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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERN1-TEX2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERN1-TEX2
FusionPDB ID: 27446
FusionGDB2.0 ID: 27446
HgeneTgene
Gene symbol

ERN1

TEX2

Gene ID

2081

55852

Gene nameendoplasmic reticulum to nucleus signaling 1testis expressed 2
SynonymsIRE1|IRE1P|IRE1a|hIRE1pHT008|TMEM96
Cytomap

17q23.3

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase/endoribonuclease IRE1ER to nucleus signalling 1inositol-requiring 1inositol-requiring enzyme 1inositol-requiring protein 1ire1-alphaprotein kinase/endoribonucleasetestis-expressed protein 2testis expressed sequence 2testis-expressed sequence 2 proteintransmembrane protein 96
Modification date2020032920200313
UniProtAcc

O75460

.
Ensembl transtripts involved in fusion geneENST idsENST00000433197, ENST00000577567, 
ENST00000606895, 		ENST00000581812, 
ENST00000258991, ENST00000583097, 
ENST00000584379, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 9 X 7=44112 X 12 X 5=720
# samples 1018
** MAII scorelog2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERN1 [Title/Abstract] AND TEX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERN1(62141346)-TEX2(62238293), # samples:3
Anticipated loss of major functional domain due to fusion event.ERN1-TEX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERN1-TEX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERN1-TEX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERN1-TEX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERN1

GO:0001935

endothelial cell proliferation

23529610

HgeneERN1

GO:0006468

protein phosphorylation

9637683

HgeneERN1

GO:0007257

activation of JUN kinase activity

10650002

HgeneERN1

GO:0033120

positive regulation of RNA splicing

11779464|19622636

HgeneERN1

GO:0034620

cellular response to unfolded protein

19328063

HgeneERN1

GO:0034976

response to endoplasmic reticulum stress

10650002

HgeneERN1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

23529610

HgeneERN1

GO:0036289

peptidyl-serine autophosphorylation

20103773

HgeneERN1

GO:0036498

IRE1-mediated unfolded protein response

9637683|11779465|19328063|29198525

HgeneERN1

GO:0046777

protein autophosphorylation

9637683|19328063

HgeneERN1

GO:0070054

mRNA splicing, via endonucleolytic cleavage and ligation

11779464|19328063|19622636|21317875

HgeneERN1

GO:0071333

cellular response to glucose stimulus

20103773

HgeneERN1

GO:0098787

mRNA cleavage involved in mRNA processing

21317875

HgeneERN1

GO:1901142

insulin metabolic process

20103773


check buttonFusion gene breakpoints across ERN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TEX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5K6-01AERN1chr17

62141345

-TEX2chr17

62238292

-
ChimerDB4ACCTCGA-OR-A5K6-01AERN1chr17

62141346

-TEX2chr17

62238293

-
ChimerDB4ACCTCGA-OR-A5K6ERN1chr17

62141345

-TEX2chr17

62238293

-
ChimerDB4LIHCTCGA-BC-A10R-01AERN1chr17

62157022

-TEX2chr17

62254831

-
ChimerDB4LIHCTCGA-CC-A7IJ-01AERN1chr17

62157022

-TEX2chr17

62272455

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000433197ERN1chr1762157022-ENST00000258991TEX2chr1762272455-3881378272138703
ENST00000433197ERN1chr1762157022-ENST00000583097TEX2chr1762272455-3413378272117696
ENST00000433197ERN1chr1762157022-ENST00000584379TEX2chr1762272455-3400378272117696

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000433197ENST00000258991ERN1chr1762157022-TEX2chr1762272455-0.0002306850.9997693
ENST00000433197ENST00000583097ERN1chr1762157022-TEX2chr1762272455-0.0003982960.9996018
ENST00000433197ENST00000584379ERN1chr1762157022-TEX2chr1762272455-0.0004061220.9995939

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27446_27446_1_ERN1-TEX2_ERN1_chr17_62157022_ENST00000433197_TEX2_chr17_62272455_ENST00000258991_length(amino acids)=703AA_BP=117
MSSRRPRPVLCPYRPRSQGRVLAMPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTH
VEEPAFLPDPNDGSLYTLGSKNNEGLTGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDL
SDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWF
RRFILASKLKSEIKKSSGVSGGKPAPVFLAPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCV
PQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGV
AVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEP
SGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPP

--------------------------------------------------------------

>27446_27446_2_ERN1-TEX2_ERN1_chr17_62157022_ENST00000433197_TEX2_chr17_62272455_ENST00000583097_length(amino acids)=696AA_BP=117
MSSRRPRPVLCPYRPRSQGRVLAMPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTH
VEEPAFLPDPNDGSLYTLGSKNNEGLTGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDL
SDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWF
RRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSP
QRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQ
AFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQL
LPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKAR

--------------------------------------------------------------

>27446_27446_3_ERN1-TEX2_ERN1_chr17_62157022_ENST00000433197_TEX2_chr17_62272455_ENST00000584379_length(amino acids)=696AA_BP=117
MSSRRPRPVLCPYRPRSQGRVLAMPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTH
VEEPAFLPDPNDGSLYTLGSKNNEGLTGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDL
SDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWF
RRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSP
QRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQ
AFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQL
LPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKAR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:62141346/chr17:62238293)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERN1

O75460

.
FUNCTION: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875, PubMed:28128204). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTEX2chr17:62141345chr17:62238292ENST000002589916121039_1042897.33333333333341135.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141345chr17:62238292ENST000005830976121039_1042890.33333333333341128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141345chr17:62238292ENST000005843796121039_1042890.33333333333341128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141345chr17:62238293ENST000002589916121039_1042897.33333333333341135.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141345chr17:62238293ENST000005830976121039_1042890.33333333333341128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141345chr17:62238293ENST000005843796121039_1042890.33333333333341128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141346chr17:62238293ENST000002589916121039_1042897.33333333333341135.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141346chr17:62238293ENST000005830976121039_1042890.33333333333341128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62141346chr17:62238293ENST000005843796121039_1042890.33333333333341128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62157022chr17:62254831ENST000002589914121039_1042815.01135.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62157022chr17:62254831ENST00000258991412816_821815.01135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62254831ENST000005830974121039_1042808.01128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62157022chr17:62254831ENST00000583097412816_821808.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62254831ENST000005843794121039_1042808.01128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62157022chr17:62254831ENST00000584379412816_821808.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62272455ENST000002589911121039_1042548.01135.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62157022chr17:62272455ENST00000258991112816_821548.01135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62272455ENST000005830971121039_1042548.01128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62157022chr17:62272455ENST00000583097112816_821548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62272455ENST000005843791121039_1042548.01128.0Compositional biasNote=Poly-Pro
TgeneTEX2chr17:62157022chr17:62272455ENST00000584379112816_821548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62254831ENST00000258991412816_1101815.01135.0DomainSMP-LTD
TgeneTEX2chr17:62157022chr17:62254831ENST00000583097412816_1101808.01128.0DomainSMP-LTD
TgeneTEX2chr17:62157022chr17:62254831ENST00000584379412816_1101808.01128.0DomainSMP-LTD
TgeneTEX2chr17:62157022chr17:62272455ENST00000258991112816_1101548.01135.0DomainSMP-LTD
TgeneTEX2chr17:62157022chr17:62272455ENST00000583097112816_1101548.01128.0DomainSMP-LTD
TgeneTEX2chr17:62157022chr17:62272455ENST00000584379112816_1101548.01128.0DomainSMP-LTD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022571_832362.3333333333333978.0DomainProtein kinase
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022835_963362.3333333333333978.0DomainKEN
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11571_832071.0DomainProtein kinase
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11835_963071.0DomainKEN
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022571_832362.3333333333333978.0DomainProtein kinase
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022835_963362.3333333333333978.0DomainKEN
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11571_832071.0DomainProtein kinase
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11835_963071.0DomainKEN
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022571_832362.3333333333333978.0DomainProtein kinase
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022835_963362.3333333333333978.0DomainKEN
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11571_832071.0DomainProtein kinase
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11835_963071.0DomainKEN
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422571_83294.0978.0DomainProtein kinase
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422835_96394.0978.0DomainKEN
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11571_832071.0DomainProtein kinase
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11835_963071.0DomainKEN
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422571_83294.0978.0DomainProtein kinase
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422835_96394.0978.0DomainKEN
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11571_832071.0DomainProtein kinase
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11835_963071.0DomainKEN
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022577_585362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022643_645362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022690_693362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11577_585071.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11643_645071.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11690_693071.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022577_585362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022643_645362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022690_693362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11577_585071.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11643_645071.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11690_693071.0Nucleotide bindingATP
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022577_585362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022643_645362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022690_693362.3333333333333978.0Nucleotide bindingATP
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11577_585071.0Nucleotide bindingATP
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11643_645071.0Nucleotide bindingATP
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11690_693071.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422577_58594.0978.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422643_64594.0978.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422690_69394.0978.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11577_585071.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11643_645071.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11690_693071.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422577_58594.0978.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422643_64594.0978.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422690_69394.0978.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11577_585071.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11643_645071.0Nucleotide bindingATP
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11690_693071.0Nucleotide bindingATP
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022906_907362.3333333333333978.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11906_907071.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022906_907362.3333333333333978.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11906_907071.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022906_907362.3333333333333978.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11906_907071.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422906_90794.0978.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11906_907071.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422906_90794.0978.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11906_907071.0RegionInteracts with hydroxy-aryl-aldehyde inhibitors
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-102219_443362.3333333333333978.0Topological domainLumenal
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022465_977362.3333333333333978.0Topological domainCytoplasmic
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-1119_443071.0Topological domainLumenal
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11465_977071.0Topological domainCytoplasmic
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-102219_443362.3333333333333978.0Topological domainLumenal
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022465_977362.3333333333333978.0Topological domainCytoplasmic
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-1119_443071.0Topological domainLumenal
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11465_977071.0Topological domainCytoplasmic
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-102219_443362.3333333333333978.0Topological domainLumenal
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022465_977362.3333333333333978.0Topological domainCytoplasmic
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-1119_443071.0Topological domainLumenal
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11465_977071.0Topological domainCytoplasmic
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-42219_44394.0978.0Topological domainLumenal
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422465_97794.0978.0Topological domainCytoplasmic
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-1119_443071.0Topological domainLumenal
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11465_977071.0Topological domainCytoplasmic
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-42219_44394.0978.0Topological domainLumenal
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422465_97794.0978.0Topological domainCytoplasmic
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-1119_443071.0Topological domainLumenal
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11465_977071.0Topological domainCytoplasmic
HgeneERN1chr17:62141345chr17:62238292ENST00000433197-1022444_464362.3333333333333978.0TransmembraneHelical
HgeneERN1chr17:62141345chr17:62238292ENST00000606895-11444_464071.0TransmembraneHelical
HgeneERN1chr17:62141345chr17:62238293ENST00000433197-1022444_464362.3333333333333978.0TransmembraneHelical
HgeneERN1chr17:62141345chr17:62238293ENST00000606895-11444_464071.0TransmembraneHelical
HgeneERN1chr17:62141346chr17:62238293ENST00000433197-1022444_464362.3333333333333978.0TransmembraneHelical
HgeneERN1chr17:62141346chr17:62238293ENST00000606895-11444_464071.0TransmembraneHelical
HgeneERN1chr17:62157022chr17:62254831ENST00000433197-422444_46494.0978.0TransmembraneHelical
HgeneERN1chr17:62157022chr17:62254831ENST00000606895-11444_464071.0TransmembraneHelical
HgeneERN1chr17:62157022chr17:62272455ENST00000433197-422444_46494.0978.0TransmembraneHelical
HgeneERN1chr17:62157022chr17:62272455ENST00000606895-11444_464071.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238292ENST00000258991612138_141897.33333333333341135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238292ENST00000258991612159_162897.33333333333341135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238292ENST0000025899161243_51897.33333333333341135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238292ENST00000258991612816_821897.33333333333341135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238292ENST00000583097612138_141890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238292ENST00000583097612159_162890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238292ENST0000058309761243_51890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238292ENST00000583097612816_821890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238292ENST00000584379612138_141890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238292ENST00000584379612159_162890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238292ENST0000058437961243_51890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238292ENST00000584379612816_821890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238293ENST00000258991612138_141897.33333333333341135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238293ENST00000258991612159_162897.33333333333341135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238293ENST0000025899161243_51897.33333333333341135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238293ENST00000258991612816_821897.33333333333341135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238293ENST00000583097612138_141890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238293ENST00000583097612159_162890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238293ENST0000058309761243_51890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238293ENST00000583097612816_821890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238293ENST00000584379612138_141890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238293ENST00000584379612159_162890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141345chr17:62238293ENST0000058437961243_51890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238293ENST00000584379612816_821890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141346chr17:62238293ENST00000258991612138_141897.33333333333341135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141346chr17:62238293ENST00000258991612159_162897.33333333333341135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141346chr17:62238293ENST0000025899161243_51897.33333333333341135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141346chr17:62238293ENST00000258991612816_821897.33333333333341135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141346chr17:62238293ENST00000583097612138_141890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141346chr17:62238293ENST00000583097612159_162890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141346chr17:62238293ENST0000058309761243_51890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141346chr17:62238293ENST00000583097612816_821890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141346chr17:62238293ENST00000584379612138_141890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141346chr17:62238293ENST00000584379612159_162890.33333333333341128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62141346chr17:62238293ENST0000058437961243_51890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141346chr17:62238293ENST00000584379612816_821890.33333333333341128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62254831ENST00000258991412138_141815.01135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62254831ENST00000258991412159_162815.01135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62254831ENST0000025899141243_51815.01135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62254831ENST00000583097412138_141808.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62254831ENST00000583097412159_162808.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62254831ENST0000058309741243_51808.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62254831ENST00000584379412138_141808.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62254831ENST00000584379412159_162808.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62254831ENST0000058437941243_51808.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62272455ENST00000258991112138_141548.01135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62272455ENST00000258991112159_162548.01135.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62272455ENST0000025899111243_51548.01135.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62272455ENST00000583097112138_141548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62272455ENST00000583097112159_162548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62272455ENST0000058309711243_51548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62157022chr17:62272455ENST00000584379112138_141548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62272455ENST00000584379112159_162548.01128.0Compositional biasNote=Poly-Ser
TgeneTEX2chr17:62157022chr17:62272455ENST0000058437911243_51548.01128.0Compositional biasNote=Poly-Glu
TgeneTEX2chr17:62141345chr17:62238292ENST00000258991612816_1101897.33333333333341135.0DomainSMP-LTD
TgeneTEX2chr17:62141345chr17:62238292ENST00000583097612816_1101890.33333333333341128.0DomainSMP-LTD
TgeneTEX2chr17:62141345chr17:62238292ENST00000584379612816_1101890.33333333333341128.0DomainSMP-LTD
TgeneTEX2chr17:62141345chr17:62238293ENST00000258991612816_1101897.33333333333341135.0DomainSMP-LTD
TgeneTEX2chr17:62141345chr17:62238293ENST00000583097612816_1101890.33333333333341128.0DomainSMP-LTD
TgeneTEX2chr17:62141345chr17:62238293ENST00000584379612816_1101890.33333333333341128.0DomainSMP-LTD
TgeneTEX2chr17:62141346chr17:62238293ENST00000258991612816_1101897.33333333333341135.0DomainSMP-LTD
TgeneTEX2chr17:62141346chr17:62238293ENST00000583097612816_1101890.33333333333341128.0DomainSMP-LTD
TgeneTEX2chr17:62141346chr17:62238293ENST00000584379612816_1101890.33333333333341128.0DomainSMP-LTD
TgeneTEX2chr17:62141345chr17:62238292ENST00000258991612475_495897.33333333333341135.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238292ENST00000258991612497_517897.33333333333341135.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238292ENST00000583097612475_495890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238292ENST00000583097612497_517890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238292ENST00000584379612475_495890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238292ENST00000584379612497_517890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238293ENST00000258991612475_495897.33333333333341135.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238293ENST00000258991612497_517897.33333333333341135.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238293ENST00000583097612475_495890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238293ENST00000583097612497_517890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238293ENST00000584379612475_495890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141345chr17:62238293ENST00000584379612497_517890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141346chr17:62238293ENST00000258991612475_495897.33333333333341135.0TransmembraneHelical
TgeneTEX2chr17:62141346chr17:62238293ENST00000258991612497_517897.33333333333341135.0TransmembraneHelical
TgeneTEX2chr17:62141346chr17:62238293ENST00000583097612475_495890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141346chr17:62238293ENST00000583097612497_517890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141346chr17:62238293ENST00000584379612475_495890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62141346chr17:62238293ENST00000584379612497_517890.33333333333341128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62254831ENST00000258991412475_495815.01135.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62254831ENST00000258991412497_517815.01135.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62254831ENST00000583097412475_495808.01128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62254831ENST00000583097412497_517808.01128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62254831ENST00000584379412475_495808.01128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62254831ENST00000584379412497_517808.01128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62272455ENST00000258991112475_495548.01135.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62272455ENST00000258991112497_517548.01135.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62272455ENST00000583097112475_495548.01128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62272455ENST00000583097112497_517548.01128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62272455ENST00000584379112475_495548.01128.0TransmembraneHelical
TgeneTEX2chr17:62157022chr17:62272455ENST00000584379112497_517548.01128.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERN1
TEX2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ERN1-TEX2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERN1-TEX2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource