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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FARP1-PABPC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FARP1-PABPC1
	FusionPDB ID: 29380
	FusionGDB2.0 ID: 29380
		Hgene	Tgene
	Gene symbol	FARP1	PABPC1
	Gene ID	10160	26986
	Gene name	FERM, ARH/RhoGEF and pleckstrin domain protein 1	poly(A) binding protein cytoplasmic 1
	Synonyms	CDEP\|FARP1-IT1\|PLEKHC2\|PPP1R75	PAB1\|PABP\|PABP1\|PABPC2\|PABPL1
	Cytomap	13q32.2	8q22.3
	Type of gene	protein-coding	protein-coding
	Description	FERM, ARHGEF and pleckstrin domain-containing protein 1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)FERM, RhoGEF and pleckstrin domain-containing protein 1PH domain-containing family C member 2chondrocyte-derived ezrin-li	polyadenylate-binding protein 1poly(A) binding protein, cytoplasmic 2
	Modification date	20200313	20200313
	UniProtAcc	Q9Y4F1	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000319562, ENST00000376586, ENST00000595437, ENST00000376581, ENST00000593990,	ENST00000519596, ENST00000318607, ENST00000519004, ENST00000522387,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 13 X 10=2470	28 X 33 X 9=8316
	# samples	22	35
	** MAII score	log2(22/2470*10)=-3.48893561294738 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(35/8316*10)=-4.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FARP1 [Title/Abstract] AND PABPC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FARP1(99030172)-PABPC1(101725409), # samples:1
Anticipated loss of major functional domain due to fusion event.	FARP1-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FARP1-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FARP1-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FARP1-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FARP1	GO:0010923	negative regulation of phosphatase activity	19389623
Tgene	PABPC1	GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	18447585

Fusion gene breakpoints across FARP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PABPC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A486-01A	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000595437	FARP1	chr13	99030172	+	ENST00000318607	PABPC1	chr8	101725409	-	2448	735	239	2002	587
ENST00000595437	FARP1	chr13	99030172	+	ENST00000519004	PABPC1	chr8	101725409	-	2265	735	239	2002	587
ENST00000595437	FARP1	chr13	99030172	+	ENST00000522387	PABPC1	chr8	101725409	-	2203	735	239	2002	587
ENST00000376586	FARP1	chr13	99030172	+	ENST00000318607	PABPC1	chr8	101725409	-	2545	832	336	2099	587
ENST00000376586	FARP1	chr13	99030172	+	ENST00000519004	PABPC1	chr8	101725409	-	2362	832	336	2099	587
ENST00000376586	FARP1	chr13	99030172	+	ENST00000522387	PABPC1	chr8	101725409	-	2300	832	336	2099	587
ENST00000319562	FARP1	chr13	99030172	+	ENST00000318607	PABPC1	chr8	101725409	-	2474	761	265	2028	587
ENST00000319562	FARP1	chr13	99030172	+	ENST00000519004	PABPC1	chr8	101725409	-	2291	761	265	2028	587
ENST00000319562	FARP1	chr13	99030172	+	ENST00000522387	PABPC1	chr8	101725409	-	2229	761	265	2028	587

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000595437	ENST00000318607	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.001679616	0.9983204
ENST00000595437	ENST00000519004	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.002579412	0.99742055
ENST00000595437	ENST00000522387	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.003472147	0.99652785
ENST00000376586	ENST00000318607	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.002081659	0.9979183
ENST00000376586	ENST00000519004	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.002924772	0.9970752
ENST00000376586	ENST00000522387	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.003540246	0.9964598
ENST00000319562	ENST00000318607	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.001871814	0.99812824
ENST00000319562	ENST00000519004	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.002691072	0.99730897
ENST00000319562	ENST00000522387	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-	0.003294238	0.99670583

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29380_29380_1_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000319562_PABPC1_chr8_101725409_ENST00000318607_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_2_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000319562_PABPC1_chr8_101725409_ENST00000519004_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_3_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000319562_PABPC1_chr8_101725409_ENST00000522387_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_4_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000376586_PABPC1_chr8_101725409_ENST00000318607_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_5_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000376586_PABPC1_chr8_101725409_ENST00000519004_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_6_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000376586_PABPC1_chr8_101725409_ENST00000522387_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_7_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000595437_PABPC1_chr8_101725409_ENST00000318607_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_8_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000595437_PABPC1_chr8_101725409_ENST00000519004_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

>29380_29380_9_FARP1-PABPC1_FARP1_chr13_99030172_ENST00000595437_PABPC1_chr8_101725409_ENST00000522387_length(amino acids)=587AA_BP=166
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK
ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQWPALSVKVMTDESGK
SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGT
ITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYF
MAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAA
AATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEID

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:99030172/chr8:101725409)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FARP1 Q9Y4F1	.
FUNCTION: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

495_501

214.33333333333334

311.0

Compositional bias

Note=Poly-Ala

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

294_370

214.33333333333334

311.0

Domain

RRM 4

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

542_619

214.33333333333334

311.0

Domain

PABC

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

541_636

214.33333333333334

311.0

Region

(Microbial infection) Binding to HRSV M2-1 protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000319562

449_453

165.33333333333334

1046.0

Compositional bias

Note=Poly-Glu

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000376581

449_453

130.0

Compositional bias

Note=Poly-Glu

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000319562

40_320

165.33333333333334

1046.0

Domain

FERM

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000319562

540_730

165.33333333333334

1046.0

Domain

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000319562

759_856

165.33333333333334

1046.0

Domain

PH 1

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000319562

932_1029

165.33333333333334

1046.0

Domain

PH 2

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000376581

40_320

130.0

Domain

FERM

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000376581

540_730

130.0

Domain

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000376581

759_856

130.0

Domain

PH 1

Hgene

FARP1

chr13:99030172

chr8:101725409

ENST00000376581

932_1029

130.0

Domain

PH 2

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

11_89

214.33333333333334

311.0

Domain

RRM 1

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

191_268

214.33333333333334

311.0

Domain

RRM 3

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

99_175

214.33333333333334

311.0

Domain

RRM 2

Tgene

PABPC1

chr13:99030172

chr8:101725409

ENST00000318607

166_289

214.33333333333334

311.0

Region

Note=CSDE1-binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FARP1
PABPC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to FARP1-PABPC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FARP1-PABPC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source