UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ESRRG-ACBD3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ESRRG-ACBD3
FusionPDB ID: 27588
FusionGDB2.0 ID: 27588
HgeneTgene
Gene symbol

ESRRG

ACBD3

Gene ID

2104

64746

Gene nameestrogen related receptor gammaacyl-CoA binding domain containing 3
SynonymsERR-gamma|ERR3|ERRg|ERRgamma|NR3B3GCP60|GOCAP1|GOLPH1|PAP7
Cytomap

1q41

1q42.12

Type of geneprotein-codingprotein-coding
Descriptionestrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3Golgi resident protein GCP60PBR- and PKA-associated protein 7PKA (RIalpha)-associated proteinacyl-Coenzyme A binding domain containing 3golgi complex associated protein 1, 60kDagolgi phosphoprotein 1peripheral benzodiazepine receptor-associated prot
Modification date2020031320200313
UniProtAcc

P62508

Q9H3P7

Ensembl transtripts involved in fusion geneENST idsENST00000359162, ENST00000360012, 
ENST00000361395, ENST00000361525, 
ENST00000366937, ENST00000366938, 
ENST00000366940, ENST00000391890, 
ENST00000408911, ENST00000463665, 
ENST00000487276, ENST00000493603, 
ENST00000493748, ENST00000471371, 
ENST00000464927, ENST00000366812, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 2=728 X 7 X 5=280
# samples 68
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ESRRG [Title/Abstract] AND ACBD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ESRRG(216850418)-ACBD3(226353701), # samples:1
Anticipated loss of major functional domain due to fusion event.ESRRG-ACBD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESRRG-ACBD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESRRG-ACBD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESRRG-ACBD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESRRG-ACBD3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ESRRG-ACBD3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ESRRG-ACBD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911


check buttonFusion gene breakpoints across ESRRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACBD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0IQ-01AESRRGchr1

216850418

-ACBD3chr1

226353701

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361395ESRRGchr1216850418-ENST00000366812ACBD3chr1226353701-38586261931926577
ENST00000493748ESRRGchr1216850418-ENST00000366812ACBD3chr1226353701-425010185852318577
ENST00000408911ESRRGchr1216850418-ENST00000366812ACBD3chr1226353701-38586261211926601

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361395ENST00000366812ESRRGchr1216850418-ACBD3chr1226353701-0.0002735280.9997265
ENST00000493748ENST00000366812ESRRGchr1216850418-ACBD3chr1226353701-0.0002828360.9997172
ENST00000408911ENST00000366812ESRRGchr1216850418-ACBD3chr1226353701-0.0002194570.9997806

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27588_27588_1_ESRRG-ACBD3_ESRRG_chr1_216850418_ENST00000361395_ACBD3_chr1_226353701_ENST00000366812_length(amino acids)=577AA_BP=144
MRKGIRLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDD
CSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQEKDGKAFHPTYEEKLKLVALHKQVLMGPYNPDTCPE
VGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEER
LRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVV
VAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGE
VVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIVPVYRRDCHEEV

--------------------------------------------------------------

>27588_27588_2_ESRRG-ACBD3_ESRRG_chr1_216850418_ENST00000408911_ACBD3_chr1_226353701_ENST00000366812_length(amino acids)=601AA_BP=168
MGCTNNGCRSHMDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGL
DSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQEKDGKAFHPTYE
EKLKLVALHKQVLMGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERR
RREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQ
YMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTR
PQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKA

--------------------------------------------------------------

>27588_27588_3_ESRRG-ACBD3_ESRRG_chr1_216850418_ENST00000493748_ACBD3_chr1_226353701_ENST00000366812_length(amino acids)=577AA_BP=144
MSQFERLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDD
CSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQEKDGKAFHPTYEEKLKLVALHKQVLMGPYNPDTCPE
VGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEER
LRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVV
VAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGE
VVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIVPVYRRDCHEEV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:216850418/chr1:226353701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESRRG

P62508

ACBD3

Q9H3P7

FUNCTION: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. {ECO:0000250, ECO:0000269|PubMed:11864604, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653, ECO:0000269|PubMed:23836911}.FUNCTION: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESRRGchr1:216850418chr1:226353701ENST00000366937-38128_148162.33333333333334471.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000408911-27128_148157.33333333333334459.0Zinc fingerNR C4-type
TgeneACBD3chr1:216850418chr1:226353701ENST0000036681208174_25795.33333333333333529.0Coiled coilOntology_term=ECO:0000255
TgeneACBD3chr1:216850418chr1:226353701ENST0000036681208182_24095.33333333333333529.0Compositional biasNote=Glu-rich
TgeneACBD3chr1:216850418chr1:226353701ENST0000036681208196_23895.33333333333333529.0Compositional biasNote=Arg-rich
TgeneACBD3chr1:216850418chr1:226353701ENST0000036681208384_52695.33333333333333529.0DomainGOLD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESRRGchr1:216850418chr1:226353701ENST00000359162-38125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000360012-27125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000361395-38125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000361525-49125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000366937-38125_200162.33333333333334471.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000366938-38125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000366940-49125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000391890-49125_200134.33333333333334443.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000408911-27125_200157.33333333333334459.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000463665-48125_200134.33333333333334397.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000487276-49125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000493603-49125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000493748-49125_200134.33333333333334436.0DNA bindingNuclear receptor
HgeneESRRGchr1:216850418chr1:226353701ENST00000359162-38233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000360012-27233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000361395-38233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000361525-49233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000366937-38233_457162.33333333333334471.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000366938-38233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000366940-49233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000391890-49233_457134.33333333333334443.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000408911-27233_457157.33333333333334459.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000463665-48233_457134.33333333333334397.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000487276-49233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000493603-49233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000493748-49233_457134.33333333333334436.0DomainNR LBD
HgeneESRRGchr1:216850418chr1:226353701ENST00000359162-38128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000359162-38164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000360012-27128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000360012-27164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000361395-38128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000361395-38164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000361525-49128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000361525-49164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000366937-38164_188162.33333333333334471.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000366938-38128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000366938-38164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000366940-49128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000366940-49164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000391890-49128_148134.33333333333334443.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000391890-49164_188134.33333333333334443.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000408911-27164_188157.33333333333334459.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000463665-48128_148134.33333333333334397.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000463665-48164_188134.33333333333334397.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000487276-49128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000487276-49164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000493603-49128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000493603-49164_188134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000493748-49128_148134.33333333333334436.0Zinc fingerNR C4-type
HgeneESRRGchr1:216850418chr1:226353701ENST00000493748-49164_188134.33333333333334436.0Zinc fingerNR C4-type
TgeneACBD3chr1:216850418chr1:226353701ENST000003668120821_6095.33333333333333529.0Compositional biasNote=Pro-rich
TgeneACBD3chr1:216850418chr1:226353701ENST000003668120883_17495.33333333333333529.0DomainACB


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ESRRG
ACBD3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ESRRG-ACBD3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ESRRG-ACBD3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource