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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EWSR1-ABR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EWSR1-ABR
FusionPDB ID: 27815
FusionGDB2.0 ID: 27815
HgeneTgene
Gene symbol

EWSR1

ABR

Gene ID

2130

29

Gene nameEWS RNA binding protein 1ABR activator of RhoGEF and GTPase
SynonymsEWS|EWS-FLI1|bK984G1.4MDB
Cytomap

22q12.2

17p13.3

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogeneactive breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related
Modification date2020032920200313
UniProtAcc

Q01844

Q15018

Ensembl transtripts involved in fusion geneENST idsENST00000331029, ENST00000332035, 
ENST00000332050, ENST00000333395, 
ENST00000397938, ENST00000406548, 
ENST00000414183, 		ENST00000544583, 
ENST00000574437, ENST00000291107, 
ENST00000536794, ENST00000543210, 
ENST00000572441, ENST00000573895, 
ENST00000302538, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 91 X 16=6406417 X 14 X 9=2142
# samples 9821
** MAII scorelog2(98/64064*10)=-6.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2142*10)=-3.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EWSR1 [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EWSR1(29669853)-ABR(1028702), # samples:4
Anticipated loss of major functional domain due to fusion event.EWSR1-ABR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EWSR1-ABR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EWSR1-ABR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EWSR1-ABR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABR

GO:0090630

activation of GTPase activity

7479768


check buttonFusion gene breakpoints across EWSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7421-01AEWSR1chr22

29669853

-ABRchr17

1028702

-
ChimerDB4HNSCTCGA-CV-7421-01AEWSR1chr22

29669853

+ABRchr17

1028702

-
ChimerDB4HNSCTCGA-CV-7421EWSR1chr22

29669853

+ABRchr17

1028702

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332050EWSR1chr2229669853+ENST00000302538ABRchr171028702-56355543283072914
ENST00000397938EWSR1chr2229669853+ENST00000302538ABRchr171028702-56265453193063914
ENST00000406548EWSR1chr2229669853+ENST00000302538ABRchr171028702-5371290642808914
ENST00000331029EWSR1chr2229669853+ENST00000302538ABRchr171028702-5353272462790914
ENST00000414183EWSR1chr2229669853+ENST00000302538ABRchr171028702-5328247212765914
ENST00000333395EWSR1chr2229669853+ENST00000302538ABRchr171028702-5326245192763914
ENST00000332035EWSR1chr2229669853+ENST00000302538ABRchr171028702-5318237112755914

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332050ENST00000302538EWSR1chr2229669853+ABRchr171028702-0.0010594160.99894065
ENST00000397938ENST00000302538EWSR1chr2229669853+ABRchr171028702-0.0010576760.9989423
ENST00000406548ENST00000302538EWSR1chr2229669853+ABRchr171028702-0.0010821820.9989178
ENST00000331029ENST00000302538EWSR1chr2229669853+ABRchr171028702-0.0010979680.99890196
ENST00000414183ENST00000302538EWSR1chr2229669853+ABRchr171028702-0.0010912110.99890876
ENST00000333395ENST00000302538EWSR1chr2229669853+ABRchr171028702-0.0010820260.99891794
ENST00000332035ENST00000302538EWSR1chr2229669853+ABRchr171028702-0.0010807720.99891925

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27815_27815_1_EWSR1-ABR_EWSR1_chr22_29669853_ENST00000331029_ABR_chr17_1028702_ENST00000302538_length(amino acids)=914AA_BP=75
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF

--------------------------------------------------------------

>27815_27815_2_EWSR1-ABR_EWSR1_chr22_29669853_ENST00000332035_ABR_chr17_1028702_ENST00000302538_length(amino acids)=914AA_BP=75
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF

--------------------------------------------------------------

>27815_27815_3_EWSR1-ABR_EWSR1_chr22_29669853_ENST00000332050_ABR_chr17_1028702_ENST00000302538_length(amino acids)=914AA_BP=75
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF

--------------------------------------------------------------

>27815_27815_4_EWSR1-ABR_EWSR1_chr22_29669853_ENST00000333395_ABR_chr17_1028702_ENST00000302538_length(amino acids)=914AA_BP=75
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF

--------------------------------------------------------------

>27815_27815_5_EWSR1-ABR_EWSR1_chr22_29669853_ENST00000397938_ABR_chr17_1028702_ENST00000302538_length(amino acids)=914AA_BP=75
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF

--------------------------------------------------------------

>27815_27815_6_EWSR1-ABR_EWSR1_chr22_29669853_ENST00000406548_ABR_chr17_1028702_ENST00000302538_length(amino acids)=914AA_BP=75
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF

--------------------------------------------------------------

>27815_27815_7_EWSR1-ABR_EWSR1_chr22_29669853_ENST00000414183_ABR_chr17_1028702_ENST00000302538_length(amino acids)=914AA_BP=75
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29669853/chr17:1028702)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EWSR1

Q01844

ABR

Q15018

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41617_2775.33333333333333601.0RepeatNote=2
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41628_3475.33333333333333601.0RepeatNote=3
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41635_4275.33333333333333601.0RepeatNote=4
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41643_5075.33333333333333601.0RepeatNote=5
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41651_5975.33333333333333601.0RepeatNote=6
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41660_6875.33333333333333601.0RepeatNote=7
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41669_7575.33333333333333601.0RepeatNote=8
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+4168_1675.33333333333333601.0RepeatNote=1
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4917_2775.33333333333333355.0RepeatNote=2
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4928_3475.33333333333333355.0RepeatNote=3
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4935_4275.33333333333333355.0RepeatNote=4
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4943_5075.33333333333333355.0RepeatNote=5
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4951_5975.33333333333333355.0RepeatNote=6
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4960_6875.33333333333333355.0RepeatNote=7
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4969_7575.33333333333333355.0RepeatNote=8
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+498_1675.33333333333333355.0RepeatNote=1
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41717_2775.33333333333333657.0RepeatNote=2
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41728_3475.33333333333333657.0RepeatNote=3
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41735_4275.33333333333333657.0RepeatNote=4
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41743_5075.33333333333333657.0RepeatNote=5
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41751_5975.33333333333333657.0RepeatNote=6
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41760_6875.33333333333333657.0RepeatNote=7
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41769_7575.33333333333333657.0RepeatNote=8
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+4178_1675.33333333333333657.0RepeatNote=1
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41717_2775.33333333333333656.0RepeatNote=2
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41728_3475.33333333333333656.0RepeatNote=3
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41735_4275.33333333333333656.0RepeatNote=4
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41743_5075.33333333333333656.0RepeatNote=5
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41751_5975.33333333333333656.0RepeatNote=6
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41760_6875.33333333333333656.0RepeatNote=7
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41769_7575.33333333333333656.0RepeatNote=8
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+4178_1675.33333333333333656.0RepeatNote=1
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41817_2775.33333333333333662.0RepeatNote=2
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41828_3475.33333333333333662.0RepeatNote=3
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41835_4275.33333333333333662.0RepeatNote=4
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41843_5075.33333333333333662.0RepeatNote=5
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41851_5975.33333333333333662.0RepeatNote=6
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41860_6875.33333333333333662.0RepeatNote=7
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41869_7575.33333333333333662.0RepeatNote=8
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+4188_1675.33333333333333662.0RepeatNote=1
TgeneABRchr22:29669853chr17:1028702ENST00000291107022417_4200823.0Compositional biasNote=Poly-Leu
TgeneABRchr22:29669853chr17:1028702ENST00000302538023417_42020.333333333333332860.0Compositional biasNote=Poly-Leu
TgeneABRchr22:29669853chr17:1028702ENST0000054321008417_4200311.0Compositional biasNote=Poly-Leu
TgeneABRchr22:29669853chr17:1028702ENST00000544583023417_4200814.0Compositional biasNote=Poly-Leu
TgeneABRchr22:29669853chr17:1028702ENST00000574437022417_4200814.0Compositional biasNote=Poly-Leu
TgeneABRchr22:29669853chr17:1028702ENST00000291107022301_4590823.0DomainPH
TgeneABRchr22:29669853chr17:1028702ENST00000291107022484_6130823.0DomainC2
TgeneABRchr22:29669853chr17:1028702ENST00000291107022647_8450823.0DomainRho-GAP
TgeneABRchr22:29669853chr17:1028702ENST0000029110702291_2840823.0DomainDH
TgeneABRchr22:29669853chr17:1028702ENST00000302538023301_45920.333333333333332860.0DomainPH
TgeneABRchr22:29669853chr17:1028702ENST00000302538023484_61320.333333333333332860.0DomainC2
TgeneABRchr22:29669853chr17:1028702ENST00000302538023647_84520.333333333333332860.0DomainRho-GAP
TgeneABRchr22:29669853chr17:1028702ENST0000030253802391_28420.333333333333332860.0DomainDH
TgeneABRchr22:29669853chr17:1028702ENST0000054321008301_4590311.0DomainPH
TgeneABRchr22:29669853chr17:1028702ENST0000054321008484_6130311.0DomainC2
TgeneABRchr22:29669853chr17:1028702ENST0000054321008647_8450311.0DomainRho-GAP
TgeneABRchr22:29669853chr17:1028702ENST000005432100891_2840311.0DomainDH
TgeneABRchr22:29669853chr17:1028702ENST00000544583023301_4590814.0DomainPH
TgeneABRchr22:29669853chr17:1028702ENST00000544583023484_6130814.0DomainC2
TgeneABRchr22:29669853chr17:1028702ENST00000544583023647_8450814.0DomainRho-GAP
TgeneABRchr22:29669853chr17:1028702ENST0000054458302391_2840814.0DomainDH
TgeneABRchr22:29669853chr17:1028702ENST00000574437022301_4590814.0DomainPH
TgeneABRchr22:29669853chr17:1028702ENST00000574437022484_6130814.0DomainC2
TgeneABRchr22:29669853chr17:1028702ENST00000574437022647_8450814.0DomainRho-GAP
TgeneABRchr22:29669853chr17:1028702ENST0000057443702291_2840814.0DomainDH

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416300_34075.33333333333333601.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416454_51375.33333333333333601.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416559_64075.33333333333333601.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49300_34075.33333333333333355.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49454_51375.33333333333333355.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49559_64075.33333333333333355.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417300_34075.33333333333333657.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417454_51375.33333333333333657.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417559_64075.33333333333333657.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417300_34075.33333333333333656.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417454_51375.33333333333333656.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417559_64075.33333333333333656.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418300_34075.33333333333333662.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418454_51375.33333333333333662.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418559_64075.33333333333333662.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416256_28575.33333333333333601.0DomainNote=IQ
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416361_44775.33333333333333601.0DomainRRM
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49256_28575.33333333333333355.0DomainNote=IQ
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49361_44775.33333333333333355.0DomainRRM
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417256_28575.33333333333333657.0DomainNote=IQ
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417361_44775.33333333333333657.0DomainRRM
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417256_28575.33333333333333656.0DomainNote=IQ
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417361_44775.33333333333333656.0DomainRRM
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418256_28575.33333333333333662.0DomainNote=IQ
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418361_44775.33333333333333662.0DomainRRM
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416639_65675.33333333333333601.0MotifNuclear localization signal
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49639_65675.33333333333333355.0MotifNuclear localization signal
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417639_65675.33333333333333657.0MotifNuclear localization signal
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417639_65675.33333333333333656.0MotifNuclear localization signal
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418639_65675.33333333333333662.0MotifNuclear localization signal
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+4161_28575.33333333333333601.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+4168_28575.33333333333333601.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+491_28575.33333333333333355.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+498_28575.33333333333333355.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+4171_28575.33333333333333657.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+4178_28575.33333333333333657.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+4171_28575.33333333333333656.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+4178_28575.33333333333333656.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+4181_28575.33333333333333662.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+4188_28575.33333333333333662.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416111_11675.33333333333333601.0RepeatNote=12
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416117_12575.33333333333333601.0RepeatNote=13
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416126_15675.33333333333333601.0RepeatNote=14
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416157_16375.33333333333333601.0RepeatNote=15
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416164_17075.33333333333333601.0RepeatNote=16
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416171_17775.33333333333333601.0RepeatNote=17
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416178_18875.33333333333333601.0RepeatNote=18
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416189_19375.33333333333333601.0RepeatNote=19
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416194_20175.33333333333333601.0RepeatNote=20
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416202_20675.33333333333333601.0RepeatNote=21
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416207_21275.33333333333333601.0RepeatNote=22
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416213_21875.33333333333333601.0RepeatNote=23
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416219_22475.33333333333333601.0RepeatNote=24
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416225_23075.33333333333333601.0RepeatNote=25
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416231_23875.33333333333333601.0RepeatNote=26
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416239_24575.33333333333333601.0RepeatNote=27
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416246_25275.33333333333333601.0RepeatNote=28
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416253_25975.33333333333333601.0RepeatNote=29
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416260_27675.33333333333333601.0RepeatNote=30
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416277_28575.33333333333333601.0RepeatNote=31
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41676_8475.33333333333333601.0RepeatNote=9
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41685_9175.33333333333333601.0RepeatNote=10
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+41692_11075.33333333333333601.0RepeatNote=11
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49111_11675.33333333333333355.0RepeatNote=12
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49117_12575.33333333333333355.0RepeatNote=13
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49126_15675.33333333333333355.0RepeatNote=14
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49157_16375.33333333333333355.0RepeatNote=15
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49164_17075.33333333333333355.0RepeatNote=16
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49171_17775.33333333333333355.0RepeatNote=17
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49178_18875.33333333333333355.0RepeatNote=18
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49189_19375.33333333333333355.0RepeatNote=19
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49194_20175.33333333333333355.0RepeatNote=20
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49202_20675.33333333333333355.0RepeatNote=21
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49207_21275.33333333333333355.0RepeatNote=22
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49213_21875.33333333333333355.0RepeatNote=23
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49219_22475.33333333333333355.0RepeatNote=24
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49225_23075.33333333333333355.0RepeatNote=25
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49231_23875.33333333333333355.0RepeatNote=26
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49239_24575.33333333333333355.0RepeatNote=27
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49246_25275.33333333333333355.0RepeatNote=28
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49253_25975.33333333333333355.0RepeatNote=29
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49260_27675.33333333333333355.0RepeatNote=30
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49277_28575.33333333333333355.0RepeatNote=31
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4976_8475.33333333333333355.0RepeatNote=9
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4985_9175.33333333333333355.0RepeatNote=10
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+4992_11075.33333333333333355.0RepeatNote=11
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417111_11675.33333333333333657.0RepeatNote=12
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417117_12575.33333333333333657.0RepeatNote=13
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417126_15675.33333333333333657.0RepeatNote=14
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417157_16375.33333333333333657.0RepeatNote=15
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417164_17075.33333333333333657.0RepeatNote=16
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417171_17775.33333333333333657.0RepeatNote=17
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417178_18875.33333333333333657.0RepeatNote=18
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417189_19375.33333333333333657.0RepeatNote=19
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417194_20175.33333333333333657.0RepeatNote=20
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417202_20675.33333333333333657.0RepeatNote=21
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417207_21275.33333333333333657.0RepeatNote=22
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417213_21875.33333333333333657.0RepeatNote=23
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417219_22475.33333333333333657.0RepeatNote=24
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417225_23075.33333333333333657.0RepeatNote=25
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417231_23875.33333333333333657.0RepeatNote=26
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417239_24575.33333333333333657.0RepeatNote=27
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417246_25275.33333333333333657.0RepeatNote=28
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417253_25975.33333333333333657.0RepeatNote=29
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417260_27675.33333333333333657.0RepeatNote=30
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417277_28575.33333333333333657.0RepeatNote=31
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41776_8475.33333333333333657.0RepeatNote=9
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41785_9175.33333333333333657.0RepeatNote=10
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+41792_11075.33333333333333657.0RepeatNote=11
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417111_11675.33333333333333656.0RepeatNote=12
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417117_12575.33333333333333656.0RepeatNote=13
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417126_15675.33333333333333656.0RepeatNote=14
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417157_16375.33333333333333656.0RepeatNote=15
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417164_17075.33333333333333656.0RepeatNote=16
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417171_17775.33333333333333656.0RepeatNote=17
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417178_18875.33333333333333656.0RepeatNote=18
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417189_19375.33333333333333656.0RepeatNote=19
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417194_20175.33333333333333656.0RepeatNote=20
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417202_20675.33333333333333656.0RepeatNote=21
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417207_21275.33333333333333656.0RepeatNote=22
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417213_21875.33333333333333656.0RepeatNote=23
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417219_22475.33333333333333656.0RepeatNote=24
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417225_23075.33333333333333656.0RepeatNote=25
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417231_23875.33333333333333656.0RepeatNote=26
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417239_24575.33333333333333656.0RepeatNote=27
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417246_25275.33333333333333656.0RepeatNote=28
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417253_25975.33333333333333656.0RepeatNote=29
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417260_27675.33333333333333656.0RepeatNote=30
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417277_28575.33333333333333656.0RepeatNote=31
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41776_8475.33333333333333656.0RepeatNote=9
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41785_9175.33333333333333656.0RepeatNote=10
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+41792_11075.33333333333333656.0RepeatNote=11
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418111_11675.33333333333333662.0RepeatNote=12
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418117_12575.33333333333333662.0RepeatNote=13
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418126_15675.33333333333333662.0RepeatNote=14
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418157_16375.33333333333333662.0RepeatNote=15
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418164_17075.33333333333333662.0RepeatNote=16
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418171_17775.33333333333333662.0RepeatNote=17
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418178_18875.33333333333333662.0RepeatNote=18
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418189_19375.33333333333333662.0RepeatNote=19
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418194_20175.33333333333333662.0RepeatNote=20
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418202_20675.33333333333333662.0RepeatNote=21
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418207_21275.33333333333333662.0RepeatNote=22
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418213_21875.33333333333333662.0RepeatNote=23
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418219_22475.33333333333333662.0RepeatNote=24
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418225_23075.33333333333333662.0RepeatNote=25
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418231_23875.33333333333333662.0RepeatNote=26
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418239_24575.33333333333333662.0RepeatNote=27
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418246_25275.33333333333333662.0RepeatNote=28
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418253_25975.33333333333333662.0RepeatNote=29
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418260_27675.33333333333333662.0RepeatNote=30
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418277_28575.33333333333333662.0RepeatNote=31
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41876_8475.33333333333333662.0RepeatNote=9
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41885_9175.33333333333333662.0RepeatNote=10
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+41892_11075.33333333333333662.0RepeatNote=11
HgeneEWSR1chr22:29669853chr17:1028702ENST00000332035+416518_54975.33333333333333601.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29669853chr17:1028702ENST00000333395+49518_54975.33333333333333355.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29669853chr17:1028702ENST00000397938+417518_54975.33333333333333657.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29669853chr17:1028702ENST00000406548+417518_54975.33333333333333656.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29669853chr17:1028702ENST00000414183+418518_54975.33333333333333662.0Zinc fingerRanBP2-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1708_EWSR1_29669853_ABR_1028702_ranked_0.pdbEWSR12966985329669853ENST00000302538ABRchr171028702-
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTDFSYGTDEYDGEGNE
EQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATAT
TSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEEL
KVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKD
GFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK
ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTV
HNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYD
KTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVR
QCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN
CMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISF
914


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EWSR1_pLDDT.png
all structure
all structure
ABR_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EWSR1PRTFDC1, ZDHHC3, MSC, SLC22A24, MYO1F, KXD1, KHDRBS2, DNAJB3, FASN, NLE1, MNS1, PRUNE2, WWP2, NDUFB1, BNIP3L, NSUN4, KRR1, WWP1, RMND5B, SLC1A1, RASL11B, DFFA, WDR37, RPS15A, CPSF6, C11orf16, YY1AP1, RNF183, MTCP1, TULP2, RBPMS, KEL, MYOZ2, FAM131C, HMGA1, NPPB, HERPUD1, CD177, RPL31, VPS72, ACTL6A, RAD23A, MAGEA11, CFDP1, DMRTB1, CXADR, ZNF165, SSBP2, TPGS2, RAB37, CETP, NDUFV1, DYNLL2, NBPF3, CEACAM5, GPBP1L1, SERP2, GNPDA1, C19orf57, ELAVL3, ELAVL4, LILRA3, BAD, CCDC7, MRPS18B, CUEDC2, CNST, TSPAN3, CCDC91, TRIM37, NINL, NTNG2, CPSF7, PGLS, EPT1, MYL6, SMAD4, TMSB4Y, TRPV5, MVK, MAPK1IP1L, MDFI, MTMR9, PLSCR1, RALYL, PDHX, C10orf12, RHOXF2, MATK, SALL2, AGT, KCNMB1, SUV39H2, SMNDC1, ARHGDIA, PUF60, GSK3B, ILK, CD2BP2, BARD1, CREBBP, BTK, SF1, SNRPC, ELK1, PTK2B, CALM1, POU4F1, EZH2, IRF3, TONSL, RFX3, HLTF, SUPT4H1, ZNF184, HIST1H2BN, BLZF1, HDAC3, FXR2, HMGN4, POLR3A, ECD, ZBTB1, SCMH1, SUZ12, E2F8, TRIM5, ZNF383, DHX9, SMN1, PCM1, RAD21, NDRG1, CEBPA, ELAVL1, SIRT7, HNRNPA1, TSG101, TP53, POLR2A, YBX1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, KCND3, ATN1, ATXN3, ERCC5, HBP1, HSPA2, PCBP1, USP7, SRSF5, TMEM126A, SAP30BP, GORASP2, MBD3, MRPS9, HAX1, SFXN1, ITGA5, TCIRG1, RNF168, GEMIN5, HAS1, MTCH1, NDUFA5, MCAT, MRPL57, HDAC2, ESR1, FN1, VCAM1, ITGA4, CD81, PRMT1, SF3B4, EP300, PRRC2A, EWSR1, FUS, ITGB5, NONO, TRAF3, HNRNPUL1, EPAS1, CHERP, CDK12, ITCH, WBP4, rev, RPA3, RPA2, RPA1, HSPA5, RIOK2, TRAF1, TRAF2, SEC24D, TFG, SEC24A, SSBP3, PRR13, ATPAF2, PEF1, JUN, CUL7, OBSL1, CCDC8, RNF2, BMI1, EGFR, ABL1, SRPK1, ABCE1, PRMT8, RPS6KB2, ACAA2, ACAT1, EIF4H, ANXA2, HIP1R, PICALM, POR, NTRK1, SCARNA22, NPM1, KRT2, PRDX2, S100A9, YWHAZ, DDX17, PCLO, ANXA6, SEC24C, GIPC1, CSRP2, FHL1, HNRNPA3, CTTN, MARCKSL1, PARP1, SERPINB3, CCDC50, KIF2A, KRT6B, HIST1H1D, STK38, H2AFV, PACSIN2, U2AF1, RSL24D1, XRCC5, ESYT3, RPL29, SDF2L1, LRP1B, MSN, SEC23A, RPL7A, SNX18, PPIL1, RPS27A, IGHM, SUMO3, GTF2I, RUVBL1, KRT16, RBM8A, RPL8, SRSF9, ZC3HAV1L, GAPDH, ETV3, IGF2R, COL5A2, HNRNPD, ANP32B, WAC, TFAP2A, TTN, CBR3, ARGLU1, HNRNPAB, SRRT, ATP1B3, COPS7B, PRR12, ATF3, NOMO3, NOMO1, NOMO2, EYA3, C1orf198, MAZ, U2AF2, SSB, TRA2B, C1orf52, HMGB1, HMGB1P10, RPRD1A, HNRNPH3, EIF5A2, C1orf131, SEC13, MAPRE1, CSTF2T, SRSF3, LENG1, UPF1, HDGFRP2, RPS10P7, RPS10P11, RPS10, RPS10P13, RPS10P4, RPS10P22, DACH1, ANO1, NCOR1, MLX, SUMO1P3, SUMO1, WIZ, PFDN6, ARFIP2, ZHX3, EEF1B2, MBIP, BAG6, DENND2A, PRCC, SRSF1, EIF4ENIF1, SPTAN1, CDCA8, PLS3, API5P1, API5, PSMA4, DNTTIP1, AKAP8, NCOA3, SMTN, FBRS, SMARCE1, ERC1, WBP11, SPTBN1, NFRKB, OLA1, ZNF207, R3HDM1, TRIM33, SAFB, UBFD1, SRSF7, SRSF2, GATA6, VDAC1P1, VDAC1, IL16, GMNN, ILF2, MED4, QKI, VCL, MFAP1, SNAP29, PADI1, BCL9, BCL9L, PKM, GPATCH11, CASC3, PSMC6, CACYBP, RPL12P6, RPL12P32, RPL12P14, RPL12, RPL12P2, RPL12P35, RPL12P19, TPI1, TPI1P1, CHAF1A, MIA3, CIC, SDCBP, CA2, FKBP3, ACE, NKX2-5, CSTF2, PFDN2, UBTF, FAM207A, LOC729774, BRD8, C12orf45, C1orf35, TCF20, SOD1, SPAG7, MED8, ETS2, ALDOC, FKBP4, INCENP, CEP85, CECR2, TFE3, SUPT16HP1, SUPT16H, MAPT, HTATSF1, RPS18P12, RPS18P5, KPNA2, TMX1, CKAP4, HSPE1, COPRS, PTGES3, LAMP2, ERLIN2, CTNNBL1, TOMM22, NRBF2, C9orf78, NCOA6, MED26, RANBP1, LOC389842, LOC727803, HMGB3, CANX, PUS7, RPSAP19, RPSA, RPSAP18, RPSAP58, RPSAP15, RPSAP8, RPSAP9, RPSAP12, RPSAP29, RPSAP61, ARHGAP17, USF1, PSIP1, SNRPEP2, SNRPE, NUDT5, PPM1G, OTUB1, AHCY, COPS3, NSMCE2, SAE1, PROSER1, GRWD1, CREB5, TAF9B, RBM33, EDF1, PGK1, FAM114A2, SRRM1, RAD23B, CIAPIN1, CIAPIN1P, LRRC59, PABPN1, KMT2A, RPRD1B, GPATCH8, CCDC43, DGCR14, PPP1R2, ERICH1, EIF5A, EIF5AL1, BAG3, PCNA, SOX7, PNISR, FAM168A, MED15, SRSF11, SIRT1, RSF1, MAML1, HPRT1, SPDL1, CRTC3, CEP55, CDV3, ALYREF, RNF40, STOML2, DGCR8, NUCKS1, UBN2, PSMD7, WNT10A, HMBS, KHDRBS1, VBP1, NCSTN, CDCA2, SFSWAP, ZRANB2, DDB1, RBBP6, ZEB1, SRSF6, LOC644422, EIF2S1, RFX5, RPS19, RPS19P3, TALDO1, CWC15, CDCA5, LOC645086, C11orf58, TXN, STX12, PHRF1, BSG, TAF4, SH3GL1, LIN37, HRNR, FAM192A, RRBP1, KIAA0907, GOLGB1, PAX9, P4HB, CHMP5, LDHB, CALR, SUMO2P1, SUMO2, PDIA6, AHSA1, EN2, CCDC124, RPLP0P6, RPLP0P2, RPLP0P3, RPLP0, NIPBL, PDLIM4, PRKCSH, C15orf39, HNRNPDL, PDIA4, NUP210, RPLP2P3, RPLP2, PRDX4, DAZAP1, UBE2T, PHAX, AMOT, MARCKS, LOC284685, SMARCC1, BCORL1, RFC4, GLRX3, ANP32E, HYOU1, NPM3, ATF7IP, SARNP, TRA2A, HDGF, STIP1, PELP1, KCTD12, GLO1, PCF11, CLIC1, DNAJC8, RNF114, SLC4A1AP, FAM50A, GTF2A1, PRPF40A, CDC37, PPIAP22, PPIA, SMARCC2, MEGF11, KIAA1143, DENR, LAMP1, MYBL2, PITX1, UBE2MP1, UBE2M, CHTF8, OTX1, NACA, FNBP4, GTF2F2, GLTSCR1, GTF2E1, PQBP1, EMD, RNF113A, GPALPP1, SNRPA, RRP15, RPS25, RPS25P8, GMEB2, LNPEP, DNAJB1, IGBP1P1, IGBP1, HINT1, ARID1A, PPIB, ANXA11, MATR3, Sgol2, PPARGC1A, MCM2, Ksr1, UBASH3B, SFPQ, CAPN13, HEY1, BRCA1, MTCH2, PPIE, TBX3, BMP4, CTNNB1, GSK3A, HNF1B, TCF7L2, TRIP4, YAF2, ZNF217, AAR2, PIH1D1, EFTUD2, TNIP2, CHD3, CHD4, HEXIM1, MEPCE, LARP7, RUNX1, AGR2, RECQL4, REST, CDK9, SMARCA4, DDIT3, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H1, RC3H2, ATG16L1, PHB, DISC1, NR2C2, UBQLN2, ZFYVE21, XRCC6, AGRN, USP19, HIST1H4A, APEX1, DDX5, SNRNP70, SNRPB, SNRPD1, SNRPD2, SNRPD3, RNU1-1, RBMX, HNRNPM, HNRNPA2B1, TAF15, DDX3X, TARDBP, CLINT1, HNRNPL, NUMA1, ZFR, SNRNP200, ZNF326, HNRNPK, SF3B1, TOE1, HSPA8, SNRPB2, DDX20, GOT2, ILF3, PRPF6, ZNF638, HNRNPF, HNRNPH1, HNRNPR, VCP, CAD, CCAR2, DDX23, GEMIN4, HSPA1A, PCMTD1, POTEF, PRMT5, RBM45, SAFB2, SF3B2, SF3B3, SNRPF, SRSF4, THRAP3, TIA1, TTC7A, ZCCHC8, ITFG1, ARAF, BRD7, SOX2, ARIH2, PLEKHA4, NGB, OPTN, ZC3H18, CELF1, MKI67, INS, Apc2, FBP1, N, ZNF768, SYNCRIP, KDM5C, DDX58, OGT, SPOP, UFL1, DDRGK1, WDR5, TPX2, MALL, SOX21, POU3F3, PTP4A3, TRIM8, RCHY1, nsp14, SOX5,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EWSR1all structure
ABR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EWSR1-ABR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EWSR1-ABR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEWSR1C0553580Ewings sarcoma3CTD_human;ORPHANET
HgeneEWSR1C0002736Amyotrophic Lateral Sclerosis1GENOMICS_ENGLAND
HgeneEWSR1C0033578Prostatic Neoplasms1CTD_human
HgeneEWSR1C0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
HgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human
HgeneEWSR1C0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneEWSR1C0334584Spongioblastoma1CTD_human
HgeneEWSR1C0334596Medulloepithelioma1CTD_human
HgeneEWSR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneEWSR1C0700367Ependymoblastoma1CTD_human
HgeneEWSR1C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
HgeneEWSR1C1275278Extraskeletal Myxoid Chondrosarcoma1ORPHANET