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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FAM160B1-ATP2A2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FAM160B1-ATP2A2
FusionPDB ID: 28620
FusionGDB2.0 ID: 28620
HgeneTgene
Gene symbol

FAM160B1

ATP2A2

Gene ID

57700

488

Gene namefamily with sequence similarity 160 member B1ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
SynonymsKIAA1600|bA106M7.3ATP2B|DAR|DD|SERCA2
Cytomap

10q25.3

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM160B1sarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slow
Modification date2020031320200313
UniProtAcc

Q5W0V3

P16615

Ensembl transtripts involved in fusion geneENST idsENST00000369248, ENST00000369250, 
ENST00000369246, 		ENST00000550248, 
ENST00000552636, ENST00000308664, 
ENST00000395494, ENST00000539276, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 5 X 5=17519 X 23 X 6=2622
# samples 723
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2622*10)=-3.51096191927738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FAM160B1 [Title/Abstract] AND ATP2A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FAM160B1(116606126)-ATP2A2(110770401), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM160B1-ATP2A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM160B1-ATP2A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATP2A2

GO:0032469

endoplasmic reticulum calcium ion homeostasis

16402920

TgeneATP2A2

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

16402920

TgeneATP2A2

GO:0070588

calcium ion transmembrane transport

16402920

TgeneATP2A2

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

16402920


check buttonFusion gene breakpoints across FAM160B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP2A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08FFAM160B1chr10

116606126

+ATP2A2chr12

110770401

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369250FAM160B1chr10116606126+ENST00000308664ATP2A2chr12110770401+441717334436311195
ENST00000369250FAM160B1chr10116606126+ENST00000395494ATP2A2chr12110770401+838517334437661240
ENST00000369250FAM160B1chr10116606126+ENST00000539276ATP2A2chr12110770401+462317334437661240
ENST00000369248FAM160B1chr10116606126+ENST00000308664ATP2A2chr12110770401+441717334436311195
ENST00000369248FAM160B1chr10116606126+ENST00000395494ATP2A2chr12110770401+838517334437661240
ENST00000369248FAM160B1chr10116606126+ENST00000539276ATP2A2chr12110770401+462317334437661240

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369250ENST00000308664FAM160B1chr10116606126+ATP2A2chr12110770401+0.0005825910.9994174
ENST00000369250ENST00000395494FAM160B1chr10116606126+ATP2A2chr12110770401+0.000217520.9997825
ENST00000369250ENST00000539276FAM160B1chr10116606126+ATP2A2chr12110770401+0.0002441810.9997558
ENST00000369248ENST00000308664FAM160B1chr10116606126+ATP2A2chr12110770401+0.0005825910.9994174
ENST00000369248ENST00000395494FAM160B1chr10116606126+ATP2A2chr12110770401+0.000217520.9997825
ENST00000369248ENST00000539276FAM160B1chr10116606126+ATP2A2chr12110770401+0.0002441810.9997558

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28620_28620_1_FAM160B1-ATP2A2_FAM160B1_chr10_116606126_ENST00000369248_ATP2A2_chr12_110770401_ENST00000308664_length(amino acids)=1195AA_BP=49
MPPCPNRCRRRSFSGPRVLAERPPRRPPRPGALRSRRAARAHLKRPGQALPRSSARPPRPAPAFTLERPRQPQQGRRRRIEELSRSSRER
LLQSRDRMFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLL
HHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFL
ENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVN
SLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPG
KRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPET
LAEISRHPLRHRLIEHCDHISDEMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKG
VYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID
RCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKL
CRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGD
GVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLL
WVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDF
EGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKI

--------------------------------------------------------------

>28620_28620_2_FAM160B1-ATP2A2_FAM160B1_chr10_116606126_ENST00000369248_ATP2A2_chr12_110770401_ENST00000395494_length(amino acids)=1240AA_BP=49
MPPCPNRCRRRSFSGPRVLAERPPRRPPRPGALRSRRAARAHLKRPGQALPRSSARPPRPAPAFTLERPRQPQQGRRRRIEELSRSSRER
LLQSRDRMFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLL
HHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFL
ENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVN
SLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPG
KRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPET
LAEISRHPLRHRLIEHCDHISDEMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKG
VYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID
RCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKL
CRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGD
GVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLL
WVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDF
EGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKI

--------------------------------------------------------------

>28620_28620_3_FAM160B1-ATP2A2_FAM160B1_chr10_116606126_ENST00000369248_ATP2A2_chr12_110770401_ENST00000539276_length(amino acids)=1240AA_BP=49
MPPCPNRCRRRSFSGPRVLAERPPRRPPRPGALRSRRAARAHLKRPGQALPRSSARPPRPAPAFTLERPRQPQQGRRRRIEELSRSSRER
LLQSRDRMFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLL
HHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFL
ENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVN
SLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPG
KRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPET
LAEISRHPLRHRLIEHCDHISDEMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKG
VYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID
RCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKL
CRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGD
GVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLL
WVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDF
EGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKI

--------------------------------------------------------------

>28620_28620_4_FAM160B1-ATP2A2_FAM160B1_chr10_116606126_ENST00000369250_ATP2A2_chr12_110770401_ENST00000308664_length(amino acids)=1195AA_BP=49
MPPCPNRCRRRSFSGPRVLAERPPRRPPRPGALRSRRAARAHLKRPGQALPRSSARPPRPAPAFTLERPRQPQQGRRRRIEELSRSSRER
LLQSRDRMFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLL
HHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFL
ENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVN
SLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPG
KRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPET
LAEISRHPLRHRLIEHCDHISDEMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKG
VYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID
RCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKL
CRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGD
GVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLL
WVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDF
EGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKI

--------------------------------------------------------------

>28620_28620_5_FAM160B1-ATP2A2_FAM160B1_chr10_116606126_ENST00000369250_ATP2A2_chr12_110770401_ENST00000395494_length(amino acids)=1240AA_BP=49
MPPCPNRCRRRSFSGPRVLAERPPRRPPRPGALRSRRAARAHLKRPGQALPRSSARPPRPAPAFTLERPRQPQQGRRRRIEELSRSSRER
LLQSRDRMFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLL
HHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFL
ENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVN
SLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPG
KRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPET
LAEISRHPLRHRLIEHCDHISDEMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKG
VYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID
RCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKL
CRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGD
GVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLL
WVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDF
EGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKI

--------------------------------------------------------------

>28620_28620_6_FAM160B1-ATP2A2_FAM160B1_chr10_116606126_ENST00000369250_ATP2A2_chr12_110770401_ENST00000539276_length(amino acids)=1240AA_BP=49
MPPCPNRCRRRSFSGPRVLAERPPRRPPRPGALRSRRAARAHLKRPGQALPRSSARPPRPAPAFTLERPRQPQQGRRRRIEELSRSSRER
LLQSRDRMFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLL
HHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFL
ENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVN
SLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPG
KRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPET
LAEISRHPLRHRLIEHCDHISDEMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKG
VYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID
RCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKL
CRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGD
GVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLL
WVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDF
EGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:116606126/chr12:110770401)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM160B1

Q5W0V3

ATP2A2

P16615

FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721777_786365.0998.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721808_827365.0998.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721851_896365.0998.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721917_929365.0998.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721949_963365.0998.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721985_1042365.0998.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619777_786338.01016.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619808_827338.01016.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619851_896338.01016.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619917_929338.01016.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619949_963338.01016.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619985_1042338.01016.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720777_786365.01043.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720808_827365.01043.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720851_896365.01043.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720917_929365.01043.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720949_963365.01043.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720985_1042365.01043.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721757_776365.0998.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721828_850365.0998.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721897_916365.0998.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721930_948365.0998.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721964_984365.0998.0TransmembraneHelical%3B Name%3D10
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619757_776338.01016.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619828_850338.01016.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619897_916338.01016.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619930_948338.01016.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619964_984338.01016.0TransmembraneHelical%3B Name%3D10
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720757_776365.01043.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720828_850365.01043.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720897_916365.01043.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720930_948365.01043.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720964_984365.01043.0TransmembraneHelical%3B Name%3D10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721111_253365.0998.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST000003086647211_48365.0998.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721274_295365.0998.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721314_756365.0998.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST0000030866472170_89365.0998.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619111_253338.01016.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST000003954946191_48338.01016.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619274_295338.01016.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619314_756338.01016.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST0000039549461970_89338.01016.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720111_253365.01043.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST000005392767201_48365.01043.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720274_295365.01043.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720314_756365.01043.0Topological domainCytoplasmic
TgeneATP2A2chr10:116606126chr12:110770401ENST0000053927672070_89365.01043.0Topological domainLumenal
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721254_273365.0998.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr10:116606126chr12:110770401ENST00000308664721296_313365.0998.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr10:116606126chr12:110770401ENST0000030866472149_69365.0998.0TransmembraneHelical%3B Name%3D1
TgeneATP2A2chr10:116606126chr12:110770401ENST0000030866472190_110365.0998.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619254_273338.01016.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr10:116606126chr12:110770401ENST00000395494619296_313338.01016.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr10:116606126chr12:110770401ENST0000039549461949_69338.01016.0TransmembraneHelical%3B Name%3D1
TgeneATP2A2chr10:116606126chr12:110770401ENST0000039549461990_110338.01016.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720254_273365.01043.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr10:116606126chr12:110770401ENST00000539276720296_313365.01043.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr10:116606126chr12:110770401ENST0000053927672049_69365.01043.0TransmembraneHelical%3B Name%3D1
TgeneATP2A2chr10:116606126chr12:110770401ENST0000053927672090_110365.01043.0TransmembraneHelical%3B Name%3D2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FAM160B1
ATP2A2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FAM160B1-ATP2A2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FAM160B1-ATP2A2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource