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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ETV6-NTRK3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ETV6-NTRK3
FusionPDB ID: 27735
FusionGDB2.0 ID: 27735
HgeneTgene
Gene symbol

ETV6

NTRK3

Gene ID

2120

4916

Gene nameETS variant transcription factor 6neurotrophic receptor tyrosine kinase 3
SynonymsTEL|TEL/ABL|THC5GP145-TrkC|TRKC|gp145(trkC)
Cytomap

12p13.2

15q25.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)NT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C
Modification date2020031320200313
UniProtAcc

P41212

Q16288

Ensembl transtripts involved in fusion geneENST idsENST00000396373, ENST00000544715, 
ENST00000355254, ENST00000357724, 
ENST00000360948, ENST00000394480, 
ENST00000557856, ENST00000540489, 
ENST00000558306, ENST00000317501, 
ENST00000542733, ENST00000558676, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score59 X 37 X 25=5457515 X 19 X 11=3135
# samples 5815
** MAII scorelog2(58/54575*10)=-6.55604351475058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/3135*10)=-4.38543103719352
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ETV6 [Title/Abstract] AND NTRK3 [Title/Abstract] AND fusion [Title/Abstract]

A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma (pmid: 9462753)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ETV6(12006495)-NTRK3(88576276), # samples:23
NTRK3(88669502)-ETV6(12022358), # samples:3
Anticipated loss of major functional domain due to fusion event.ETV6-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ETV6-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ETV6-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ETV6-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
NTRK3-ETV6 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502

TgeneNTRK3

GO:0000187

activation of MAPK activity

23027130

TgeneNTRK3

GO:0001933

negative regulation of protein phosphorylation

23027130

TgeneNTRK3

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

23027130

TgeneNTRK3

GO:0008284

positive regulation of cell proliferation

23027130

TgeneNTRK3

GO:0010628

positive regulation of gene expression

23027130

TgeneNTRK3

GO:0030335

positive regulation of cell migration

23027130

TgeneNTRK3

GO:0032148

activation of protein kinase B activity

23027130

TgeneNTRK3

GO:0033138

positive regulation of peptidyl-serine phosphorylation

23027130

TgeneNTRK3

GO:0050927

positive regulation of positive chemotaxis

23027130

TgeneNTRK3

GO:0090630

activation of GTPase activity

23027130

TgeneNTRK3

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027130


check buttonFusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4acute myeloid leukemia;mesoblastic nephromaAF041811ETV6chr12

12022903

NTRK3chr15

88419991
ChimerDB4BRCATCGA-AO-A03U-01BETV6chr12

12022902

+NTRK3chr15

88483983

-
ChimerDB4BRCATCGA-AO-A03U-01BETV6chr12

12022903

-NTRK3chr15

88483984

-
ChimerDB4BRCATCGA-AO-A03U-01BETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerDB4BRCATCGA-AO-A03UETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerDB4COADTCGA-CK-5913-01AETV6chr12

12022903

-NTRK3chr15

88483984

-
ChimerDB4COADTCGA-CK-5913-01AETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerDB4COADTCGA-CK-5913ETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerDB4COADTCGA-CK-5916-01AETV6chr12

12022903

-NTRK3chr15

88483984

-
ChimerDB4COADTCGA-CK-5916-01AETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerDB4SKCMTCGA-EB-A51B-01AETV6chr12

12022903

-NTRK3chr15

88483984

-
ChimerDB4SKCMTCGA-EB-A51B-01AETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerDB4SKCMTCGA-EB-A51BETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerDB4THCATCGA-CE-A27D-01AETV6chr12

12006495

-NTRK3chr15

88576276

-
ChimerDB4THCATCGA-CE-A27D-01AETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-CE-A27DETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-DJ-A3UV-01AETV6chr12

12006495

-NTRK3chr15

88576276

-
ChimerDB4THCATCGA-DJ-A3UV-01AETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-DJ-A4V0-01AETV6chr12

12006495

-NTRK3chr15

88576276

-
ChimerDB4THCATCGA-DJ-A4V0-01AETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-DJ-A4V0ETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-E8-A438-01AETV6chr12

12006495

-NTRK3chr15

88576276

-
ChimerDB4THCATCGA-E8-A438-01AETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-E8-A438ETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-EL-A3ZN-01AETV6chr12

12006495

-NTRK3chr15

88576276

-
ChimerDB4THCATCGA-EL-A3ZN-01AETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerDB4THCATCGA-FE-A3PD-01AETV6chr12

12006495

-NTRK3chr15

88576276

-
ChimerDB4THCATCGA-FE-A3PD-01AETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerKB3..ETV6chr12

12006495

+NTRK3chr15

88483984

-
ChimerKB3..ETV6chr12

12006495

+NTRK3chr15

88576276

-
ChimerKB3..ETV6chr12

12022903

+NTRK3chr15

88420143

-
ChimerKB3..ETV6chr12

12022903

+NTRK3chr15

88483984

-
ChimerKB4..ETV6chr12

12006360

+NTRK3chr15

12006360

-
ChimerKB4..ETV6chr12

12022357

+NTRK3chr15

12022357

-
ChiTaRS5.0N/AAF041811ETV6chr12

12022903

+NTRK3chr15

88483987

-
ChiTaRS5.0N/AAF125808ETV6chr12

12022903

+NTRK3chr15

88483987

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396373ETV6chr1212006495+ENST00000394480NTRK3chr1588483984-35667372741629451
ENST00000396373ETV6chr1212006495+ENST00000557856NTRK3chr1588483984-17747372741629451
ENST00000396373ETV6chr1212006495+ENST00000357724NTRK3chr1588483984-18167372741671465
ENST00000396373ETV6chr1212006495+ENST00000355254NTRK3chr1588483984-17747372741629451
ENST00000396373ETV6chr1212006495+ENST00000360948NTRK3chr1588483984-18167372741671465
ENST00000396373ETV6chr1212006495+ENST00000542733NTRK3chr1588483984-15737372741299341
ENST00000396373ETV6chr1212006495+ENST00000558676NTRK3chr1588483984-14747372741293339
ENST00000396373ETV6chr1212006495+ENST00000394480NTRK3chr1588576276-37557372741818514
ENST00000396373ETV6chr1212006495+ENST00000557856NTRK3chr1588576276-19637372741818514
ENST00000396373ETV6chr1212006495+ENST00000357724NTRK3chr1588576276-20057372741860528
ENST00000396373ETV6chr1212006495+ENST00000355254NTRK3chr1588576276-19637372741818514
ENST00000396373ETV6chr1212006495+ENST00000360948NTRK3chr1588576276-20057372741860528
ENST00000396373ETV6chr1212006495+ENST00000542733NTRK3chr1588576276-17627372741488404
ENST00000396373ETV6chr1212006495+ENST00000558676NTRK3chr1588576276-16637372741482402
ENST00000396373ETV6chr1212006495+ENST00000317501NTRK3chr1588576276-31587372741179301
ENST00000396373ETV6chr1212022903+ENST00000394480NTRK3chr1588483984-411212832742175633
ENST00000396373ETV6chr1212022903+ENST00000557856NTRK3chr1588483984-232012832742175633
ENST00000396373ETV6chr1212022903+ENST00000357724NTRK3chr1588483984-236212832742217647
ENST00000396373ETV6chr1212022903+ENST00000355254NTRK3chr1588483984-232012832742175633
ENST00000396373ETV6chr1212022903+ENST00000360948NTRK3chr1588483984-236212832742217647
ENST00000396373ETV6chr1212022903+ENST00000542733NTRK3chr1588483984-211912832741845523
ENST00000396373ETV6chr1212022903+ENST00000558676NTRK3chr1588483984-202012832741839521
ENST00000396373ETV6chr1212022903+ENST00000394480NTRK3chr1588483984-411212832742175633
ENST00000396373ETV6chr1212022903+ENST00000557856NTRK3chr1588483984-232012832742175633
ENST00000396373ETV6chr1212022903+ENST00000357724NTRK3chr1588483984-236212832742217647
ENST00000396373ETV6chr1212022903+ENST00000355254NTRK3chr1588483984-232012832742175633
ENST00000396373ETV6chr1212022903+ENST00000360948NTRK3chr1588483984-236212832742217647
ENST00000396373ETV6chr1212022903+ENST00000542733NTRK3chr1588483984-211912832741845523
ENST00000396373ETV6chr1212022903+ENST00000558676NTRK3chr1588483984-202012832741839521
ENST00000396373ETV6chr1212006495+ENST00000394480NTRK3chr1588576276-37557372741818514
ENST00000396373ETV6chr1212006495+ENST00000557856NTRK3chr1588576276-19637372741818514
ENST00000396373ETV6chr1212006495+ENST00000357724NTRK3chr1588576276-20057372741860528
ENST00000396373ETV6chr1212006495+ENST00000355254NTRK3chr1588576276-19637372741818514
ENST00000396373ETV6chr1212006495+ENST00000360948NTRK3chr1588576276-20057372741860528
ENST00000396373ETV6chr1212006495+ENST00000542733NTRK3chr1588576276-17627372741488404
ENST00000396373ETV6chr1212006495+ENST00000558676NTRK3chr1588576276-16637372741482402
ENST00000396373ETV6chr1212006495+ENST00000317501NTRK3chr1588576276-31587372741179301
ENST00000396373ETV6chr1212022902+ENST00000394480NTRK3chr1588483983-411212832742175633
ENST00000396373ETV6chr1212022902+ENST00000557856NTRK3chr1588483983-232012832742175633
ENST00000396373ETV6chr1212022902+ENST00000357724NTRK3chr1588483983-236212832742217647
ENST00000396373ETV6chr1212022902+ENST00000355254NTRK3chr1588483983-232012832742175633
ENST00000396373ETV6chr1212022902+ENST00000360948NTRK3chr1588483983-236212832742217647
ENST00000396373ETV6chr1212022902+ENST00000542733NTRK3chr1588483983-211912832741845523
ENST00000396373ETV6chr1212022902+ENST00000558676NTRK3chr1588483983-202012832741839521
ENST00000396373ETV6chr1212022903+ENST00000394480NTRK3chr1588483987-411212832742175633
ENST00000396373ETV6chr1212022903+ENST00000557856NTRK3chr1588483987-232012832742175633
ENST00000396373ETV6chr1212022903+ENST00000357724NTRK3chr1588483987-236212832742217647
ENST00000396373ETV6chr1212022903+ENST00000355254NTRK3chr1588483987-232012832742175633
ENST00000396373ETV6chr1212022903+ENST00000360948NTRK3chr1588483987-236212832742217647
ENST00000396373ETV6chr1212022903+ENST00000542733NTRK3chr1588483987-211912832741845523
ENST00000396373ETV6chr1212022903+ENST00000558676NTRK3chr1588483987-202012832741839521

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396373ENST00000394480ETV6chr1212022903+NTRK3chr1588483984-0.0101467590.9898532
ENST00000396373ENST00000557856ETV6chr1212022903+NTRK3chr1588483984-0.0227787530.97722125
ENST00000396373ENST00000357724ETV6chr1212022903+NTRK3chr1588483984-0.0223444870.97765553
ENST00000396373ENST00000355254ETV6chr1212022903+NTRK3chr1588483984-0.0227787530.97722125
ENST00000396373ENST00000360948ETV6chr1212022903+NTRK3chr1588483984-0.0223444870.97765553
ENST00000396373ENST00000542733ETV6chr1212022903+NTRK3chr1588483984-0.0258394390.9741606
ENST00000396373ENST00000558676ETV6chr1212022903+NTRK3chr1588483984-0.0236825140.9763175
ENST00000396373ENST00000394480ETV6chr1212006495+NTRK3chr1588576276-0.0043337360.99566627
ENST00000396373ENST00000557856ETV6chr1212006495+NTRK3chr1588576276-0.0075681390.9924319
ENST00000396373ENST00000357724ETV6chr1212006495+NTRK3chr1588576276-0.007548870.99245113
ENST00000396373ENST00000355254ETV6chr1212006495+NTRK3chr1588576276-0.0075681390.9924319
ENST00000396373ENST00000360948ETV6chr1212006495+NTRK3chr1588576276-0.007548870.99245113
ENST00000396373ENST00000542733ETV6chr1212006495+NTRK3chr1588576276-0.0058231060.99417686
ENST00000396373ENST00000558676ETV6chr1212006495+NTRK3chr1588576276-0.0062425350.9937575
ENST00000396373ENST00000317501ETV6chr1212006495+NTRK3chr1588576276-0.0030167140.99698323
ENST00000396373ENST00000394480ETV6chr1212022902+NTRK3chr1588483983-0.0101467590.9898532
ENST00000396373ENST00000557856ETV6chr1212022902+NTRK3chr1588483983-0.0227787530.97722125
ENST00000396373ENST00000357724ETV6chr1212022902+NTRK3chr1588483983-0.0223444870.97765553
ENST00000396373ENST00000355254ETV6chr1212022902+NTRK3chr1588483983-0.0227787530.97722125
ENST00000396373ENST00000360948ETV6chr1212022902+NTRK3chr1588483983-0.0223444870.97765553
ENST00000396373ENST00000542733ETV6chr1212022902+NTRK3chr1588483983-0.0258394390.9741606
ENST00000396373ENST00000558676ETV6chr1212022902+NTRK3chr1588483983-0.0236825140.9763175
ENST00000396373ENST00000394480ETV6chr1212022903+NTRK3chr1588483987-0.0101467590.9898532
ENST00000396373ENST00000557856ETV6chr1212022903+NTRK3chr1588483987-0.0227787530.97722125
ENST00000396373ENST00000357724ETV6chr1212022903+NTRK3chr1588483987-0.0223444870.97765553
ENST00000396373ENST00000355254ETV6chr1212022903+NTRK3chr1588483987-0.0227787530.97722125
ENST00000396373ENST00000360948ETV6chr1212022903+NTRK3chr1588483987-0.0223444870.97765553
ENST00000396373ENST00000542733ETV6chr1212022903+NTRK3chr1588483987-0.0258394390.9741606
ENST00000396373ENST00000558676ETV6chr1212022903+NTRK3chr1588483987-0.0236825140.9763175

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27735_27735_1_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88483984_ENST00000355254_length(amino acids)=451AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP
RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT
TESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL

--------------------------------------------------------------

>27735_27735_2_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88483984_ENST00000357724_length(amino acids)=465AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP
RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPI
RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL

--------------------------------------------------------------

>27735_27735_3_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88483984_ENST00000360948_length(amino acids)=465AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP
RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPI
RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL

--------------------------------------------------------------

>27735_27735_4_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88483984_ENST00000394480_length(amino acids)=451AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP
RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT
TESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL

--------------------------------------------------------------

>27735_27735_5_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88483984_ENST00000542733_length(amino acids)=341AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP

--------------------------------------------------------------

>27735_27735_6_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88483984_ENST00000557856_length(amino acids)=451AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP
RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT
TESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL

--------------------------------------------------------------

>27735_27735_7_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88483984_ENST00000558676_length(amino acids)=339AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP

--------------------------------------------------------------

>27735_27735_8_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000317501_length(amino acids)=301AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGILNLKDNRDHLVPSTHYIYEEPEVQSGEVSYPRSHGFREIMLN

--------------------------------------------------------------

>27735_27735_9_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000355254_length(amino acids)=514AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA
SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS

--------------------------------------------------------------

>27735_27735_10_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000357724_length(amino acids)=528AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA
SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW

--------------------------------------------------------------

>27735_27735_11_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000360948_length(amino acids)=528AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA
SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW

--------------------------------------------------------------

>27735_27735_12_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000394480_length(amino acids)=514AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA
SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS

--------------------------------------------------------------

>27735_27735_13_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000542733_length(amino acids)=404AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA

--------------------------------------------------------------

>27735_27735_14_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000557856_length(amino acids)=514AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA
SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS

--------------------------------------------------------------

>27735_27735_15_ETV6-NTRK3_ETV6_chr12_12006495_ENST00000396373_NTRK3_chr15_88576276_ENST00000558676_length(amino acids)=402AA_BP=154
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA

--------------------------------------------------------------

>27735_27735_16_ETV6-NTRK3_ETV6_chr12_12022902_ENST00000396373_NTRK3_chr15_88483983_ENST00000355254_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_17_ETV6-NTRK3_ETV6_chr12_12022902_ENST00000396373_NTRK3_chr15_88483983_ENST00000357724_length(amino acids)=647AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTML
PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK

--------------------------------------------------------------

>27735_27735_18_ETV6-NTRK3_ETV6_chr12_12022902_ENST00000396373_NTRK3_chr15_88483983_ENST00000360948_length(amino acids)=647AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTML
PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK

--------------------------------------------------------------

>27735_27735_19_ETV6-NTRK3_ETV6_chr12_12022902_ENST00000396373_NTRK3_chr15_88483983_ENST00000394480_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_20_ETV6-NTRK3_ETV6_chr12_12022902_ENST00000396373_NTRK3_chr15_88483983_ENST00000542733_length(amino acids)=523AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG

--------------------------------------------------------------

>27735_27735_21_ETV6-NTRK3_ETV6_chr12_12022902_ENST00000396373_NTRK3_chr15_88483983_ENST00000557856_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_22_ETV6-NTRK3_ETV6_chr12_12022902_ENST00000396373_NTRK3_chr15_88483983_ENST00000558676_length(amino acids)=521AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG

--------------------------------------------------------------

>27735_27735_23_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483984_ENST00000355254_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_24_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483984_ENST00000357724_length(amino acids)=647AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTML
PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK

--------------------------------------------------------------

>27735_27735_25_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483984_ENST00000360948_length(amino acids)=647AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTML
PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK

--------------------------------------------------------------

>27735_27735_26_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483984_ENST00000394480_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_27_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483984_ENST00000542733_length(amino acids)=523AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG

--------------------------------------------------------------

>27735_27735_28_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483984_ENST00000557856_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_29_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483984_ENST00000558676_length(amino acids)=521AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG

--------------------------------------------------------------

>27735_27735_30_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483987_ENST00000355254_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_31_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483987_ENST00000357724_length(amino acids)=647AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTML
PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK

--------------------------------------------------------------

>27735_27735_32_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483987_ENST00000360948_length(amino acids)=647AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTML
PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK

--------------------------------------------------------------

>27735_27735_33_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483987_ENST00000394480_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_34_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483987_ENST00000542733_length(amino acids)=523AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG

--------------------------------------------------------------

>27735_27735_35_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483987_ENST00000557856_length(amino acids)=633AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>27735_27735_36_ETV6-NTRK3_ETV6_chr12_12022903_ENST00000396373_NTRK3_chr15_88483987_ENST00000558676_length(amino acids)=521AA_BP=336
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12006495/chr15:88576276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

NTRK3

Q16288

FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETV6chr12:12006495chr15:88576276ENST00000396373+4840_124154.33333333333334453.0DomainPNT
HgeneETV6chr12:12022902chr15:88483983ENST00000396373+5840_124336.3333333333333453.0DomainPNT
HgeneETV6chr12:12022903chr15:88483984ENST00000396373+5840_124336.3333333333333453.0DomainPNT
HgeneETV6chr12:12022903chr15:88483987ENST00000396373+5840_124336.3333333333333453.0DomainPNT
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115538_839465.3333333333333613.0DomainProtein kinase
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118538_839465.3333333333333826.0DomainProtein kinase
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119538_839465.3333333333333840.0DomainProtein kinase
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219538_839465.3333333333333826.0DomainProtein kinase
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014538_839465.3333333333333613.0DomainProtein kinase
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015538_8390613.0DomainProtein kinase
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218538_839528.3333333333334826.0DomainProtein kinase
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219538_839528.3333333333334840.0DomainProtein kinase
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319538_839528.3333333333334826.0DomainProtein kinase
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014538_8390613.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015538_8390613.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218538_839528.3333333333334826.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219538_839528.3333333333334840.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319538_839528.3333333333334826.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014538_8390613.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015538_8390613.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218538_839528.3333333333334826.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219538_839528.3333333333334840.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319538_839528.3333333333334826.0DomainProtein kinase
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014538_8390613.0DomainProtein kinase
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115544_552465.3333333333333613.0Nucleotide bindingATP
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118544_552465.3333333333333826.0Nucleotide bindingATP
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119544_552465.3333333333333840.0Nucleotide bindingATP
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219544_552465.3333333333333826.0Nucleotide bindingATP
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014544_552465.3333333333333613.0Nucleotide bindingATP
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218544_552528.3333333333334826.0Nucleotide bindingATP
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219544_552528.3333333333334840.0Nucleotide bindingATP
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319544_552528.3333333333334826.0Nucleotide bindingATP
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218544_552528.3333333333334826.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219544_552528.3333333333334840.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319544_552528.3333333333334826.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218544_552528.3333333333334826.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219544_552528.3333333333334840.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319544_552528.3333333333334826.0Nucleotide bindingATP
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022902chr15:88483983ENST0000031750101532_4290613.0Topological domainExtracellular
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022902chr15:88483983ENST0000054048901432_4290613.0Topological domainExtracellular
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483984ENST0000031750101532_4290613.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483984ENST0000054048901432_4290613.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483987ENST0000031750101532_4290613.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483987ENST0000054048901432_4290613.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022902chr15:88483983ENST00000317501015430_4530613.0TransmembraneHelical
TgeneNTRK3chr12:12022902chr15:88483983ENST00000540489014430_4530613.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483984ENST00000317501015430_4530613.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483984ENST00000540489014430_4530613.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483987ENST00000317501015430_4530613.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483987ENST00000540489014430_4530613.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETV6chr12:12006495chr15:88576276ENST00000396373+48339_420154.33333333333334453.0DNA bindingETS
HgeneETV6chr12:12022902chr15:88483983ENST00000396373+58339_420336.3333333333333453.0DNA bindingETS
HgeneETV6chr12:12022903chr15:88483984ENST00000396373+58339_420336.3333333333333453.0DNA bindingETS
HgeneETV6chr12:12022903chr15:88483987ENST00000396373+58339_420336.3333333333333453.0DNA bindingETS
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115160_209465.3333333333333613.0DomainNote=LRRCT
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115210_300465.3333333333333613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115309_382465.3333333333333613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118160_209465.3333333333333826.0DomainNote=LRRCT
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118210_300465.3333333333333826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118309_382465.3333333333333826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119160_209465.3333333333333840.0DomainNote=LRRCT
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119210_300465.3333333333333840.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119309_382465.3333333333333840.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219160_209465.3333333333333826.0DomainNote=LRRCT
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219210_300465.3333333333333826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219309_382465.3333333333333826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014160_209465.3333333333333613.0DomainNote=LRRCT
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014210_300465.3333333333333613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014309_382465.3333333333333613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218160_209528.3333333333334826.0DomainNote=LRRCT
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219160_209528.3333333333334840.0DomainNote=LRRCT
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219210_300528.3333333333334840.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219309_382528.3333333333334840.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319160_209528.3333333333334826.0DomainNote=LRRCT
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218160_209528.3333333333334826.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219160_209528.3333333333334840.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219210_300528.3333333333334840.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219309_382528.3333333333334840.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319160_209528.3333333333334826.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218160_209528.3333333333334826.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219160_209528.3333333333334840.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219210_300528.3333333333334840.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219309_382528.3333333333334840.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319160_209528.3333333333334826.0DomainNote=LRRCT
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319210_300528.3333333333334826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319309_382528.3333333333334826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115104_125465.3333333333333613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115128_149465.3333333333333613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118104_125465.3333333333333826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118128_149465.3333333333333826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119104_125465.3333333333333840.0RepeatNote=LRR 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119128_149465.3333333333333840.0RepeatNote=LRR 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219104_125465.3333333333333826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219128_149465.3333333333333826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014104_125465.3333333333333613.0RepeatNote=LRR 1
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014128_149465.3333333333333613.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218104_125528.3333333333334826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218128_149528.3333333333334826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219104_125528.3333333333334840.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219128_149528.3333333333334840.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319104_125528.3333333333334826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319128_149528.3333333333334826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218104_125528.3333333333334826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218128_149528.3333333333334826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219104_125528.3333333333334840.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219128_149528.3333333333334840.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319104_125528.3333333333334826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319128_149528.3333333333334826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218104_125528.3333333333334826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218128_149528.3333333333334826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219104_125528.3333333333334840.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219128_149528.3333333333334840.0RepeatNote=LRR 2
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319104_125528.3333333333334826.0RepeatNote=LRR 1
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319128_149528.3333333333334826.0RepeatNote=LRR 2
TgeneNTRK3chr12:12006495chr15:88576276ENST00000317501111532_429465.3333333333333613.0Topological domainExtracellular
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115454_839465.3333333333333613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12006495chr15:88576276ENST00000355254111832_429465.3333333333333826.0Topological domainExtracellular
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118454_839465.3333333333333826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12006495chr15:88576276ENST00000360948111932_429465.3333333333333840.0Topological domainExtracellular
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119454_839465.3333333333333840.0Topological domainCytoplasmic
TgeneNTRK3chr12:12006495chr15:88576276ENST00000394480121932_429465.3333333333333826.0Topological domainExtracellular
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219454_839465.3333333333333826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12006495chr15:88576276ENST00000540489101432_429465.3333333333333613.0Topological domainExtracellular
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014454_839465.3333333333333613.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022902chr15:88483983ENST00000355254121832_429528.3333333333334826.0Topological domainExtracellular
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218454_839528.3333333333334826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022902chr15:88483983ENST00000360948121932_429528.3333333333334840.0Topological domainExtracellular
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219454_839528.3333333333334840.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022902chr15:88483983ENST00000394480131932_429528.3333333333334826.0Topological domainExtracellular
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319454_839528.3333333333334826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483984ENST00000355254121832_429528.3333333333334826.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218454_839528.3333333333334826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483984ENST00000360948121932_429528.3333333333334840.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219454_839528.3333333333334840.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483984ENST00000394480131932_429528.3333333333334826.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319454_839528.3333333333334826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483987ENST00000355254121832_429528.3333333333334826.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218454_839528.3333333333334826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483987ENST00000360948121932_429528.3333333333334840.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219454_839528.3333333333334840.0Topological domainCytoplasmic
TgeneNTRK3chr12:12022903chr15:88483987ENST00000394480131932_429528.3333333333334826.0Topological domainExtracellular
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319454_839528.3333333333334826.0Topological domainCytoplasmic
TgeneNTRK3chr12:12006495chr15:88576276ENST000003175011115430_453465.3333333333333613.0TransmembraneHelical
TgeneNTRK3chr12:12006495chr15:88576276ENST000003552541118430_453465.3333333333333826.0TransmembraneHelical
TgeneNTRK3chr12:12006495chr15:88576276ENST000003609481119430_453465.3333333333333840.0TransmembraneHelical
TgeneNTRK3chr12:12006495chr15:88576276ENST000003944801219430_453465.3333333333333826.0TransmembraneHelical
TgeneNTRK3chr12:12006495chr15:88576276ENST000005404891014430_453465.3333333333333613.0TransmembraneHelical
TgeneNTRK3chr12:12022902chr15:88483983ENST000003552541218430_453528.3333333333334826.0TransmembraneHelical
TgeneNTRK3chr12:12022902chr15:88483983ENST000003609481219430_453528.3333333333334840.0TransmembraneHelical
TgeneNTRK3chr12:12022902chr15:88483983ENST000003944801319430_453528.3333333333334826.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483984ENST000003552541218430_453528.3333333333334826.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483984ENST000003609481219430_453528.3333333333334840.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483984ENST000003944801319430_453528.3333333333334826.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483987ENST000003552541218430_453528.3333333333334826.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483987ENST000003609481219430_453528.3333333333334840.0TransmembraneHelical
TgeneNTRK3chr12:12022903chr15:88483987ENST000003944801319430_453528.3333333333334826.0TransmembraneHelical


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (63) >>>63.pdbFusion protein BP residue: 154
CIF file (63) >>>63.cif		ETV6chr1212006495+NTRK3chr1588576276-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVI
ENPQYFRQGHNCHKPDTWVFSNIDNHGILNLKDNRDHLVPSTHYIYEEPE
VQSGEVSYPRSHGFREIMLNPISLPGHSKPLNHGIYVEDVNVYFSKGRHG
301
3D view using mol* of 63 (AA BP:154)
PDB file (99) >>>99.pdbFusion protein BP residue: 154
CIF file (99) >>>99.cif		ETV6chr1212006495+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKAL
KDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD
LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQH
339
3D view using mol* of 99 (AA BP:154)
PDB file (102) >>>102.pdbFusion protein BP residue: 154
CIF file (102) >>>102.cif		ETV6chr1212006495+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKAL
KDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD
LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQH
341
3D view using mol* of 102 (AA BP:154)
PDB file (162) >>>162.pdbFusion protein BP residue: 154
CIF file (162) >>>162.cif		ETV6chr1212006495+NTRK3chr1588576276-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVI
ENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLS
PTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGD
PLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS
QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR
402
3D view using mol* of 162 (AA BP:154)
PDB file (164) >>>164.pdbFusion protein BP residue: 154
CIF file (164) >>>164.cif		ETV6chr1212006495+NTRK3chr1588576276-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVI
ENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLS
PTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGD
PLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS
QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR
404
3D view using mol* of 164 (AA BP:154)
PDB file (219) >>>219.pdbFusion protein BP residue: 154
CIF file (219) >>>219.cif		ETV6chr1212006495+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKAL
KDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD
LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQH
FVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMP
PESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV
LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL
451
3D view using mol* of 219 (AA BP:154)
PDB file (239) >>>239.pdbFusion protein BP residue: 154
CIF file (239) >>>239.cif		ETV6chr1212006495+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKAL
KDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD
LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQH
FVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWC
EVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQL
SNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL
465
3D view using mol* of 239 (AA BP:154)
PDB file (326) >>>326.pdbFusion protein BP residue: 154
CIF file (326) >>>326.cif		ETV6chr1212006495+NTRK3chr1588576276-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVI
ENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLS
PTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGD
PLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS
QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR
VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS
NTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILH
514
3D view using mol* of 326 (AA BP:154)
PDB file (339) >>>339.pdbFusion protein BP residue: 336
CIF file (339) >>>339.cif		ETV6chr1212022903+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRP
LRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE
SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKR
ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL
TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLL
521
3D view using mol* of 339 (AA BP:336)
PDB file (348) >>>348.pdbFusion protein BP residue: 336
CIF file (348) >>>348.cif		ETV6chr1212022903+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRP
LRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE
SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKR
ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL
TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLL
523
3D view using mol* of 348 (AA BP:336)
PDB file (357) >>>357.pdbFusion protein BP residue: 154
CIF file (357) >>>357.cif		ETV6chr1212006495+NTRK3chr1588576276-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVI
ENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLS
PTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGD
PLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS
QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR
LFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW
EIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREP
528
3D view using mol* of 357 (AA BP:154)
PDB file (504) >>>504.pdbFusion protein BP residue: 336
CIF file (504) >>>504.cif		ETV6chr1212022903+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRP
LRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE
SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKR
ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL
TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLL
VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSF
GVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGC
633
3D view using mol* of 504 (AA BP:336)
PDB file (521) >>>521.pdbFusion protein BP residue: 336
CIF file (521) >>>521.cif		ETV6chr1212022903+NTRK3chr1588483984-
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRL
PAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKE
DFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQ
NHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRP
LRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSE
SHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKR
ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL
TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLL
VKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESI
MYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERP
647
3D view using mol* of 521 (AA BP:336)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ETV6_pLDDT.png
all structure
all structure
NTRK3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ETV6_NTRK3_63_PAE.png (AA BP:154)
all structure
ETV6_NTRK3_63_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_63_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_63_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_99_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_99_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_99_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_102_PAE.png (AA BP:154)
all structure
ETV6_NTRK3_102_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_102_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_102_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_162_PAE.png (AA BP:154)
all structure
ETV6_NTRK3_162_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_162_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_162_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_164_PAE.png (AA BP:154)
all structure
ETV6_NTRK3_164_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_164_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_164_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_219_PAE.png (AA BP:154)
all structure
ETV6_NTRK3_219_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_219_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_219_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_239_PAE.png (AA BP:154)
all structure
ETV6_NTRK3_239_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_239_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_239_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_326_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_326_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_326_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_339_pLDDT.png (AA BP:336)
all structure
ETV6_NTRK3_339_pLDDT_and_active_sites.png (AA BP:336)
all structure
ETV6_NTRK3_339_violinplot.png (AA BP:336)
all structure
ETV6_NTRK3_348_pLDDT.png (AA BP:336)
all structure
ETV6_NTRK3_348_pLDDT_and_active_sites.png (AA BP:336)
all structure
ETV6_NTRK3_348_violinplot.png (AA BP:336)
all structure
ETV6_NTRK3_357_pLDDT.png (AA BP:154)
all structure
ETV6_NTRK3_357_pLDDT_and_active_sites.png (AA BP:154)
all structure
ETV6_NTRK3_357_violinplot.png (AA BP:154)
all structure
ETV6_NTRK3_504_pLDDT.png (AA BP:336)
all structure
ETV6_NTRK3_504_pLDDT_and_active_sites.png (AA BP:336)
all structure
ETV6_NTRK3_504_violinplot.png (AA BP:336)
all structure
ETV6_NTRK3_521_pLDDT.png (AA BP:336)
all structure
ETV6_NTRK3_521_pLDDT_and_active_sites.png (AA BP:336)
all structure
ETV6_NTRK3_521_violinplot.png (AA BP:336)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
ETV6_NTRK3_63.png
all structure
ETV6_NTRK3_162.png
all structure
ETV6_NTRK3_164.png
all structure
ETV6_NTRK3_219.png
all structure
ETV6_NTRK3_239.png
all structure
ETV6_NTRK3_326.png
all structure
ETV6_NTRK3_339.png
all structure
ETV6_NTRK3_357.png
all structure
ETV6_NTRK3_504.png
all structure
ETV6_NTRK3_521.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
630.9591441.003433.8950.6730.5980.7660.3620.9090.3980.696Chain A: 63,66,67,70,84,85,86,87,88,89,93,96,97,98
,101,104,105,187,189,190,191,192,193,194,195,196,1
97,198,199,201
991.0711291.095392.7350.490.780.9621.1730.9621.2190.709Chain A: 168,169,170,171,172,173,174,175,176,178,1
96,198,214,218,227,243,244,245,246,247,249,250,309
,310,312,322,323,324
1021.0112621.027914.7810.6070.7150.9040.5991.0490.5710.858Chain A: 96,97,98,100,101,104,105,168,169,170,171,
172,173,174,175,176,178,196,198,214,218,227,243,24
4,245,246,247,248,249,250,252,253,254,255,256,257,
258,259,260,261,262,263,265,266,271,272,273,274,27
5,303,305,307,308,309,310,312,322,323,324,325,326,
327
1621.0541281.095386.9040.540.7280.9270.920.8651.0631.939Chain A: 238,261,263,270,273,274,276,277,280,283,2
84,304,362,364,367,387,388,389,390,391,392,395
1641.0432131.077659.2460.5570.7250.9230.9740.9141.0650.86Chain A: 231,233,234,235,236,237,238,239,241,259,2
61,277,281,290,306,307,308,309,310,311,312,313,315
,316,317,319,320,321,325,326,328,329,332,333,334,3
35,336,337,368,372,373,375,385,386,387,388
2191.0087411.0322292.6120.5870.6980.8970.5751.0020.5740.862Chain A: 47,48,49,50,55,56,57,59,60,61,62,63,64,88
,89,90,92,93,94,95,96,97,98,101,102,105,114,117,11
8,120,121,123,124,125,126,127,128,129,130,131,132,
133,134,135,136,137,138,139,172,173,174,175,176,19
8,200,201,202,204,207,210,211,214,217,218,221,226,
227,241,243,248,252,253,254,256,257,258,261,262,26
3,264,265,266,267,268,269,270,271,272,273,274,296,
301,302,303,304,305,307,308,309,310,321,322,323,32
4,325,327,328,329,330,331,332,333,334,335,336,337,
341,342,343,344,345,347,348,357,359,374,379,380,38
1,384,385,386,387,388,389,390
2391.0376171.0611989.0570.580.7360.9540.8140.9850.8260.944Chain A: 57,58,59,63,88,89,90,92,93,94,95,96,97,98
,102,114,117,118,121,122,124,125,126,143,144,145,1
46,148,168,170,171,174,175,196,198,200,201,202,207
,210,211,213,214,217,218,221,226,227,228,229,241,2
43,244,245,246,247,248,249,250,252,253,254,256,257
,258,259,260,261,262,263,264,265,266,267,268,270,2
71,272,274,275,276,296,300,301,302,303,304,305,307
,308,309,310,312,321,322,323,324,325,326,327,328,3
30,331,333,334,335,349,352,353,354,356,357,358,359
,361,362,371,373,374,375,388,391,392,393,394,395,3
96,398,399,400,401,402,404
3261.0183101.064971.7190.6220.6720.8090.5170.8560.6040.804Chain A: 192,193,194,195,196,197,198,199,200,201,2
02,203,204,205,206,236,237,238,261,263,264,265,270
,273,274,276,277,280,304,363,364,365,366,367,368,3
73,386,387,388,389,390,391,392,395,398,399,401,402
,404,405,406,407,408,409,417,418,419,420,421,422,4
23,424,455
3391.0142791.059944.6220.6560.6660.8140.5060.860.5891.255Chain A: 93,95,96,97,98,99,100,101,104,105,114,117
,118,328,329,330,331,332,333,334,335,336,338,339,3
57,368,375,380,382,383,384,389,392,393,395,396,398
,399,400,401,402,403,404,410,411,412,413,477,481,4
82,483,486,506,507,508,509,510,511,513,514
3481.021991.039649.9850.5670.7240.9860.8661.0290.8420.785Chain A: 350,351,352,353,354,355,356,357,358,360,3
78,380,396,400,409,411,425,426,427,428,429,430,431
,432,435,436,438,439,440,441,442,444,445,446,447,4
48,449,450,451,452,453,454,455,456,485,487,491,492
,494,504,505,506,507,508,509
3571.0262631.0531131.90.5970.7160.9280.4850.9710.51.089Chain A: 57,58,59,92,93,95,96,97,98,99,100,114,117
,118,121,124,126,127,128,315,316,319,320,328,329,3
70,371,372,392,393,394,395,396,397,398,399,401,402
,404,412,423,424,425,451,456,457,458,459,461,462,4
63,464,465,466,469,470
5041.0623421.089912.380.470.7631.0610.9350.9470.9881.037Chain A: 57,58,59,90,92,93,95,96,118,121,122,124,1
25,126,350,352,353,354,360,378,427,428,429,430,431
,432,434,435,436,438,439,440,444,445,446,447,448,4
49,450,451,452,453,454,455,456,489,491,494,506,508
,509,511,512,513,515,516,529,530,556,561,562,563,5
64,566,568
5211.1931041.204187.2780.3420.9641.2871.8920.9641.9620.963Chain A: 268,269,270,271,272,357,380,396,399,400,4
03,408,409,410,411,425,478,483,484,485,503,504,505
,506,507

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2, EGLN3, NKX2-1, TRAF2, AXIN1, ESR2, LMNA, TP53BP1, BRCA1, MDC1, KIAA1429, WWP2, ESR1, BRD4, NFE2L2, MAD2L1, B4GALT2, KLHL9, KLHL13, SUMO2, ARHGAP32, SEC16A, XPOT, PIAS2, CEP152, NUP214, NUP62, NUP98, SEC13, RBM11, ECH1, ZNF146, TRIP6, CEP85, NUP54, TAB3, ALMS1, CEP192, PPIL4, RQCD1, SDCCAG3, NUP88, TBL1Y, KIAA1671, C2orf44, GRPEL1, TNRC6C, MID1IP1, CYLD, ZMYM2, LIMD1, SPATA2, TNRC6B, TIMM13, FLOT1, LGALS3BP, FLOT2, HNRNPUL1,
NTRK3NTF3, FRS2, SHC1, PLCG1, SQSTM1, PTPN1, APP, HSP90AA1, IRAK3, TNK2, NTRK1, SH3BP4, PTPRS, MYADM, C1GALT1, GNB2, C6orf120, MTOR, LGALS1, PTCD2, TMEM11, PAG1, EFR3A, TBC1D24, GNB4, TMEM192, INTS7, DENND4A, FAM171A2, KIAA0391, EPHA2, ATP7B, CXCR4, ACAD10, HRAS, EHD4, RPTOR, HEATR6, SLC39A11, NDFIP1, ERBB2, NELFB, HEY1, WDR13, KPNA4, NSD1, DOK6, SORT1, Ngfr, DDX58, UBE3C, LINGO1, NEU3, ACAD9,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ETV6all structure
NTRK3all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ETV6-NTRK3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
ETV6NTRK3Resistance To Entrectinib And SelitrectinibPubMed34429303

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Related Diseases to ETV6-NTRK3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
ETV6NTRK3Pediatric GliomaPubMed34429303
ETV6NTRK3Mammary Analog Secretory Carcinoma Of Salivary GlandMyCancerGenome
ETV6NTRK3FibrosarcomaMyCancerGenome
ETV6NTRK3Colon AdenocarcinomaMyCancerGenome
ETV6NTRK3Pancreatic AdenocarcinomaMyCancerGenome
ETV6NTRK3Thyroid Gland Papillary CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C4015537THROMBOCYTOPENIA 54CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia3CTD_human;GENOMICS_ENGLAND
HgeneETV6C0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
HgeneETV6C1332965Congenital Mesoblastic Nephroma2ORPHANET
HgeneETV6C0006413Burkitt Lymphoma1ORPHANET
HgeneETV6C0013146Drug abuse1CTD_human
HgeneETV6C0013170Drug habituation1CTD_human
HgeneETV6C0013222Drug Use Disorders1CTD_human
HgeneETV6C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneETV6C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneETV6C0023467Leukemia, Myelocytic, Acute1CGI;CTD_human;GENOMICS_ENGLAND
HgeneETV6C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneETV6C0038580Substance Dependence1CTD_human
HgeneETV6C0038586Substance Use Disorders1CTD_human
HgeneETV6C0087031Juvenile-Onset Still Disease1CTD_human
HgeneETV6C0236969Substance-Related Disorders1CTD_human
HgeneETV6C0238463Papillary thyroid carcinoma1ORPHANET
HgeneETV6C0376544Hematopoietic Neoplasms1CTD_human
HgeneETV6C0376545Hematologic Neoplasms1CTD_human
HgeneETV6C0740858Substance abuse problem1CTD_human
HgeneETV6C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
HgeneETV6C1510472Drug Dependence1CTD_human
HgeneETV6C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1ORPHANET
HgeneETV6C1838656Macrocytosis, Familial1CTD_human
HgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneETV6C3495559Juvenile arthritis1CTD_human
HgeneETV6C3714758Juvenile psoriatic arthritis1CTD_human
HgeneETV6C4316881Prescription Drug Abuse1CTD_human
HgeneETV6C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneETV6C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneNTRK3C0036341Schizophrenia3PSYGENET
TgeneNTRK3C0041696Unipolar Depression2PSYGENET
TgeneNTRK3C1269683Major Depressive Disorder2PSYGENET
TgeneNTRK3C1332965Congenital Mesoblastic Nephroma2ORPHANET
TgeneNTRK3C0014175Endometriosis1CTD_human
TgeneNTRK3C0017638Glioma1CTD_human
TgeneNTRK3C0019569Hirschsprung Disease1GENOMICS_ENGLAND
TgeneNTRK3C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneNTRK3C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneNTRK3C0038220Status Epilepticus1CTD_human
TgeneNTRK3C0238463Papillary thyroid carcinoma1ORPHANET
TgeneNTRK3C0259783mixed gliomas1CTD_human
TgeneNTRK3C0269102Endometrioma1CTD_human
TgeneNTRK3C0270823Petit mal status1CTD_human
TgeneNTRK3C0311335Grand Mal Status Epilepticus1CTD_human
TgeneNTRK3C0393734Complex Partial Status Epilepticus1CTD_human
TgeneNTRK3C0525045Mood Disorders1PSYGENET
TgeneNTRK3C0555198Malignant Glioma1CTD_human
TgeneNTRK3C0751522Status Epilepticus, Subclinical1CTD_human
TgeneNTRK3C0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneNTRK3C0751524Simple Partial Status Epilepticus1CTD_human
TgeneNTRK3C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human