UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:FAF1-EPS15

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FAF1-EPS15
FusionPDB ID: 28233
FusionGDB2.0 ID: 28233
HgeneTgene
Gene symbol

FAF1

EPS15

Gene ID

11124

2060

Gene nameFas associated factor 1epidermal growth factor receptor pathway substrate 15
SynonymsCGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1AF-1P|AF1P|MLLT5
Cytomap

1p32.3

1p32.3

Type of geneprotein-codingprotein-coding
DescriptionFAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3Aepidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p
Modification date2020031320200313
UniProtAcc

Q9UNN5

Q9UBC2

Ensembl transtripts involved in fusion geneENST idsENST00000371778, ENST00000396153, 
ENST00000472808, ENST00000545823, 
ENST00000396122, ENST00000493793, 
ENST00000371730, ENST00000371733, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 9=434711 X 14 X 5=770
# samples 3114
** MAII scorelog2(31/4347*10)=-3.80967997500385
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FAF1 [Title/Abstract] AND EPS15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FAF1(51323601)-EPS15(51946986), # samples:2
EPS15(51984870)-FAF1(51323669), # samples:1
Anticipated loss of major functional domain due to fusion event.EPS15-FAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPS15-FAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAF1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAF1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAF1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAF1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAF1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FAF1-EPS15 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FAF1-EPS15 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAF1

GO:0010942

positive regulation of cell death

15596450

TgeneEPS15

GO:0048268

clathrin coat assembly

12807910


check buttonFusion gene breakpoints across FAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPS15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-2F-A9KP-01AFAF1chr1

51171458

-EPS15chr1

51946986

-
ChimerDB4STADTCGA-BR-A4QI-01AFAF1chr1

51323601

-EPS15chr1

51946986

-
ChimerDB4STADTCGA-BR-A4QIFAF1chr1

51323600

-EPS15chr1

51946986

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396153FAF1chr151323600-ENST00000371730EPS15chr151946986-52595661402821893
ENST00000396153FAF1chr151323600-ENST00000371733EPS15chr151946986-566156614032231027
ENST00000396153FAF1chr151323601-ENST00000371730EPS15chr151946986-52595661402821893
ENST00000396153FAF1chr151323601-ENST00000371733EPS15chr151946986-566156614032231027
ENST00000396153FAF1chr151171458-ENST00000371730EPS15chr151946986-5802110914033641074
ENST00000396153FAF1chr151171458-ENST00000371733EPS15chr151946986-6204110914037661208

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396153ENST00000371730FAF1chr151323600-EPS15chr151946986-0.0001192880.9998807
ENST00000396153ENST00000371733FAF1chr151323600-EPS15chr151946986-0.0001134740.9998865
ENST00000396153ENST00000371730FAF1chr151323601-EPS15chr151946986-0.0001192880.9998807
ENST00000396153ENST00000371733FAF1chr151323601-EPS15chr151946986-0.0001134740.9998865
ENST00000396153ENST00000371730FAF1chr151171458-EPS15chr151946986-7.60E-050.99992394
ENST00000396153ENST00000371733FAF1chr151171458-EPS15chr151946986-0.0002026520.9997974

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28233_28233_1_FAF1-EPS15_FAF1_chr1_51171458_ENST00000396153_EPS15_chr1_51946986_ENST00000371730_length(amino acids)=1074AA_BP=323
MPSSWPATVRPDPHPDQSSCPGCCDAGSAGCRRAAGAPEGYRVHERLALPALPRPLARRPARRLARQPLGARRRRRRWRRRSQEVPSASQ
VRASLPEPRNSAAAMASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAP
TSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNS
LYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGL
PDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS
LSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKY
DEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQK
NIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQL
EEQLKEVRKKCAEEAQLARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFK
DDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGG
GFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGN

--------------------------------------------------------------

>28233_28233_2_FAF1-EPS15_FAF1_chr1_51171458_ENST00000396153_EPS15_chr1_51946986_ENST00000371733_length(amino acids)=1208AA_BP=323
MPSSWPATVRPDPHPDQSSCPGCCDAGSAGCRRAAGAPEGYRVHERLALPALPRPLARRPARRLARQPLGARRRRRRWRRRSQEVPSASQ
VRASLPEPRNSAAAMASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAP
TSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNS
LYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGL
PDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS
LSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKY
DEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQK
NIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQL
EEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLME
MKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSE
LDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAAN
NSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEP
PALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEW

--------------------------------------------------------------

>28233_28233_3_FAF1-EPS15_FAF1_chr1_51323600_ENST00000396153_EPS15_chr1_51946986_ENST00000371730_length(amino acids)=893AA_BP=142
MPSSWPATVRPDPHPDQSSCPGCCDAGSAGCRRAAGAPEGYRVHERLALPALPRPLARRPARRLARQPLGARRRRRRWRRRSQEVPSASQ
VRASLPEPRNSAAAMASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLP
DLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSL
SPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYD
EIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKN
IIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLE
EQLKEVRKKCAEEAQLARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKD
DPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGG
FADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGND

--------------------------------------------------------------

>28233_28233_4_FAF1-EPS15_FAF1_chr1_51323600_ENST00000396153_EPS15_chr1_51946986_ENST00000371733_length(amino acids)=1027AA_BP=142
MPSSWPATVRPDPHPDQSSCPGCCDAGSAGCRRAAGAPEGYRVHERLALPALPRPLARRPARRLARQPLGARRRRRRWRRRSQEVPSASQ
VRASLPEPRNSAAAMASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLP
DLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSL
SPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYD
EIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKN
IIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLE
EQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEM
KDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSEL
DNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANN
SSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPP
ALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWA

--------------------------------------------------------------

>28233_28233_5_FAF1-EPS15_FAF1_chr1_51323601_ENST00000396153_EPS15_chr1_51946986_ENST00000371730_length(amino acids)=893AA_BP=142
MPSSWPATVRPDPHPDQSSCPGCCDAGSAGCRRAAGAPEGYRVHERLALPALPRPLARRPARRLARQPLGARRRRRRWRRRSQEVPSASQ
VRASLPEPRNSAAAMASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLP
DLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSL
SPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYD
EIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKN
IIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLE
EQLKEVRKKCAEEAQLARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKD
DPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGG
FADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGND

--------------------------------------------------------------

>28233_28233_6_FAF1-EPS15_FAF1_chr1_51323601_ENST00000396153_EPS15_chr1_51946986_ENST00000371733_length(amino acids)=1027AA_BP=142
MPSSWPATVRPDPHPDQSSCPGCCDAGSAGCRRAAGAPEGYRVHERLALPALPRPLARRPARRLARQPLGARRRRRRWRRRSQEVPSASQ
VRASLPEPRNSAAAMASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLP
DLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSL
SPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYD
EIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKN
IIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLE
EQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEM
KDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSEL
DNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANN
SSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPP
ALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:51323601/chr1:51946986)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAF1

Q9UNN5

EPS15

Q9UBC2

FUNCTION: Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}.FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAF1chr1:51171458chr1:51946986ENST00000371778-8201_57219.0651.0DomainUBA
HgeneFAF1chr1:51171458chr1:51946986ENST00000396153-7191_57219.0651.0DomainUBA
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025173_18411.0897.0Calcium bindingNote=1
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025236_24711.0897.0Calcium bindingNote=2
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025173_18411.0897.0Calcium bindingNote=1
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025236_24711.0897.0Calcium bindingNote=2
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025173_18411.0897.0Calcium bindingNote=1
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025236_24711.0897.0Calcium bindingNote=2
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025768_85011.0897.0Compositional biasNote=Pro-rich
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025768_85011.0897.0Compositional biasNote=Pro-rich
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025768_85011.0897.0Compositional biasNote=Pro-rich
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025128_21611.0897.0DomainEH 2
TgeneEPS15chr1:51171458chr1:51946986ENST0000037173302515_10411.0897.0DomainEH 1
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025160_19511.0897.0DomainEF-hand 1
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025223_25811.0897.0DomainEF-hand 2
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025224_31411.0897.0DomainEH 3
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025851_87011.0897.0DomainUIM 1
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025877_89611.0897.0DomainUIM 2
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025128_21611.0897.0DomainEH 2
TgeneEPS15chr1:51323600chr1:51946986ENST0000037173302515_10411.0897.0DomainEH 1
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025160_19511.0897.0DomainEF-hand 1
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025223_25811.0897.0DomainEF-hand 2
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025224_31411.0897.0DomainEH 3
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025851_87011.0897.0DomainUIM 1
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025877_89611.0897.0DomainUIM 2
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025128_21611.0897.0DomainEH 2
TgeneEPS15chr1:51323601chr1:51946986ENST0000037173302515_10411.0897.0DomainEH 1
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025160_19511.0897.0DomainEF-hand 1
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025223_25811.0897.0DomainEF-hand 2
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025224_31411.0897.0DomainEH 3
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025851_87011.0897.0DomainUIM 1
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025877_89611.0897.0DomainUIM 2
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025768_77411.0897.0MotifNote=SH3-binding
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025768_77411.0897.0MotifNote=SH3-binding
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025768_77411.0897.0MotifNote=SH3-binding
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025599_82711.0897.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025599_82711.0897.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025599_82711.0897.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025599_60111.0897.0RepeatNote=1
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025623_62511.0897.0RepeatNote=2
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025629_63111.0897.0RepeatNote=3
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025634_63611.0897.0RepeatNote=4
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025640_64211.0897.0RepeatNote=5
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025645_64711.0897.0RepeatNote=6
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025651_65311.0897.0RepeatNote=7
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025664_66611.0897.0RepeatNote=8
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025672_67411.0897.0RepeatNote=9
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025692_69411.0897.0RepeatNote=10
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025709_71111.0897.0RepeatNote=11
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025737_73911.0897.0RepeatNote=12
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025798_80011.0897.0RepeatNote=13
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025804_80611.0897.0RepeatNote=14
TgeneEPS15chr1:51171458chr1:51946986ENST00000371733025825_82711.0897.0RepeatNote=15
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025599_60111.0897.0RepeatNote=1
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025623_62511.0897.0RepeatNote=2
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025629_63111.0897.0RepeatNote=3
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025634_63611.0897.0RepeatNote=4
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025640_64211.0897.0RepeatNote=5
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025645_64711.0897.0RepeatNote=6
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025651_65311.0897.0RepeatNote=7
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025664_66611.0897.0RepeatNote=8
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025672_67411.0897.0RepeatNote=9
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025692_69411.0897.0RepeatNote=10
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025709_71111.0897.0RepeatNote=11
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025737_73911.0897.0RepeatNote=12
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025798_80011.0897.0RepeatNote=13
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025804_80611.0897.0RepeatNote=14
TgeneEPS15chr1:51323600chr1:51946986ENST00000371733025825_82711.0897.0RepeatNote=15
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025599_60111.0897.0RepeatNote=1
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025623_62511.0897.0RepeatNote=2
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025629_63111.0897.0RepeatNote=3
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025634_63611.0897.0RepeatNote=4
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025640_64211.0897.0RepeatNote=5
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025645_64711.0897.0RepeatNote=6
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025651_65311.0897.0RepeatNote=7
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025664_66611.0897.0RepeatNote=8
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025672_67411.0897.0RepeatNote=9
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025692_69411.0897.0RepeatNote=10
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025709_71111.0897.0RepeatNote=11
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025737_73911.0897.0RepeatNote=12
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025798_80011.0897.0RepeatNote=13
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025804_80611.0897.0RepeatNote=14
TgeneEPS15chr1:51323601chr1:51946986ENST00000371733025825_82711.0897.0RepeatNote=15

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAF1chr1:51171458chr1:51946986ENST00000371778-820569_646219.0651.0DomainUBX
HgeneFAF1chr1:51171458chr1:51946986ENST00000396153-719569_646219.0651.0DomainUBX
HgeneFAF1chr1:51323600chr1:51946986ENST00000371778-3201_5738.0651.0DomainUBA
HgeneFAF1chr1:51323600chr1:51946986ENST00000371778-320569_64638.0651.0DomainUBX
HgeneFAF1chr1:51323600chr1:51946986ENST00000396153-2191_5738.0651.0DomainUBA
HgeneFAF1chr1:51323600chr1:51946986ENST00000396153-219569_64638.0651.0DomainUBX
HgeneFAF1chr1:51323601chr1:51946986ENST00000371778-3201_5738.0651.0DomainUBA
HgeneFAF1chr1:51323601chr1:51946986ENST00000371778-320569_64638.0651.0DomainUBX
HgeneFAF1chr1:51323601chr1:51946986ENST00000396153-2191_5738.0651.0DomainUBA
HgeneFAF1chr1:51323601chr1:51946986ENST00000396153-219569_64638.0651.0DomainUBX


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EPS15RNF11, SNAP91, AGFG1, NAGPA, STON2, HGS, AP2A2, DNM2, AP2A1, EGFR, CLINT1, EPN1, SCAMP1, STAM2, GRB2, CRK, RAB11FIP2, Synj1, REPS2, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2E1, SLC6A3, PARK2, USP8, CD4, EPS15, OCLN, UBQLN1, UBC, NEDD4, GJA1, TGFB1, Zwint, FCHO2, ITSN1, ITSN2, ELAVL1, RAD23A, UBQLN2, EPN3, SH3BP4, AP1B1, NUMB, SPG20, TFAP2A, ABL1, AP2B1, IQGAP1, KRT85, KRT1, KRT10, KRT2, AP2M1, KRT14, KRT86, KRT5, KRT6A, KRT16, KRT9, HSPA8, KRT35, HSPA9, KRT17, KRT33B, KRT83, BMP2K, KRT34, KRT82, NONO, KRT38, KRT75, KRT79, PRDX1, KRT36, KRT32, MAP4, HSPA1L, HSPA1B, KRT37, HSPA5, KRT73, AP2S1, NECAP2, TRAF2, MCCC2, KRT4, ACTB, KRT3, VPRBP, TUBB, HIST4H4, PCCB, KRTAP9-3, NECAP1, VSIG8, CCT3, CRKL, Dab2, FN1, VCAM1, Fcho2, LAPTM5, ITGA4, OPTN, RABL6, EPHA2, CORO7, UBI4, AGFG2, SLC25A41, AURKA, SPC25, Numb, NTRK1, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, PDLIM7, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, Actb, Flot1, Myh9, Myo1c, Tpm1, Lima1, Calml3, Myh10, Sec24c, Flnb, MAPK14, AP1G1, MYO6, SPOPL, SGIP1, FCHO1, CDH1, RUNDC3A, LSR, STAMBPL1, CCDC172, OXCT1, MTNR1A, RNF26, fcho1, HNRNPL, STK40, DYRK1A, PLK1, DVL2, MIB1, ORF7a, ESR1, TRIM56, KIF14, Rnf183, DNAJC5, DDX58, ACBD5, CLTA, VASP, NAA40, RNPS1, MACC1, SYCE1, RARRES1, POLR2J3, EPS15L1, C15orf59, ZCCHC10, SYNC, INO80E, DNAJC6, RUFY4,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FAF1
EPS15all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEPS15chr1:51171458chr1:51946986ENST000003717330252_33011.0897.0DAB2
TgeneEPS15chr1:51323600chr1:51946986ENST000003717330252_33011.0897.0DAB2
TgeneEPS15chr1:51323601chr1:51946986ENST000003717330252_33011.0897.0DAB2


Top

Related Drugs to FAF1-EPS15


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to FAF1-EPS15


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource