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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ESRP1-MYSM1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ESRP1-MYSM1
	FusionPDB ID: 27563
	FusionGDB2.0 ID: 27563
		Hgene	Tgene
	Gene symbol	ESRP1	MYSM1
	Gene ID	54845	114803
	Gene name	epithelial splicing regulatory protein 1	Myb like, SWIRM and MPN domains 1
	Synonyms	DFNB109\|RBM35A\|RMB35A	2A-DUB\|2ADUB\|BMFS4
	Cytomap	8q22.1	1p32.1
	Type of gene	protein-coding	protein-coding
	Description	epithelial splicing regulatory protein 1RNA-binding motif protein 35ARNA-binding protein 35A	histone H2A deubiquitinase MYSM1myb-like, SWIRM and MPN domain-containing protein 1
	Modification date	20200313	20200320
	UniProtAcc	Q6NXG1	Q5VVJ2
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000358397, ENST00000423620, ENST00000433389, ENST00000454170, ENST00000523347,	ENST00000493821, ENST00000472487,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 7 X 6=378	5 X 4 X 4=80
	# samples	9	5
	** MAII score	log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ESRP1 [Title/Abstract] AND MYSM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ESRP1(95680478)-MYSM1(59150923), # samples:1
Anticipated loss of major functional domain due to fusion event.	ESRP1-MYSM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ESRP1-MYSM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ESRP1-MYSM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ESRP1-MYSM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ESRP1	GO:0043484	regulation of RNA splicing	19285943

Fusion gene breakpoints across ESRP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYSM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	195N	ESRP1	chr8	95680478	+	MYSM1	chr1	59150923	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000423620	ESRP1	chr8	95680478	+	ENST00000472487	MYSM1	chr1	59150923	-	8824	1478	20	3565	1181
ENST00000433389	ESRP1	chr8	95680478	+	ENST00000472487	MYSM1	chr1	59150923	-	8769	1423	34	3510	1158
ENST00000358397	ESRP1	chr8	95680478	+	ENST00000472487	MYSM1	chr1	59150923	-	8724	1378	145	3465	1106
ENST00000454170	ESRP1	chr8	95680478	+	ENST00000472487	MYSM1	chr1	59150923	-	8699	1353	120	3440	1106

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000423620	ENST00000472487	ESRP1	chr8	95680478	+	MYSM1	chr1	59150923	-	4.02E-05	0.9999598
ENST00000433389	ENST00000472487	ESRP1	chr8	95680478	+	MYSM1	chr1	59150923	-	3.73E-05	0.9999628
ENST00000358397	ENST00000472487	ESRP1	chr8	95680478	+	MYSM1	chr1	59150923	-	3.58E-05	0.99996424
ENST00000454170	ENST00000472487	ESRP1	chr8	95680478	+	MYSM1	chr1	59150923	-	3.40E-05	0.9999659

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27563_27563_1_ESRP1-MYSM1_ESRP1_chr8_95680478_ENST00000358397_MYSM1_chr1_59150923_ENST00000472487_length(amino acids)=1106AA_BP=410
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLD
KETPNQKTGHNLQVKNEDKGTKAWTPSCLRGRADPNLNAVKIEKLSDDEEVDITDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEF
ITSDSQEALFSKSSRGCLQNEKQDETLSSSEITLWTEKQSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLND
NEMLFHSCQMVEESHEEEELKPPEQEIEIDRNIIQEEEKQAIPEFFEGRQAKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGD
VNCIGRIHTYLELIGAINFGCEQAVYNRPQTVDKVRIRDRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSAEELA
KRREEEKGRPVKSLKVPRPTKSSFDPFQLIPCNFFSEEKQEPFQVKVASEALLIMDLHAHVSMAEVIGLLGGRYSEVDKVVEVCAAEPCN
SLSTGLQCEMDPVSQTQASETLAVRGFSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRNNPLPYSQITCLVIS
EEISPDGSYRLPYKFEVQQMLEEPQWGLVFEKTRWIIEKYRLSHSSVPMDKIFRRDSDLTCLQKLLECMRKTLSKVTNCFMAEEFLTEIE

--------------------------------------------------------------

>27563_27563_2_ESRP1-MYSM1_ESRP1_chr8_95680478_ENST00000423620_MYSM1_chr1_59150923_ENST00000472487_length(amino acids)=1181AA_BP=485
MRPPSHPPSCPGRGAPTRCGLGWLVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGIT
AGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFC
LCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEP
YNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQR
HKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFV
LFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLDKETPNQKTGHNLQVK
NEDKGTKAWTPSCLRGRADPNLNAVKIEKLSDDEEVDITDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEFITSDSQEALFSKSSR
GCLQNEKQDETLSSSEITLWTEKQSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLNDNEMLFHSCQMVEESH
EEEELKPPEQEIEIDRNIIQEEEKQAIPEFFEGRQAKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIG
AINFGCEQAVYNRPQTVDKVRIRDRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSAEELAKRREEEKGRPVKSLK
VPRPTKSSFDPFQLIPCNFFSEEKQEPFQVKVASEALLIMDLHAHVSMAEVIGLLGGRYSEVDKVVEVCAAEPCNSLSTGLQCEMDPVSQ
TQASETLAVRGFSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRNNPLPYSQITCLVISEEISPDGSYRLPYKF
EVQQMLEEPQWGLVFEKTRWIIEKYRLSHSSVPMDKIFRRDSDLTCLQKLLECMRKTLSKVTNCFMAEEFLTEIENLFLSNYKSNQENGV

--------------------------------------------------------------

>27563_27563_3_ESRP1-MYSM1_ESRP1_chr8_95680478_ENST00000433389_MYSM1_chr1_59150923_ENST00000472487_length(amino acids)=1158AA_BP=462
MVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVV
DLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVL
LPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKM
ELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKI
AGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRY
IELFRSTAAEVQQAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLDKETPNQKTGHNLQVKNEDKGTKAWTPSCLRGRADPNLN
AVKIEKLSDDEEVDITDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEFITSDSQEALFSKSSRGCLQNEKQDETLSSSEITLWTEK
QSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLNDNEMLFHSCQMVEESHEEEELKPPEQEIEIDRNIIQEEE
KQAIPEFFEGRQAKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAVYNRPQTVDKVRIR
DRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSAEELAKRREEEKGRPVKSLKVPRPTKSSFDPFQLIPCNFFSEE
KQEPFQVKVASEALLIMDLHAHVSMAEVIGLLGGRYSEVDKVVEVCAAEPCNSLSTGLQCEMDPVSQTQASETLAVRGFSVIGWYHSHPA
FDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRNNPLPYSQITCLVISEEISPDGSYRLPYKFEVQQMLEEPQWGLVFEKTRWIIE

--------------------------------------------------------------

>27563_27563_4_ESRP1-MYSM1_ESRP1_chr8_95680478_ENST00000454170_MYSM1_chr1_59150923_ENST00000472487_length(amino acids)=1106AA_BP=410
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLD
KETPNQKTGHNLQVKNEDKGTKAWTPSCLRGRADPNLNAVKIEKLSDDEEVDITDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEF
ITSDSQEALFSKSSRGCLQNEKQDETLSSSEITLWTEKQSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLND
NEMLFHSCQMVEESHEEEELKPPEQEIEIDRNIIQEEEKQAIPEFFEGRQAKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGD
VNCIGRIHTYLELIGAINFGCEQAVYNRPQTVDKVRIRDRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSAEELA
KRREEEKGRPVKSLKVPRPTKSSFDPFQLIPCNFFSEEKQEPFQVKVASEALLIMDLHAHVSMAEVIGLLGGRYSEVDKVVEVCAAEPCN
SLSTGLQCEMDPVSQTQASETLAVRGFSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRNNPLPYSQITCLVIS
EEISPDGSYRLPYKFEVQQMLEEPQWGLVFEKTRWIIEKYRLSHSSVPMDKIFRRDSDLTCLQKLLECMRKTLSKVTNCFMAEEFLTEIE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:95680478/chr1:59150923)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ESRP1 Q6NXG1	MYSM1 Q5VVJ2
FUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250\|UniProtKB:Q3US41, ECO:0000269\|PubMed:19285943}.	FUNCTION: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250\|UniProtKB:Q69Z66, ECO:0000269\|PubMed:17707232, ECO:0000269\|PubMed:22169041, ECO:0000269\|PubMed:24062447, ECO:0000269\|PubMed:26220525, ECO:0000269\|PubMed:28115216, ECO:0000269\|PubMed:33086059}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000358397

225_302

411.0

1099.6666666666667

Domain

RRM 1

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000358397

326_406

411.0

1099.6666666666667

Domain

RRM 2

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000423620

225_302

411.0

660.0

Domain

RRM 1

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000423620

326_406

411.0

660.0

Domain

RRM 2

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000433389

225_302

411.0

1074.3333333333333

Domain

RRM 1

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000433389

326_406

411.0

1074.3333333333333

Domain

RRM 2

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000454170

225_302

411.0

609.0

Domain

RRM 1

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000454170

326_406

411.0

609.0

Domain

RRM 2

Tgene

MYSM1

chr8:95680478

chr1:59150923

ENST00000472487

372_470

133.0

829.0

Domain

SWIRM

Tgene

MYSM1

chr8:95680478

chr1:59150923

ENST00000472487

577_709

133.0

829.0

Domain

MPN

Tgene

MYSM1

chr8:95680478

chr1:59150923

ENST00000472487

656_669

133.0

829.0

Motif

JAMM motif

Tgene

MYSM1

chr8:95680478

chr1:59150923

ENST00000472487

774_778

133.0

829.0

Motif

Note=LXXLL motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000358397

445_525

411.0

1099.6666666666667

Domain

RRM 3

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000423620

445_525

411.0

660.0

Domain

RRM 3

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000433389

445_525

411.0

1074.3333333333333

Domain

RRM 3

Hgene

ESRP1

chr8:95680478

chr1:59150923

ENST00000454170

445_525

411.0

609.0

Domain

RRM 3

Tgene

MYSM1

chr8:95680478

chr1:59150923

ENST00000472487

116_167

133.0

829.0

Domain

SANT

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

ESRP1

ATXN1, RNF2, BMI1, RNF111, RGPD8, RGPD5, RBPMS, RGPD3, RBPMS2, ATXN2, THUMPD3, ZNF703, HELZ, ELAVL2, GPATCH8, BIRC6, ESR2, MED25, KLHDC7B, OXER1, DAZAP2, KRTAP19-5, ARID5A, PRR20B, PRR20A, PRR20D, PRR20C, PRR20E, ESR1, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR7-1, MIR9-1, MIR15B, MIR19B1, MIR19B2, MIR20B, MIR21, MIR25, MIR29C, MIR34A, MIR34B, MIR106A, MIR106B, MIR128-2, MIR138-1, MIR138-2, MIR141, MIR155, MIR200A, MIR200C, MIR222, MIR363, H1F0, CIT, KIF14, KIF20A, PRC1, PAK6, RANBP2, MRPS24, ZC3H10, ALG13, Rbm38, Rbm47,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ESRP1
MYSM1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ESRP1-MYSM1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ESRP1-MYSM1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ESRP1	C4693935	DEAFNESS, AUTOSOMAL RECESSIVE 109	1	GENOMICS_ENGLAND;UNIPROT