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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ESR1-C6orf211

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ESR1-C6orf211
	FusionPDB ID: 27537
	FusionGDB2.0 ID: 27537
		Hgene	Tgene
	Gene symbol	ESR1	C6orf211
	Gene ID	2099	79624
	Gene name	estrogen receptor 1	acidic residue methyltransferase 1
	Synonyms	ER\|ESR\|ESRA\|ESTRR\|Era\|NR3A1	C6orf211
	Cytomap	6q25.1-q25.2	6q25.1
	Type of gene	protein-coding	protein-coding
	Description	estrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alpha	damage-control phosphatase ARMT1UPF0364 protein C6orf211protein-glutamate O-methyltransferasesugar phosphate phosphatase ARMT1
	Modification date	20200329	20200313
	UniProtAcc	P03372	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000206249, ENST00000338799, ENST00000406599, ENST00000440973, ENST00000443427, ENST00000456483, ENST00000427531, ENST00000482101,	ENST00000483931, ENST00000545879, ENST00000367294,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 18 X 8=3024	3 X 3 X 4=36
	# samples	35	4
	** MAII score	log2(35/3024*10)=-3.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ESR1 [Title/Abstract] AND C6orf211 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ESR1(152023140)-C6orf211(151785588), # samples:2
Anticipated loss of major functional domain due to fusion event.	ESR1-C6orf211 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ESR1-C6orf211 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ESR1-C6orf211 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ESR1-C6orf211 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ESR1	GO:0006366	transcription by RNA polymerase II	15831516
Hgene	ESR1	GO:0010629	negative regulation of gene expression	21695196
Hgene	ESR1	GO:0030520	intracellular estrogen receptor signaling pathway	9841876
Hgene	ESR1	GO:0032355	response to estradiol	15304487
Hgene	ESR1	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	7651415\|16043358
Hgene	ESR1	GO:0043433	negative regulation of DNA-binding transcription factor activity	10816575
Hgene	ESR1	GO:0043627	response to estrogen	11581164
Hgene	ESR1	GO:0045893	positive regulation of transcription, DNA-templated	9841876\|20074560
Hgene	ESR1	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	9841876
Hgene	ESR1	GO:0045944	positive regulation of transcription by RNA polymerase II	11544182\|12047722\|15345745\|15831516\|18563714
Hgene	ESR1	GO:0051091	positive regulation of DNA-binding transcription factor activity	9328340\|10681512
Hgene	ESR1	GO:0071392	cellular response to estradiol stimulus	15831516
Tgene	C6orf211	GO:0032259	methylation	25732820

Fusion gene breakpoints across ESR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C6orf211 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A1NA-01A	ESR1	chr6	152023140	-	C6orf211	chr6	151785588	+
ChimerDB4	BRCA	TCGA-E9-A1NA-01A	ESR1	chr6	152023140	+	C6orf211	chr6	151785588	+
ChimerDB4	OV	TCGA-23-1111-01A	ESR1	chr6	152129499	+	C6orf211	chr6	151775683	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000440973	ESR1	chr6	152129499	+	ENST00000367294	C6orf211	chr6	151775683	+	3098	822	370	2106	578
ENST00000338799	ESR1	chr6	152129499	+	ENST00000367294	C6orf211	chr6	151775683	+	4188	1912	1460	3196	578
ENST00000456483	ESR1	chr6	152129499	+	ENST00000367294	C6orf211	chr6	151775683	+	2946	670	218	1954	578
ENST00000443427	ESR1	chr6	152129499	+	ENST00000367294	C6orf211	chr6	151775683	+	2989	713	261	1997	578
ENST00000206249	ESR1	chr6	152129499	+	ENST00000367294	C6orf211	chr6	151775683	+	3090	814	362	2098	578
ENST00000406599	ESR1	chr6	152129499	+	ENST00000367294	C6orf211	chr6	151775683	+	2962	686	234	1970	578

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000440973	ENST00000367294	ESR1	chr6	152129499	+	C6orf211	chr6	151775683	+	0.000377367	0.9996226
ENST00000338799	ENST00000367294	ESR1	chr6	152129499	+	C6orf211	chr6	151775683	+	0.000383076	0.99961686
ENST00000456483	ENST00000367294	ESR1	chr6	152129499	+	C6orf211	chr6	151775683	+	0.000320763	0.9996792
ENST00000443427	ENST00000367294	ESR1	chr6	152129499	+	C6orf211	chr6	151775683	+	0.000349987	0.99965
ENST00000206249	ENST00000367294	ESR1	chr6	152129499	+	C6orf211	chr6	151775683	+	0.000315984	0.999684
ENST00000406599	ENST00000367294	ESR1	chr6	152129499	+	C6orf211	chr6	151775683	+	0.000314585	0.9996854

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27537_27537_1_ESR1-C6orf211_ESR1_chr6_152129499_ENST00000206249_C6orf211_chr6_151775683_ENST00000367294_length(amino acids)=578AA_BP=148
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRSFAYLTIKDRIPQILTKVIDTLHRHKSEF
FEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPP
IDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILL
NDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMS
KCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTL

--------------------------------------------------------------

>27537_27537_2_ESR1-C6orf211_ESR1_chr6_152129499_ENST00000338799_C6orf211_chr6_151775683_ENST00000367294_length(amino acids)=578AA_BP=148
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRSFAYLTIKDRIPQILTKVIDTLHRHKSEF
FEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPP
IDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILL
NDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMS
KCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTL

--------------------------------------------------------------

>27537_27537_3_ESR1-C6orf211_ESR1_chr6_152129499_ENST00000406599_C6orf211_chr6_151775683_ENST00000367294_length(amino acids)=578AA_BP=148
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRSFAYLTIKDRIPQILTKVIDTLHRHKSEF
FEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPP
IDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILL
NDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMS
KCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTL

--------------------------------------------------------------

>27537_27537_4_ESR1-C6orf211_ESR1_chr6_152129499_ENST00000440973_C6orf211_chr6_151775683_ENST00000367294_length(amino acids)=578AA_BP=148
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRSFAYLTIKDRIPQILTKVIDTLHRHKSEF
FEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPP
IDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILL
NDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMS
KCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTL

--------------------------------------------------------------

>27537_27537_5_ESR1-C6orf211_ESR1_chr6_152129499_ENST00000443427_C6orf211_chr6_151775683_ENST00000367294_length(amino acids)=578AA_BP=148
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRSFAYLTIKDRIPQILTKVIDTLHRHKSEF
FEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPP
IDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILL
NDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMS
KCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTL

--------------------------------------------------------------

>27537_27537_6_ESR1-C6orf211_ESR1_chr6_152129499_ENST00000456483_C6orf211_chr6_151775683_ENST00000367294_length(amino acids)=578AA_BP=148
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRSFAYLTIKDRIPQILTKVIDTLHRHKSEF
FEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPP
IDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILL
NDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMS
KCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:152023140/chr6:151785588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ESR1 P03372	.
FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. {ECO:0000269\|PubMed:10681512, ECO:0000269\|PubMed:10816575, ECO:0000269\|PubMed:11477071, ECO:0000269\|PubMed:11682626, ECO:0000269\|PubMed:14764652, ECO:0000269\|PubMed:15078875, ECO:0000269\|PubMed:15891768, ECO:0000269\|PubMed:16043358, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:16684779, ECO:0000269\|PubMed:17922032, ECO:0000269\|PubMed:17932106, ECO:0000269\|PubMed:18247370, ECO:0000269\|PubMed:19350539, ECO:0000269\|PubMed:20074560, ECO:0000269\|PubMed:20705611, ECO:0000269\|PubMed:21330404, ECO:0000269\|PubMed:22083956, ECO:0000269\|PubMed:7651415, ECO:0000269\|PubMed:9328340}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C6orf211

chr6:152129499

chr6:151775683

ENST00000367294

401_404

13.666666666666666

442.0

Motif

Subfamily III RTxK motif

Tgene

C6orf211

chr6:152129499

chr6:151775683

ENST00000367294

253_254

13.666666666666666

442.0

Region

Substrate binding

Tgene

C6orf211

chr6:152129499

chr6:151775683

ENST00000367294

367_371

13.666666666666666

442.0

Region

Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000206249

185_250

150.66666666666666

596.0

DNA binding

Nuclear receptor

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000338799

185_250

150.66666666666666

596.0

DNA binding

Nuclear receptor

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000440973

185_250

150.66666666666666

596.0

DNA binding

Nuclear receptor

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000443427

185_250

150.66666666666666

596.0

DNA binding

Nuclear receptor

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000456483

185_250

150.66666666666666

484.0

DNA binding

Nuclear receptor

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000206249

311_547

150.66666666666666

596.0

Domain

NR LBD

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000338799

311_547

150.66666666666666

596.0

Domain

NR LBD

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000440973

311_547

150.66666666666666

596.0

Domain

NR LBD

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000443427

311_547

150.66666666666666

596.0

Domain

NR LBD

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000456483

311_547

150.66666666666666

484.0

Domain

NR LBD

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000206249

251_310

150.66666666666666

596.0

Region

Note=Hinge

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000206249

264_595

150.66666666666666

596.0

Region

Note=Self-association

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000206249

311_595

150.66666666666666

596.0

Region

Note=Transactivation AF-2

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000338799

251_310

150.66666666666666

596.0

Region

Note=Hinge

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000338799

264_595

150.66666666666666

596.0

Region

Note=Self-association

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000338799

311_595

150.66666666666666

596.0

Region

Note=Transactivation AF-2

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000440973

251_310

150.66666666666666

596.0

Region

Note=Hinge

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000440973

264_595

150.66666666666666

596.0

Region

Note=Self-association

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000440973

311_595

150.66666666666666

596.0

Region

Note=Transactivation AF-2

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000443427

251_310

150.66666666666666

596.0

Region

Note=Hinge

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000443427

264_595

150.66666666666666

596.0

Region

Note=Self-association

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000443427

311_595

150.66666666666666

596.0

Region

Note=Transactivation AF-2

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000456483

251_310

150.66666666666666

484.0

Region

Note=Hinge

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000456483

264_595

150.66666666666666

484.0

Region

Note=Self-association

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000456483

311_595

150.66666666666666

484.0

Region

Note=Transactivation AF-2

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000206249

185_205

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000206249

221_245

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000338799

185_205

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000338799

221_245

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000440973

185_205

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000440973

221_245

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000443427

185_205

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000443427

221_245

150.66666666666666

596.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000456483

185_205

150.66666666666666

484.0

Zinc finger

NR C4-type

Hgene

ESR1

chr6:152129499

chr6:151775683

ENST00000456483

221_245

150.66666666666666

484.0

Zinc finger

NR C4-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ESR1
C6orf211

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000206249	+	1	8	262_595	150.66666666666666	596.0	AKAP13
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000338799	+	2	9	262_595	150.66666666666666	596.0	AKAP13
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000440973	+	3	10	262_595	150.66666666666666	596.0	AKAP13
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000443427	+	2	9	262_595	150.66666666666666	596.0	AKAP13
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000456483	+	2	8	262_595	150.66666666666666	484.0	AKAP13
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000206249	+	1	8	35_174	150.66666666666666	596.0	DDX5%3B self-association
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000338799	+	2	9	35_174	150.66666666666666	596.0	DDX5%3B self-association
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000440973	+	3	10	35_174	150.66666666666666	596.0	DDX5%3B self-association
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000443427	+	2	9	35_174	150.66666666666666	596.0	DDX5%3B self-association
Hgene	ESR1	chr6:152129499	chr6:151775683	ENST00000456483	+	2	8	35_174	150.66666666666666	484.0	DDX5%3B self-association

Top

Related Drugs to ESR1-C6orf211

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ESR1-C6orf211

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source