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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AGO2-DDX5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AGO2-DDX5
FusionPDB ID: 2903
FusionGDB2.0 ID: 2903
HgeneTgene
Gene symbol

AGO2

DDX5

Gene ID

27161

1655

Gene nameargonaute RISC catalytic component 2DEAD-box helicase 5
SynonymsCASC7|EIF2C2|LINC00980|PPD|Q10G17P1|HLR1|HUMP68|p68
Cytomap

8q24.3

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionprotein argonaute-2PAZ Piwi domain proteinargonaute 2, RISC catalytic componentcancer susceptibility candidate 7cancer susceptibility candidate 7 (non-protein coding)eukaryotic translation initiation factor 2C, 2long intergenic non-protein coding RNprobable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA h
Modification date2020032720200313
UniProtAcc

Q9UKV8

Q5T1V6

Ensembl transtripts involved in fusion geneENST idsENST00000220592, ENST00000519980, 
ENST00000517293, 		ENST00000580026, 
ENST00000225792, ENST00000450599, 
ENST00000578804, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 13 X 12=202820 X 12 X 8=1920
# samples 2819
** MAII scorelog2(28/2028*10)=-2.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1920*10)=-3.33703498727757
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AGO2 [Title/Abstract] AND DDX5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AGO2(141595218)-DDX5(62500960), # samples:1
Anticipated loss of major functional domain due to fusion event.AGO2-DDX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGO2-DDX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGO2-DDX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGO2-DDX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGO2

GO:0010501

RNA secondary structure unwinding

19966796

HgeneAGO2

GO:0031054

pre-miRNA processing

16424907|17671087|18178619|19966796

HgeneAGO2

GO:0035087

siRNA loading onto RISC involved in RNA interference

19966796

HgeneAGO2

GO:0035196

production of miRNAs involved in gene silencing by miRNA

19966796|23661684

HgeneAGO2

GO:0035278

miRNA mediated inhibition of translation

17671087|19801630

HgeneAGO2

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

15260970|17524464

HgeneAGO2

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

18178619|19966796

HgeneAGO2

GO:0045766

positive regulation of angiogenesis

27208409

HgeneAGO2

GO:0045947

negative regulation of translational initiation

17524464|19801630

HgeneAGO2

GO:0090625

mRNA cleavage involved in gene silencing by siRNA

15260970

HgeneAGO2

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027

TgeneDDX5

GO:0000122

negative regulation of transcription by RNA polymerase II

15298701

TgeneDDX5

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

21343338

TgeneDDX5

GO:0000956

nuclear-transcribed mRNA catabolic process

23788676


check buttonFusion gene breakpoints across AGO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AAGO2chr8

141595218

-DDX5chr17

62500960

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000220592AGO2chr8141595218-ENST00000225792DDX5chr1762500960-24363281132128671
ENST00000220592AGO2chr8141595218-ENST00000450599DDX5chr1762500960-21933281131891592
ENST00000220592AGO2chr8141595218-ENST00000578804DDX5chr1762500960-21383281132128671
ENST00000519980AGO2chr8141595218-ENST00000225792DDX5chr1762500960-2363255402055671
ENST00000519980AGO2chr8141595218-ENST00000450599DDX5chr1762500960-2120255401818592
ENST00000519980AGO2chr8141595218-ENST00000578804DDX5chr1762500960-2065255402055671

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000220592ENST00000225792AGO2chr8141595218-DDX5chr1762500960-0.0010410210.99895895
ENST00000220592ENST00000450599AGO2chr8141595218-DDX5chr1762500960-0.0006383950.9993616
ENST00000220592ENST00000578804AGO2chr8141595218-DDX5chr1762500960-0.0013039810.998696
ENST00000519980ENST00000225792AGO2chr8141595218-DDX5chr1762500960-0.0009955530.9990044
ENST00000519980ENST00000450599AGO2chr8141595218-DDX5chr1762500960-0.0005979230.99940205
ENST00000519980ENST00000578804AGO2chr8141595218-DDX5chr1762500960-0.0012096290.99879044

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2903_2903_1_AGO2-DDX5_AGO2_chr8_141595218_ENST00000220592_DDX5_chr17_62500960_ENST00000225792_length(amino acids)=671AA_BP=71
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNRFGAPRFGGSRAGPLSGKK
FGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQ
GWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRD
LERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG
ALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAP
ILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRS
RGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDS

--------------------------------------------------------------

>2903_2903_2_AGO2-DDX5_AGO2_chr8_141595218_ENST00000220592_DDX5_chr17_62500960_ENST00000450599_length(amino acids)=592AA_BP=71
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNRFGAPRFGGSRAGPLSGKK
FGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIY
GGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAED
FLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDW
VLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLL
QLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGN

--------------------------------------------------------------

>2903_2903_3_AGO2-DDX5_AGO2_chr8_141595218_ENST00000220592_DDX5_chr17_62500960_ENST00000578804_length(amino acids)=671AA_BP=71
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNRFGAPRFGGSRAGPLSGKK
FGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQ
GWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRD
LERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG
ALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAP
ILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRS
RGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDS

--------------------------------------------------------------

>2903_2903_4_AGO2-DDX5_AGO2_chr8_141595218_ENST00000519980_DDX5_chr17_62500960_ENST00000225792_length(amino acids)=671AA_BP=71
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNRFGAPRFGGSRAGPLSGKK
FGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQ
GWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRD
LERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG
ALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAP
ILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRS
RGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDS

--------------------------------------------------------------

>2903_2903_5_AGO2-DDX5_AGO2_chr8_141595218_ENST00000519980_DDX5_chr17_62500960_ENST00000450599_length(amino acids)=592AA_BP=71
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNRFGAPRFGGSRAGPLSGKK
FGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIY
GGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAED
FLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDW
VLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLL
QLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGN

--------------------------------------------------------------

>2903_2903_6_AGO2-DDX5_AGO2_chr8_141595218_ENST00000519980_DDX5_chr17_62500960_ENST00000578804_length(amino acids)=671AA_BP=71
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNRFGAPRFGGSRAGPLSGKK
FGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQ
GWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRD
LERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG
ALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAP
ILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRS
RGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:141595218/chr17:62500960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGO2

Q9UKV8

DDX5

Q5T1V6

FUNCTION: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDDX5chr8:141595218chr17:62500960ENST00000225792013125_30014.666666666666666615.0DomainHelicase ATP-binding
TgeneDDX5chr8:141595218chr17:62500960ENST00000225792013328_47514.666666666666666615.0DomainHelicase C-terminal
TgeneDDX5chr8:141595218chr17:62500960ENST00000225792013248_25114.666666666666666615.0MotifNote=DEAD box
TgeneDDX5chr8:141595218chr17:62500960ENST0000022579201394_12214.666666666666666615.0MotifNote=Q motif
TgeneDDX5chr8:141595218chr17:62500960ENST00000225792013114_11614.666666666666666615.0Nucleotide bindingNote=ATP
TgeneDDX5chr8:141595218chr17:62500960ENST00000225792013138_14514.666666666666666615.0Nucleotide bindingNote=ATP
TgeneDDX5chr8:141595218chr17:62500960ENST00000225792013477_61414.666666666666666615.0RegionNote=Transactivation domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219235_34871.66666666666667860.0DomainPAZ
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219517_81871.66666666666667860.0DomainPiwi
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218235_34871.66666666666667826.0DomainPAZ
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218517_81871.66666666666667826.0DomainPiwi


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
DDX5STK24, HDAC1, CREBBP, EP300, AKAP8, FBL, OTUB1, MEPCE, CDK9, HNRNPA1, HNRNPH1, KHDRBS2, IPO11, TCEA1, AIRE, MYOD1, SMARCA4, TBP, POLR2A, MGMT, SRRM1, SRRM2, tat, PIAS1, MBD3, CHD3, ESR1, TADA2A, SMN1, CD4, DGCR8, ZWINT, Cdk1, AI837181, Ybx1, CALM1, EBNA-LP, PIK3CA, PSMA3, TNNT1, VHL, SMARCAD1, YY1, NDRG1, HDGF, CENPA, MBNL1, SF3A2, ARRB2, ERG, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDX5, DDX17, HDAC2, HDAC3, BBLF2-BBLF3, INPPL1, SHC1, CRK, AKT1, DHX15, SRSF1, SF3B3, U2AF2, DHX38, SNRPA1, EIF4A3, PRKDC, SF3A1, HNRNPM, HNRNPF, SNRPD1, RBMX, SYNCRIP, U2AF1, SART1, PRPF40A, IGF2BP3, SNW1, PRPF19, SNRPD2, VTN, MCM7, SYN1, RPS20, XRCC4, RPS16, HNRNPA0, EEF2, PRSS1, THRAP3, GOLIM4, EPRS, RPL19, SRP14, SMURF1, FN1, VCAM1, RBM10, WBP11, HNRNPK, DHX9, RBM4, HNRNPH2, HNRNPH3, KHDRBS1, RBFOX2, IL7R, MAP1LC3A, ITGA4, CTNNB1, CD81, IGSF8, FBXW4, FBXO46, SP1, MAPK10, FBXO6, TARDBP, PARK2, PIN1, DBNL, ERO1L, FKBP10, LRSAM1, PABPC4, PRPSAP1, WDR4, rev, RPA1, RPA2, RPA3, STAU1, MDM2, SPRTN, AURKA, AURKB, CEP250, TP53, TUBGCP3, FUS, MAPKAPK2, DROSHA, NXF1, CUL7, OBSL1, CCDC8, UBE2I, EZH2, SUZ12, EED, RNF2, SMAD3, ABL1, ARAF, CDK2, DAPK1, ILK, MAST3, SGK2, SRPK1, TNK1, TYK2, LUZP4, RPS6KB2, UNK, NTRK1, ATXN2, ATXN2L, C14orf166, CPSF6, DDX18, DNAJC2, ELAC2, GTPBP4, HNRNPR, IMPDH1, SBDS, SKIV2L2, TRMT6, DHX36, EDC4, EIF2A, GMPS, LUC7L2, NACA, UPF1, SFN, SCARNA22, FRS3, gag, XPO1, HNRNPU, RPL10, MATR3, Bcas2, Bag2, Fus, SKI, MCM2, MCM5, Ksr1, CDC5L, CDC37, CRBN, CBX7, RYBP, WWP2, DERL1, EGFR, YPEL5, RMND5A, MAEA, RANBP9, ARMC8, NR2E1, CYLD, CD2BP2, INO80B, TRIM25, HOTAIR, HEY1, BRCA1, LMNA, MTF1, FBXO7, IQGAP1, TMPO, WDR77, MTCH2, PCBP1, PPIE, CCNT1, GSK3A, MAP2K3, MED12, POLD1, TGFB1, TRIP4, ZNF217, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD4, LARP7, RNF4, TNF, RIOK1, SQSTM1, HEXIM1, RUNX1, DPF2, RNF123, NBN, SNAI1, AGR2, RECQL4, ZFP36L2, CNTNAP1, MYC, Prkaa1, Prkab1, CDK5RAP2, METTL3, METTL14, WTAP, KIAA1429, PSME3, PHF1, PHB, FAF1, RBX1, KIN, USP14, NR2C2, UCHL3, PPP1CC, SETD1A, ZFYVE21, XRCC6, CTCF, AGRN, VRK1, HIST1H4A, PSMD14, APEX1, SNRNP70, EWSR1, TAF15, SNRPC, ITFG1, GSK3B, CDC6, BIRC3, BRD7, ERCC6, SOX2, TRIM28, CMTR1, PLEKHA4, MAGEA3, KCTD10, PINK1, YAP1, TFCP2, FANCD2, ORF50, ZC3H18, PTK6, STAG2, MAU2, HSCB, CELF1, ELAVL1, DUX4L9, DUX4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, ACACA, C12orf49, INS, SUMO2, NDN, BRD4, NUPR1, RBM45, CIC, Apc2, RBM39, FBP1, nsp13ab, LGALS9, IFI16, EIF3F, DDX58, OGT, SPOP, UFL1, DDRGK1, NR4A1, DDX23, NIFK, RPL31, SLC26A4-AS1, E2F1, FZR1, WDR5, PAGE4, NAA40, BTF3, AGO2, AGO1, RCHY1, NBR1, nsp14, RB1CC1, DDX3X, ZEB1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AGO2
DDX5all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219311_31671.66666666666667860.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219524_56671.66666666666667860.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219709_71071.66666666666667860.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219753_76171.66666666666667860.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219790_81271.66666666666667860.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218311_31671.66666666666667826.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218524_56671.66666666666667826.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218709_71071.66666666666667826.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218753_76171.66666666666667826.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218790_81271.66666666666667826.0guide RNA
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219587_59071.66666666666667860.0GW182 family members
HgeneAGO2chr8:141595218chr17:62500960ENST00000220592-219650_66071.66666666666667860.0GW182 family members
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218587_59071.66666666666667826.0GW182 family members
HgeneAGO2chr8:141595218chr17:62500960ENST00000519980-218650_66071.66666666666667826.0GW182 family members


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Related Drugs to AGO2-DDX5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AGO2-DDX5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDDX5C0014175Endometriosis1CTD_human
TgeneDDX5C0269102Endometrioma1CTD_human