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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FBXW11-NPM1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FBXW11-NPM1
FusionPDB ID: 29884
FusionGDB2.0 ID: 29884
HgeneTgene
Gene symbol

FBXW11

NPM1

Gene ID

23291

4869

Gene nameF-box and WD repeat domain containing 11nucleophosmin 1
SynonymsBTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|HosB23|NPM
Cytomap

5q35.1

5q35.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homolognucleophosminnucleolar protein NO38nucleophosmin (nucleolar phosphoprotein B23, numatrin)nucleophosmin/nucleoplasmin family, member 1testicular tissue protein Li 128
Modification date2020032920200329
UniProtAcc

Q9UKB1

P06748

Ensembl transtripts involved in fusion geneENST idsENST00000265094, ENST00000296933, 
ENST00000393802, ENST00000425623, 
ENST00000522891, 		ENST00000296930, 
ENST00000351986, ENST00000393820, 
ENST00000517671, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 6 X 9=70210 X 9 X 3=270
# samples 1311
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FBXW11 [Title/Abstract] AND NPM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FBXW11(171433461)-NPM1(170832305), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXW11-NPM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-NPM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-NPM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-NPM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

HgeneFBXW11

GO:0016567

protein ubiquitination

16885022

HgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

HgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneNPM1

GO:0006281

DNA repair

19188445

TgeneNPM1

GO:0006334

nucleosome assembly

11602260

TgeneNPM1

GO:0006913

nucleocytoplasmic transport

16041368

TgeneNPM1

GO:0008104

protein localization

18420587

TgeneNPM1

GO:0008284

positive regulation of cell proliferation

22528486

TgeneNPM1

GO:0032071

regulation of endodeoxyribonuclease activity

19188445

TgeneNPM1

GO:0034644

cellular response to UV

19160485

TgeneNPM1

GO:0043066

negative regulation of apoptotic process

12882984

TgeneNPM1

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

12882984

TgeneNPM1

GO:0045727

positive regulation of translation

12882984

TgeneNPM1

GO:0045893

positive regulation of transcription, DNA-templated

22528486

TgeneNPM1

GO:0045944

positive regulation of transcription by RNA polymerase II

19160485

TgeneNPM1

GO:0060699

regulation of endoribonuclease activity

19188445

TgeneNPM1

GO:0060735

regulation of eIF2 alpha phosphorylation by dsRNA

12882984

TgeneNPM1

GO:1902751

positive regulation of cell cycle G2/M phase transition

22528486


check buttonFusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NPM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1563FBXW11chr5

171433461

-NPM1chr5

170832305

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296933FBXW11chr5171433461-ENST00000517671NPM1chr5170832305+950416555100151
ENST00000296933FBXW11chr5171433461-ENST00000296930NPM1chr5170832305+1204416555100151
ENST00000296933FBXW11chr5171433461-ENST00000351986NPM1chr5170832305+95141628393121
ENST00000296933FBXW11chr5171433461-ENST00000393820NPM1chr5170832305+1247416618100172
ENST00000265094FBXW11chr5171433461-ENST00000517671NPM1chr5170832305+71718338027117
ENST00000265094FBXW11chr5171433461-ENST00000296930NPM1chr5170832305+97118357398113
ENST00000265094FBXW11chr5171433461-ENST00000351986NPM1chr5170832305+71818338027117
ENST00000265094FBXW11chr5171433461-ENST00000393820NPM1chr5170832305+10141833852128
ENST00000393802FBXW11chr5171433461-ENST00000517671NPM1chr5170832305+72719339037117
ENST00000393802FBXW11chr5171433461-ENST00000296930NPM1chr5170832305+98119367408113
ENST00000393802FBXW11chr5171433461-ENST00000351986NPM1chr5170832305+72819339037117
ENST00000393802FBXW11chr5171433461-ENST00000393820NPM1chr5170832305+10241933950132

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296933ENST00000517671FBXW11chr5171433461-NPM1chr5170832305+0.78167280.21832721
ENST00000296933ENST00000296930FBXW11chr5171433461-NPM1chr5170832305+0.799860240.2001397
ENST00000296933ENST00000351986FBXW11chr5171433461-NPM1chr5170832305+0.779715360.22028461
ENST00000296933ENST00000393820FBXW11chr5171433461-NPM1chr5170832305+0.7366550.26334497
ENST00000265094ENST00000517671FBXW11chr5171433461-NPM1chr5170832305+0.0233491420.9766509
ENST00000265094ENST00000296930FBXW11chr5171433461-NPM1chr5170832305+0.020660220.9793397
ENST00000265094ENST00000351986FBXW11chr5171433461-NPM1chr5170832305+0.0235423240.97645766
ENST00000265094ENST00000393820FBXW11chr5171433461-NPM1chr5170832305+0.181839780.8181602
ENST00000393802ENST00000517671FBXW11chr5171433461-NPM1chr5170832305+0.0330445580.9669554
ENST00000393802ENST00000296930FBXW11chr5171433461-NPM1chr5170832305+0.0337043630.96629566
ENST00000393802ENST00000351986FBXW11chr5171433461-NPM1chr5170832305+0.0330405650.9669594
ENST00000393802ENST00000393820FBXW11chr5171433461-NPM1chr5170832305+0.255563470.74443656

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29884_29884_1_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000296930_length(amino acids)=113AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINY

--------------------------------------------------------------

>29884_29884_2_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000351986_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------

>29884_29884_3_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000393820_length(amino acids)=128AA_BP=1
MLMTLSMDYICLSFSFLPIFGLNLHVVPRTVQCAFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPP

--------------------------------------------------------------

>29884_29884_4_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000517671_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------

>29884_29884_5_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000296930_length(amino acids)=151AA_BP=1
MMNLASTLGREPPFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPPRSPRAAANGPGGGGDGGGGRG

--------------------------------------------------------------

>29884_29884_6_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000351986_length(amino acids)=121AA_BP=
MSKLLTLQVCTSYAHRPVLLSARSSASGCQEPATWCQRLGPTTLCGPRRLLGGVVPDLRTAFAEGEGGAAGGPGGLAARVGAIAASASAA

--------------------------------------------------------------

>29884_29884_7_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000393820_length(amino acids)=172AA_BP=1
MLMTLSMDYICLSFSFLPIFGLNLHVVPRTVQCAFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPP

--------------------------------------------------------------

>29884_29884_8_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000517671_length(amino acids)=151AA_BP=1
MMNLASTLGREPPFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPPRSPRAAANGPGGGGDGGGGRG

--------------------------------------------------------------

>29884_29884_9_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000296930_length(amino acids)=113AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINY

--------------------------------------------------------------

>29884_29884_10_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000351986_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------

>29884_29884_11_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000393820_length(amino acids)=132AA_BP=1
MLMTLSMDYICLSFSFLPIFGLNLHVVPRTVQCAFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPP

--------------------------------------------------------------

>29884_29884_12_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000517671_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171433461/chr5:170832305)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW11

Q9UKB1

NPM1

P06748

FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781, ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269|PubMed:19730691}.FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). {ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610191_197194.0266.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711243_294223.0295.0RegionNote=Required for nucleolar localization
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610243_294194.0266.0RegionNote=Required for nucleolar localization
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710243_294223.0260.0RegionNote=Required for nucleolar localization
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812243_294223.0295.0RegionNote=Required for nucleolar localization

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113129_16715.01360.3333333333333DomainF-box
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113129_16715.01283.6666666666667DomainF-box
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112129_16715.0592.0DomainF-box
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-11367_11615.01360.3333333333333RegionHomodimerization domain D
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-11367_11615.01283.6666666666667RegionHomodimerization domain D
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-11267_11615.0592.0RegionHomodimerization domain D
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113238_27515.01360.3333333333333RepeatNote=WD 1
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113278_31515.01360.3333333333333RepeatNote=WD 2
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113318_35515.01360.3333333333333RepeatNote=WD 3
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113361_39815.01360.3333333333333RepeatNote=WD 4
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113401_44015.01360.3333333333333RepeatNote=WD 5
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113442_47815.01360.3333333333333RepeatNote=WD 6
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113490_52715.01360.3333333333333RepeatNote=WD 7
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113238_27515.01283.6666666666667RepeatNote=WD 1
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113278_31515.01283.6666666666667RepeatNote=WD 2
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113318_35515.01283.6666666666667RepeatNote=WD 3
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113361_39815.01283.6666666666667RepeatNote=WD 4
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113401_44015.01283.6666666666667RepeatNote=WD 5
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113442_47815.01283.6666666666667RepeatNote=WD 6
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113490_52715.01283.6666666666667RepeatNote=WD 7
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112238_27515.0592.0RepeatNote=WD 1
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112278_31515.0592.0RepeatNote=WD 2
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112318_35515.0592.0RepeatNote=WD 3
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112361_39815.0592.0RepeatNote=WD 4
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112401_44015.0592.0RepeatNote=WD 5
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112442_47815.0592.0RepeatNote=WD 6
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112490_52715.0592.0RepeatNote=WD 7
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711120_132223.0295.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711161_188223.0295.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000002969307111_9223.0295.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610120_132194.0266.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610161_188194.0266.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000003519866101_9194.0266.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710120_132223.0260.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710161_188223.0260.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000003938207101_9223.0260.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812120_132223.0295.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812161_188223.0295.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000005176718121_9223.0295.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711152_157223.0295.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711191_197223.0295.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610152_157194.0266.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710152_157223.0260.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710191_197223.0260.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812152_157223.0295.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812191_197223.0295.0MotifNuclear localization signal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NPM1TCERG1, LYAR, USF2, HIST3H3, SWAP70, HAND2, NCL, OTUB1, AKT1, CDT1, RRP1B, Rrp1b, GRB2, CENPF, CASKIN1, CDC14A, PIK3R1, NUP98, PPID, GRB7, NCAPG, NUMA1, NSUN2, PADI4, TP53, BARD1, BRCA1, H2AFX, CDKN2A, HMGA2, HMGA1, HCVgp1, YY1, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, EP300, tat, PML, RARA, CTNNBL1, FANCA, FANCC, TFAP2A, HDAC1, HDAC2, SMARCA4, DOT1L, ACACA, HNRNPM, HNRNPU, DDX21, HIST1H1C, SIRT1, YBX1, PC, YBX3, H1FX, HIST1H1A, ESR1, Trp53, Cdkn2a, CDK5RAP3, ZNF668, UBC, RYK, SMN1, CD4, YWHAQ, USP36, CTCF, HDAC5, CDKN1A, NOP56, CENPA, AFF1, DYRK2, TOP1, CDK2, SREK1, SENP3, RB1, PARP1, HJURP, ARRB1, ARRB2, SIRT7, NPM3, NPM1, FBXO25, IRF1, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, MDM2, PA2G4, PPP2R1A, MID1, GZF1, APEX1, COPS2, PLCG1, FBXO6, GAPDH, SIAH1, PTBP1, SRSF1, APP, RPL14, RPS6, RPL24, RPL6, NAP1L1, HNRNPR, RPS4X, PRPF6, LAMP2, SURF4, RPL10L, NAP1L4, ZYX, NUP62, NUP50, RPL5, YWHAE, FMNL1, CPSF6, HNRNPH1, PAPOLG, JUNB, MC4R, HIVEP2, CPSF1, CPSF2, CPSF4, CPSF3, FN1, VCAM1, CSNK2A1, NOS2, UBL4A, ITGA4, CBX2, CBX4, CBX8, PHB, EIF2AK2, XPO1, GZMM, PAN2, CD81, IGSF8, ICAM1, PRKCZ, KIF11, SQSTM1, FLNA, LLGL1, HSP90AA1, TRIM21, TUBA1C, HSP90AB1, PARD6B, CDC37, TUBB3, MRPL46, KCTD2, CLTC, MRPL50, VCP, KCTD5, MRPL12, HSPA5, PTRF, MRPL52, EEF1A1, KCTD17, TAB1, BAG2, ANXA2, EIF5A, PPIL4, MRPL38, STK38, FLNB, LGALS1, C1QBP, COPB1, MRPL37, MRPL49, KEAP1, PRDX4, WDR26, PSMC4, SDPR, SLC25A3, RPS12, EEF1B2, NIPSNAP1, EEF1G, MRPL39, DDX3X, RNH1, OSBPL1A, EIF3H, MRPL54, ENO1, MYCBP, MRPL18, MAP1B, PSMD1, EEF1D, DNAJC13, HSPB1, CFL1, FLNC, PPP1CC, RPLP1, CEP152, SNRPD1, ATP5A1, ARHGAP5, PRKAR1A, MRPL53, GID8, YWHAZ, CCT2, EIF3E, LAMB2, DICER1, CHCHD4, MRPL19, SNRPD2, GRWD1, TPR, PSMD4, PSMC5, PPP2CA, UNC5C, SLC25A5, PTPN14, RPS5, TTC27, BOLA2, EIF4A1, TUFM, S100A10, IMPG1, NUDT21, UTRN, MRPL44, EIF3M, MRPL43, PKM, IMPDH2, TRRAP, CHCHD6, RANBP6, EIF3I, TAB2, MRPL24, DZIP1, IPO5, AGR2, MRPS30, ICT1, PRDX6, TCP1, RCOR1, GRN, TXN, RPLP0, PCBP1, MRPL28, MRPL10, TAF3, EPAS1, CHCHD3, TXNDC12, ELMO2, SRRT, MRPL11, EIF2S1, SNRPF, KTN1, FGD6, UQCRH, RBBP4, DNAJA1, CTTN, USP15, NUDCD1, RPS28, JAK1, PROS1, PYGB, KDR, EEF2, FASN, AKAP11, CSNK2B, DNAJA2, EIF3G, DHX15, MRPS26, HNRNPA0, DOCK4, PRKCI, VASP, COPE, SAMM50, TEX15, PSME3, PPM1G, COPG1, CALU, S100A11, HSPA4, PSMD12, POLR2E, TRIM28, SLAIN2, RPL10, GOLGA2, GOLGA3, PRKCA, IPO9, PARK7, SPIN1, PPA1, BANP, DSTN, GNAI2, HOXA7, ABCC1, RELA, ACY1, TARDBP, PARK2, KPNA1, ARMCX3, LIMCH1, OSBP, TRMT61A, rev, RPA1, RPA2, RPA3, ERG, LGR4, STAU1, ELF4, AURKA, HUWE1, FUS, COX8A, NPM2, MOV10, NXF1, PHF6, CUL7, OBSL1, CCDC8, SIRT6, EBNA1BP2, NOL12, RPL10A, POP4, ZNF22, NSA2, TAF1D, NIFK, RPL26L1, NIP7, RPL4, RPF1, CCDC137, KNOP1, RBM28, RPL7A, POP1, DDX24, FTSJ3, RRS1, RPL3, ZFP62, ZNF512, DDX56, DDX27, GLYR1, MAK16, CEBPZ, RSL1D1, HP1BP3, REXO4, DDX31, MYBBP1A, NOP16, C3orf17, RRP8, GNL2, PAPD5, RSL24D1, SURF6, GTPBP4, KIAA0020, NOP2, NVL, GLTSCR2, URB1, RPL23A, GPATCH4, TEX10, RPS8, NOC3L, BRIX1, DDX54, PWP1, RBM34, NMNAT1, CENPC, SENP5, RPL36AL, PAK1IP1, ZNF800, RPL7L1, RPL37A, RPF2, PELP1, NOC2L, RPP40, RBMX2, CENPV, PPAN-P2RY11, SDAD1, RPP38, RPP25, SPTY2D1, RPP25L, POP7, RPS6KB2, UTP15, NTRK1, EWSR1, CLK1, HIST1H3E, BYSL, CHD1, DDX1, DECR1, EIF1AX, EIF4G2, FBL, FAU, HIST1H1D, HIST1H1B, RPSA, MKI67, MPG, EXOSC10, RPL7, RPL8, RPL9, RPL11, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL27, RPL27A, RPL29, RPL32, RPL37, RPL38, RPS2, RPS3, RPS3A, RPS9, RPS10, RPS11, RPS13, RPS14, RPS15, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS29, SKIV2L, SRP72, XPC, IFRD2, HIST1H2BC, SMARCA5, CGGBP1, EIF3A, EIF3C, PABPC4, USP10, TTC37, JADE3, ABCF2, G3BP1, GNB2L1, EMG1, IGF2BP3, PSIP1, SUPT16H, RPL35, PDCD11, LARP4B, RRP12, LARP1, RPL13A, RPL36, MTHFD1L, AHCTF1, FAM98A, SERBP1, GNL3, SND1, NOB1, RPS27L, DDX47, EIF3L, RTCB, TRMT112, DHX29, MTPAP, NAT10, TSR1, NKRF, MEPCE, BCCIP, PNO1, MRPS22, WDR18, SCAF1, NOL6, DDX50, CCDC86, MUS81, ZNF622, DHX57, H2AFV, LARP4, WBSCR22, Eif3a, Eif3e, Ktn1, Rpl35, Srp72, Rrbp1, GAN, HEMGN, TMUB1, CRY1, DNAJB4, MCM2, GLI1, Mdm2, SP1, U2AF2, RC3H1, EIF2S2, EGFR, WWP2, CD24, ZNF746, DDX51, MAGED2, HNRNPA2B1, HNRNPD, HNRNPA1, RPL23, RPS7, HIST1H2BB, HIST1H2AA, CBX3, CYLD, INO80B, LMNA, YAP1, MTF1, BRD1, HDAC6, FBXW7, CENPW, API5, CTNNB1, MAP2K3, BMP4, CCNT1, DIMT1, MATN2, TRIP4, CUL4B, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, LARP7, RNF31, TNF, FAM188B, SPDL1, HEXIM1, SNAI1, RECQL4, GPC1, REST, ZFP36L2, MYC, CDK9, Prkab1, NEK2, METTL3, METTL14, KIAA1429, RC3H2, PSMA3, ACTC1, ESR2, FAF1, RBX1, BRCA2, DISC1, NR2C2, UBQLN2, MTDH, GADD45A, AGRN, ATXN3, VRK1, VRK3, DYRK1A, SNRNP70, ITFG1, GHET1, ARAF, HMGB1, BIRC3, NFX1, BRD7, N, SOX2, PPIA, CACYBP, RNR1, CMTR1, ARIH2, PLEKHA4, RAD18, PINK1, WHSC1, FANCD2, SAMD12, LINC01554, ZC3H18, CAMK2A, FYN, PTPN12, RPS6KA3, STX7, IL7R, GPC3, RP1, KMT2A, SUZ12, BSX, LEMD1, ZCCHC7, SYNE2, ZBTB9, R3HDM4, ZNF496, PIKFYVE, COL8A1, PMS2, TRDN, PLCZ1, ASPM, TTN, SETD2, BDP1, C4orf47, CFAP54, HIST2H2BC, AIM2, SYT7, LTN1, EPRS, FST, LMOD1, MCAM, RPL34, MYT1, DYNC1I2, KIF22, ZNF181, ATAT1, TRMT10B, RBM44, ANKS3, FILIP1, FAM9A, SUPT20H, THOC2, CENPI, BICD1, CCL13, JPH2, NDST4, SARDH, SLC27A6, LECT2, HMGN4, OPA1, ITGB1, HIVEP1, PNRC1, PDE4DIP, CAPRIN2, C1orf110, MICAL1, STAB2, CEP63, NGRN, CAMSAP3, ARHGEF9, SNIP1, ORF14, ILF3, LRRC31, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, BRD3, SP110, TRIM24, ZMYND8, LRRC59, NMRAL1, SUMO2, Rnf183, BRD4, NUPR1, RBM45, CIC, Apc2, RBM39, FBP1, ASXL1, vpr, RIN3, DNAJC19, DNAJC25, DNAJC2, OGT, DDRGK1, UFL1, CD3EAP, DDX23, HIST1H2BG, ACTG1, ALKBH4, DNAJC10, GLUD2, HIST1H2AE, HIST1H3F, HIST1H4J, HLCS, HSPA1B, MALT1, PEG10, PLD3, UBB, AIP, BCORL1, BID, CSK, LCK, PSMG1, RAB21, RBM11, VDAC1, RPL31, ZNF330, TRIM37, FZR1, WDR5, PAGE4, NUDCD2, NAA40, BGLT3, CCDC140, RPL23AP32, MTG2, NGDN, UTP18, PRPF4B, WDR74, WDR36, DKC1, DDX52, EPB41L5, ZBTB11, H2AFY, CIRH1A, SRSF5, DUSP11, DDX10, TSPYL1, IMP3, RBM19, NOM1, ZC3HAV1, RPP14, UTP14A, WDR12, DNTTIP2, MPHOSPH10, RRP1, WDR3, BUD13, RPLP2, C14orf169, ZNF771, AATF, C1orf35, OASL, NLE1, BMS1, BOP1, STAU2, TAF1C, WDR55, ZNF638, RFC1, FYTTD1, WDR43, C7orf50, SRPK2, LUC7L, FAM111A, PBRM1, NOL10, TAF1A, TBL3, ZNF770, BAZ1B, ESF1, TTF1, LAS1L, RPP30, ZNF16, RRP15, ABT1, SPRTN, ULK1, TRAF6, BTF3, SLFN11, NLRP7, RCHY1, DIDO1, CCNF, FAM129A, ATR, ATM, PSMD9, ZEB1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FBXW11
NPM1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FBXW11-NPM1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FBXW11-NPM1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNPM1C0026998Acute Myeloid Leukemia, M16CTD_human;ORPHANET
TgeneNPM1C1879321Acute Myeloid Leukemia (AML-M2)6CTD_human;ORPHANET
TgeneNPM1C0023467Leukemia, Myelocytic, Acute5CGI;CTD_human
TgeneNPM1C0023487Acute Promyelocytic Leukemia2CGI;CTD_human;ORPHANET
TgeneNPM1C0024623Malignant neoplasm of stomach1CTD_human
TgeneNPM1C0038356Stomach Neoplasms1CTD_human
TgeneNPM1C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneNPM1C0206182Lymphomatoid Papulosis1ORPHANET
TgeneNPM1C0265965Dyskeratosis Congenita1CTD_human;GENOMICS_ENGLAND
TgeneNPM1C1148551X-Linked Dyskeratosis Congenita1CTD_human
TgeneNPM1C1301362Primary Cutaneous Anaplastic Large Cell Lymphoma1ORPHANET
TgeneNPM1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneNPM1C2930974Acute erythroleukemia1CTD_human
TgeneNPM1C2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneNPM1C2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneNPM1C2930977Acute erythroleukemia - M6b subtype1CTD_human