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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FAT1-APP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FAT1-APP
FusionPDB ID: 29449
FusionGDB2.0 ID: 29449
HgeneTgene
Gene symbol

FAT1

APP

Gene ID

2195

351

Gene nameFAT atypical cadherin 1amyloid beta precursor protein
SynonymsCDHF7|CDHR8|FAT|ME5|hFat1AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

4q35.2

21q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homologamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei
Modification date2020031320200329
UniProtAcc

Q14517

Q8NEU8

Ensembl transtripts involved in fusion geneENST idsENST00000441802, ENST00000512347, 
ENST00000348990, ENST00000354192, 
ENST00000357903, ENST00000358918, 
ENST00000359726, ENST00000439274, 
ENST00000440126, ENST00000448388, 
ENST00000474136, ENST00000346798, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 17 X 8=217625 X 18 X 10=4500
# samples 2027
** MAII scorelog2(20/2176*10)=-3.44360665147561
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4500*10)=-4.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FAT1 [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FAT1(187627717)-APP(27372497), # samples:1
Anticipated loss of major functional domain due to fusion event.FAT1-APP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT1-APP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT1-APP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT1-APP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

TgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across FAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-PC-A5DN-01AFAT1chr4

187627717

-APPchr21

27372497

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441802FAT1chr4187627717-ENST00000346798APPchr2127372497-6043347521049221570

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441802ENST00000346798FAT1chr4187627717-APPchr2127372497-0.000452420.99954754

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29449_29449_1_FAT1-APP_FAT1_chr4_187627717_ENST00000441802_APP_chr21_27372497_ENST00000346798_length(amino acids)=1570AA_BP=1088
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETEVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAAS
TPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMAR
VEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYN
VPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPV
DARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:187627717/chr21:27372497)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT1

Q14517

APP

Q8NEU8

FUNCTION: [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227150_2571088.33333333333334589.0DomainCadherin 2
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-22735_1491088.33333333333334589.0DomainCadherin 1
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227368_4631088.33333333333334589.0DomainCadherin 3
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227464_5691088.33333333333334589.0DomainCadherin 4
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227570_6731088.33333333333334589.0DomainCadherin 5
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227718_8221088.33333333333334589.0DomainCadherin 6
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227823_9271088.33333333333334589.0DomainCadherin 7
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227928_10341088.33333333333334589.0DomainCadherin 8
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016230_2600696.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016274_2800696.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015230_2600640.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015274_2800640.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017230_2600715.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017274_2800715.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518374_565288.3333333333333771.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001628_1890696.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016374_5650696.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201528_1890640.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015374_5650640.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517374_565288.3333333333333752.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517374_565288.3333333333333753.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601728_1890715.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017374_5650715.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517374_565283.3333333333333747.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518344_365288.3333333333333771.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518724_734288.3333333333333771.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016344_3650696.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016724_7340696.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015344_3650640.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015724_7340640.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517344_365288.3333333333333752.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517724_734288.3333333333333752.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517344_365288.3333333333333753.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517724_734288.3333333333333753.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017344_3650715.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017724_7340715.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517344_365283.3333333333333747.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517724_734283.3333333333333747.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518391_423288.3333333333333771.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518491_522288.3333333333333771.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518523_540288.3333333333333771.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016131_1890696.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016181_1880696.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001628_1230696.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016391_4230696.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016491_5220696.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016523_5400696.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001696_1100696.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015131_1890640.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015181_1880640.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201528_1230640.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015391_4230640.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015491_5220640.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015523_5400640.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201596_1100640.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517391_423288.3333333333333752.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517491_522288.3333333333333752.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517523_540288.3333333333333752.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517391_423288.3333333333333753.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517491_522288.3333333333333753.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517523_540288.3333333333333753.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017131_1890715.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017181_1880715.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601728_1230715.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017391_4230715.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017491_5220715.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017523_5400715.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601796_1100715.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517391_423283.3333333333333747.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517491_522283.3333333333333747.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517523_540283.3333333333333747.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518723_770288.3333333333333771.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001618_7010696.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016723_7700696.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201518_7010640.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015723_7700640.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517723_770288.3333333333333752.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517723_770288.3333333333333753.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601718_7010715.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017723_7700715.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517723_770283.3333333333333747.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518702_722288.3333333333333771.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016702_7220696.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015702_7220640.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517702_722288.3333333333333752.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517702_722288.3333333333333753.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017702_7220715.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517702_722283.3333333333333747.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271035_11391088.33333333333334589.0DomainCadherin 9
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271140_12451088.33333333333334589.0DomainCadherin 10
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271246_13571088.33333333333334589.0DomainCadherin 11
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271359_14561088.33333333333334589.0DomainCadherin 12
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271457_15621088.33333333333334589.0DomainCadherin 13
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271563_16671088.33333333333334589.0DomainCadherin 14
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271668_17651088.33333333333334589.0DomainCadherin 15
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271766_18791088.33333333333334589.0DomainCadherin 16
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271880_19791088.33333333333334589.0DomainCadherin 17
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271980_20811088.33333333333334589.0DomainCadherin 18
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272082_21821088.33333333333334589.0DomainCadherin 19
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272183_22831088.33333333333334589.0DomainCadherin 20
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272284_23901088.33333333333334589.0DomainCadherin 21
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272391_24921088.33333333333334589.0DomainCadherin 22
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272493_25961088.33333333333334589.0DomainCadherin 23
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272597_27031088.33333333333334589.0DomainCadherin 24
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272704_28091088.33333333333334589.0DomainCadherin 25
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272810_29181088.33333333333334589.0DomainCadherin 26
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272919_30231088.33333333333334589.0DomainCadherin 27
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273024_31251088.33333333333334589.0DomainCadherin 28
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273126_32301088.33333333333334589.0DomainCadherin 29
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273231_33351088.33333333333334589.0DomainCadherin 30
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273336_34401088.33333333333334589.0DomainCadherin 31
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273441_35451088.33333333333334589.0DomainCadherin 32
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273546_36471088.33333333333334589.0DomainCadherin 33
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273790_38271088.33333333333334589.0DomainEGF-like 1
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273829_40091088.33333333333334589.0DomainLaminin G-like
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274013_40501088.33333333333334589.0DomainEGF-like 2
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274052_40881088.33333333333334589.0DomainEGF-like 3
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274089_41251088.33333333333334589.0DomainEGF-like 4
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274127_41631088.33333333333334589.0DomainEGF-like 5%3B calcium-binding
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274204_42141088.33333333333334589.0MotifNuclear localization signal
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274378_43821088.33333333333334589.0MotifPTB-like motif
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-22722_41811088.33333333333334589.0Topological domainExtracellular
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274203_45881088.33333333333334589.0Topological domainCytoplasmic
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274182_42021088.33333333333334589.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518230_260288.3333333333333771.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518274_280288.3333333333333771.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517230_260288.3333333333333752.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517274_280288.3333333333333752.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517230_260288.3333333333333753.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517274_280288.3333333333333753.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517230_260283.3333333333333747.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517274_280283.3333333333333747.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851828_189288.3333333333333771.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351728_189288.3333333333333752.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851728_189288.3333333333333753.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651728_189283.3333333333333747.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518131_189288.3333333333333771.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518181_188288.3333333333333771.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851828_123288.3333333333333771.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851896_110288.3333333333333771.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517131_189288.3333333333333752.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517181_188288.3333333333333752.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351728_123288.3333333333333752.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351796_110288.3333333333333752.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517131_189288.3333333333333753.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517181_188288.3333333333333753.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851728_123288.3333333333333753.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851796_110288.3333333333333753.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517131_189283.3333333333333747.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517181_188283.3333333333333747.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651728_123283.3333333333333747.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651796_110283.3333333333333747.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851818_701288.3333333333333771.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351718_701288.3333333333333752.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851718_701288.3333333333333753.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651718_701283.3333333333333747.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FAT1
APP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FAT1-APP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FAT1-APP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource