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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ESRP1-RAF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ESRP1-RAF1
FusionPDB ID: 27566
FusionGDB2.0 ID: 27566
HgeneTgene
Gene symbol

ESRP1

RAF1

Gene ID

54845

6037

Gene nameepithelial splicing regulatory protein 1ribonuclease A family member 3
SynonymsDFNB109|RBM35A|RMB35AECP|RAF1|RNS3
Cytomap

8q22.1

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionepithelial splicing regulatory protein 1RNA-binding motif protein 35ARNA-binding protein 35Aeosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3
Modification date2020031320200313
UniProtAcc

Q6NXG1

P04049

Ensembl transtripts involved in fusion geneENST idsENST00000358397, ENST00000423620, 
ENST00000433389, ENST00000454170, 
ENST00000523347, 		ENST00000534997, 
ENST00000542177, ENST00000251849, 
ENST00000442415, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 7 X 6=37819 X 16 X 7=2128
# samples 918
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2128*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ESRP1 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ESRP1(95690599)-RAF1(12647800), # samples:1
Anticipated loss of major functional domain due to fusion event.ESRP1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESRP1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESRP1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESRP1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAF1-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RAF1-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RAF1-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
RAF1-ESRP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RAF1-ESRP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESRP1

GO:0043484

regulation of RNA splicing

19285943

TgeneRAF1

GO:0002227

innate immune response in mucosa

12860195

TgeneRAF1

GO:0019731

antibacterial humoral response

12860195

TgeneRAF1

GO:0043152

induction of bacterial agglutination

23992292

TgeneRAF1

GO:0045087

innate immune response

23992292

TgeneRAF1

GO:0050829

defense response to Gram-negative bacterium

23992292

TgeneRAF1

GO:0050830

defense response to Gram-positive bacterium

12860195|23992292

TgeneRAF1

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195


check buttonFusion gene breakpoints across ESRP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..ESRP1chr8

95690599

+RAF1chr3

12647798

-
ChiTaRS5.0N/AGU149302ESRP1chr8

95690599

+RAF1chr3

12647800

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423620ESRP1chr895690599+ENST00000251849RAF1chr312647798-433220532034181132
ENST00000423620ESRP1chr895690599+ENST00000442415RAF1chr312647798-419520532034781152
ENST00000433389ESRP1chr895690599+ENST00000251849RAF1chr312647798-428920103433751113
ENST00000433389ESRP1chr895690599+ENST00000442415RAF1chr312647798-415220103434351133
ENST00000358397ESRP1chr895690599+ENST00000251849RAF1chr312647798-4232195314533181057
ENST00000358397ESRP1chr895690599+ENST00000442415RAF1chr312647798-4095195314533781077
ENST00000454170ESRP1chr895690599+ENST00000251849RAF1chr312647798-4219194012033051061
ENST00000454170ESRP1chr895690599+ENST00000442415RAF1chr312647798-4082194012033651081
ENST00000423620ESRP1chr895690599+ENST00000251849RAF1chr312647800-433220532034181132
ENST00000423620ESRP1chr895690599+ENST00000442415RAF1chr312647800-419520532034781152
ENST00000433389ESRP1chr895690599+ENST00000251849RAF1chr312647800-428920103433751113
ENST00000433389ESRP1chr895690599+ENST00000442415RAF1chr312647800-415220103434351133
ENST00000358397ESRP1chr895690599+ENST00000251849RAF1chr312647800-4232195314533181057
ENST00000358397ESRP1chr895690599+ENST00000442415RAF1chr312647800-4095195314533781077
ENST00000454170ESRP1chr895690599+ENST00000251849RAF1chr312647800-4219194012033051061
ENST00000454170ESRP1chr895690599+ENST00000442415RAF1chr312647800-4082194012033651081

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423620ENST00000251849ESRP1chr895690599+RAF1chr312647800-0.0015161030.99848396
ENST00000423620ENST00000442415ESRP1chr895690599+RAF1chr312647800-0.0018799240.99812
ENST00000433389ENST00000251849ESRP1chr895690599+RAF1chr312647800-0.0022218490.9977781
ENST00000433389ENST00000442415ESRP1chr895690599+RAF1chr312647800-0.0020850130.99791497
ENST00000358397ENST00000251849ESRP1chr895690599+RAF1chr312647800-0.0015212130.99847883
ENST00000358397ENST00000442415ESRP1chr895690599+RAF1chr312647800-0.0018825880.99811745
ENST00000454170ENST00000251849ESRP1chr895690599+RAF1chr312647800-0.0020204920.9979796
ENST00000454170ENST00000442415ESRP1chr895690599+RAF1chr312647800-0.0018473350.9981527

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27566_27566_1_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000358397_RAF1_chr3_12647798_ENST00000251849_length(amino acids)=1057AA_BP=602
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESV
SRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTP
VPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTR
HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAM

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>27566_27566_2_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000358397_RAF1_chr3_12647798_ENST00000442415_length(amino acids)=1077AA_BP=602
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESV
SRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPS
ALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVD
PTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKS
NNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMV

--------------------------------------------------------------

>27566_27566_3_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000358397_RAF1_chr3_12647800_ENST00000251849_length(amino acids)=1057AA_BP=602
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESV
SRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTP
VPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTR
HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAM

--------------------------------------------------------------

>27566_27566_4_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000358397_RAF1_chr3_12647800_ENST00000442415_length(amino acids)=1077AA_BP=602
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESV
SRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPS
ALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVD
PTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKS
NNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMV

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>27566_27566_5_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000423620_RAF1_chr3_12647798_ENST00000251849_length(amino acids)=1132AA_BP=677
MRPPSHPPSCPGRGAPTRCGLGWLVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGIT
AGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFC
LCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEP
YNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQR
HKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFV
LFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFL
GEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTF
PAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPH
AFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQE
KNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN
LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPT
GSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEER

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>27566_27566_6_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000423620_RAF1_chr3_12647798_ENST00000442415_length(amino acids)=1152AA_BP=677
MRPPSHPPSCPGRGAPTRCGLGWLVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGIT
AGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFC
LCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEP
YNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQR
HKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFV
LFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFL
GEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTF
PAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPH
AFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWS
QPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAV
LRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGD
FGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKN

--------------------------------------------------------------

>27566_27566_7_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000423620_RAF1_chr3_12647800_ENST00000251849_length(amino acids)=1132AA_BP=677
MRPPSHPPSCPGRGAPTRCGLGWLVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGIT
AGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFC
LCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEP
YNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQR
HKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFV
LFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFL
GEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTF
PAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPH
AFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQE
KNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN
LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPT
GSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEER

--------------------------------------------------------------

>27566_27566_8_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000423620_RAF1_chr3_12647800_ENST00000442415_length(amino acids)=1152AA_BP=677
MRPPSHPPSCPGRGAPTRCGLGWLVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGIT
AGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFC
LCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEP
YNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQR
HKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFV
LFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFL
GEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTF
PAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPH
AFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWS
QPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAV
LRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGD
FGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKN

--------------------------------------------------------------

>27566_27566_9_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000433389_RAF1_chr3_12647798_ENST00000251849_length(amino acids)=1113AA_BP=658
MVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVV
DLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVL
LPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKM
ELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKI
AGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRY
IELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPS
GDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVI
LNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQ
RSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIE
ASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHV
QETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPF
SFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK

--------------------------------------------------------------

>27566_27566_10_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000433389_RAF1_chr3_12647798_ENST00000442415_length(amino acids)=1133AA_BP=658
MVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVV
DLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVL
LPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKM
ELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKI
AGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRY
IELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPS
GDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVI
LNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQ
RSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQ
EKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKD
NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP
TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEE

--------------------------------------------------------------

>27566_27566_11_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000433389_RAF1_chr3_12647800_ENST00000251849_length(amino acids)=1113AA_BP=658
MVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVV
DLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVL
LPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKM
ELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKI
AGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRY
IELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPS
GDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVI
LNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQ
RSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIE
ASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHV
QETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPF
SFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK

--------------------------------------------------------------

>27566_27566_12_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000433389_RAF1_chr3_12647800_ENST00000442415_length(amino acids)=1133AA_BP=658
MVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVV
DLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVL
LPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKM
ELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKI
AGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRY
IELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPS
GDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVI
LNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQ
RSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQ
EKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKD
NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP
TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEE

--------------------------------------------------------------

>27566_27566_13_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000454170_RAF1_chr3_12647798_ENST00000251849_length(amino acids)=1061AA_BP=606
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRM
RESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQ
PKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVL
RKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDF
GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNC

--------------------------------------------------------------

>27566_27566_14_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000454170_RAF1_chr3_12647798_ENST00000442415_length(amino acids)=1081AA_BP=606
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRM
RESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSES
ASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHR
DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPV

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>27566_27566_15_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000454170_RAF1_chr3_12647800_ENST00000251849_length(amino acids)=1061AA_BP=606
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRM
RESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQ
PKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVL
RKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDF
GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNC

--------------------------------------------------------------

>27566_27566_16_ESRP1-RAF1_ESRP1_chr8_95690599_ENST00000454170_RAF1_chr3_12647800_ENST00000442415_length(amino acids)=1081AA_BP=606
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQ
SVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSRYGASQ
VEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEAL
VRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGIL
FVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRN
GLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRRM
RESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSES
ASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHR
DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:95690599/chr3:12647800)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESRP1

Q6NXG1

RAF1

P04049

FUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250|UniProtKB:Q3US41, ECO:0000269|PubMed:19285943}.FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESRP1chr8:95690599chr3:12647800ENST00000358397+1316225_302602.66666666666661099.6666666666667DomainRRM 1
HgeneESRP1chr8:95690599chr3:12647800ENST00000358397+1316326_406602.66666666666661099.6666666666667DomainRRM 2
HgeneESRP1chr8:95690599chr3:12647800ENST00000358397+1316445_525602.66666666666661099.6666666666667DomainRRM 3
HgeneESRP1chr8:95690599chr3:12647800ENST00000423620+1315225_302602.6666666666666660.0DomainRRM 1
HgeneESRP1chr8:95690599chr3:12647800ENST00000423620+1315326_406602.6666666666666660.0DomainRRM 2
HgeneESRP1chr8:95690599chr3:12647800ENST00000423620+1315445_525602.6666666666666660.0DomainRRM 3
HgeneESRP1chr8:95690599chr3:12647800ENST00000433389+1316225_302606.66666666666661074.3333333333333DomainRRM 1
HgeneESRP1chr8:95690599chr3:12647800ENST00000433389+1316326_406606.66666666666661074.3333333333333DomainRRM 2
HgeneESRP1chr8:95690599chr3:12647800ENST00000433389+1316445_525606.66666666666661074.3333333333333DomainRRM 3
HgeneESRP1chr8:95690599chr3:12647800ENST00000454170+1314225_302606.6666666666666609.0DomainRRM 1
HgeneESRP1chr8:95690599chr3:12647800ENST00000454170+1314326_406606.6666666666666609.0DomainRRM 2
HgeneESRP1chr8:95690599chr3:12647800ENST00000454170+1314445_525606.6666666666666609.0DomainRRM 3
TgeneRAF1chr8:95690599chr3:12647800ENST00000251849417349_609193.66666666666666649.0DomainProtein kinase
TgeneRAF1chr8:95690599chr3:12647800ENST00000442415418349_609193.66666666666666669.0DomainProtein kinase
TgeneRAF1chr8:95690599chr3:12647800ENST00000251849417355_363193.66666666666666649.0Nucleotide bindingATP
TgeneRAF1chr8:95690599chr3:12647800ENST00000442415418355_363193.66666666666666669.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAF1chr8:95690599chr3:12647800ENST0000025184941756_131193.66666666666666649.0DomainRBD
TgeneRAF1chr8:95690599chr3:12647800ENST0000044241541856_131193.66666666666666669.0DomainRBD
TgeneRAF1chr8:95690599chr3:12647800ENST00000251849417138_184193.66666666666666649.0Zinc fingerPhorbol-ester/DAG-type
TgeneRAF1chr8:95690599chr3:12647800ENST00000442415418138_184193.66666666666666669.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (784) >>>784.pdbFusion protein BP residue: 602
CIF file (784) >>>784.cif		ESRP1chr895690599+RAF1chr312647798-
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHE
VLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGV
GTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGS
PDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRF
SDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNI
AKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKA
TGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHC
PITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIE
LFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSP
PSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAY
YPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFN
TSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPS
ALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYY
WEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFR
NEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQ
MFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYEL
MTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKK
VKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTT
1057
3D view using mol* of 784 (AA BP:602)
PDB file (786) >>>786.pdbFusion protein BP residue: 606
CIF file (786) >>>786.cif		ESRP1chr895690599+RAF1chr312647798-
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHE
VLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGV
GTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGS
PDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRF
SDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNI
AKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKA
TGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHC
PITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIE
LFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLP
CLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMN
YTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHA
FTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSES
ASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRD
SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQF
QAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDF
GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV
LYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVAD
CVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINAC
1061
3D view using mol* of 786 (AA BP:606)
PDB file (791) >>>791.pdbFusion protein BP residue: 602
CIF file (791) >>>791.cif		ESRP1chr895690599+RAF1chr312647798-
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHE
VLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGV
GTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGS
PDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRF
SDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNI
AKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKA
TGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHC
PITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIE
LFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSP
PSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMNYTAY
YPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFN
TSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSR
RFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPV
SGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD
VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVT
QWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKS
NNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQD
NNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLS
KLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSAS
1077
3D view using mol* of 791 (AA BP:602)
PDB file (794) >>>794.pdbFusion protein BP residue: 606
CIF file (794) >>>794.cif		ESRP1chr895690599+RAF1chr312647798-
MTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQLHE
VLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGV
GTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGS
PDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNHRF
SDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGLNI
AKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKA
TGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHC
PITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRYIE
LFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
GLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLP
CLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLFMN
YTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHA
FTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPR
AWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGK
WHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL
AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHR
DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVI
RMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYAS
PDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
1081
3D view using mol* of 794 (AA BP:606)
PDB file (806) >>>806.pdbFusion protein BP residue: 658
CIF file (806) >>>806.cif		ESRP1chr895690599+RAF1chr312647798-
MVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPP
IVMTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQL
HEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNI
GVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCP
GSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNH
RFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGL
NIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVY
KATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQ
HCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRY
IELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIR
LRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSA
DRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCK
LPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLF
MNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTP
HAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHS
ESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQ
RDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPE
QFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHV
QETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYG
IVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLV
ADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDIN
1113
3D view using mol* of 806 (AA BP:658)
PDB file (823) >>>823.pdbFusion protein BP residue: 677
CIF file (823) >>>823.cif		ESRP1chr895690599+RAF1chr312647798-
MRPPSHPPSCPGRGAPTRCGLGWLVTAFCTSSSKEGGWALFLFLLEEGLA
QVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGITAGATGAKLGS
DEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESL
SSASQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKK
NVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSR
YGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNT
VVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVS
EEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQ
VIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFV
LFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLP
TPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTH
GVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSA
EEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVIL
NPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRR
MRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMV
STTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR
ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKG
KWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN
LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIH
RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEV
IRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYA
SPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKI
1132
3D view using mol* of 823 (AA BP:677)
PDB file (824) >>>824.pdbFusion protein BP residue: 658
CIF file (824) >>>824.cif		ESRP1chr895690599+RAF1chr312647798-
MVTAFCTSSSKEGGWALFLFLLEEGLAQVFSFSLPHHLTASRPPLSPSPP
IVMTASPDYLVVLFGITAGATGAKLGSDEKELILLFWKVVDLANKKVGQL
HEVLVRPDQLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNI
GVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCP
GSPDIDKLDVATMTEYLNFEKSSSVSRYGASQVEDMGNIILAMISEPYNH
RFSDPERVNYKFESGTCSKMELIDDNTVVRARGLPWQSSDQDIARFFKGL
NIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVY
KATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQ
HCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDLLGKRY
IELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIR
LRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSA
DRAFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCK
LPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAGTQLF
MNYTAYYPRLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTP
HAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSAS
PRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQ
RERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKD
NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNII
HRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPE
VIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGY
ASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK
1133
3D view using mol* of 824 (AA BP:658)
PDB file (832) >>>832.pdbFusion protein BP residue: 677
CIF file (832) >>>832.cif		ESRP1chr895690599+RAF1chr312647798-
MRPPSHPPSCPGRGAPTRCGLGWLVTAFCTSSSKEGGWALFLFLLEEGLA
QVFSFSLPHHLTASRPPLSPSPPIVMTASPDYLVVLFGITAGATGAKLGS
DEKELILLFWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDVESL
SSASQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKK
NVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVATMTEYLNFEKSSSVSR
YGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKMELIDDNT
VVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVS
EEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQ
VIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFV
LFACEEYAQNALRKHKDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLP
TPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTH
GVHMVLNHQGRPSGDAFIQMKSADRAFMAAQKCHKKNMKDRYVEVFQCSA
EEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVIL
NPRALQPSTAYYPAGTQLFMNYTAYYPRLFPNSTIGDSGVPALPSLTMRR
MRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMV
STTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSS
PNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEA
SEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAV
LRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLI
DIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW
SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGEL
PYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEER
PLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLP
1152
3D view using mol* of 832 (AA BP:677)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ESRP1_pLDDT.png
all structure
all structure
RAF1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ESRP1_RAF1_784_pLDDT.png (AA BP:602)
all structure
ESRP1_RAF1_784_pLDDT_and_active_sites.png (AA BP:602)
all structure
ESRP1_RAF1_784_violinplot.png (AA BP:602)
all structure
ESRP1_RAF1_786_pLDDT.png (AA BP:606)
all structure
ESRP1_RAF1_786_pLDDT_and_active_sites.png (AA BP:606)
all structure
ESRP1_RAF1_786_violinplot.png (AA BP:606)
all structure
ESRP1_RAF1_791_pLDDT.png (AA BP:602)
all structure
ESRP1_RAF1_791_pLDDT_and_active_sites.png (AA BP:602)
all structure
ESRP1_RAF1_791_violinplot.png (AA BP:602)
all structure
ESRP1_RAF1_794_pLDDT.png (AA BP:606)
all structure
ESRP1_RAF1_794_pLDDT_and_active_sites.png (AA BP:606)
all structure
ESRP1_RAF1_794_violinplot.png (AA BP:606)
all structure
ESRP1_RAF1_806_pLDDT.png (AA BP:658)
all structure
ESRP1_RAF1_806_pLDDT_and_active_sites.png (AA BP:658)
all structure
ESRP1_RAF1_806_violinplot.png (AA BP:658)
all structure
ESRP1_RAF1_823_pLDDT.png (AA BP:677)
all structure
ESRP1_RAF1_823_pLDDT_and_active_sites.png (AA BP:677)
all structure
ESRP1_RAF1_823_violinplot.png (AA BP:677)
all structure
ESRP1_RAF1_824_pLDDT.png (AA BP:658)
all structure
ESRP1_RAF1_824_pLDDT_and_active_sites.png (AA BP:658)
all structure
ESRP1_RAF1_824_violinplot.png (AA BP:658)
all structure
ESRP1_RAF1_832_pLDDT.png (AA BP:677)
all structure
ESRP1_RAF1_832_pLDDT_and_active_sites.png (AA BP:677)
all structure
ESRP1_RAF1_832_violinplot.png (AA BP:677)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
ESRP1_RAF1_784.png
all structure
ESRP1_RAF1_786.png
all structure
ESRP1_RAF1_791.png
all structure
ESRP1_RAF1_794.png
all structure
ESRP1_RAF1_806.png
all structure
ESRP1_RAF1_823.png
all structure
ESRP1_RAF1_824.png
all structure
ESRP1_RAF1_832.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
7841.0755611.11052.3240.430.7871.0381.1220.9591.170.878Chain A: 664,665,666,667,668,669,670,671,672,673,6
74,764,765,767,768,769,770,772,782,784,806,815,817
,828,830,831,832,833,836,837,839,840,844,875,876,8
77,878,879,881,882,884,894,895,896,897,898,899,900
,902,903,905,906,907,908,909,910,911,912,913,914,9
15,916,917,918,919,920,921,922,925,928,931,932,933
,934,938,939,942,955,956,957,958,961,962,963,964,9
66
7861.0084091.0341391.5510.6010.6960.9050.4080.9940.4110.747Chain A: 217,228,230,231,232,233,234,258,259,260,2
61,262,264,266,267,268,289,292,293,294,296,298,299
,300,304,306,307,308,310,311,312,313,410,411,414,4
15,429,430,431,432,433,434,435,436,437,438,440,473
,474,475,476,478,479,480,481,482,483,485,494,525,5
26,528,529,531,532,533,534,676,677,679
7911.0583801.1021052.3240.5520.7270.9320.8510.8411.0120.97Chain A: 670,671,672,673,784,785,786,787,788,789,7
90,792,802,804,826,829,834,835,836,837,848,850,851
,852,853,854,855,856,857,859,860,864,896,897,898,8
99,901,902,904,914,915,916,918,919,920,922,923,924
,925,926,927,928,929,930,931,932,933,934,935,936,9
37,940,941,942,945,948,949,950,951,952,953,954,958
,959,962,983,984,987
7941.0862851.114593.0470.450.7921.0441.180.9241.2770.715Chain A: 674,675,676,677,678,679,787,788,789,790,7
91,793,794,795,796,806,808,826,830,839,841,852,854
,855,856,857,858,859,860,861,863,864,901,903,905,9
06,908,918,919,920,922,940
8061.03185991.07122338.9170.62660.70190.88220.69380.88940.780.7122Chain A: 76,79,80,81,168,169,172,173,175,176,178,2
69,282,283,285,286,287,288,289,291,292,295,296,298
,310,311,312,313,314,316,317,318,319,320,337,338,3
39,340,341,342,343,344,345,346,348,350,358,359,360
,361,362,363,364,365,367,368,378,383,412,414,415,4
16,417,432,435,436,439,442,452,453,454,455,460,462
,463,465,466,467,469,656,657,722,723,724,725,726,7
27,728,729,730,731,802,803,804,805,806,807,808,809
,810,813,833,834,852,856,859,860,863,864,865,866,8
72,873,874,875,876,878,879,923,927
8231.07962471.1256521.360.52590.75170.99720.99880.81411.22690.8581Chain A: 90,91,99,101,102,103,104,105,130,131,132,
191,192,194,195,196,197,198,199,201,202,203,204,20
9,281,282,283,284,285,286,314,315,317,318,319,320,
321,322,323,324,325,326,327,360,363,364,365,366
8241.05865801.09011777.7690.54370.75141.00250.8070.92270.87460.734Chain A: 76,79,80,81,168,169,171,172,173,174,175,1
76,178,179,180,181,186,258,259,260,261,262,263,282
,283,284,285,286,287,288,289,291,292,294,295,296,2
97,298,299,300,301,302,303,304,305,311,312,315,316
,317,318,319,320,337,340,341,342,343,344,345,346,3
48,350,381,383,432,433,435,436,439,440,442,453,454
,455,460,650,653,656,657,659,725,726,727,728,729,7
30,731,823,826,827,853,854,883,885,886,887,888,890
,891,892,893,894,907,968
8321.08282301.1261474.3690.49340.76091.03191.19290.82981.43761.179Chain A: 90,99,101,102,103,104,131,191,192,194,195
,196,197,198,199,200,201,202,203,204,209,281,282,2
83,284,285,286,314,315,317,318,319,320,321,322,323
,324,325,326,327,349,360,363,364,365,366

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
823ZINC000001529323DB00563Methotrexate-6.20471-8.66591
823ZINC000052509366DB08881Vemurafenib-8.12494-8.56894
823ZINC000085537017DB06441Cangrelor-8.34269-8.35669
823ZINC000043100953DB09042Tedizolid phosphate-8.2696-8.3546
823ZINC000100022637DB00932Tipranavir-8.17419-8.31189
823ZINC000100016058DB00932Tipranavir-8.17419-8.31189
823ZINC000007997897DB00735Naftifine-8.17213-8.25163
823ZINC000096006023DB06590Ceftaroline fosamil-7.65873-8.20383
823ZINC000100074252DB08934Sofosbuvir-8.18413-8.18683
823ZINC000003794794DB01204Mitoxantrone-8.05242-8.05242
823ZINC000003831490DB00795Sulfasalazine-7.75449-8.04359
823ZINC000000897089DB00358Mefloquine-7.9809-7.9834
823ZINC000004654889DB01046Lubiprostone-7.94773-7.95123
823ZINC000035328014DB09053Ibrutinib-7.89571-7.89571
823ZINC000002169830DB00194Vidarabine-7.88421-7.88421
823ZINC000034806477DB08899Enzalutamide-7.78663-7.78663
823ZINC000019796080DB00450Droperidol-6.67056-7.78276
823ZINC000000968326DB01132Pioglitazone-7.24366-7.72636
823ZINC000003806063DB06207Silodosin-7.64807-7.65177
823ZINC000003920719DB01076Atorvastatin-7.62574-7.62794

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000001529323DB00563MethotrexateSmall moleculeCN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=OApproved
ZINC000052509366DB08881VemurafenibSmall moleculeCCCS(=O)(=O)NC1=C(F)C(C(=O)C2=CNC3=NC=C(C=C23)C2=CC=C(Cl)C=C2)=C(F)C=C1Approved
ZINC000085537017DB06441CangrelorSmall moleculeCSCCNC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC(SCCC(F)(F)F)=N1Approved
ZINC000043100953DB09042Tedizolid phosphateSmall moleculeCN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=OApproved
ZINC000100016058DB00932TipranavirSmall molecule[H][C@@](CC)(C1=CC(NS(=O)(=O)C2=NC=C(C=C2)C(F)(F)F)=CC=C1)C1=C(O)C[C@@](CCC)(CCC2=CC=CC=C2)OC1=OApproved|Investigational
ZINC000007997897DB00735NaftifineSmall moleculeCN(CC=CC1=CC=CC=C1)CC1=CC=CC2=CC=CC=C12Approved
ZINC000003794794DB01204MitoxantroneSmall moleculeOCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C1=C(C(O)=CC=C1O)C2=OApproved|Investigational
ZINC000003831490DB00795SulfasalazineSmall moleculeOC(=O)C1=CC(=CC=C1O)N=NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=C1Approved
ZINC000004654889DB01046LubiprostoneSmall molecule[H][C@@]12CC(=O)[C@H](CCCCCCC(O)=O)[C@@]1([H])CC[C@@](O)(O2)C(F)(F)CCCCApproved|Investigational
ZINC000035328014DB09053IbrutinibSmall moleculeNC1=NC=NC2=C1C(=NN2[C@@H]1CCCN(C1)C(=O)C=C)C1=CC=C(OC2=CC=CC=C2)C=C1Approved
ZINC000002169830DB00194VidarabineSmall moleculeNC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1OApproved|Investigational
ZINC000034806477DB08899EnzalutamideSmall moleculeCNC(=O)C1=C(F)C=C(C=C1)N1C(=S)N(C(=O)C1(C)C)C1=CC=C(C#N)C(=C1)C(F)(F)FApproved
ZINC000019796080DB00450DroperidolSmall moleculeFC1=CC=C(C=C1)C(=O)CCCN1CCC(=CC1)N1C(=O)NC2=CC=CC=C12Approved|Vet_approved
ZINC000003806063DB06207SilodosinSmall moleculeC[C@H](CC1=CC2=C(N(CCCO)CC2)C(=C1)C(N)=O)NCCOC1=CC=CC=C1OCC(F)(F)FApproved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000001529323454.4449.001693.276161.373365.593166.3101298.4956.2511.758.4841021
ZINC000001529323454.4446.446760.449167.842425.587167.0201350.6496.2511.758.4491021
ZINC000001529323454.4446.083766.74168.735420.347177.65801359.4316.2511.758.4061021
ZINC000052509366489.9236.563709.38163.325140.676266.537138.8421320.97416.58.871110001
ZINC000052509366489.9236.736681.737134.514159.424252.969134.831288.8416.59.009396.98301
ZINC000085537017776.3537.43927.054287.655393.58554.42191.3941783.369320.68.4621031
ZINC000085537017776.3535.036918.307262.294312.53251.82291.6611775.566320.68.6031031
ZINC000043100953450.3228.428720.625174.492308.419199.97437.7411252.9792139.192117.34511
ZINC000043100953450.3228.806708.392174.655291.009204.37638.3521241.0022139.026120.70611
ZINC000100022637602.6672.686889.996308.606122.685340.827117.8781721.049110.58.78184.70622
ZINC000100022637602.6676.754963.159295.054156.83392.931118.3431774.853110.58.82179.71722
ZINC000100022637602.6673.375895.97302.669123.512351.589118.21717.752110.59.221184.46722
ZINC000100022637602.6676.6936.97295.639136.586386.748117.9971755.375110.59.414183.25922
ZINC000100016058602.6672.678889.922308.544122.79340.729117.8591721.059110.58.781184.68422
ZINC000100016058602.6676.758963.41295.105156.807393.137118.3611775.179110.58.82179.73622
ZINC000100016058602.6673.374889.351302.566123.522345.063118.2011715.256110.59.221184.34822
ZINC000100016058602.6676.588936.703295.837135.958386.916117.9921755.476110.59.409183.39722
ZINC000007997897287.4040.789607.9141.9030.103465.89501056.595028.523310010
ZINC000007997897287.4040.718598.565138.9570459.60801048.049028.531310010
ZINC000007997897287.4040.791521.98157.9712.38361.6280973.251028.498310000
ZINC000100074252529.45810.002757.843328.488185.987215.18528.1841461.691314.99.46248.34720
ZINC000003794794444.4865.02786.306339.526291.766155.01401393.6349.97.456117.85912
ZINC000003831490398.39211.456689.8960249.043440.090.7641175.35829.259.07257.2901
ZINC000003831490398.3929.283686.120248.534437.58601173.21818.259.253260.08601
ZINC000003831490398.39210.96683.2190246.802436.41801167.99129.259.54257.48501
ZINC000000897089378.3177.024589.936192.76554.441122.198220.5321034.58724.29.632310000
ZINC000004654889390.4672.323736.326502.739179.226054.3611295.03425.510.638283.23201
ZINC000035328014440.5046.348769.186208.575125.446435.16501380.845278.616110001
ZINC000002169830267.2443.396469.3695.245259.374114.7410784.03510.88.527244.32700
ZINC000034806477464.43711.82736.167210.88160.431165.722199.1341310.661179.245110001
ZINC000019796080379.4335.336690.754177.289126.948339.68946.8281214.622168.72386.62500
ZINC000019796080379.4334.227703.161188.25122.749345.33746.8251231.012168.619387.34500
ZINC000019796080379.4336.26700.949186.412123.449344.26346.8251227.254168.598387.21500
ZINC000000968326356.4394.606651.231258.441124.988224.39643.4071141.92414.759.063310000
ZINC000000968326356.4393.454646.881263.838124.365223.67635.0031134.98814.759.205310000
ZINC000000968326356.4392.644650.951259.64127.388220.543.4231141.59314.759.146310000
ZINC000000968326356.4393.415646.869264.846124.171223.6934.1631135.11114.759.231310000
ZINC000003806063495.5417.248777.091396.106109.009176.05295.9241474.25347.458.086280.03601
ZINC000003920719558.6485.239835.829215.87164.78424.91230.2661654.3636.98.701171.67621


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000001529323CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc10.1241138130.41007312
ZINC000052509366CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F0.1945668110.319044599
ZINC000085537017CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)(O)O[P@](=O)(O)C(Cl)(Cl)P(=O)(O)O)[C@@H](O)[C@H]1O0.0178895410.259362736
ZINC000043100953Cn1nnc(-c2ccc(-c3ccc(N4C[C@H](COP(=O)(O)O)OC4=O)cc3F)cn2)n10.0928451070.135775423
ZINC000100022637CCC[C@@]1(CCc2ccccc2)CC(=O)C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)=C(O)O10.055934750.326126876
ZINC000100016058CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O10.061501210.324751744
ZINC000007997897CN(C/C=Cc1ccccc1)Cc1cccc2ccccc120.3947728360.303491673
ZINC000096006023CCO/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n10.0272335820.191312451
ZINC000100074252CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc10.0342156180.409501034
ZINC000003794794O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c210.1629240550.487926509
ZINC000003831490O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O0.2402493720.486708998
ZINC000000897089O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN10.0827248270.290697747
ZINC000004654889CCCCC(F)(F)[C@@]1(O)CC[C@@H]2[C@H](CCCCCCC(=O)O)C(=O)C[C@H]2O10.0416409450.235639163
ZINC000035328014C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C10.132507410.288330473
ZINC000002169830Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O0.0795547680.347763769
ZINC000034806477CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F0.1592565510.18339076
ZINC000019796080O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc10.2197276360.259906112
ZINC000000968326CCc1ccc(CCOc2ccc(C[C@@H]3SC(=O)NC3=O)cc2)nc10.1622557910.381863632
ZINC000003806063C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F0.1090666520.137514353
ZINC000003920719CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)O0.0997401320.409629169


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ESRP1ATXN1, RNF2, BMI1, RNF111, RGPD8, RGPD5, RBPMS, RGPD3, RBPMS2, ATXN2, THUMPD3, ZNF703, HELZ, ELAVL2, GPATCH8, BIRC6, ESR2, MED25, KLHDC7B, OXER1, DAZAP2, KRTAP19-5, ARID5A, PRR20B, PRR20A, PRR20D, PRR20C, PRR20E, ESR1, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR7-1, MIR9-1, MIR15B, MIR19B1, MIR19B2, MIR20B, MIR21, MIR25, MIR29C, MIR34A, MIR34B, MIR106A, MIR106B, MIR128-2, MIR138-1, MIR138-2, MIR141, MIR155, MIR200A, MIR200C, MIR222, MIR363, H1F0, CIT, KIF14, KIF20A, PRC1, PAK6, RANBP2, MRPS24, ZC3H10, ALG13, Rbm38, Rbm47,
RAF1YWHAQ, YWHAG, YWHAZ, Hras, SFN, HRAS, VDAC1, PEBP4, CNKSR1, RASD2, CNKSR2, ERAS, SPRY4, SPRY2, YWHAB, OIP5, PHKA2, CCT3, MYC, AR, MRAS, KRAS, LRPAP1, RRAS2, SHOC2, TSC22D3, STK26, MAPK1, MAPK3, PRKCE, BCL2, BCL2L1, PEBP1, MAP2K1, GRB10, NRAS, MAPK8IP3, AKT1, HSP90AA1, GNG4, GNB2, VAV1, RHEB, RAP1A, SRC, FYN, RB1, RBL2, PRKG1, JAK2, YWHAH, CFLAR, CDC25A, BRAF, MAP3K1, PDGFRB, MAP3K5, MAPK7, PHB, BAG1, PAK1, PRKCZ, RRAS, PRPF6, UBE2D2, YWHAE, NR3C1, LCK, LTK, JAK1, XIAP, BIRC2, BIRC3, STUB1, Arrb2, EEF1A1, HSP82, HSPA8, HSPA5, CALM1, SGK1, NEDD4, SCNN1B, NEDD4L, STK3, BRAP, WDR83, KSR1, LATS1, MAP2K2, Rfxank, RFXANK, PPP1CC, VCP, HSPD1, BAD, BCL6, BIRC7, PIN1, MMS19, PPP2R1A, PPP2R2B, PPP2CA, HSPA4, RAF1, PPP2CB, MAPK8, RBBP8, YY1, PKM, CDK20, HIPK4, TBXA2R, SH3KBP1, ILK, GPRASP2, CDC37, IRS4, FAM96B, HUWE1, Prkab1, RANBP9, TMEM70, PACSIN3, NPLOC4, PRKAR1A, DCAF8, PURA, FYCO1, MYBPC1, COPS7A, MOV10, NXF1, EGFR, CALU, CCT8, DNAJA1, EMD, TIMM50, LOX, ARRB2, AGTR1, CASZ1, MRC2, PDLIM2, HERC2, XPO1, ACOX1, PCDH7, MAD2L1, SYNPO, TMEM63B, EEF1E1, COPS5, SS18L2, Smn1, Cep152, Aldh4a1, Ksr1, NUP133, RPGRIP1L, NCAPG2, NUP107, MSH2, LAS1L, AMER1, NUP160, EIF3D, SPATA7, NPHP4, DYNLL2, DYNLL1, IQCB1, RMDN3, TRIM25, Mapkbp1, EGLN3, RIPK4, MAPK6, CSNK1A1, HERC1, LZTR1, QKI, COPS3, TRIM28, MAEA, NANOG, ITCH, IRF7, PSMB9, MAP2K5, CDK4, CDK6, CDKN2B, FGFR4, MAP2K3, NF2, PDGFRA, TEAD2, RASSF1, ABCB5, BECN1, CBLC, GLIS2, GRM1, HGF, MAP2K6, ARNT, CCND2, CD44, CDKN2A, CDKN2C, EPHA2, ERBB2, KEAP1, LATS2, MET, NF1, TERT, DUSP2, MBP, PAK2, PLEKHA4, CRBN, ARAF, SLC25A3, TUBB4B, TUBB, HSPA6, HSP90AB3P, HSP90AB1, HSPA1A, HSPB1, BAG2, CCT7, DSG1, CCT2, CCT4, CCT6A, TCP1, AKAP8L, ATAD3A, ABCD3, SLC25A22, TMEM33, TUBA4A, HPX, MGST1, TUBB4A, TMEM161A, HSP90AB2P, CCAR2, SLC25A10, FANCD2, TUBB6, HSD17B12, SLC25A11, SLC25A1, ARL1, DNAJA2, DPM1, CCT5, AIFM1, SQSTM1, TUBG2, TUBG1, STK39, GCN1L1, ABCF2, POLD1, NUBP2, TM9SF3, NCLN, SEC61A2, SEC61A1, ALDH1A3, TUBB3, POLR2B, IARS2, TMED1, CIT, AURKB, KIF20A, BRD1, TRIM66, HAX1, CUL4A, ACTR1A, AKAP1, FLOT1, LAMTOR1, LMAN1, RAB2A, RAB4A, STX7, NPAS1, OPALIN, METTL21B, SSSCA1, FAM174A, CRKL, DDB1, DICER1, LDHB, PIK3R1, NONO, DVL2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ESRP1all structure
RAF1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ESRP1-RAF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ESRP1-RAF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
ESRP1RAF1Dendritic Cell TumorMyCancerGenome
ESRP1RAF1Not Otherwise SpecifiedMyCancerGenome
ESRP1RAF1Esophageal AdenocarcinomaMyCancerGenome
ESRP1RAF1Gastric AdenocarcinomaMyCancerGenome
ESRP1RAF1GlioblastomaMyCancerGenome
ESRP1RAF1High-Grade GliomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneESRP1C4693935DEAFNESS, AUTOSOMAL RECESSIVE 1091GENOMICS_ENGLAND;UNIPROT
TgeneRAF1C0028326Noonan Syndrome10CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRAF1C0175704LEOPARD Syndrome7CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneRAF1C1969057Noonan Syndrome 54CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRAF1C1969056LEOPARD SYNDROME 23CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRAF1C0007194Hypertrophic Cardiomyopathy2CTD_human
TgeneRAF1C0041409Turner Syndrome, Male2CTD_human
TgeneRAF1C1519086Pilomyxoid astrocytoma2ORPHANET
TgeneRAF1C1527404Female Pseudo-Turner Syndrome2CTD_human
TgeneRAF1C4551472Hypertrophic obstructive cardiomyopathy2CTD_human
TgeneRAF1C4551602Noonan Syndrome 12CTD_human
TgeneRAF1C0006142Malignant neoplasm of breast1CTD_human
TgeneRAF1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneRAF1C0007193Cardiomyopathy, Dilated1CTD_human
TgeneRAF1C0017638Glioma1CTD_human
TgeneRAF1C0020429Hyperalgesia1CTD_human
TgeneRAF1C0022665Kidney Neoplasm1CTD_human
TgeneRAF1C0023903Liver neoplasms1CTD_human
TgeneRAF1C0024121Lung Neoplasms1CTD_human
TgeneRAF1C0242379Malignant neoplasm of lung1CTD_human
TgeneRAF1C0259783mixed gliomas1CTD_human
TgeneRAF1C0340427Familial dilated cardiomyopathy1ORPHANET
TgeneRAF1C0345904Malignant neoplasm of liver1CTD_human
TgeneRAF1C0345967Malignant mesothelioma1CTD_human
TgeneRAF1C0458247Allodynia1CTD_human
TgeneRAF1C0555198Malignant Glioma1CTD_human
TgeneRAF1C0587248Costello syndrome (disorder)1CLINGEN
TgeneRAF1C0678222Breast Carcinoma1CTD_human
TgeneRAF1C0740457Malignant neoplasm of kidney1CTD_human
TgeneRAF1C0751211Hyperalgesia, Primary1CTD_human
TgeneRAF1C0751212Hyperalgesia, Secondary1CTD_human
TgeneRAF1C0751213Tactile Allodynia1CTD_human
TgeneRAF1C0751214Hyperalgesia, Thermal1CTD_human
TgeneRAF1C1257931Mammary Neoplasms, Human1CTD_human
TgeneRAF1C1275081Cardio-facio-cutaneous syndrome1CLINGEN
TgeneRAF1C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneRAF1C1458155Mammary Neoplasms1CTD_human
TgeneRAF1C2936719Mechanical Allodynia1CTD_human
TgeneRAF1C4014656CARDIOMYOPATHY, DILATED, 1NN1CTD_human;UNIPROT
TgeneRAF1C4551484Leopard Syndrome 11CTD_human;GENOMICS_ENGLAND
TgeneRAF1C4704874Mammary Carcinoma, Human1CTD_human
TgeneRAF1C4721610Carcinoma, Ovarian Epithelial1CTD_human