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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AGAP3-CUX1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AGAP3-CUX1
FusionPDB ID: 2817
FusionGDB2.0 ID: 2817
HgeneTgene
Gene symbol

AGAP3

CUX1

Gene ID

116988

1523

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 3cut like homeobox 1
SynonymsAGAP-3|CENTG3|CRAG|MRIP-1|cnt-g3CASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75
Cytomap

7q36.1

7q22.1

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 3CRAM-associated GTPaseCRMP (collapsin response mediator protein) associatedMR1-interacting proteincentaurin-gamma-3protein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317
Modification date2020031320200320
UniProtAcc

Q96P47

P39880

Ensembl transtripts involved in fusion geneENST idsENST00000397238, ENST00000473312, 
ENST00000479901, ENST00000335367, 
ENST00000463381, ENST00000476375, 
ENST00000560541, ENST00000292535, 
ENST00000360264, ENST00000425244, 
ENST00000546411, ENST00000549414, 
ENST00000550008, ENST00000556210, 
ENST00000292538, ENST00000393824, 
ENST00000437600, ENST00000547394, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 6 X 10=90026 X 23 X 9=5382
# samples 1429
** MAII scorelog2(14/900*10)=-2.68449817427207
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5382*10)=-4.21401758562548
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AGAP3 [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AGAP3(150784159)-CUX1(101916637), # samples:1
Anticipated loss of major functional domain due to fusion event.AGAP3-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP3-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP3-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP3-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AGAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CUX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315466AGAP3chr7

150784159

+CUX1chr7

101916637

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000473312AGAP3chr7150784159+ENST00000437600CUX1chr7101916637+198033101112370
ENST00000473312AGAP3chr7150784159+ENST00000292538CUX1chr7101916637+198033101112370
ENST00000473312AGAP3chr7150784159+ENST00000393824CUX1chr7101916637+150133101112370
ENST00000473312AGAP3chr7150784159+ENST00000547394CUX1chr7101916637+198033101112370
ENST00000479901AGAP3chr7150784159+ENST00000437600CUX1chr7101916637+198033101112370
ENST00000479901AGAP3chr7150784159+ENST00000292538CUX1chr7101916637+198033101112370
ENST00000479901AGAP3chr7150784159+ENST00000393824CUX1chr7101916637+150133101112370
ENST00000479901AGAP3chr7150784159+ENST00000547394CUX1chr7101916637+198033101112370
ENST00000397238AGAP3chr7150784159+ENST00000437600CUX1chr7101916637+198033101112370
ENST00000397238AGAP3chr7150784159+ENST00000292538CUX1chr7101916637+198033101112370
ENST00000397238AGAP3chr7150784159+ENST00000393824CUX1chr7101916637+150133101112370
ENST00000397238AGAP3chr7150784159+ENST00000547394CUX1chr7101916637+198033101112370

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000473312ENST00000437600AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000473312ENST00000292538AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000473312ENST00000393824AGAP3chr7150784159+CUX1chr7101916637+0.0189080010.981092
ENST00000473312ENST00000547394AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000479901ENST00000437600AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000479901ENST00000292538AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000479901ENST00000393824AGAP3chr7150784159+CUX1chr7101916637+0.0189080010.981092
ENST00000479901ENST00000547394AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000397238ENST00000437600AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000397238ENST00000292538AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537
ENST00000397238ENST00000393824AGAP3chr7150784159+CUX1chr7101916637+0.0189080010.981092
ENST00000397238ENST00000547394AGAP3chr7150784159+CUX1chr7101916637+0.0208845960.97911537

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2817_2817_1_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000397238_CUX1_chr7_101916637_ENST00000292538_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_2_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000397238_CUX1_chr7_101916637_ENST00000393824_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_3_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000397238_CUX1_chr7_101916637_ENST00000437600_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_4_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000397238_CUX1_chr7_101916637_ENST00000547394_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_5_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000473312_CUX1_chr7_101916637_ENST00000292538_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_6_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000473312_CUX1_chr7_101916637_ENST00000393824_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_7_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000473312_CUX1_chr7_101916637_ENST00000437600_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_8_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000473312_CUX1_chr7_101916637_ENST00000547394_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_9_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000479901_CUX1_chr7_101916637_ENST00000292538_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_10_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000479901_CUX1_chr7_101916637_ENST00000393824_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_11_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000479901_CUX1_chr7_101916637_ENST00000437600_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

--------------------------------------------------------------

>2817_2817_12_AGAP3-CUX1_AGAP3_chr7_150784159_ENST00000479901_CUX1_chr7_101916637_ENST00000547394_length(amino acids)=370AA_BP=110
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI
ERIEDLALQNQIREHVISIEGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAP
ASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEER
LDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHEND

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:150784159/chr7:101916637)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGAP3

Q96P47

CUX1

P39880

FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}.FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+11898_105110.33333333333333912.0Nucleotide bindingGTP
TgeneCUX1chr7:150784159chr7:101916637ENST0000029253502456_40701506.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST000002925381323502_556418.3333333333333679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST0000036026402456_40701517.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST000003938241222502_556379.3333333333333640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST000004376001323502_556416.3333333333333677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST0000054641102456_4070.01404.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST000005473941222502_556402.3333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST0000054941402356_4070.01484.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST0000055000802256_4070.01450.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST0000055621002256_4070.01348.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST000002925350241406_143801506.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:150784159chr7:101916637ENST000003602640241406_143801517.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:150784159chr7:101916637ENST0000042524412221406_1438372.3333333333333633.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:150784159chr7:101916637ENST000005464110241406_14380.01404.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:150784159chr7:101916637ENST000005494140231406_14380.01484.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:150784159chr7:101916637ENST000005500080221406_14380.01450.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:150784159chr7:101916637ENST000005562100221406_14380.01348.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:150784159chr7:101916637ENST000002925350241117_120401506.0DNA bindingCUT 3
TgeneCUX1chr7:150784159chr7:101916637ENST000002925350241244_130301506.0DNA bindingHomeobox
TgeneCUX1chr7:150784159chr7:101916637ENST00000292535024542_62901506.0DNA bindingCUT 1
TgeneCUX1chr7:150784159chr7:101916637ENST00000292535024934_102101506.0DNA bindingCUT 2
TgeneCUX1chr7:150784159chr7:101916637ENST000003602640241117_120401517.0DNA bindingCUT 3
TgeneCUX1chr7:150784159chr7:101916637ENST000003602640241244_130301517.0DNA bindingHomeobox
TgeneCUX1chr7:150784159chr7:101916637ENST00000360264024542_62901517.0DNA bindingCUT 1
TgeneCUX1chr7:150784159chr7:101916637ENST00000360264024934_102101517.0DNA bindingCUT 2
TgeneCUX1chr7:150784159chr7:101916637ENST0000042524412221117_1204372.3333333333333633.0DNA bindingCUT 3
TgeneCUX1chr7:150784159chr7:101916637ENST0000042524412221244_1303372.3333333333333633.0DNA bindingHomeobox
TgeneCUX1chr7:150784159chr7:101916637ENST000004252441222542_629372.3333333333333633.0DNA bindingCUT 1
TgeneCUX1chr7:150784159chr7:101916637ENST000004252441222934_1021372.3333333333333633.0DNA bindingCUT 2
TgeneCUX1chr7:150784159chr7:101916637ENST000005464110241117_12040.01404.0DNA bindingCUT 3
TgeneCUX1chr7:150784159chr7:101916637ENST000005464110241244_13030.01404.0DNA bindingHomeobox
TgeneCUX1chr7:150784159chr7:101916637ENST00000546411024542_6290.01404.0DNA bindingCUT 1
TgeneCUX1chr7:150784159chr7:101916637ENST00000546411024934_10210.01404.0DNA bindingCUT 2
TgeneCUX1chr7:150784159chr7:101916637ENST000005494140231117_12040.01484.0DNA bindingCUT 3
TgeneCUX1chr7:150784159chr7:101916637ENST000005494140231244_13030.01484.0DNA bindingHomeobox
TgeneCUX1chr7:150784159chr7:101916637ENST00000549414023542_6290.01484.0DNA bindingCUT 1
TgeneCUX1chr7:150784159chr7:101916637ENST00000549414023934_10210.01484.0DNA bindingCUT 2
TgeneCUX1chr7:150784159chr7:101916637ENST000005500080221117_12040.01450.0DNA bindingCUT 3
TgeneCUX1chr7:150784159chr7:101916637ENST000005500080221244_13030.01450.0DNA bindingHomeobox
TgeneCUX1chr7:150784159chr7:101916637ENST00000550008022542_6290.01450.0DNA bindingCUT 1
TgeneCUX1chr7:150784159chr7:101916637ENST00000550008022934_10210.01450.0DNA bindingCUT 2
TgeneCUX1chr7:150784159chr7:101916637ENST000005562100221117_12040.01348.0DNA bindingCUT 3
TgeneCUX1chr7:150784159chr7:101916637ENST000005562100221244_13030.01348.0DNA bindingHomeobox
TgeneCUX1chr7:150784159chr7:101916637ENST00000556210022542_6290.01348.0DNA bindingCUT 1
TgeneCUX1chr7:150784159chr7:101916637ENST00000556210022934_10210.01348.0DNA bindingCUT 2
TgeneCUX1chr7:150784159chr7:101916637ENST000002925381323641_678418.3333333333333679.0Topological domainLumenal
TgeneCUX1chr7:150784159chr7:101916637ENST000003938241222641_678379.3333333333333640.0Topological domainLumenal
TgeneCUX1chr7:150784159chr7:101916637ENST000004376001323641_678416.3333333333333677.0Topological domainLumenal
TgeneCUX1chr7:150784159chr7:101916637ENST000005473941222641_678402.3333333333333663.0Topological domainLumenal
TgeneCUX1chr7:150784159chr7:101916637ENST000002925381323620_640418.3333333333333679.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr7:150784159chr7:101916637ENST000003938241222620_640379.3333333333333640.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr7:150784159chr7:101916637ENST000004376001323620_640416.3333333333333677.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr7:150784159chr7:101916637ENST000005473941222620_640402.3333333333333663.0TransmembraneHelical%3B Anchor for type IV membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118367_605110.33333333333333912.0DomainPH
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118626_746110.33333333333333912.0DomainArf-GAP
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118142_146110.33333333333333912.0Nucleotide bindingGTP
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118198_201110.33333333333333912.0Nucleotide bindingGTP
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+11884_375110.33333333333333912.0RegionNote=Small GTPase-like
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118748_777110.33333333333333912.0RepeatNote=ANK 1
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118785_814110.33333333333333912.0RepeatNote=ANK 2
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118818_847110.33333333333333912.0RepeatNote=ANK 3
HgeneAGAP3chr7:150784159chr7:101916637ENST00000397238+118641_664110.33333333333333912.0Zinc fingerC4-type
TgeneCUX1chr7:150784159chr7:101916637ENST00000292538132367_450418.3333333333333679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST00000393824122267_450379.3333333333333640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST00000425244122256_407372.3333333333333633.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST00000437600132367_450416.3333333333333677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST00000547394122267_450402.3333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:150784159chr7:101916637ENST0000029253813231_619418.3333333333333679.0Topological domainCytoplasmic
TgeneCUX1chr7:150784159chr7:101916637ENST0000039382412221_619379.3333333333333640.0Topological domainCytoplasmic
TgeneCUX1chr7:150784159chr7:101916637ENST0000043760013231_619416.3333333333333677.0Topological domainCytoplasmic
TgeneCUX1chr7:150784159chr7:101916637ENST0000054739412221_619402.3333333333333663.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AGAP3
CUX1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AGAP3-CUX1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AGAP3-CUX1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource