ERBB4-IKZF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERBB4-IKZF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERBB4-IKZF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERBB4-IKZF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB4

GO:0007165

signal transduction

10572067

HgeneERBB4

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

10353604|18334220

HgeneERBB4

GO:0016477

cell migration

9135143

HgeneERBB4

GO:0018108

peptidyl-tyrosine phosphorylation

18334220

HgeneERBB4

GO:0046777

protein autophosphorylation

18334220


check buttonFusion gene breakpoints across ERBB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IKZF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2026ERBB4chr2

212812154

-IKZF2chr2

213921823

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000436443ERBB4chr2212812154-ENST00000457361IKZF2chr2213921823-98297323112173620
ENST00000436443ERBB4chr2212812154-ENST00000342002IKZF2chr2213921823-41717323112173620
ENST00000436443ERBB4chr2212812154-ENST00000434687IKZF2chr2213921823-41717323112173620
ENST00000436443ERBB4chr2212812154-ENST00000374319IKZF2chr2213921823-22847323112095594
ENST00000342788ERBB4chr2212812154-ENST00000457361IKZF2chr2213921823-98297323112173620
ENST00000342788ERBB4chr2212812154-ENST00000342002IKZF2chr2213921823-41717323112173620
ENST00000342788ERBB4chr2212812154-ENST00000434687IKZF2chr2213921823-41717323112173620
ENST00000342788ERBB4chr2212812154-ENST00000374319IKZF2chr2213921823-22847323112095594
ENST00000402597ERBB4chr2212812154-ENST00000457361IKZF2chr2213921823-951842101862620
ENST00000402597ERBB4chr2212812154-ENST00000342002IKZF2chr2213921823-386042101862620
ENST00000402597ERBB4chr2212812154-ENST00000434687IKZF2chr2213921823-386042101862620
ENST00000402597ERBB4chr2212812154-ENST00000374319IKZF2chr2213921823-197342101784594

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000436443ENST00000457361ERBB4chr2212812154-IKZF2chr2213921823-4.25E-050.99995756
ENST00000436443ENST00000342002ERBB4chr2212812154-IKZF2chr2213921823-0.0001651030.9998349
ENST00000436443ENST00000434687ERBB4chr2212812154-IKZF2chr2213921823-0.0001651030.9998349
ENST00000436443ENST00000374319ERBB4chr2212812154-IKZF2chr2213921823-0.0012683360.9987317
ENST00000342788ENST00000457361ERBB4chr2212812154-IKZF2chr2213921823-4.25E-050.99995756
ENST00000342788ENST00000342002ERBB4chr2212812154-IKZF2chr2213921823-0.0001651030.9998349
ENST00000342788ENST00000434687ERBB4chr2212812154-IKZF2chr2213921823-0.0001651030.9998349
ENST00000342788ENST00000374319ERBB4chr2212812154-IKZF2chr2213921823-0.0012683360.9987317
ENST00000402597ENST00000457361ERBB4chr2212812154-IKZF2chr2213921823-3.95E-050.99996054
ENST00000402597ENST00000342002ERBB4chr2212812154-IKZF2chr2213921823-0.0001501920.9998498
ENST00000402597ENST00000434687ERBB4chr2212812154-IKZF2chr2213921823-0.0001501920.9998498
ENST00000402597ENST00000374319ERBB4chr2212812154-IKZF2chr2213921823-0.0014964410.99850357

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27228_27228_1_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000342788_IKZF2_chr2_213921823_ENST00000342002_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

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>27228_27228_2_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000342788_IKZF2_chr2_213921823_ENST00000374319_length(amino acids)=594AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCG
RSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEKLMRF
SYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYSQVYHPNRIERPISRETADSHENNMDG
PISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFK

--------------------------------------------------------------

>27228_27228_3_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000342788_IKZF2_chr2_213921823_ENST00000434687_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

--------------------------------------------------------------

>27228_27228_4_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000342788_IKZF2_chr2_213921823_ENST00000457361_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

--------------------------------------------------------------

>27228_27228_5_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000402597_IKZF2_chr2_213921823_ENST00000342002_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

--------------------------------------------------------------

>27228_27228_6_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000402597_IKZF2_chr2_213921823_ENST00000374319_length(amino acids)=594AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCG
RSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEKLMRF
SYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYSQVYHPNRIERPISRETADSHENNMDG
PISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFK

--------------------------------------------------------------

>27228_27228_7_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000402597_IKZF2_chr2_213921823_ENST00000434687_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

--------------------------------------------------------------

>27228_27228_8_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000402597_IKZF2_chr2_213921823_ENST00000457361_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

--------------------------------------------------------------

>27228_27228_9_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000436443_IKZF2_chr2_213921823_ENST00000342002_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

--------------------------------------------------------------

>27228_27228_10_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000436443_IKZF2_chr2_213921823_ENST00000374319_length(amino acids)=594AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCG
RSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEKLMRF
SYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYSQVYHPNRIERPISRETADSHENNMDG
PISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFK

--------------------------------------------------------------

>27228_27228_11_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000436443_IKZF2_chr2_213921823_ENST00000434687_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

--------------------------------------------------------------

>27228_27228_12_ERBB4-IKZF2_ERBB4_chr2_212812154_ENST00000436443_IKZF2_chr2_213921823_ENST00000457361_length(amino acids)=620AA_BP=139
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVA
LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTANSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIE
SSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYA
CRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVI
EKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYS
QVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:212812154/chr2:213921823)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB4

Q15303

IKZF2

Q9UKS7

FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}.FUNCTION: Associates with Ikaros at centromeric heterochromatin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIKZF2chr2:212812154chr2:213921823ENST0000037431939112_13446.333333333333336501.0Zinc fingerC2H2-type 1
TgeneIKZF2chr2:212812154chr2:213921823ENST0000037431939140_16246.333333333333336501.0Zinc fingerC2H2-type 2
TgeneIKZF2chr2:212812154chr2:213921823ENST0000037431939168_19046.333333333333336501.0Zinc fingerC2H2-type 3
TgeneIKZF2chr2:212812154chr2:213921823ENST0000037431939196_21946.333333333333336501.0Zinc fingerC2H2-type 4
TgeneIKZF2chr2:212812154chr2:213921823ENST0000037431939471_49346.333333333333336501.0Zinc fingerC2H2-type 5
TgeneIKZF2chr2:212812154chr2:213921823ENST0000037431939499_52346.333333333333336501.0Zinc fingerC2H2-type 6
TgeneIKZF2chr2:212812154chr2:213921823ENST0000043468739112_13446.333333333333336527.0Zinc fingerC2H2-type 1
TgeneIKZF2chr2:212812154chr2:213921823ENST0000043468739140_16246.333333333333336527.0Zinc fingerC2H2-type 2
TgeneIKZF2chr2:212812154chr2:213921823ENST0000043468739168_19046.333333333333336527.0Zinc fingerC2H2-type 3
TgeneIKZF2chr2:212812154chr2:213921823ENST0000043468739196_21946.333333333333336527.0Zinc fingerC2H2-type 4
TgeneIKZF2chr2:212812154chr2:213921823ENST0000043468739471_49346.333333333333336527.0Zinc fingerC2H2-type 5
TgeneIKZF2chr2:212812154chr2:213921823ENST0000043468739499_52346.333333333333336527.0Zinc fingerC2H2-type 6
TgeneIKZF2chr2:212812154chr2:213921823ENST0000045736128112_13446.333333333333336527.0Zinc fingerC2H2-type 1
TgeneIKZF2chr2:212812154chr2:213921823ENST0000045736128140_16246.333333333333336527.0Zinc fingerC2H2-type 2
TgeneIKZF2chr2:212812154chr2:213921823ENST0000045736128168_19046.333333333333336527.0Zinc fingerC2H2-type 3
TgeneIKZF2chr2:212812154chr2:213921823ENST0000045736128196_21946.333333333333336527.0Zinc fingerC2H2-type 4
TgeneIKZF2chr2:212812154chr2:213921823ENST0000045736128471_49346.333333333333336527.0Zinc fingerC2H2-type 5
TgeneIKZF2chr2:212812154chr2:213921823ENST0000045736128499_52346.333333333333336527.0Zinc fingerC2H2-type 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328186_334140.333333333333341309.0Compositional biasNote=Cys-rich
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328496_633140.333333333333341309.0Compositional biasNote=Cys-rich
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328186_334140.333333333333341299.0Compositional biasNote=Cys-rich
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328496_633140.333333333333341299.0Compositional biasNote=Cys-rich
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327186_334140.333333333333341293.0Compositional biasNote=Cys-rich
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327496_633140.333333333333341293.0Compositional biasNote=Cys-rich
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328718_985140.333333333333341309.0DomainProtein kinase
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328718_985140.333333333333341299.0DomainProtein kinase
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327718_985140.333333333333341293.0DomainProtein kinase
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-3281032_1035140.333333333333341309.0MotifNote=PPxY motif 1
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-3281053_1056140.333333333333341309.0MotifNote=PPxY motif 2
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-3281298_1301140.333333333333341309.0MotifNote=PPxY motif 3
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-3281306_1308140.333333333333341309.0MotifNote=PDZ-binding
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328676_684140.333333333333341309.0MotifNote=Nuclear localization signal
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-3281032_1035140.333333333333341299.0MotifNote=PPxY motif 1
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-3281053_1056140.333333333333341299.0MotifNote=PPxY motif 2
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-3281298_1301140.333333333333341299.0MotifNote=PPxY motif 3
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-3281306_1308140.333333333333341299.0MotifNote=PDZ-binding
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328676_684140.333333333333341299.0MotifNote=Nuclear localization signal
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-3271032_1035140.333333333333341293.0MotifNote=PPxY motif 1
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-3271053_1056140.333333333333341293.0MotifNote=PPxY motif 2
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-3271298_1301140.333333333333341293.0MotifNote=PPxY motif 3
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-3271306_1308140.333333333333341293.0MotifNote=PDZ-binding
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327676_684140.333333333333341293.0MotifNote=Nuclear localization signal
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328724_732140.333333333333341309.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328797_799140.333333333333341309.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328843_848140.333333333333341309.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328724_732140.333333333333341299.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328797_799140.333333333333341299.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328843_848140.333333333333341299.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327724_732140.333333333333341293.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327797_799140.333333333333341293.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327843_848140.333333333333341293.0Nucleotide bindingATP
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-32826_651140.333333333333341309.0Topological domainExtracellular
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328676_1308140.333333333333341309.0Topological domainCytoplasmic
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-32826_651140.333333333333341299.0Topological domainExtracellular
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328676_1308140.333333333333341299.0Topological domainCytoplasmic
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-32726_651140.333333333333341293.0Topological domainExtracellular
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327676_1308140.333333333333341293.0Topological domainCytoplasmic
HgeneERBB4chr2:212812154chr2:213921823ENST00000342788-328652_675140.333333333333341309.0TransmembraneHelical
HgeneERBB4chr2:212812154chr2:213921823ENST00000402597-328652_675140.333333333333341299.0TransmembraneHelical
HgeneERBB4chr2:212812154chr2:213921823ENST00000436443-327652_675140.333333333333341293.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERBB4all structure
IKZF2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ERBB4-IKZF2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERBB4-IKZF2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERBB4C0005586Bipolar Disorder5PSYGENET
HgeneERBB4C0036341Schizophrenia4PSYGENET
HgeneERBB4C0004238Atrial Fibrillation2CTD_human
HgeneERBB4C0235480Paroxysmal atrial fibrillation2CTD_human
HgeneERBB4C2585653Persistent atrial fibrillation2CTD_human
HgeneERBB4C3468561familial atrial fibrillation2CTD_human
HgeneERBB4C0002736Amyotrophic Lateral Sclerosis1ORPHANET
HgeneERBB4C0007114Malignant neoplasm of skin1CTD_human
HgeneERBB4C0016978gallbladder neoplasm1CTD_human
HgeneERBB4C0025202melanoma1CGI;CTD_human
HgeneERBB4C0037286Skin Neoplasms1CTD_human
HgeneERBB4C0153452Malignant neoplasm of gallbladder1CTD_human
HgeneERBB4C3715155AMYOTROPHIC LATERAL SCLEROSIS 191CTD_human;GENOMICS_ENGLAND;UNIPROT