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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ETV6-JAK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ETV6-JAK2
FusionPDB ID: 27724
FusionGDB2.0 ID: 27724
HgeneTgene
Gene symbol

ETV6

JAK2

Gene ID

2120

3717

Gene nameETS variant transcription factor 6Janus kinase 2
SynonymsTEL|TEL/ABL|THC5JTK10|THCYT3
Cytomap

12p13.2

9p24.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)tyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)
Modification date2020031320200329
UniProtAcc

P41212

O60674

Ensembl transtripts involved in fusion geneENST idsENST00000396373, ENST00000544715, 
ENST00000487310, ENST00000381652, 
ENST00000539801, ENST00000544510, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score59 X 37 X 25=5457522 X 26 X 9=5148
# samples 5815
** MAII scorelog2(58/54575*10)=-6.55604351475058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/5148*10)=-5.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ETV6 [Title/Abstract] AND JAK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.ETV6-JAK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ETV6-JAK2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ETV6-JAK2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ETV6-JAK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502

TgeneJAK2

GO:0010811

positive regulation of cell-substrate adhesion

10925297

TgeneJAK2

GO:0019221

cytokine-mediated signaling pathway

8609418

TgeneJAK2

GO:0033209

tumor necrosis factor-mediated signaling pathway

8609418

TgeneJAK2

GO:0034612

response to tumor necrosis factor

8609418

TgeneJAK2

GO:0035409

histone H3-Y41 phosphorylation

19783980

TgeneJAK2

GO:0035722

interleukin-12-mediated signaling pathway

7528775

TgeneJAK2

GO:0046677

response to antibiotic

16280321

TgeneJAK2

GO:0050727

regulation of inflammatory response

10925297

TgeneJAK2

GO:0060396

growth hormone receptor signaling pathway

10925297

TgeneJAK2

GO:0070671

response to interleukin-12

7528775


check buttonFusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across JAK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..ETV6chr12

12006495

+JAK2chr9

5078305

+
ChimerKB3..ETV6chr12

12006495

+JAK2chr9

5080228

+
ChimerKB3..ETV6chr12

12022903

+JAK2chr9

5069021

+
ChimerKB3..ETV6chr12

12022903

+JAK2chr9

5069924

+
ChimerKB3..ETV6chr12

12022903

+JAK2chr9

5081724

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396373ETV6chr1212006495+ENST00000539801JAK2chr95080228+20287372742004576
ENST00000396373ETV6chr1212006495+ENST00000381652JAK2chr95080228+33977372742004576
ENST00000396373ETV6chr1212006495+ENST00000544510JAK2chr95080228+20637372742004576
ENST00000396373ETV6chr1212022903+ENST00000539801JAK2chr95069924+319212832743168964
ENST00000396373ETV6chr1212022903+ENST00000381652JAK2chr95069924+456112832743168964
ENST00000396373ETV6chr1212022903+ENST00000544510JAK2chr95069924+322712832743168964
ENST00000396373ETV6chr1212022903+ENST00000539801JAK2chr95081724+227112832742247657
ENST00000396373ETV6chr1212022903+ENST00000381652JAK2chr95081724+364012832742247657
ENST00000396373ETV6chr1212022903+ENST00000544510JAK2chr95081724+230612832742247657

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27724_27724_1_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000381652_length(amino acids)=576AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEVLQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMR
IGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGV
CYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE
YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPD

--------------------------------------------------------------

>27724_27724_2_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000539801_length(amino acids)=576AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEVLQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMR
IGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGV
CYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE
YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPD

--------------------------------------------------------------

>27724_27724_3_ETV6-JAK2_ETV6_chr12_12006495_ENST00000396373_JAK2_chr9_5080228_ENST00000544510_length(amino acids)=576AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEVLQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMR
IGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGV
CYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE
YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPD

--------------------------------------------------------------

>27724_27724_4_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000381652_length(amino acids)=964AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADKSNLLVFRTNGVSDVPTSPTLQR
PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVC
GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP
KDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST
EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLA
TRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND

--------------------------------------------------------------

>27724_27724_5_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000539801_length(amino acids)=964AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADKSNLLVFRTNGVSDVPTSPTLQR
PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVC
GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP
KDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST
EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLA
TRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND

--------------------------------------------------------------

>27724_27724_6_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5069924_ENST00000544510_length(amino acids)=964AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADKSNLLVFRTNGVSDVPTSPTLQR
PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVC
GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP
KDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST
EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLA
TRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND

--------------------------------------------------------------

>27724_27724_7_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=657AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADYELLTENDMLPNMRIGALGFSGA
FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNL
KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE
SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC

--------------------------------------------------------------

>27724_27724_8_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=657AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADYELLTENDMLPNMRIGALGFSGA
FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNL
KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE
SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC

--------------------------------------------------------------

>27724_27724_9_ETV6-JAK2_ETV6_chr12_12022903_ENST00000396373_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=657AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADYELLTENDMLPNMRIGALGFSGA
FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNL
KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE
SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

JAK2

O60674

FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (439) >>>439.pdbFusion protein BP residue: 154
CIF file (439) >>>439.cif		ETV6chr1212006495+JAK2chr95080228+
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSA
LDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLN
SLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQ
HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQY
TSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE
YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKS
PPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECW
576
3D view using mol* of 439 (AA BP:154)
PDB file (536) >>>536.pdbFusion protein BP residue: 336
CIF file (536) >>>536.cif		ETV6chr1212022903+JAK2chr95081724+
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRP
LRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE
SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADYELLTENDMLPNM
RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNT
GEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNL
KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHR
DLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES
LTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIV
FHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ
657
3D view using mol* of 536 (AA BP:336)
PDB file (737) >>>737.pdbFusion protein BP residue: 336
CIF file (737) >>>737.cif		ETV6chr1212022903+JAK2chr95069924+
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRP
LRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE
SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADKSNLLVFRTNGVS
DVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVG
DYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVC
GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENT
LIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPW
VPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED
RHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTE
NDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRY
DPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCY
SAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLG
TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI
FWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND
KQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRD
964
3D view using mol* of 737 (AA BP:336)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ETV6_pLDDT.png
all structure
all structure
JAK2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ETV6_JAK2_439_pLDDT.png (AA BP:154)
all structure
ETV6_JAK2_439_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_JAK2_439_violinplot.png (AA BP:154)
all structure
ETV6_JAK2_536_pLDDT.png (AA BP:336)
all structure
ETV6_JAK2_536_pLDDT_and_active_sites.png (AA BP:336)
all structure
ETV6_JAK2_536_violinplot.png (AA BP:336)
all structure
ETV6_JAK2_737_pLDDT.png (AA BP:336)
all structure
ETV6_JAK2_737_pLDDT_and_active_sites.png (AA BP:336)
all structure
ETV6_JAK2_737_violinplot.png (AA BP:336)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
ETV6_JAK2_439.png
all structure
ETV6_JAK2_536.png
all structure
ETV6_JAK2_737.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
4391.0215501.0271335.2990.4820.730.9330.611.0760.5660.766Chain A: 10,12,13,14,15,16,17,18,19,20,299,300,301
,302,303,304,305,306,307,324,326,328,334,335,338,3
39,341,342,346,355,371,373,374,375,376,379,380,382
,383,386,418,419,420,422,423,424,425,427,437,438,4
39,440,441,442,443,452,453,454,455,456,457,458,459
,460,461,462,463,464,465,469,470,471,472,473,475,4
90,495,497,500,501,502,516,519,520,523,524,527
5361.1071111.106210.9450.4640.8591.0771.4711.071.3740.74Chain A: 319,321,322,323,324,378,380,388,405,407,4
23,427,436,452,454,455,456,457,458,459,460,464,465
,468,469,506,508,518,519,520
7371.07442071.0242489.1180.42020.80931.08130.54031.23130.43880.7503Chain A: 383,384,385,386,387,388,389,391,411,413,4
60,461,464,465,467,468,471,504,505,507,508,509,510
,512,530,531,532,533,534,536,543,546,547,550,551,5
52,566,570,577,584,585,587,594

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
737ZINC000008577218DB00158Folic acid-8.30279-8.48149
737ZINC000068204830DB09102Daclatasvir-7.52421-8.36441
737ZINC000000895081DB04272Citric acid-7.55169-7.55169
737ZINC000006382803DB00352Tioguanine-6.47654-7.39634
737ZINC000001530636DB00927Famotidine-6.68105-7.36525
737ZINC000006467621DB11115Ensulizole-6.65882-7.22542
737ZINC000001530886DB00966Telmisartan-6.50748-7.21768
737ZINC000011616925DB06813Pralatrexate-7.17498-7.21648
737ZINC000003812862DB00282Pamidronic acid-6.9365-7.047
737ZINC000003927870DB01073Fludarabine-5.85379-7.00269
737ZINC000002599970DB00983Formoterol-6.98689-6.99909
737ZINC000001530600DB00369Cidofovir-6.3585-6.9118
737ZINC000003939013DB06717Fosaprepitant-6.87302-6.87892
737ZINC000000599734DB00448Lansoprazole-6.85394-6.87344
737ZINC000001550477DB01259Lapatinib-6.76323-6.85203
737ZINC000001540998DB00642Pemetrexed-6.85106-6.85106
737ZINC000030691754DB12364Betrixaban-6.84202-6.84242
737ZINC000001530579DB01136Carvedilol-6.79739-6.84049
737ZINC000000968330DB00412Rosiglitazone-6.26925-6.83605
737ZINC000043100953DB09042Tedizolid phosphate-6.74755-6.83255

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000008577218DB00158Folic acidSmall moleculeNC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1Approved|Nutraceutical|Vet_approved
ZINC000068204830DB09102DaclatasvirSmall moleculeCOC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC=C(N1)C1=CC=C(C=C1)C1=CC=C(C=C1)C1=CN=C(N1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)CApproved|Investigational
ZINC000000895081DB04272Citric acidSmall moleculeOC(=O)CC(O)(CC(O)=O)C(O)=OApproved|Nutraceutical|Vet_approved
ZINC000006382803DB00352TioguanineSmall moleculeNC1=NC(=S)C2=C(N1)N=CN2Approved
ZINC000001530636DB00927FamotidineSmall moleculeNC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1Approved
ZINC000006467621DB11115EnsulizoleSmall moleculeOS(=O)(=O)C1=CC2=C(C=C1)N=C(N2)C1=CC=CC=C1Approved
ZINC000001530886DB00966TelmisartanSmall moleculeCCCC1=NC2=C(C=C(C=C2C)C2=NC3=CC=CC=C3N2C)N1CC1=CC=C(C=C1)C1=CC=CC=C1C(O)=OApproved|Investigational
ZINC000003812862DB00282Pamidronic acidSmall moleculeNCCC(O)(P(O)(O)=O)P(O)(O)=OApproved
ZINC000003927870DB01073FludarabineSmall moleculeNC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1OApproved
ZINC000001530600DB00369CidofovirSmall moleculeNC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1Approved
ZINC000003939013DB06717FosaprepitantSmall moleculeC[C@@H](O[C@H]1OCCN(CC2=NC(=O)N(N2)P(O)(O)=O)[C@H]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)FApproved
ZINC000000599734DB00448LansoprazoleSmall moleculeCC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1Approved|Investigational
ZINC000001550477DB01259LapatinibSmall moleculeCS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1Approved|Investigational
ZINC000001540998DB00642PemetrexedSmall moleculeNC1=NC(=O)C2=C(NC=C2CCC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N1Approved|Investigational
ZINC000030691754DB12364BetrixabanSmall moleculeCOC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC1=CC=C(Cl)C=N1Approved|Investigational
ZINC000000968330DB00412RosiglitazoneSmall moleculeCN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1Approved|Investigational
ZINC000043100953DB09042Tedizolid phosphateSmall moleculeCN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=OApproved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000008577218441.40213.51755.446101.238451.657202.55101308.0746.2512.758.351021
ZINC000008577218441.40214.14754.923100.926451.592202.40501306.4516.2512.758.3021021
ZINC000008577218441.40214.323755.349100.67452.288202.39101307.5776.2512.758.3991021
ZINC000068204830738.8859.1861185.225698.369189.608297.24802297.4812.512.58.424156.2531
ZINC000068204830738.88512.7281242.653732.724195.462314.46702325.8512.512.58.586156.99331
ZINC000068204830738.8855.6591215.343718.68189.061307.60202308.8542.512.58.456157.66831
ZINC000068204830738.8853.0361238.237724.613189.774323.84902337.4652.512.58.529158.58831
ZINC000068204830738.8856.6121209.345719.031182.477307.83702307.3472.512.58.288159.64831
ZINC000068204830738.8854.8491244.561737.115179.716327.73102332.7592.512.58.571160.79831
ZINC000000895081192.1257.318360.53863.461297.07700576.01235.7511.1116.42501
ZINC000006382803167.1882.913334.0990174.67282.56276.865508.157458.609368.38600
ZINC000006382803167.18810.353334.2370175.32682.48776.423508.122458.464368.2800
ZINC000006382803167.1883.972333.7640164.06191.94377.76507.0323.848.378369.61600
ZINC000001530636337.4328.496521.83399.501273.3951.82697.115914.026798.5235.23410
ZINC000001530636337.43213.115494.303116.816261.31243.15673.019882.5675.58.82239.67810
ZINC000001530636337.4326.659521.267100.72277.97650.89391.678913.905798.611234.15111
ZINC000001530636337.43211.671559.823101.56332.16638.03588.062950.185798.602223.15711
ZINC000001530636337.4328.716590.73582.084369.40446.6192.637969.1575.58.538220.34511
ZINC000001530636337.4323.147583.852100.402354.87439.07989.497971.384798.705218.77711
ZINC000006467621274.2949.514495.1790165.642327.0772.46816.85725.59.09370.24100
ZINC000006467621274.2945.937496.1670165.586328.1242.456817.80525.59.121370.28800
ZINC000006467621274.2949.57496.8940166.022328.3772.495819.64625.58.954370.26400
ZINC000001530886514.6267.48850.985294.329111.948444.70901601.819158.498186.97921
ZINC000001530886514.6263.392898.781323.212100.491475.07801648.918158.623191.31421
ZINC000001530886514.6266.83830.587285.837116.397428.35301580.24158.44185.14421
ZINC000001530886514.6268.764825.335324.05451.458449.82301592.388158.537110021
ZINC000011616925477.47911.281822.957165.593429.097228.26601456.2616.7510.758.5611021
ZINC000011616925477.47911.071819.821164.432424.835230.55401455.0526.7510.758.5591021
ZINC000003812862235.079.08382.84949.638327.04906.162620.9837.759.111011
ZINC000003812862235.0711.837382.22754.693321.34806.185620.45137.759.0751011
ZINC000003812862235.074.081379.43356.179318.68404.57620.40637.759.2241011
ZINC000003927870365.21410.011558.49373.58358.73476.06350.116953.163614.18.5981021
ZINC000003927870365.2146.236564.92782.608356.66668.68256.971956.451614.18.731021
ZINC000002599970344.415.946630.817255.555164.209211.05301131.10747.28.775368.96100
ZINC000002599970344.416.639655.84259.44181.011215.38901154.47647.28.821266.12500
ZINC000001530600279.18910.973485.753106.478301.21375.1182.945819.936512.48.977118.28601
ZINC000001530600279.18913.189481.116107.174307.99561.4654.483817.63512.48.916116.85501
ZINC000003939013614.4138.497848.811197.658230.498155.328265.3271570.389010.49.064130.07713
ZINC000000599734369.3617.029628.695122.70880.977284.054140.9571073.54316.58.976380.56500
ZINC000000599734369.3616.333629.454122.38590.343278.682138.0431074.9916.58.986378.63600
ZINC000001550477581.068.763984.429219.392136.563520.447108.0271738.43918.258.353175.11221
ZINC000001550477581.068.228914.704239.85389.107476.75108.9941676.88418.258.025182.62721
ZINC000001540998427.4167.537697.496150.841394.572152.08301258.6386.259.758.2991021
ZINC000030691754451.91110.54790.066238.941130.476348.60572.0441393.50427.258.365110001
ZINC000001530579406.483.59771.844251.89869.588450.35901346.2635.458.152310000
ZINC000001530579406.482.515741.073230.19480.63430.24901326.27535.458.074310000
ZINC000000968330357.4261.368624.189191.363122.323275.29435.2091104.24515.258.364310000
ZINC000000968330357.4261.059632.881175.808136.284288.28232.5061111.81415.258.367396.28500
ZINC000000968330357.4262.667631.991174.467135.907288.93432.6821112.19815.258.43396.3900
ZINC000000968330357.4263.759634.057177.006120.765293.19343.0931110.56615.258.52310000
ZINC000043100953450.3228.428720.625174.492308.419199.97437.7411252.9792139.192117.34511
ZINC000043100953450.3228.806708.392174.655291.009204.37638.3521241.0022139.026120.70611


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000008577218Nc1nc(O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n10.1276881860.392534973
ZINC000068204830COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C0.0399710920.226481814
ZINC000000895081O=C(O)CC(O)(CC(=O)O)C(=O)O0.2341418360.605941862
ZINC000006382803Nc1nc2nc[nH]c2c(=S)[nH]10.100054570.571375233
ZINC000001530636N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs10.0885838660.372327259
ZINC000006467621O=S(=O)(O)c1ccc2[nH]c(-c3ccccc3)nc2c10.385041040.405031793
ZINC000001530886CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc10.2177627810.303280041
ZINC000011616925C#CC[C@H](Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc10.0709730990.360339774
ZINC000003812862NCCC(O)(P(=O)(O)O)P(=O)(O)O0.0953442180.466020225
ZINC000003927870Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O0.0505854450.380605086
ZINC000002599970COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc10.1338630780.246482573
ZINC000001530600Nc1ccn(C[C@@H](CO)OCP(=O)(O)O)c(=O)n10.0801497210.307248667
ZINC000003939013C[C@@H](O[C@H]1OCCN(Cc2nn(P(=O)(O)O)c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c10.0337349880.137363501
ZINC000000599734Cc1c(OCC(F)(F)F)ccnc1C[S@@](=O)c1nc2ccccc2[nH]10.1205135880.361439881
ZINC000001550477CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o10.187595690.281219747
ZINC000001540998Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]10.1316721170.436006307
ZINC000030691754COc1ccc(NC(=O)c2ccc(C(=N)N(C)C)cc2)c(C(=O)Nc2ccc(Cl)cn2)c10.2746192950.219857351
ZINC000001530579COc1ccccc1OCCNC[C@H](O)COc1cccc2[nH]c3ccccc3c120.1930583230.176144892
ZINC000000968330CN(CCOc1ccc(C[C@H]2SC(=O)NC2=O)cc1)c1ccccn10.1553268710.273380926
ZINC000043100953Cn1nnc(-c2ccc(-c3ccc(N4C[C@H](COP(=O)(O)O)OC4=O)cc3F)cn2)n10.0928451070.135775423


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2, EGLN3, NKX2-1, TRAF2, AXIN1, ESR2, LMNA, TP53BP1, BRCA1, MDC1, KIAA1429, WWP2, ESR1, BRD4, NFE2L2, MAD2L1, B4GALT2, KLHL9, KLHL13, SUMO2, ARHGAP32, SEC16A, XPOT, PIAS2, CEP152, NUP214, NUP62, NUP98, SEC13, RBM11, ECH1, ZNF146, TRIP6, CEP85, NUP54, TAB3, ALMS1, CEP192, PPIL4, RQCD1, SDCCAG3, NUP88, TBL1Y, KIAA1671, C2orf44, GRPEL1, TNRC6C, MID1IP1, CYLD, ZMYM2, LIMD1, SPATA2, TNRC6B, TIMM13, FLOT1, LGALS3BP, FLOT2, HNRNPUL1,
JAK2PRMT5, SOCS1, PPIA, IL12RB2, EPOR, FYN, STAT5A, STAT5B, SH2B2, CXCR4, DNAJA3, HSPA8, TEC, PTPN12, PTK2, CSF2RB, GHR, VAV1, SIRPA, IRS1, BRCA1, GRB2, EGFR, PTK2B, PTPN11, TNFRSF1A, SOCS3, PTPN6, LYN, HTR2A, ERBB2, ELP2, KIT, RAF1, SH2B1, IL5RA, PPP2R1B, IFNGR1, IFNGR2, CCR5, PRLR, IL6ST, SHC1, GRB10, TUB, TSHR, STAT3, INSR, STAM, PTPN1, STAM2, IL2RB, CTLA4, ALK, IKBKG, FGFR1, STAT1, HSP90AA1, HSP90AB1, ASB2, SKP2, GTF2I, HIST3H3, HIST2H3C, CDKN1B, VHL, PIK3R1, MAP3K5, AGTR1, PTAFR, JAK2, IL4R, IL2RG, PPP1CC, ERBB3, CALM1, SRC, JAK3, PLCG1, HES1, HES5, Ifngr1, ASS1, RBMX, TRAF6, EZH2, DTX3L, EMD, KPNB1, NAP1L1, RCN1, SLC2A1, UBP1, ARL11, HSFY1, HDAC6, HNRNPL, CBL, RNF123, Lmo4, GOLPH3, IGF1R, PARP9, LNX1, LDOC1, CSK, MPL, CUL4A, CUL4B, M, JAK1, AMY1C, BPIFA2, ARHGAP18, BACH1, IGHA2, HMMR, MUC7, CST2, IGJ, PBK, MUC5B, SPRR3, ZG16B, VCP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ETV6all structure
JAK2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ETV6-JAK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
ETV6JAK2Nilotinib Or DasatinibPubMed32279331

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Related Diseases to ETV6-JAK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
ETV6JAK2Myeloid NeoplasmsPubMed32279331
ETV6JAK2Invasive Breast CarcinomaMyCancerGenome
ETV6JAK2Breast Invasive Ductal CarcinomaMyCancerGenome
ETV6JAK2Gastric AdenocarcinomaMyCancerGenome
ETV6JAK2Lung AdenocarcinomaMyCancerGenome
ETV6JAK2Colon AdenocarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C4015537THROMBOCYTOPENIA 54CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia3CTD_human;GENOMICS_ENGLAND
HgeneETV6C0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
HgeneETV6C1332965Congenital Mesoblastic Nephroma2ORPHANET
HgeneETV6C0006413Burkitt Lymphoma1ORPHANET
HgeneETV6C0013146Drug abuse1CTD_human
HgeneETV6C0013170Drug habituation1CTD_human
HgeneETV6C0013222Drug Use Disorders1CTD_human
HgeneETV6C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneETV6C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneETV6C0023467Leukemia, Myelocytic, Acute1CGI;CTD_human;GENOMICS_ENGLAND
HgeneETV6C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneETV6C0038580Substance Dependence1CTD_human
HgeneETV6C0038586Substance Use Disorders1CTD_human
HgeneETV6C0087031Juvenile-Onset Still Disease1CTD_human
HgeneETV6C0236969Substance-Related Disorders1CTD_human
HgeneETV6C0238463Papillary thyroid carcinoma1ORPHANET
HgeneETV6C0376544Hematopoietic Neoplasms1CTD_human
HgeneETV6C0376545Hematologic Neoplasms1CTD_human
HgeneETV6C0740858Substance abuse problem1CTD_human
HgeneETV6C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
HgeneETV6C1510472Drug Dependence1CTD_human
HgeneETV6C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1ORPHANET
HgeneETV6C1838656Macrocytosis, Familial1CTD_human
HgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneETV6C3495559Juvenile arthritis1CTD_human
HgeneETV6C3714758Juvenile psoriatic arthritis1CTD_human
HgeneETV6C4316881Prescription Drug Abuse1CTD_human
HgeneETV6C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneETV6C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneJAK2C0032463Polycythemia Vera12CTD_human;ORPHANET;UNIPROT
TgeneJAK2C0040028Thrombocythemia, Essential10CTD_human;ORPHANET
TgeneJAK2C0001815Primary Myelofibrosis9CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneJAK2C3489628Thrombocytosis, Autosomal Dominant8CTD_human
TgeneJAK2C0019154Hepatic Vein Thrombosis3CTD_human;ORPHANET
TgeneJAK2C0856761Budd-Chiari Syndrome3CTD_human;ORPHANET
TgeneJAK2C0009324Ulcerative Colitis2CTD_human
TgeneJAK2C0027022Myeloproliferative disease2CTD_human
TgeneJAK2C0151744Myocardial Ischemia2CTD_human
TgeneJAK2C0836924Thrombocytosis2CTD_human
TgeneJAK2C3281125THROMBOCYTHEMIA 32UNIPROT
TgeneJAK2C0000786Spontaneous abortion1CTD_human
TgeneJAK2C0000822Abortion, Tubal1CTD_human
TgeneJAK2C0006663Calcinosis1CTD_human
TgeneJAK2C0007873Uterine Cervical Neoplasm1CTD_human
TgeneJAK2C0018824Heart valve disease1CTD_human
TgeneJAK2C0019207Hepatoma, Morris1CTD_human
TgeneJAK2C0019208Hepatoma, Novikoff1CTD_human
TgeneJAK2C0021368Inflammation1CTD_human
TgeneJAK2C0023418leukemia1CTD_human
TgeneJAK2C0023467Leukemia, Myelocytic, Acute1CGI;CTD_human;UNIPROT
TgeneJAK2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneJAK2C0023904Liver Neoplasms, Experimental1CTD_human
TgeneJAK2C0025472Mesenteric Vascular Occlusion1CTD_human
TgeneJAK2C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneJAK2C0032461Polycythemia1CTD_human
TgeneJAK2C0032962Pregnancy Complications1CTD_human
TgeneJAK2C0033578Prostatic Neoplasms1CTD_human
TgeneJAK2C0040038Thromboembolism1CTD_human
TgeneJAK2C0042487Venous Thrombosis1CTD_human
TgeneJAK2C0086404Experimental Hepatoma1CTD_human
TgeneJAK2C0149871Deep Vein Thrombosis1CTD_human
TgeneJAK2C0263628Tumoral calcinosis1CTD_human
TgeneJAK2C0376358Malignant neoplasm of prostate1CTD_human
TgeneJAK2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneJAK2C0521174Microcalcification1CTD_human
TgeneJAK2C1527405Erythrocytosis1CTD_human
TgeneJAK2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneJAK2C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneJAK2C3495676Anorectal Malformations1GENOMICS_ENGLAND
TgeneJAK2C3830362Early Pregnancy Loss1CTD_human
TgeneJAK2C4048328cervical cancer1CTD_human
TgeneJAK2C4303761Familial thrombocytosis1ORPHANET
TgeneJAK2C4552766Miscarriage1CTD_human