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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FAT3-DPP3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FAT3-DPP3
FusionPDB ID: 29474
FusionGDB2.0 ID: 29474
HgeneTgene
Gene symbol

FAT3

DPP3

Gene ID

120114

10072

Gene nameFAT atypical cadherin 3dipeptidyl peptidase 3
SynonymsCDHF15|CDHR10|hFat3DPPIII
Cytomap

11q14.3

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 3FAT tumor suppressor homolog 3cadherin family member 15cadherin-related family member 10dipeptidyl peptidase 3DPP IIIdipeptidyl aminopeptidase IIIdipeptidyl arylamidase IIIdipeptidyl peptidase IIIenkephalinase B
Modification date2020031320200313
UniProtAcc

Q8TDW7

Q9NY33

Ensembl transtripts involved in fusion geneENST idsENST00000298047, ENST00000409404, 
ENST00000525166, ENST00000541502, 
ENST00000489716, ENST00000533797, 
ENST00000533799, ENST00000360510, 
ENST00000453114, ENST00000530165, 
ENST00000532677, ENST00000541961, 
ENST00000531863, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 3=27010 X 9 X 4=360
# samples 1010
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FAT3 [Title/Abstract] AND DPP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FAT3(92088570)-DPP3(66276550), # samples:3
Anticipated loss of major functional domain due to fusion event.FAT3-DPP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT3-DPP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT3-DPP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT3-DPP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAT3-DPP3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FAT3-DPP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FAT3-DPP3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FAT3-DPP3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDPP3

GO:0006508

proteolysis

9425109|10387075


check buttonFusion gene breakpoints across FAT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-97-A4M3-01AFAT3chr11

92088570

-DPP3chr11

66276550

+
ChimerDB4LUADTCGA-97-A4M3-01AFAT3chr11

92088570

+DPP3chr11

66276550

+
ChimerDB4LUADTCGA-97-A4M3FAT3chr11

92088570

+DPP3chr11

66276549

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541502FAT3chr1192088570+ENST00000531863DPP3chr1166276550+378133091734811154
ENST00000409404FAT3chr1192088570+ENST00000531863DPP3chr1166276550+378133091734811154
ENST00000298047FAT3chr1192088570+ENST00000531863DPP3chr1166276550+378133091734811154
ENST00000525166FAT3chr1192088570+ENST00000531863DPP3chr1166276550+333628642230361004
ENST00000541502FAT3chr1192088570+ENST00000531863DPP3chr1166276549+378133091734811154
ENST00000409404FAT3chr1192088570+ENST00000531863DPP3chr1166276549+378133091734811154
ENST00000298047FAT3chr1192088570+ENST00000531863DPP3chr1166276549+378133091734811154
ENST00000525166FAT3chr1192088570+ENST00000531863DPP3chr1166276549+333628642230361004

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541502ENST00000531863FAT3chr1192088570+DPP3chr1166276550+0.0001401090.9998599
ENST00000409404ENST00000531863FAT3chr1192088570+DPP3chr1166276550+0.0001401090.9998599
ENST00000298047ENST00000531863FAT3chr1192088570+DPP3chr1166276550+0.0001401090.9998599
ENST00000525166ENST00000531863FAT3chr1192088570+DPP3chr1166276550+0.000126340.99987364
ENST00000541502ENST00000531863FAT3chr1192088570+DPP3chr1166276549+0.0001401090.9998599
ENST00000409404ENST00000531863FAT3chr1192088570+DPP3chr1166276549+0.0001401090.9998599
ENST00000298047ENST00000531863FAT3chr1192088570+DPP3chr1166276549+0.0001401090.9998599
ENST00000525166ENST00000531863FAT3chr1192088570+DPP3chr1166276549+0.000126340.99987364

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29474_29474_1_FAT3-DPP3_FAT3_chr11_92088570_ENST00000298047_DPP3_chr11_66276549_ENST00000531863_length(amino acids)=1154AA_BP=1097
MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG
FFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV
TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT
HVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK
AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK
EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP
EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS
GVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR
QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ
KSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY
SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASG
AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY

--------------------------------------------------------------

>29474_29474_2_FAT3-DPP3_FAT3_chr11_92088570_ENST00000298047_DPP3_chr11_66276550_ENST00000531863_length(amino acids)=1154AA_BP=1097
MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG
FFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV
TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT
HVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK
AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK
EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP
EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS
GVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR
QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ
KSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY
SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASG
AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY

--------------------------------------------------------------

>29474_29474_3_FAT3-DPP3_FAT3_chr11_92088570_ENST00000409404_DPP3_chr11_66276549_ENST00000531863_length(amino acids)=1154AA_BP=1097
MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG
FFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV
TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT
HVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK
AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK
EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP
EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS
GVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR
QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ
KSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY
SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASG
AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY

--------------------------------------------------------------

>29474_29474_4_FAT3-DPP3_FAT3_chr11_92088570_ENST00000409404_DPP3_chr11_66276550_ENST00000531863_length(amino acids)=1154AA_BP=1097
MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG
FFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV
TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT
HVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK
AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK
EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP
EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS
GVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR
QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ
KSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY
SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASG
AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY

--------------------------------------------------------------

>29474_29474_5_FAT3-DPP3_FAT3_chr11_92088570_ENST00000525166_DPP3_chr11_66276549_ENST00000531863_length(amino acids)=1004AA_BP=947
MNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKL
YGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK
QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYF
KINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYS
IASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAV
SAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQ
KLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMET
GQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV
LTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET
HDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG
SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADA

--------------------------------------------------------------

>29474_29474_6_FAT3-DPP3_FAT3_chr11_92088570_ENST00000525166_DPP3_chr11_66276550_ENST00000531863_length(amino acids)=1004AA_BP=947
MNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKL
YGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK
QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYF
KINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYS
IASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAV
SAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQ
KLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMET
GQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV
LTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET
HDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG
SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADA

--------------------------------------------------------------

>29474_29474_7_FAT3-DPP3_FAT3_chr11_92088570_ENST00000541502_DPP3_chr11_66276549_ENST00000531863_length(amino acids)=1154AA_BP=1097
MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG
FFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV
TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT
HVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK
AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK
EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP
EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS
GVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR
QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ
KSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY
SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASG
AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY

--------------------------------------------------------------

>29474_29474_8_FAT3-DPP3_FAT3_chr11_92088570_ENST00000541502_DPP3_chr11_66276550_ENST00000531863_length(amino acids)=1154AA_BP=1097
MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG
FFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV
TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT
HVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK
AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK
EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP
EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS
GVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR
QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ
KSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY
SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASG
AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:92088570/chr11:66276550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT3

Q8TDW7

DPP3

Q9NY33

FUNCTION: May play a role in the interactions between neurites derived from specific subsets of neurons during development. {ECO:0000250}.FUNCTION: Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127159_2661097.33333333333334590.0DomainCadherin 2
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127264_3751097.33333333333334590.0DomainCadherin 3
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127377_4721097.33333333333334590.0DomainCadherin 4
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+12744_1581097.33333333333334590.0DomainCadherin 1
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127473_5781097.33333333333334590.0DomainCadherin 5
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127579_6811097.33333333333334590.0DomainCadherin 6
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127727_8311097.33333333333334590.0DomainCadherin 7
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127832_9361097.33333333333334590.0DomainCadherin 8
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+127937_10431097.33333333333334590.0DomainCadherin 9
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125159_2661097.33333333333334558.0DomainCadherin 2
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125264_3751097.33333333333334558.0DomainCadherin 3
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125377_4721097.33333333333334558.0DomainCadherin 4
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+12544_1581097.33333333333334558.0DomainCadherin 1
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125473_5781097.33333333333334558.0DomainCadherin 5
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125579_6811097.33333333333334558.0DomainCadherin 6
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125727_8311097.33333333333334558.0DomainCadherin 7
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125832_9361097.33333333333334558.0DomainCadherin 8
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+125937_10431097.33333333333334558.0DomainCadherin 9
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127159_2661097.33333333333334590.0DomainCadherin 2
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127264_3751097.33333333333334590.0DomainCadherin 3
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127377_4721097.33333333333334590.0DomainCadherin 4
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+12744_1581097.33333333333334590.0DomainCadherin 1
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127473_5781097.33333333333334590.0DomainCadherin 5
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127579_6811097.33333333333334590.0DomainCadherin 6
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127727_8311097.33333333333334590.0DomainCadherin 7
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127832_9361097.33333333333334590.0DomainCadherin 8
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+127937_10431097.33333333333334590.0DomainCadherin 9
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125159_2661097.33333333333334558.0DomainCadherin 2
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125264_3751097.33333333333334558.0DomainCadherin 3
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125377_4721097.33333333333334558.0DomainCadherin 4
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+12544_1581097.33333333333334558.0DomainCadherin 1
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125473_5781097.33333333333334558.0DomainCadherin 5
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125579_6811097.33333333333334558.0DomainCadherin 6
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125727_8311097.33333333333334558.0DomainCadherin 7
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125832_9361097.33333333333334558.0DomainCadherin 8
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+125937_10431097.33333333333334558.0DomainCadherin 9

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1274406_44771097.33333333333334590.0Compositional biasNote=Pro-rich
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1254406_44771097.33333333333334558.0Compositional biasNote=Pro-rich
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1274406_44771097.33333333333334590.0Compositional biasNote=Pro-rich
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1254406_44771097.33333333333334558.0Compositional biasNote=Pro-rich
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271044_11481097.33333333333334590.0DomainCadherin 10
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271149_12541097.33333333333334590.0DomainCadherin 11
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271255_13591097.33333333333334590.0DomainCadherin 12
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271363_14601097.33333333333334590.0DomainCadherin 13
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271461_15661097.33333333333334590.0DomainCadherin 14
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271567_17691097.33333333333334590.0DomainCadherin 15
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271770_18831097.33333333333334590.0DomainCadherin 16
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271884_19861097.33333333333334590.0DomainCadherin 17
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1271983_20841097.33333333333334590.0DomainCadherin 18
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272085_21861097.33333333333334590.0DomainCadherin 19
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272187_22871097.33333333333334590.0DomainCadherin 20
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272288_23941097.33333333333334590.0DomainCadherin 21
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272395_24961097.33333333333334590.0DomainCadherin 22
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272497_26001097.33333333333334590.0DomainCadherin 23
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272601_27081097.33333333333334590.0DomainCadherin 24
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272709_28141097.33333333333334590.0DomainCadherin 25
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272815_29241097.33333333333334590.0DomainCadherin 26
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1272925_30291097.33333333333334590.0DomainCadherin 27
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273030_31311097.33333333333334590.0DomainCadherin 28
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273132_32361097.33333333333334590.0DomainCadherin 29
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273237_33411097.33333333333334590.0DomainCadherin 30
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273342_34461097.33333333333334590.0DomainCadherin 31
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273447_35511097.33333333333334590.0DomainCadherin 32
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273552_36531097.33333333333334590.0DomainCadherin 33
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273795_38331097.33333333333334590.0DomainEGF-like 1
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1273835_40181097.33333333333334590.0DomainLaminin G-like
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1274021_40581097.33333333333334590.0DomainEGF-like 2
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1274060_40961097.33333333333334590.0DomainEGF-like 3
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1274098_41341097.33333333333334590.0DomainEGF-like 4%3B calcium-binding
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251044_11481097.33333333333334558.0DomainCadherin 10
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251149_12541097.33333333333334558.0DomainCadherin 11
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251255_13591097.33333333333334558.0DomainCadherin 12
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251363_14601097.33333333333334558.0DomainCadherin 13
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251461_15661097.33333333333334558.0DomainCadherin 14
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251567_17691097.33333333333334558.0DomainCadherin 15
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251770_18831097.33333333333334558.0DomainCadherin 16
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251884_19861097.33333333333334558.0DomainCadherin 17
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1251983_20841097.33333333333334558.0DomainCadherin 18
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252085_21861097.33333333333334558.0DomainCadherin 19
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252187_22871097.33333333333334558.0DomainCadherin 20
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252288_23941097.33333333333334558.0DomainCadherin 21
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252395_24961097.33333333333334558.0DomainCadherin 22
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252497_26001097.33333333333334558.0DomainCadherin 23
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252601_27081097.33333333333334558.0DomainCadherin 24
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252709_28141097.33333333333334558.0DomainCadherin 25
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252815_29241097.33333333333334558.0DomainCadherin 26
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1252925_30291097.33333333333334558.0DomainCadherin 27
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253030_31311097.33333333333334558.0DomainCadherin 28
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253132_32361097.33333333333334558.0DomainCadherin 29
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253237_33411097.33333333333334558.0DomainCadherin 30
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253342_34461097.33333333333334558.0DomainCadherin 31
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253447_35511097.33333333333334558.0DomainCadherin 32
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253552_36531097.33333333333334558.0DomainCadherin 33
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253795_38331097.33333333333334558.0DomainEGF-like 1
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1253835_40181097.33333333333334558.0DomainLaminin G-like
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1254021_40581097.33333333333334558.0DomainEGF-like 2
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1254060_40961097.33333333333334558.0DomainEGF-like 3
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1254098_41341097.33333333333334558.0DomainEGF-like 4%3B calcium-binding
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271044_11481097.33333333333334590.0DomainCadherin 10
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271149_12541097.33333333333334590.0DomainCadherin 11
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271255_13591097.33333333333334590.0DomainCadherin 12
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271363_14601097.33333333333334590.0DomainCadherin 13
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271461_15661097.33333333333334590.0DomainCadherin 14
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271567_17691097.33333333333334590.0DomainCadherin 15
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271770_18831097.33333333333334590.0DomainCadherin 16
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271884_19861097.33333333333334590.0DomainCadherin 17
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1271983_20841097.33333333333334590.0DomainCadherin 18
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272085_21861097.33333333333334590.0DomainCadherin 19
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272187_22871097.33333333333334590.0DomainCadherin 20
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272288_23941097.33333333333334590.0DomainCadherin 21
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272395_24961097.33333333333334590.0DomainCadherin 22
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272497_26001097.33333333333334590.0DomainCadherin 23
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272601_27081097.33333333333334590.0DomainCadherin 24
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272709_28141097.33333333333334590.0DomainCadherin 25
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272815_29241097.33333333333334590.0DomainCadherin 26
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1272925_30291097.33333333333334590.0DomainCadherin 27
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273030_31311097.33333333333334590.0DomainCadherin 28
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273132_32361097.33333333333334590.0DomainCadherin 29
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273237_33411097.33333333333334590.0DomainCadherin 30
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273342_34461097.33333333333334590.0DomainCadherin 31
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273447_35511097.33333333333334590.0DomainCadherin 32
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273552_36531097.33333333333334590.0DomainCadherin 33
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273795_38331097.33333333333334590.0DomainEGF-like 1
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1273835_40181097.33333333333334590.0DomainLaminin G-like
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1274021_40581097.33333333333334590.0DomainEGF-like 2
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1274060_40961097.33333333333334590.0DomainEGF-like 3
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1274098_41341097.33333333333334590.0DomainEGF-like 4%3B calcium-binding
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251044_11481097.33333333333334558.0DomainCadherin 10
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251149_12541097.33333333333334558.0DomainCadherin 11
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251255_13591097.33333333333334558.0DomainCadherin 12
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251363_14601097.33333333333334558.0DomainCadherin 13
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251461_15661097.33333333333334558.0DomainCadherin 14
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251567_17691097.33333333333334558.0DomainCadherin 15
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251770_18831097.33333333333334558.0DomainCadherin 16
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251884_19861097.33333333333334558.0DomainCadherin 17
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1251983_20841097.33333333333334558.0DomainCadherin 18
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252085_21861097.33333333333334558.0DomainCadherin 19
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252187_22871097.33333333333334558.0DomainCadherin 20
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252288_23941097.33333333333334558.0DomainCadherin 21
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252395_24961097.33333333333334558.0DomainCadherin 22
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252497_26001097.33333333333334558.0DomainCadherin 23
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252601_27081097.33333333333334558.0DomainCadherin 24
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252709_28141097.33333333333334558.0DomainCadherin 25
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252815_29241097.33333333333334558.0DomainCadherin 26
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1252925_30291097.33333333333334558.0DomainCadherin 27
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253030_31311097.33333333333334558.0DomainCadherin 28
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253132_32361097.33333333333334558.0DomainCadherin 29
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253237_33411097.33333333333334558.0DomainCadherin 30
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253342_34461097.33333333333334558.0DomainCadherin 31
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253447_35511097.33333333333334558.0DomainCadherin 32
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253552_36531097.33333333333334558.0DomainCadherin 33
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253795_38331097.33333333333334558.0DomainEGF-like 1
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1253835_40181097.33333333333334558.0DomainLaminin G-like
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1254021_40581097.33333333333334558.0DomainEGF-like 2
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1254060_40961097.33333333333334558.0DomainEGF-like 3
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1254098_41341097.33333333333334558.0DomainEGF-like 4%3B calcium-binding
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+12733_41541097.33333333333334590.0Topological domainExtracellular
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1274176_45571097.33333333333334590.0Topological domainCytoplasmic
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+12533_41541097.33333333333334558.0Topological domainExtracellular
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1254176_45571097.33333333333334558.0Topological domainCytoplasmic
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+12733_41541097.33333333333334590.0Topological domainExtracellular
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1274176_45571097.33333333333334590.0Topological domainCytoplasmic
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+12533_41541097.33333333333334558.0Topological domainExtracellular
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1254176_45571097.33333333333334558.0Topological domainCytoplasmic
HgeneFAT3chr11:92088570chr11:66276549ENST00000298047+1274155_41751097.33333333333334590.0TransmembraneHelical
HgeneFAT3chr11:92088570chr11:66276549ENST00000409404+1254155_41751097.33333333333334558.0TransmembraneHelical
HgeneFAT3chr11:92088570chr11:66276550ENST00000298047+1274155_41751097.33333333333334590.0TransmembraneHelical
HgeneFAT3chr11:92088570chr11:66276550ENST00000409404+1254155_41751097.33333333333334558.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FAT3
DPP3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FAT3-DPP3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FAT3-DPP3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource