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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCC5-CDC16

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCC5-CDC16
FusionPDB ID: 295
FusionGDB2.0 ID: 295
HgeneTgene
Gene symbol

ABCC5

CDC16

Gene ID

10057

8881

Gene nameATP binding cassette subfamily C member 5cell division cycle 16
SynonymsABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11ANAPC6|APC6|CDC16Hs|CUT9
Cytomap

3q27.1

13q34

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter Ccell division cycle protein 16 homologanaphase-promoting complex, subunit 6cell division cycle 16 homologcyclosome subunit 6
Modification date2020031320200313
UniProtAcc

O15440

Q13042

Ensembl transtripts involved in fusion geneENST idsENST00000265586, ENST00000334444, 
ENST00000382494, ENST00000392579, 
ENST00000427120, ENST00000446941, 
ENST00000492216, 		ENST00000461716, 
ENST00000252457, ENST00000252458, 
ENST00000356221, ENST00000360383, 
ENST00000375308, ENST00000375310, 
ENST00000375312, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 12 X 9=17286 X 8 X 6=288
# samples 159
** MAII scorelog2(15/1728*10)=-3.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCC5 [Title/Abstract] AND CDC16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCC5(183655689)-CDC16(115008732), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCC5-CDC16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-CDC16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-CDC16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-CDC16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-CDC16 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ABCC5-CDC16 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ABCC5-CDC16 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC5

GO:0042908

xenobiotic transport

10840050

HgeneABCC5

GO:0140115

export across plasma membrane

10840050

TgeneCDC16

GO:0070979

protein K11-linked ubiquitination

18485873


check buttonFusion gene breakpoints across ABCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDC16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E5-A4U1-01AABCC5chr3

183655689

-CDC16chr13

115008732

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334444ABCC5chr3183655689-ENST00000375312CDC16chr13115008732+5496409516941101313
ENST00000334444ABCC5chr3183655689-ENST00000360383CDC16chr13115008732+5567409516941101313
ENST00000334444ABCC5chr3183655689-ENST00000356221CDC16chr13115008732+5649409516941101313
ENST00000334444ABCC5chr3183655689-ENST00000375310CDC16chr13115008732+5567409516941101313
ENST00000334444ABCC5chr3183655689-ENST00000375308CDC16chr13115008732+5567409516941101313
ENST00000334444ABCC5chr3183655689-ENST00000252457CDC16chr13115008732+5567409516941101313
ENST00000334444ABCC5chr3183655689-ENST00000252458CDC16chr13115008732+5544409516941101313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334444ENST00000375312ABCC5chr3183655689-CDC16chr13115008732+0.0003765320.9996234
ENST00000334444ENST00000360383ABCC5chr3183655689-CDC16chr13115008732+0.0004229320.9995771
ENST00000334444ENST00000356221ABCC5chr3183655689-CDC16chr13115008732+0.0004084350.9995915
ENST00000334444ENST00000375310ABCC5chr3183655689-CDC16chr13115008732+0.0004229320.9995771
ENST00000334444ENST00000375308ABCC5chr3183655689-CDC16chr13115008732+0.0004229320.9995771
ENST00000334444ENST00000252457ABCC5chr3183655689-CDC16chr13115008732+0.0004229320.9995771
ENST00000334444ENST00000252458ABCC5chr3183655689-CDC16chr13115008732+0.0003432650.9996567

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>295_295_1_ABCC5-CDC16_ABCC5_chr3_183655689_ENST00000334444_CDC16_chr13_115008732_ENST00000252457_length(amino acids)=1313AA_BP=
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT
GVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFA
SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGF
DLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM
KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS
AILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA
RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL
GETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFS
TWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT
PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITS
SIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT
VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSL

--------------------------------------------------------------

>295_295_2_ABCC5-CDC16_ABCC5_chr3_183655689_ENST00000334444_CDC16_chr13_115008732_ENST00000252458_length(amino acids)=1313AA_BP=
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT
GVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFA
SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGF
DLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM
KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS
AILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA
RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL
GETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFS
TWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT
PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITS
SIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT
VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSL

--------------------------------------------------------------

>295_295_3_ABCC5-CDC16_ABCC5_chr3_183655689_ENST00000334444_CDC16_chr13_115008732_ENST00000356221_length(amino acids)=1313AA_BP=
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT
GVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFA
SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGF
DLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM
KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS
AILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA
RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL
GETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFS
TWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT
PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITS
SIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT
VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSL

--------------------------------------------------------------

>295_295_4_ABCC5-CDC16_ABCC5_chr3_183655689_ENST00000334444_CDC16_chr13_115008732_ENST00000360383_length(amino acids)=1313AA_BP=
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT
GVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFA
SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGF
DLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM
KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS
AILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA
RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL
GETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFS
TWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT
PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITS
SIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT
VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSL

--------------------------------------------------------------

>295_295_5_ABCC5-CDC16_ABCC5_chr3_183655689_ENST00000334444_CDC16_chr13_115008732_ENST00000375308_length(amino acids)=1313AA_BP=
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT
GVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFA
SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGF
DLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM
KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS
AILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA
RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL
GETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFS
TWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT
PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITS
SIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT
VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSL

--------------------------------------------------------------

>295_295_6_ABCC5-CDC16_ABCC5_chr3_183655689_ENST00000334444_CDC16_chr13_115008732_ENST00000375310_length(amino acids)=1313AA_BP=
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT
GVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFA
SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGF
DLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM
KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS
AILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA
RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL
GETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFS
TWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT
PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITS
SIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT
VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSL

--------------------------------------------------------------

>295_295_7_ABCC5-CDC16_ABCC5_chr3_183655689_ENST00000334444_CDC16_chr13_115008732_ENST00000375312_length(amino acids)=1313AA_BP=
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT
GVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFA
SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGF
DLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM
KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS
AILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA
RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL
GETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFS
TWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTT
PTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITS
SIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT
VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183655689/chr13:115008732)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC5

O15440

CDC16

Q13042

FUNCTION: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). {ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:24836561}.FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630179_4591284.66666666666671438.0DomainABC transmembrane type-1 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630562_7831284.66666666666671438.0DomainABC transporter 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630859_11551284.66666666666671438.0DomainABC transmembrane type-1 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-26301227_12341284.66666666666671438.0Nucleotide bindingATP 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630595_6021284.66666666666671438.0Nucleotide bindingATP 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-26301018_10381284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-26301104_11241284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-26301127_11471284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630179_1991284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630219_2391284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630296_3161284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630317_3371284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630400_4201284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630434_4541284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630608_6281284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630848_8681284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630917_9371284.66666666666671438.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-2630997_10171284.66666666666671438.0TransmembraneHelical
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519198_222179.33333333333334633.3333333333334RepeatNote=TPR 6
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519232_260179.33333333333334633.3333333333334RepeatNote=TPR 7
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519267_294179.33333333333334633.3333333333334RepeatNote=TPR 8
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519299_329179.33333333333334633.3333333333334RepeatNote=TPR 9
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519334_362179.33333333333334633.3333333333334RepeatNote=TPR 10
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519369_397179.33333333333334633.3333333333334RepeatNote=TPR 11
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519402_434179.33333333333334633.3333333333334RepeatNote=TPR 12
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519442_474179.33333333333334633.3333333333334RepeatNote=TPR 13
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519479_508179.33333333333334633.3333333333334RepeatNote=TPR 14
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518198_222180.33333333333334621.0RepeatNote=TPR 6
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518232_260180.33333333333334621.0RepeatNote=TPR 7
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518267_294180.33333333333334621.0RepeatNote=TPR 8
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518299_329180.33333333333334621.0RepeatNote=TPR 9
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518334_362180.33333333333334621.0RepeatNote=TPR 10
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518369_397180.33333333333334621.0RepeatNote=TPR 11
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518402_434180.33333333333334621.0RepeatNote=TPR 12
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518442_474180.33333333333334621.0RepeatNote=TPR 13
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518479_508180.33333333333334621.0RepeatNote=TPR 14
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519198_222180.33333333333334576.3333333333334RepeatNote=TPR 6
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519232_260180.33333333333334576.3333333333334RepeatNote=TPR 7
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519267_294180.33333333333334576.3333333333334RepeatNote=TPR 8
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519299_329180.33333333333334576.3333333333334RepeatNote=TPR 9
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519334_362180.33333333333334576.3333333333334RepeatNote=TPR 10
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519369_397180.33333333333334576.3333333333334RepeatNote=TPR 11
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519402_434180.33333333333334576.3333333333334RepeatNote=TPR 12
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519442_474180.33333333333334576.3333333333334RepeatNote=TPR 13
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519479_508180.33333333333334576.3333333333334RepeatNote=TPR 14

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC5chr3:183655689chr13:115008732ENST00000334444-26301193_14271284.66666666666671438.0DomainABC transporter 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-171193_14270533.3333333333334DomainABC transporter 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17179_4590533.3333333333334DomainABC transmembrane type-1 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17562_7830533.3333333333334DomainABC transporter 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17859_11550533.3333333333334DomainABC transmembrane type-1 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-161193_14270226.0DomainABC transporter 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16179_4590226.0DomainABC transmembrane type-1 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16562_7830226.0DomainABC transporter 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16859_11550226.0DomainABC transmembrane type-1 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-171227_12340533.3333333333334Nucleotide bindingATP 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17595_6020533.3333333333334Nucleotide bindingATP 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-161227_12340226.0Nucleotide bindingATP 2
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16595_6020226.0Nucleotide bindingATP 1
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-171018_10380533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-171104_11240533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-171127_11470533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17179_1990533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17219_2390533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17296_3160533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17317_3370533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17400_4200533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17434_4540533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17608_6280533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17848_8680533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17917_9370533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000382494-17997_10170533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-161018_10380226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-161104_11240226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-161127_11470226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16179_1990226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16219_2390226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16296_3160226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16317_3370226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16400_4200226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16434_4540226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16608_6280226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16848_8680226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16917_9370226.0TransmembraneHelical
HgeneABCC5chr3:183655689chr13:115008732ENST00000392579-16997_10170226.0TransmembraneHelical
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519128_159179.33333333333334633.3333333333334RepeatNote=TPR 4
TgeneCDC16chr3:183655689chr13:115008732ENST00000252457519164_187179.33333333333334633.3333333333334RepeatNote=TPR 5
TgeneCDC16chr3:183655689chr13:115008732ENST0000025245751937_62179.33333333333334633.3333333333334RepeatNote=TPR 2
TgeneCDC16chr3:183655689chr13:115008732ENST000002524575194_33179.33333333333334633.3333333333334RepeatNote=TPR 1
TgeneCDC16chr3:183655689chr13:115008732ENST0000025245751970_93179.33333333333334633.3333333333334RepeatNote=TPR 3
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518128_159180.33333333333334621.0RepeatNote=TPR 4
TgeneCDC16chr3:183655689chr13:115008732ENST00000356221518164_187180.33333333333334621.0RepeatNote=TPR 5
TgeneCDC16chr3:183655689chr13:115008732ENST0000035622151837_62180.33333333333334621.0RepeatNote=TPR 2
TgeneCDC16chr3:183655689chr13:115008732ENST000003562215184_33180.33333333333334621.0RepeatNote=TPR 1
TgeneCDC16chr3:183655689chr13:115008732ENST0000035622151870_93180.33333333333334621.0RepeatNote=TPR 3
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519128_159180.33333333333334576.3333333333334RepeatNote=TPR 4
TgeneCDC16chr3:183655689chr13:115008732ENST00000360383519164_187180.33333333333334576.3333333333334RepeatNote=TPR 5
TgeneCDC16chr3:183655689chr13:115008732ENST0000036038351937_62180.33333333333334576.3333333333334RepeatNote=TPR 2
TgeneCDC16chr3:183655689chr13:115008732ENST000003603835194_33180.33333333333334576.3333333333334RepeatNote=TPR 1
TgeneCDC16chr3:183655689chr13:115008732ENST0000036038351970_93180.33333333333334576.3333333333334RepeatNote=TPR 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCC5
CDC16


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCC5-CDC16


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCC5-CDC16


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource