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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FAT1-DHX36

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FAT1-DHX36
FusionPDB ID: 29453
FusionGDB2.0 ID: 29453
HgeneTgene
Gene symbol

FAT1

DHX36

Gene ID

2195

170506

Gene nameFAT atypical cadherin 1DEAH-box helicase 36
SynonymsCDHF7|CDHR8|FAT|ME5|hFat1DDX36|G4R1|MLEL1|RHAU
Cytomap

4q35.2

3q25.2

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homologATP-dependent DNA/RNA helicase DHX36ATP-dependent RNA helicase DHX36DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36DEAD/H box polypeptide 36DEAH (Asp-Glu-Ala-His) box polypeptide 36DEAH box protein 36G4 resolvase-1MLE-like protein 1RNA helicase as
Modification date2020031320200313
UniProtAcc

Q14517

Q9H2U1

Ensembl transtripts involved in fusion geneENST idsENST00000441802, ENST00000512347, 
ENST00000308361, ENST00000329463, 
ENST00000496811, ENST00000544526, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 17 X 8=21767 X 8 X 3=168
# samples 208
** MAII scorelog2(20/2176*10)=-3.44360665147561
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FAT1 [Title/Abstract] AND DHX36 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FAT1(187560875)-DHX36(154001060), # samples:1
Anticipated loss of major functional domain due to fusion event.FAT1-DHX36 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT1-DHX36 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT1-DHX36 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT1-DHX36 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDHX36

GO:0010501

RNA secondary structure unwinding

18842585|20472641|21149580|21846770|22238380

TgeneDHX36

GO:0017148

negative regulation of translation

24369427

TgeneDHX36

GO:0034605

cellular response to heat

18854321

TgeneDHX36

GO:0044806

G-quadruplex DNA unwinding

16150737|18842585

TgeneDHX36

GO:0090669

telomerase RNA stabilization

22238380

TgeneDHX36

GO:1903843

cellular response to arsenite ion

18854321


check buttonFusion gene breakpoints across FAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DHX36 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4301FAT1chr4

187560875

-DHX36chr3

154001060

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441802FAT1chr4187560875-ENST00000496811DHX36chr3154001060-8212385221045861458
ENST00000441802FAT1chr4187560875-ENST00000308361DHX36chr3154001060-5090385221045861458
ENST00000441802FAT1chr4187560875-ENST00000544526DHX36chr3154001060-5089385221045861458
ENST00000441802FAT1chr4187560875-ENST00000329463DHX36chr3154001060-4587385221045861458

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441802ENST00000496811FAT1chr4187560875-DHX36chr3154001060-0.0001240720.9998759
ENST00000441802ENST00000308361FAT1chr4187560875-DHX36chr3154001060-0.000231590.99976844
ENST00000441802ENST00000544526FAT1chr4187560875-DHX36chr3154001060-0.0002314350.99976856
ENST00000441802ENST00000329463FAT1chr4187560875-DHX36chr3154001060-0.0003368660.9996631

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29453_29453_1_FAT1-DHX36_FAT1_chr4_187560875_ENST00000441802_DHX36_chr3_154001060_ENST00000308361_length(amino acids)=1458AA_BP=1214
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS
NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGF
VSSRNPKDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLY
DCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPARIAHLVKELRKELDILLQEKIESPHPVDWNDTKSRDCAVLSAIIDLIKTQ

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>29453_29453_2_FAT1-DHX36_FAT1_chr4_187560875_ENST00000441802_DHX36_chr3_154001060_ENST00000329463_length(amino acids)=1458AA_BP=1214
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS
NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGF
VSSRNPKDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLY
DCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPARIAHLVKELRKELDILLQEKIESPHPVDWNDTKSRDCAVLSAIIDLIKTQ

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>29453_29453_3_FAT1-DHX36_FAT1_chr4_187560875_ENST00000441802_DHX36_chr3_154001060_ENST00000496811_length(amino acids)=1458AA_BP=1214
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS
NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGF
VSSRNPKDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLY
DCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPARIAHLVKELRKELDILLQEKIESPHPVDWNDTKSRDCAVLSAIIDLIKTQ

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>29453_29453_4_FAT1-DHX36_FAT1_chr4_187560875_ENST00000441802_DHX36_chr3_154001060_ENST00000544526_length(amino acids)=1458AA_BP=1214
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS
NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGF
VSSRNPKDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLY
DCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPARIAHLVKELRKELDILLQEKIESPHPVDWNDTKSRDCAVLSAIIDLIKTQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:187560875/chr3:154001060)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT1

Q14517

DHX36

Q9H2U1

FUNCTION: [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.FUNCTION: Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271035_11391214.04589.0DomainCadherin 9
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-427150_2571214.04589.0DomainCadherin 2
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-42735_1491214.04589.0DomainCadherin 1
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-427368_4631214.04589.0DomainCadherin 3
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-427464_5691214.04589.0DomainCadherin 4
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-427570_6731214.04589.0DomainCadherin 5
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-427718_8221214.04589.0DomainCadherin 6
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-427823_9271214.04589.0DomainCadherin 7
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-427928_10341214.04589.0DomainCadherin 8
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724841_905735.0980.0RegionOB-fold-like subdomains
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825841_905750.0995.0RegionOB-fold-like subdomains
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825841_905764.01009.0RegionOB-fold-like subdomains

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271140_12451214.04589.0DomainCadherin 10
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271246_13571214.04589.0DomainCadherin 11
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271359_14561214.04589.0DomainCadherin 12
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271457_15621214.04589.0DomainCadherin 13
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271563_16671214.04589.0DomainCadherin 14
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271668_17651214.04589.0DomainCadherin 15
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271766_18791214.04589.0DomainCadherin 16
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271880_19791214.04589.0DomainCadherin 17
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4271980_20811214.04589.0DomainCadherin 18
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272082_21821214.04589.0DomainCadherin 19
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272183_22831214.04589.0DomainCadherin 20
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272284_23901214.04589.0DomainCadherin 21
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272391_24921214.04589.0DomainCadherin 22
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272493_25961214.04589.0DomainCadherin 23
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272597_27031214.04589.0DomainCadherin 24
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272704_28091214.04589.0DomainCadherin 25
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272810_29181214.04589.0DomainCadherin 26
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4272919_30231214.04589.0DomainCadherin 27
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273024_31251214.04589.0DomainCadherin 28
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273126_32301214.04589.0DomainCadherin 29
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273231_33351214.04589.0DomainCadherin 30
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273336_34401214.04589.0DomainCadherin 31
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273441_35451214.04589.0DomainCadherin 32
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273546_36471214.04589.0DomainCadherin 33
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273790_38271214.04589.0DomainEGF-like 1
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4273829_40091214.04589.0DomainLaminin G-like
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274013_40501214.04589.0DomainEGF-like 2
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274052_40881214.04589.0DomainEGF-like 3
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274089_41251214.04589.0DomainEGF-like 4
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274127_41631214.04589.0DomainEGF-like 5%3B calcium-binding
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274204_42141214.04589.0MotifNuclear localization signal
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274378_43821214.04589.0MotifPTB-like motif
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-42722_41811214.04589.0Topological domainExtracellular
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274203_45881214.04589.0Topological domainCytoplasmic
HgeneFAT1chr4:187560875chr3:154001060ENST00000441802-4274182_42021214.04589.0TransmembraneHelical
TgeneDHX36chr4:187560875chr3:154001060ENST00000308361172472_157735.0980.0Coiled coilOntology_term=ECO:0000255
TgeneDHX36chr4:187560875chr3:154001060ENST00000329463182572_157750.0995.0Coiled coilOntology_term=ECO:0000255
TgeneDHX36chr4:187560875chr3:154001060ENST00000496811182572_157764.01009.0Coiled coilOntology_term=ECO:0000255
TgeneDHX36chr4:187560875chr3:154001060ENST00000308361172410_63735.0980.0Compositional biasNote=Gly-rich
TgeneDHX36chr4:187560875chr3:154001060ENST00000329463182510_63750.0995.0Compositional biasNote=Gly-rich
TgeneDHX36chr4:187560875chr3:154001060ENST00000496811182510_63764.01009.0Compositional biasNote=Gly-rich
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724217_387735.0980.0DomainHelicase ATP-binding
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724477_647735.0980.0DomainHelicase C-terminal
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825217_387750.0995.0DomainHelicase ATP-binding
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825477_647750.0995.0DomainHelicase C-terminal
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825217_387764.01009.0DomainHelicase ATP-binding
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825477_647764.01009.0DomainHelicase C-terminal
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724334_337735.0980.0MotifDEAH box
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724517_528735.0980.0MotifNuclear localization signal
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825334_337750.0995.0MotifDEAH box
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825517_528750.0995.0MotifNuclear localization signal
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825334_337764.01009.0MotifDEAH box
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825517_528764.01009.0MotifNuclear localization signal
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724233_238735.0980.0Nucleotide bindingATP
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724602_605735.0980.0Nucleotide bindingATP
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825233_238750.0995.0Nucleotide bindingATP
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825602_605750.0995.0Nucleotide bindingATP
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825233_238764.01009.0Nucleotide bindingATP
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825602_605764.01009.0Nucleotide bindingATP
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724106_386735.0980.0RegionRecA-like domain 1
TgeneDHX36chr4:187560875chr3:154001060ENST0000030836117241_104735.0980.0RegionRequired for the pre-miR-134 transport
TgeneDHX36chr4:187560875chr3:154001060ENST0000030836117241_200735.0980.0RegionNecessary for nuclear and nucleolar caps localizations
TgeneDHX36chr4:187560875chr3:154001060ENST0000030836117241_51735.0980.0RegionRequired for recruitment to cytoplasmic stress granules
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724387_628735.0980.0RegionRecA-like domain 2
TgeneDHX36chr4:187560875chr3:154001060ENST00000308361172453_105735.0980.0RegionRequired for G4-DNA- and G4-RNA-binding
TgeneDHX36chr4:187560875chr3:154001060ENST00000308361172453_75735.0980.0RegionDSM (DHX36-specific motif)
TgeneDHX36chr4:187560875chr3:154001060ENST000003083611724629_698735.0980.0RegionWH domain
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825106_386750.0995.0RegionRecA-like domain 1
TgeneDHX36chr4:187560875chr3:154001060ENST0000032946318251_104750.0995.0RegionRequired for the pre-miR-134 transport
TgeneDHX36chr4:187560875chr3:154001060ENST0000032946318251_200750.0995.0RegionNecessary for nuclear and nucleolar caps localizations
TgeneDHX36chr4:187560875chr3:154001060ENST0000032946318251_51750.0995.0RegionRequired for recruitment to cytoplasmic stress granules
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825387_628750.0995.0RegionRecA-like domain 2
TgeneDHX36chr4:187560875chr3:154001060ENST00000329463182553_105750.0995.0RegionRequired for G4-DNA- and G4-RNA-binding
TgeneDHX36chr4:187560875chr3:154001060ENST00000329463182553_75750.0995.0RegionDSM (DHX36-specific motif)
TgeneDHX36chr4:187560875chr3:154001060ENST000003294631825629_698750.0995.0RegionWH domain
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825106_386764.01009.0RegionRecA-like domain 1
TgeneDHX36chr4:187560875chr3:154001060ENST0000049681118251_104764.01009.0RegionRequired for the pre-miR-134 transport
TgeneDHX36chr4:187560875chr3:154001060ENST0000049681118251_200764.01009.0RegionNecessary for nuclear and nucleolar caps localizations
TgeneDHX36chr4:187560875chr3:154001060ENST0000049681118251_51764.01009.0RegionRequired for recruitment to cytoplasmic stress granules
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825387_628764.01009.0RegionRecA-like domain 2
TgeneDHX36chr4:187560875chr3:154001060ENST00000496811182553_105764.01009.0RegionRequired for G4-DNA- and G4-RNA-binding
TgeneDHX36chr4:187560875chr3:154001060ENST00000496811182553_75764.01009.0RegionDSM (DHX36-specific motif)
TgeneDHX36chr4:187560875chr3:154001060ENST000004968111825629_698764.01009.0RegionWH domain


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FAT1
DHX36


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FAT1-DHX36


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FAT1-DHX36


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource