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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ETNK1-MYO9B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ETNK1-MYO9B
	FusionPDB ID: 27661
	FusionGDB2.0 ID: 27661
		Hgene	Tgene
	Gene symbol	ETNK1	MYO9B
	Gene ID	55500	4650
	Gene name	ethanolamine kinase 1	myosin IXB
	Synonyms	EKI\|EKI 1\|EKI1\|Nbla10396	CELIAC4\|MYR5
	Cytomap	12p12.1	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	ethanolamine kinase 1putative protein product of Nbla10396	unconventional myosin-IXbmyosin-IXbunconventional myosin-9b
	Modification date	20200313	20200313
	UniProtAcc	Q9HBU6	Q13459
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000266517, ENST00000335148,	ENST00000593411, ENST00000397274, ENST00000594824, ENST00000595618,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 7 X 7=539	15 X 18 X 8=2160
	# samples	14	18
	** MAII score	log2(14/539*10)=-1.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/2160*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ETNK1 [Title/Abstract] AND MYO9B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ETNK1(22778520)-MYO9B(17298744), # samples:3
Anticipated loss of major functional domain due to fusion event.	ETNK1-MYO9B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ETNK1-MYO9B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ETNK1-MYO9B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ETNK1-MYO9B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ETNK1	GO:0006646	phosphatidylethanolamine biosynthetic process	11044454
Tgene	MYO9B	GO:0030048	actin filament-based movement	9490638
Tgene	MYO9B	GO:0032011	ARF protein signal transduction	15644318
Tgene	MYO9B	GO:0035385	Roundabout signaling pathway	26529257

Fusion gene breakpoints across ETNK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO9B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-OY-A56P-01A	ETNK1	chr12	22778520	-	MYO9B	chr19	17298744	+
ChimerDB4	OV	TCGA-OY-A56P-01A	ETNK1	chr12	22778520	+	MYO9B	chr19	17298744	+
ChimerDB4	OV	TCGA-OY-A56P	ETNK1	chr12	22778520	+	MYO9B	chr19	17298743	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000266517	ETNK1	chr12	22778520	+	ENST00000595618	MYO9B	chr19	17298744	+	5406	512	89	4003	1304
ENST00000266517	ETNK1	chr12	22778520	+	ENST00000594824	MYO9B	chr19	17298744	+	5383	512	89	4408	1439
ENST00000266517	ETNK1	chr12	22778520	+	ENST00000397274	MYO9B	chr19	17298744	+	5405	512	89	4003	1304
ENST00000335148	ETNK1	chr12	22778520	+	ENST00000595618	MYO9B	chr19	17298744	+	5340	446	23	3937	1304
ENST00000335148	ETNK1	chr12	22778520	+	ENST00000594824	MYO9B	chr19	17298744	+	5317	446	23	4342	1439
ENST00000335148	ETNK1	chr12	22778520	+	ENST00000397274	MYO9B	chr19	17298744	+	5339	446	23	3937	1304
ENST00000266517	ETNK1	chr12	22778520	+	ENST00000595618	MYO9B	chr19	17298743	+	5406	512	89	4003	1304
ENST00000266517	ETNK1	chr12	22778520	+	ENST00000594824	MYO9B	chr19	17298743	+	5383	512	89	4408	1439
ENST00000266517	ETNK1	chr12	22778520	+	ENST00000397274	MYO9B	chr19	17298743	+	5405	512	89	4003	1304
ENST00000335148	ETNK1	chr12	22778520	+	ENST00000595618	MYO9B	chr19	17298743	+	5340	446	23	3937	1304
ENST00000335148	ETNK1	chr12	22778520	+	ENST00000594824	MYO9B	chr19	17298743	+	5317	446	23	4342	1439
ENST00000335148	ETNK1	chr12	22778520	+	ENST00000397274	MYO9B	chr19	17298743	+	5339	446	23	3937	1304

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000266517	ENST00000595618	ETNK1	chr12	22778520	+	MYO9B	chr19	17298744	+	0.004776845	0.9952232
ENST00000266517	ENST00000594824	ETNK1	chr12	22778520	+	MYO9B	chr19	17298744	+	0.00812653	0.99187344
ENST00000266517	ENST00000397274	ETNK1	chr12	22778520	+	MYO9B	chr19	17298744	+	0.004745151	0.9952549
ENST00000335148	ENST00000595618	ETNK1	chr12	22778520	+	MYO9B	chr19	17298744	+	0.004590916	0.9954091
ENST00000335148	ENST00000594824	ETNK1	chr12	22778520	+	MYO9B	chr19	17298744	+	0.007745409	0.9922546
ENST00000335148	ENST00000397274	ETNK1	chr12	22778520	+	MYO9B	chr19	17298744	+	0.004559735	0.99544024
ENST00000266517	ENST00000595618	ETNK1	chr12	22778520	+	MYO9B	chr19	17298743	+	0.004776845	0.9952232
ENST00000266517	ENST00000594824	ETNK1	chr12	22778520	+	MYO9B	chr19	17298743	+	0.00812653	0.99187344
ENST00000266517	ENST00000397274	ETNK1	chr12	22778520	+	MYO9B	chr19	17298743	+	0.004745151	0.9952549
ENST00000335148	ENST00000595618	ETNK1	chr12	22778520	+	MYO9B	chr19	17298743	+	0.004590916	0.9954091
ENST00000335148	ENST00000594824	ETNK1	chr12	22778520	+	MYO9B	chr19	17298743	+	0.007745409	0.9922546
ENST00000335148	ENST00000397274	ETNK1	chr12	22778520	+	MYO9B	chr19	17298743	+	0.004559735	0.99544024

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27661_27661_1_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000266517_MYO9B_chr19_17298743_ENST00000397274_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

>27661_27661_2_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000266517_MYO9B_chr19_17298743_ENST00000594824_length(amino acids)=1439AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKQ
DITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPTA

--------------------------------------------------------------

>27661_27661_3_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000266517_MYO9B_chr19_17298743_ENST00000595618_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

>27661_27661_4_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000266517_MYO9B_chr19_17298744_ENST00000397274_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

>27661_27661_5_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000266517_MYO9B_chr19_17298744_ENST00000594824_length(amino acids)=1439AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKQ
DITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPTA

--------------------------------------------------------------

>27661_27661_6_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000266517_MYO9B_chr19_17298744_ENST00000595618_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

>27661_27661_7_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000335148_MYO9B_chr19_17298743_ENST00000397274_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

>27661_27661_8_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000335148_MYO9B_chr19_17298743_ENST00000594824_length(amino acids)=1439AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKQ
DITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPTA

--------------------------------------------------------------

>27661_27661_9_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000335148_MYO9B_chr19_17298743_ENST00000595618_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

>27661_27661_10_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000335148_MYO9B_chr19_17298744_ENST00000397274_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

>27661_27661_11_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000335148_MYO9B_chr19_17298744_ENST00000594824_length(amino acids)=1439AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKQ
DITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPTA

--------------------------------------------------------------

>27661_27661_12_ETNK1-MYO9B_ETNK1_chr12_22778520_ENST00000335148_MYO9B_chr19_17298744_ENST00000595618_length(amino acids)=1304AA_BP=140
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAM
ANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDF
TEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQA
CWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAA
GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQS
CKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS
RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPT
EERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELE
NAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQ
KTPIESLFIEATEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQK
KKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSD
KASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELP
EKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY
KVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:22778520/chr19:17298744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ETNK1 Q9HBU6	MYO9B Q13459
FUNCTION: Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. {ECO:0000269\|PubMed:11044454}.	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269\|PubMed:26529257, ECO:0000269\|PubMed:9490638}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ETNK1

chr12:22778520

chr19:17298743

ENST00000266517

73_83

141.0

453.0

Compositional bias

Note=Poly-Val

Hgene

ETNK1

chr12:22778520

chr19:17298743

ENST00000335148

73_83

141.0

259.0

Compositional bias

Note=Poly-Val

Hgene

ETNK1

chr12:22778520

chr19:17298744

ENST00000266517

73_83

141.0

453.0

Compositional bias

Note=Poly-Val

Hgene

ETNK1

chr12:22778520

chr19:17298744

ENST00000335148

73_83

141.0

259.0

Compositional bias

Note=Poly-Val

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1046_1071

859.0

2189.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1880_1901

859.0

2189.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1959_1989

859.0

2189.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1046_1071

859.0

2458.6666666666665

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1880_1901

859.0

2458.6666666666665

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1959_1989

859.0

2458.6666666666665

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1046_1071

859.0

2189.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1880_1901

859.0

2189.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1959_1989

859.0

2189.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1046_1071

859.0

2458.6666666666665

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1880_1901

859.0

2458.6666666666665

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1959_1989

859.0

2458.6666666666665

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1001_1023

859.0

2189.0

Domain

IQ 3

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1024_1053

859.0

2189.0

Domain

IQ 4

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1703_1888

859.0

2189.0

Domain

Rho-GAP

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

957_977

859.0

2189.0

Domain

IQ 1

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

979_1000

859.0

2189.0

Domain

IQ 2

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1001_1023

859.0

2458.6666666666665

Domain

IQ 3

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1024_1053

859.0

2458.6666666666665

Domain

IQ 4

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1703_1888

859.0

2458.6666666666665

Domain

Rho-GAP

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

957_977

859.0

2458.6666666666665

Domain

IQ 1

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

979_1000

859.0

2458.6666666666665

Domain

IQ 2

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1001_1023

859.0

2189.0

Domain

IQ 3

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1024_1053

859.0

2189.0

Domain

IQ 4

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1703_1888

859.0

2189.0

Domain

Rho-GAP

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

957_977

859.0

2189.0

Domain

IQ 1

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

979_1000

859.0

2189.0

Domain

IQ 2

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1001_1023

859.0

2458.6666666666665

Domain

IQ 3

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1024_1053

859.0

2458.6666666666665

Domain

IQ 4

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1703_1888

859.0

2458.6666666666665

Domain

Rho-GAP

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

957_977

859.0

2458.6666666666665

Domain

IQ 1

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

979_1000

859.0

2458.6666666666665

Domain

IQ 2

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1045_2157

859.0

2189.0

Region

Tail

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

940_1044

859.0

2189.0

Region

Neck or regulatory domain

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1045_2157

859.0

2458.6666666666665

Region

Tail

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

940_1044

859.0

2458.6666666666665

Region

Neck or regulatory domain

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1045_2157

859.0

2189.0

Region

Tail

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

940_1044

859.0

2189.0

Region

Neck or regulatory domain

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1045_2157

859.0

2458.6666666666665

Region

Tail

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

940_1044

859.0

2458.6666666666665

Region

Neck or regulatory domain

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

1632_1681

859.0

2189.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

1632_1681

859.0

2458.6666666666665

Zinc finger

Phorbol-ester/DAG-type

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

1632_1681

859.0

2189.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

1632_1681

859.0

2458.6666666666665

Zinc finger

Phorbol-ester/DAG-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

146_953

859.0

2189.0

Domain

Myosin motor

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

15_114

859.0

2189.0

Domain

Ras-associating

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

146_953

859.0

2458.6666666666665

Domain

Myosin motor

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

15_114

859.0

2458.6666666666665

Domain

Ras-associating

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

146_953

859.0

2189.0

Domain

Myosin motor

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

15_114

859.0

2189.0

Domain

Ras-associating

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

146_953

859.0

2458.6666666666665

Domain

Myosin motor

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

15_114

859.0

2458.6666666666665

Domain

Ras-associating

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

239_246

859.0

2189.0

Nucleotide binding

ATP

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

239_246

859.0

2458.6666666666665

Nucleotide binding

ATP

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

239_246

859.0

2189.0

Nucleotide binding

ATP

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

239_246

859.0

2458.6666666666665

Nucleotide binding

ATP

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000397274

844_855

859.0

2189.0

Region

Actin-binding

Tgene

MYO9B

chr12:22778520

chr19:17298743

ENST00000595618

844_855

859.0

2458.6666666666665

Region

Actin-binding

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000397274

844_855

859.0

2189.0

Region

Actin-binding

Tgene

MYO9B

chr12:22778520

chr19:17298744

ENST00000595618

844_855

859.0

2458.6666666666665

Region

Actin-binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ETNK1
MYO9B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ETNK1-MYO9B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ETNK1-MYO9B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source