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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FAM222B-UNC5D

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FAM222B-UNC5D
	FusionPDB ID: 28983
	FusionGDB2.0 ID: 28983
		Hgene	Tgene
	Gene symbol	FAM222B	UNC5D
	Gene ID	55731	137970
	Gene name	family with sequence similarity 222 member B	unc-5 netrin receptor D
	Synonyms	C17orf63	PRO34692\|Unc5h4
	Cytomap	17q11.2	8p12
	Type of gene	protein-coding	protein-coding
	Description	protein FAM222Buncharacterized protein C17orf63	netrin receptor UNC5Dnetrin receptor Unc5h4protein unc-5 homolog 4protein unc-5 homolog Dunc-5 homolog 4unc-5 homolog D
	Modification date	20200313	20200313
	UniProtAcc	Q8WU58	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000452648, ENST00000581381, ENST00000581407, ENST00000582059, ENST00000582266, ENST00000583953, ENST00000341217, ENST00000577682, ENST00000583522,	ENST00000287272, ENST00000404895, ENST00000416672, ENST00000420357, ENST00000449677, ENST00000453357,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	29 X 15 X 15=6525	17 X 13 X 6=1326
	# samples	43	20
	** MAII score	log2(43/6525*10)=-3.92356933675515 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1326*10)=-2.72900887033786 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FAM222B [Title/Abstract] AND UNC5D [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FAM222B(27139227)-UNC5D(35608100), # samples:1 FAM222B(27093604)-UNC5D(35608100), # samples:1
Anticipated loss of major functional domain due to fusion event.	FAM222B-UNC5D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM222B-UNC5D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM222B-UNC5D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FAM222B-UNC5D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FAM222B-UNC5D seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UNC5D	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	26235030

Fusion gene breakpoints across FAM222B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UNC5D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-50-6673-01A	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+
ChimerDB4	LUAD	TCGA-50-6673-01A	FAM222B	chr17	27139227	-	UNC5D	chr8	35608100	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341217	FAM222B	chr17	27093604	-	ENST00000287272	UNC5D	chr8	35608100	+	7212	298	283	1224	313
ENST00000341217	FAM222B	chr17	27093604	-	ENST00000453357	UNC5D	chr8	35608100	+	5324	298	283	1224	313
ENST00000341217	FAM222B	chr17	27093604	-	ENST00000404895	UNC5D	chr8	35608100	+	1287	298	283	1224	313
ENST00000341217	FAM222B	chr17	27093604	-	ENST00000420357	UNC5D	chr8	35608100	+	1510	298	283	1224	313
ENST00000341217	FAM222B	chr17	27093604	-	ENST00000416672	UNC5D	chr8	35608100	+	1870	298	283	1224	313
ENST00000341217	FAM222B	chr17	27093604	-	ENST00000449677	UNC5D	chr8	35608100	+	1972	298	283	1224	313
ENST00000577682	FAM222B	chr17	27093604	-	ENST00000287272	UNC5D	chr8	35608100	+	7179	265	250	1191	313
ENST00000577682	FAM222B	chr17	27093604	-	ENST00000453357	UNC5D	chr8	35608100	+	5291	265	250	1191	313
ENST00000577682	FAM222B	chr17	27093604	-	ENST00000404895	UNC5D	chr8	35608100	+	1254	265	250	1191	313
ENST00000577682	FAM222B	chr17	27093604	-	ENST00000420357	UNC5D	chr8	35608100	+	1477	265	250	1191	313
ENST00000577682	FAM222B	chr17	27093604	-	ENST00000416672	UNC5D	chr8	35608100	+	1837	265	250	1191	313
ENST00000577682	FAM222B	chr17	27093604	-	ENST00000449677	UNC5D	chr8	35608100	+	1939	265	250	1191	313
ENST00000583522	FAM222B	chr17	27093604	-	ENST00000287272	UNC5D	chr8	35608100	+	7276	362	347	1288	313
ENST00000583522	FAM222B	chr17	27093604	-	ENST00000453357	UNC5D	chr8	35608100	+	5388	362	347	1288	313
ENST00000583522	FAM222B	chr17	27093604	-	ENST00000404895	UNC5D	chr8	35608100	+	1351	362	347	1288	313
ENST00000583522	FAM222B	chr17	27093604	-	ENST00000420357	UNC5D	chr8	35608100	+	1574	362	347	1288	313
ENST00000583522	FAM222B	chr17	27093604	-	ENST00000416672	UNC5D	chr8	35608100	+	1934	362	347	1288	313
ENST00000583522	FAM222B	chr17	27093604	-	ENST00000449677	UNC5D	chr8	35608100	+	2036	362	347	1288	313

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341217	ENST00000287272	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.001671311	0.99832875
ENST00000341217	ENST00000453357	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.002067841	0.9979322
ENST00000341217	ENST00000404895	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.017724467	0.9822756
ENST00000341217	ENST00000420357	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.010550788	0.98944926
ENST00000341217	ENST00000416672	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.008572508	0.99142754
ENST00000341217	ENST00000449677	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.007769857	0.9922301
ENST00000577682	ENST00000287272	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.001667938	0.9983321
ENST00000577682	ENST00000453357	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.002063304	0.9979367
ENST00000577682	ENST00000404895	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.015257847	0.98474216
ENST00000577682	ENST00000420357	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.010025386	0.98997456
ENST00000577682	ENST00000416672	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.007927666	0.9920723
ENST00000577682	ENST00000449677	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.00684757	0.9931524
ENST00000583522	ENST00000287272	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.001681083	0.99831885
ENST00000583522	ENST00000453357	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.002104008	0.99789596
ENST00000583522	ENST00000404895	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.016451724	0.9835482
ENST00000583522	ENST00000420357	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.010486878	0.9895131
ENST00000583522	ENST00000416672	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.008970364	0.9910296
ENST00000583522	ENST00000449677	FAM222B	chr17	27093604	-	UNC5D	chr8	35608100	+	0.00782223	0.9921778

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28983_28983_1_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000341217_UNC5D_chr8_35608100_ENST00000287272_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_2_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000341217_UNC5D_chr8_35608100_ENST00000404895_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_3_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000341217_UNC5D_chr8_35608100_ENST00000416672_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_4_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000341217_UNC5D_chr8_35608100_ENST00000420357_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_5_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000341217_UNC5D_chr8_35608100_ENST00000449677_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_6_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000341217_UNC5D_chr8_35608100_ENST00000453357_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_7_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000577682_UNC5D_chr8_35608100_ENST00000287272_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_8_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000577682_UNC5D_chr8_35608100_ENST00000404895_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_9_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000577682_UNC5D_chr8_35608100_ENST00000416672_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_10_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000577682_UNC5D_chr8_35608100_ENST00000420357_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_11_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000577682_UNC5D_chr8_35608100_ENST00000449677_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_12_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000577682_UNC5D_chr8_35608100_ENST00000453357_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_13_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000583522_UNC5D_chr8_35608100_ENST00000287272_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_14_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000583522_UNC5D_chr8_35608100_ENST00000404895_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_15_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000583522_UNC5D_chr8_35608100_ENST00000416672_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_16_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000583522_UNC5D_chr8_35608100_ENST00000420357_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_17_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000583522_UNC5D_chr8_35608100_ENST00000449677_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

>28983_28983_18_FAM222B-UNC5D_FAM222B_chr17_27093604_ENST00000583522_UNC5D_chr8_35608100_ENST00000453357_length(amino acids)=313AA_BP=5
MDFRNEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQ
GGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV
QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:27139227/chr8:35608100)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM222B Q8WU58	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

859_936

645.0

954.0

Domain

Note=Death

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

859_936

640.0

949.0

Domain

Note=Death

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM222B

chr17:27093604

chr8:35608100

ENST00000341217

148_220

27.333333333333332

563.0

Compositional bias

Note=Gln-rich

Hgene

FAM222B

chr17:27093604

chr8:35608100

ENST00000452648

148_220

27.333333333333332

563.0

Compositional bias

Note=Gln-rich

Hgene

FAM222B

chr17:27093604

chr8:35608100

ENST00000581407

148_220

27.333333333333332

563.0

Compositional bias

Note=Gln-rich

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

153_244

645.0

954.0

Domain

Note=Ig-like C2-type

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

252_306

645.0

954.0

Domain

TSP type-1 1

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

308_360

645.0

954.0

Domain

TSP type-1 2

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

542_682

645.0

954.0

Domain

ZU5

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

54_151

645.0

954.0

Domain

Note=Ig-like

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

153_244

640.0

949.0

Domain

Note=Ig-like C2-type

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

252_306

640.0

949.0

Domain

TSP type-1 1

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

308_360

640.0

949.0

Domain

TSP type-1 2

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

542_682

640.0

949.0

Domain

ZU5

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

54_151

640.0

949.0

Domain

Note=Ig-like

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

33_379

645.0

954.0

Topological domain

Extracellular

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

401_953

645.0

954.0

Topological domain

Cytoplasmic

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

33_379

640.0

949.0

Topological domain

Extracellular

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

401_953

640.0

949.0

Topological domain

Cytoplasmic

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000404895

380_400

645.0

954.0

Transmembrane

Helical

Tgene

UNC5D

chr17:27093604

chr8:35608100

ENST00000453357

380_400

640.0

949.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FAM222B
UNC5D

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to FAM222B-UNC5D

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FAM222B-UNC5D

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source