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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FAM107B-ASH1L

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FAM107B-ASH1L
	FusionPDB ID: 28316
	FusionGDB2.0 ID: 28316
		Hgene	Tgene
	Gene symbol	FAM107B	ASH1L
	Gene ID	83641	55870
	Gene name	family with sequence similarity 107 member B	ASH1 like histone lysine methyltransferase
	Synonyms	C10orf45\|HITS	ASH1\|ASH1L1\|KMT2H\|MRD52
	Cytomap	10p13	1q22
	Type of gene	protein-coding	protein-coding
	Description	protein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein	histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L
	Modification date	20200313	20200313
	UniProtAcc	Q9H098	Q9NR48
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000181796, ENST00000378458, ENST00000378462, ENST00000378465, ENST00000378467, ENST00000378470, ENST00000468747, ENST00000478076, ENST00000479731, ENST00000496330, ENST00000471815,	ENST00000548830, ENST00000368346, ENST00000392403,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 8 X 3=240	17 X 13 X 7=1547
	# samples	10	18
	** MAII score	log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1547*10)=-3.10340438511936 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FAM107B [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FAM107B(14572330)-ASH1L(155385714), # samples:1
Anticipated loss of major functional domain due to fusion event.	FAM107B-ASH1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM107B-ASH1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM107B-ASH1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FAM107B-ASH1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FAM107B-ASH1L seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. FAM107B-ASH1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. FAM107B-ASH1L seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FAM107B-ASH1L seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ASH1L	GO:0097676	histone H3-K36 dimethylation	26002201

Fusion gene breakpoints across FAM107B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASH1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A4MI	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000181796	FAM107B	chr10	14572330	-	ENST00000368346	ASH1L	chr1	155385714	-	6361	887	183	3968	1261
ENST00000181796	FAM107B	chr10	14572330	-	ENST00000392403	ASH1L	chr1	155385714	-	5559	887	183	3953	1256
ENST00000378458	FAM107B	chr10	14572330	-	ENST00000368346	ASH1L	chr1	155385714	-	6151	677	549	3758	1069
ENST00000378458	FAM107B	chr10	14572330	-	ENST00000392403	ASH1L	chr1	155385714	-	5349	677	549	3743	1064
ENST00000478076	FAM107B	chr10	14572330	-	ENST00000368346	ASH1L	chr1	155385714	-	5823	349	149	3430	1093
ENST00000478076	FAM107B	chr10	14572330	-	ENST00000392403	ASH1L	chr1	155385714	-	5021	349	149	3415	1088
ENST00000378462	FAM107B	chr10	14572330	-	ENST00000368346	ASH1L	chr1	155385714	-	5781	307	8	3388	1126
ENST00000378462	FAM107B	chr10	14572330	-	ENST00000392403	ASH1L	chr1	155385714	-	4979	307	8	3373	1121

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000181796	ENST00000368346	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.000159025	0.999841
ENST00000181796	ENST00000392403	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.000149139	0.99985087
ENST00000378458	ENST00000368346	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.000170943	0.99982905
ENST00000378458	ENST00000392403	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.000142926	0.99985707
ENST00000478076	ENST00000368346	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.00012018	0.99987984
ENST00000478076	ENST00000392403	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.000101768	0.9998982
ENST00000378462	ENST00000368346	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.000118432	0.9998815
ENST00000378462	ENST00000392403	FAM107B	chr10	14572330	-	ASH1L	chr1	155385714	-	0.00010019	0.99989974

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28316_28316_1_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000181796_ASH1L_chr1_155385714_ENST00000368346_length(amino acids)=1261AA_BP=234
MENFLAPFELCNDSLQVMSTWKARLTKRLKSPSRSMHPFPCSALLACFGNTRESASFNQSGVADTHSTVRVQPVAKAGRQPRHPSAEGAP
EKRQDSSTHAERNGSANRNSSHRTAAQPAETPEDVPGSLDDGADCEAVVFHASIPRPSIIDTPKEEEFREEPKCLELEQKMTSDSPPEDI
DHKDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPRE
KKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQWKHNQLYKK
PDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWG
IRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALK
DMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENIN
TPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTR
RLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKV
FRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVW
QHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDK
LDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLD
KSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEI
PSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLFIPENSFR

--------------------------------------------------------------

>28316_28316_2_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000181796_ASH1L_chr1_155385714_ENST00000392403_length(amino acids)=1256AA_BP=234
MENFLAPFELCNDSLQVMSTWKARLTKRLKSPSRSMHPFPCSALLACFGNTRESASFNQSGVADTHSTVRVQPVAKAGRQPRHPSAEGAP
EKRQDSSTHAERNGSANRNSSHRTAAQPAETPEDVPGSLDDGADCEAVVFHASIPRPSIIDTPKEEEFREEPKCLELEQKMTSDSPPEDI
DHKDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPRE
KKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPL
YKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKE
PLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAG
TELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRL
TPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAA
EENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKVFRNAE
KYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDC
MGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFR
IEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHL
FYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPSLEE

--------------------------------------------------------------

>28316_28316_3_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000378458_ASH1L_chr1_155385714_ENST00000368346_length(amino acids)=1069AA_BP=42
MAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQ
KAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSN
VYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQF
IIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDY
NFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMK
PMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVA
RAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKS
PVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDV
EHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKN
EKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRN
RYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPSLEEPEREGAT

--------------------------------------------------------------

>28316_28316_4_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000378458_ASH1L_chr1_155385714_ENST00000392403_length(amino acids)=1064AA_BP=42
MAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQ
KAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDV
KPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYL
GEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSF
NVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNR
ERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARL
AQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKSPVGRD
VCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLC
EQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEER
FAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVC
TKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPSLEEPEREGATANVSE

--------------------------------------------------------------

>28316_28316_5_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000378462_ASH1L_chr1_155385714_ENST00000368346_length(amino acids)=1126AA_BP=99
MNLNCGSFDIQKESSLWGWLILVLGAFLHRSKELPQSEDSPPEDIDHKDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDL
HRELLMNQKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEH
EYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDC
LNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNL
DSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNG
LTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKH
TSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLN
LPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETAS
EADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYF
ICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFR
VPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNY
KRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRER

--------------------------------------------------------------

>28316_28316_6_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000378462_ASH1L_chr1_155385714_ENST00000392403_length(amino acids)=1121AA_BP=99
MNLNCGSFDIQKESSLWGWLILVLGAFLHRSKELPQSEDSPPEDIDHKDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDL
HRELLMNQKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEH
EYGLFPAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMI
FAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMV
IDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSK
NSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNI
HSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKK
KNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSS
ETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLR
DDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYE
IIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGG
RSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQIL

--------------------------------------------------------------

>28316_28316_7_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000478076_ASH1L_chr1_155385714_ENST00000368346_length(amino acids)=1093AA_BP=66
MHLQPDSPPEDIDHKDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKSFNEAPVEIPSPSETPAKPSEPES
TLQPVLSLIPREKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDI
LWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQC
LERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSV
NGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRR
GHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQF
SALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYK
TVEAFDADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDE
GLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQ
SYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVK
EQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEE
VLASQEQAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLR

--------------------------------------------------------------

>28316_28316_8_FAM107B-ASH1L_FAM107B_chr10_14572330_ENST00000478076_ASH1L_chr1_155385714_ENST00000392403_length(amino acids)=1088AA_BP=66
MHLQPDSPPEDIDHKDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKSFNEAPVEIPSPSETPAKPSEPES
TLQPVLSLIPREKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRIDFQLPYDILWQWK
HNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFR
AEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYR
IGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSE
EPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQT
ARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAF
DADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQ
CDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLL
SHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVY
ICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQ
EQAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLF

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:14572330/chr1:155385714)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM107B Q9H098	ASH1L Q9NR48
	FUNCTION: Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250\|UniProtKB:Q99MY8, ECO:0000269\|PubMed:21239497}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000181796

61_112

217.66666666666666

307.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

2091_2142

1942.6666666666667

2970.0

Domain

AWS

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

2145_2261

1942.6666666666667

2970.0

Domain

SET

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

2269_2285

1942.6666666666667

2970.0

Domain

Post-SET

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

2463_2533

1942.6666666666667

2970.0

Domain

Bromo

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

2661_2798

1942.6666666666667

2970.0

Domain

BAH

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

2091_2142

1942.6666666666667

2965.0

Domain

AWS

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

2145_2261

1942.6666666666667

2965.0

Domain

SET

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

2269_2285

1942.6666666666667

2965.0

Domain

Post-SET

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

2463_2533

1942.6666666666667

2965.0

Domain

Bromo

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

2661_2798

1942.6666666666667

2965.0

Domain

BAH

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

2069_2288

1942.6666666666667

2970.0

Region

Note=Catalytic domain

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

2069_2288

1942.6666666666667

2965.0

Region

Note=Catalytic domain

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

2585_2631

1942.6666666666667

2970.0

Zinc finger

Note=PHD-type

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

2585_2631

1942.6666666666667

2965.0

Zinc finger

Note=PHD-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000378458

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000378462

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000378465

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000378467

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000378470

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000468747

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000478076

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000479731

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

FAM107B

chr10:14572330

chr1:155385714

ENST00000496330

61_112

42.666666666666664

132.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

1380_1424

1942.6666666666667

2970.0

Compositional bias

Note=Pro-rich

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

1580_1791

1942.6666666666667

2970.0

Compositional bias

Note=Ser-rich

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

1380_1424

1942.6666666666667

2965.0

Compositional bias

Note=Pro-rich

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

1580_1791

1942.6666666666667

2965.0

Compositional bias

Note=Ser-rich

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

1347_1359

1942.6666666666667

2970.0

DNA binding

Note=A.T hook 2

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

1847_1859

1942.6666666666667

2970.0

DNA binding

Note=A.T hook 3

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000368346

887_899

1942.6666666666667

2970.0

DNA binding

Note=A.T hook 1

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

1347_1359

1942.6666666666667

2965.0

DNA binding

Note=A.T hook 2

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

1847_1859

1942.6666666666667

2965.0

DNA binding

Note=A.T hook 3

Tgene

ASH1L

chr10:14572330

chr1:155385714

ENST00000392403

887_899

1942.6666666666667

2965.0

DNA binding

Note=A.T hook 1

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FAM107B
ASH1L

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FAM107B-ASH1L

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FAM107B-ASH1L

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source