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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERG-APP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERG-APP
FusionPDB ID: 27334
FusionGDB2.0 ID: 27334
HgeneTgene
Gene symbol

ERG

APP

Gene ID

2078

351

Gene nameETS transcription factor ERGamyloid beta precursor protein
Synonymserg-3|p55AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

21q22.2

21q21.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avianamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei
Modification date2020032020200329
UniProtAcc

Q9Y282

Q8NEU8

Ensembl transtripts involved in fusion geneENST idsENST00000288319, ENST00000398905, 
ENST00000398907, ENST00000429727, 
ENST00000398910, ENST00000417133, 
ENST00000442448, ENST00000453032, 
ENST00000485493, ENST00000398897, 
ENST00000398911, ENST00000398919, 
ENST00000440126, ENST00000448388, 
ENST00000474136, ENST00000348990, 
ENST00000354192, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000439274, ENST00000346798, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 16 X 5=152025 X 18 X 10=4500
# samples 3127
** MAII scorelog2(31/1520*10)=-2.29373120305671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4500*10)=-4.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERG [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERG(39870286)-APP(27484463), # samples:1
ERG(40033582)-APP(27484463), # samples:1
Anticipated loss of major functional domain due to fusion event.ERG-APP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-APP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-APP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-APP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

TgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8530-01AERGchr21

40033582

-APPchr21

27484463

-
ChimerDB4STADTCGA-D7-A4Z0ERGchr21

39870286

-APPchr21

27484463

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398907ERGchr2139870286-ENST00000346798APPchr2127484463-345680622335757
ENST00000398905ERGchr2139870286-ENST00000346798APPchr2127484463-345680622335757
ENST00000288319ERGchr2139870286-ENST00000346798APPchr2127484463-34971211032376757
ENST00000429727ERGchr2139870286-ENST00000346798APPchr2127484463-343559412314757

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398907ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024018260.99759823
ENST00000398905ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024018260.99759823
ENST00000288319ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024499890.9975501
ENST00000429727ENST00000346798ERGchr2139870286-APPchr2127484463-0.0023895160.99761045

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27334_27334_1_ERG-APP_ERG_chr21_39870286_ENST00000288319_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------

>27334_27334_2_ERG-APP_ERG_chr21_39870286_ENST00000398905_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------

>27334_27334_3_ERG-APP_ERG_chr21_39870286_ENST00000398907_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------

>27334_27334_4_ERG-APP_ERG_chr21_39870286_ENST00000429727_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:39870286/chr21:27484463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

Q9Y282

APP

Q8NEU8

FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018230_26019.0771.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018274_28019.0771.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016230_26019.0696.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016274_28019.0696.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015230_2600640.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015274_2800640.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017230_26019.0752.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017274_28019.0752.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017230_26019.0753.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017274_28019.0753.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017230_26019.0715.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017274_28019.0715.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017230_26014.0747.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017274_28014.0747.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801828_18919.0771.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018374_56519.0771.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001628_18919.0696.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016374_56519.0696.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201528_1890640.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015374_5650640.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301728_18919.0752.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017374_56519.0752.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801728_18919.0753.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017374_56519.0753.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601728_18919.0715.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017374_56519.0715.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601728_18914.0747.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017374_56514.0747.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018344_36519.0771.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018724_73419.0771.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016344_36519.0696.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016724_73419.0696.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015344_3650640.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015724_7340640.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017344_36519.0752.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017724_73419.0752.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017344_36519.0753.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017724_73419.0753.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017344_36519.0715.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017724_73419.0715.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017344_36514.0747.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017724_73414.0747.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018131_18919.0771.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018181_18819.0771.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801828_12319.0771.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018391_42319.0771.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018491_52219.0771.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018523_54019.0771.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801896_11019.0771.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016131_18919.0696.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016181_18819.0696.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001628_12319.0696.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016391_42319.0696.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016491_52219.0696.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016523_54019.0696.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001696_11019.0696.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015131_1890640.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015181_1880640.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201528_1230640.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015391_4230640.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015491_5220640.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015523_5400640.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201596_1100640.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017131_18919.0752.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017181_18819.0752.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301728_12319.0752.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017391_42319.0752.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017491_52219.0752.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017523_54019.0752.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301796_11019.0752.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017131_18919.0753.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017181_18819.0753.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801728_12319.0753.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017391_42319.0753.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017491_52219.0753.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017523_54019.0753.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801796_11019.0753.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017131_18919.0715.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017181_18819.0715.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601728_12319.0715.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017391_42319.0715.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017491_52219.0715.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017523_54019.0715.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601796_11019.0715.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017131_18914.0747.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017181_18814.0747.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601728_12314.0747.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017391_42314.0747.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017491_52214.0747.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017523_54014.0747.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601796_11014.0747.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801818_70119.0771.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018723_77019.0771.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001618_70119.0696.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016723_77019.0696.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201518_7010640.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015723_7700640.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301718_70119.0752.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017723_77019.0752.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801718_70119.0753.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017723_77019.0753.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601718_70119.0715.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017723_77019.0715.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601718_70114.0747.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017723_77014.0747.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018702_72219.0771.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016702_72219.0696.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015702_7220640.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017702_72219.0752.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017702_72219.0753.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017702_72219.0715.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017702_72214.0747.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGchr21:39870286chr21:27484463ENST00000288319-110311_3916.0480.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398897-19311_3910364.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398911-110311_3910463.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398919-112311_3910487.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000417133-112311_3910487.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000442448-111311_3910463.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000288319-110113_1996.0480.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398897-19113_1990364.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398911-110113_1990463.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398919-112113_1990487.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000417133-112113_1990487.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000442448-111113_1990463.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000453032-19113_1990388.0DomainPNT


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3, EP300, APEX1, PVT1, E7, TRIM8, MEF2D, SMARCE1, FOXP1, RERE, NFIB, FLI1, NFIA, BCL9, ARID1A, KMT2D, ZNF609, TRIM24, KDM6A, MITF, SS18L1, NCOR1, PIAS1, ATXN1L, HIVEP1, GATA4, SMARCA2, SMARCA4, ATXN1, MLLT10, LMO4, TLE1, TLE3, AES, SMARCB1, NCOA6, GSE1, SS18, NCOA2, QSER1, ARID4B, BCL7A, PRRC2B, NIPBL, TET2, ZNF746, ELMSAN1, SMARCD3, ATF7IP, BCOR, C15orf39, PAXIP1, ASXL2, C11orf30, LDB1, ZFHX4, FOXP4, RYBP, KMT2C, ARID1B, KDM2B, SMARCC2, MORC4, BCL7C, MAML1, DPF1, DPF3, DPF2, CREBBP, SMARCC1, SMARCD2, ISL2, SMARCD1, ZNF521, CIC, ARID3A, BCL7B, PYGO2, PCGF1, PAGR1, DNTTIP1, HIPK2, CPVL, ZNF703, FBRS, KIAA1551, FBRSL1, HMG20A, TCF7L2, GLTSCR1, CHD7, TCF20, TRPS1, ZNF608, PRR12, SATB2, ZNF148, ZNF281, RAD54L2, NCOR2, NCOA3, PSMB5, DBN1, NFIC,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERGall structure
APP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ERG-APP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERG-APP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms7CTD_human
HgeneERGC0376358Malignant neoplasm of prostate7CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human