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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FBXW11-STK10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FBXW11-STK10
FusionPDB ID: 29890
FusionGDB2.0 ID: 29890
HgeneTgene
Gene symbol

FBXW11

STK10

Gene ID

23291

6793

Gene nameF-box and WD repeat domain containing 11serine/threonine kinase 10
SynonymsBTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|HosLOK|PRO2729
Cytomap

5q35.1

5q35.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homologserine/threonine-protein kinase 10lymphocyte-oriented kinase
Modification date2020032920200313
UniProtAcc

Q9UKB1

.
Ensembl transtripts involved in fusion geneENST idsENST00000265094, ENST00000296933, 
ENST00000393802, ENST00000425623, 
ENST00000522891, 
ENST00000517775, 
ENST00000176763, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 6 X 9=70216 X 15 X 7=1680
# samples 1317
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/1680*10)=-3.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FBXW11 [Title/Abstract] AND STK10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FBXW11(171433462)-STK10(171554425), # samples:1
FBXW11(171423894)-STK10(171554425), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXW11-STK10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-STK10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-STK10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-STK10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

HgeneFBXW11

GO:0016567

protein ubiquitination

16885022

HgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

HgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneSTK10

GO:0046777

protein autophosphorylation

12639966|18239682


check buttonFusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STK10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2000-01AFBXW11chr5

171423894

-STK10chr5

171554425

-
ChimerDB4OVTCGA-61-2000-01AFBXW11chr5

171433462

-STK10chr5

171554425

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000296933FBXW11chr5171433462-ENST00000176763STK10chr5171554425-58114162903001903
ENST00000265094FBXW11chr5171433462-ENST00000176763STK10chr5171554425-5578183572768903
ENST00000393802FBXW11chr5171433462-ENST00000176763STK10chr5171554425-5588193672778903

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296933ENST00000176763FBXW11chr5171433462-STK10chr5171554425-0.0078122850.99218774
ENST00000265094ENST00000176763FBXW11chr5171433462-STK10chr5171554425-0.0080227410.9919773
ENST00000393802ENST00000176763FBXW11chr5171433462-STK10chr5171554425-0.0080252120.9919748

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29890_29890_1_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000265094_STK10_chr5_171554425_ENST00000176763_length(amino acids)=903AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH
RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRV
LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAS
TLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVA
QEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSL
SIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAK
KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLD
RDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQ
RYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES
NMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSA

--------------------------------------------------------------

>29890_29890_2_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000296933_STK10_chr5_171554425_ENST00000176763_length(amino acids)=903AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH
RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRV
LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAS
TLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVA
QEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSL
SIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAK
KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLD
RDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQ
RYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES
NMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSA

--------------------------------------------------------------

>29890_29890_3_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000393802_STK10_chr5_171554425_ENST00000176763_length(amino acids)=903AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH
RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRV
LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAS
TLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVA
QEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSL
SIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAK
KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLD
RDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQ
RYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES
NMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171433462/chr5:171554425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW11

Q9UKB1

.
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781, ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269|PubMed:19730691}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTK10chr5:171433462chr5:171554425ENST00000176763119573_947107.0969.0Coiled coilOntology_term=ECO:0000255
TgeneSTK10chr5:171433462chr5:171554425ENST00000176763119750_884107.0969.0Compositional biasNote=Gln-rich
TgeneSTK10chr5:171433462chr5:171554425ENST00000176763119175_224107.0969.0RegionNote=Activation segment

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113129_16715.01360.3333333333333DomainF-box
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113129_16715.01283.6666666666667DomainF-box
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112129_16715.0592.0DomainF-box
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-11367_11615.01360.3333333333333RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-11367_11615.01283.6666666666667RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-11267_11615.0592.0RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113238_27515.01360.3333333333333RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113278_31515.01360.3333333333333RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113318_35515.01360.3333333333333RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113361_39815.01360.3333333333333RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113401_44015.01360.3333333333333RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113442_47815.01360.3333333333333RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113490_52715.01360.3333333333333RepeatNote=WD 7
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113238_27515.01283.6666666666667RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113278_31515.01283.6666666666667RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113318_35515.01283.6666666666667RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113361_39815.01283.6666666666667RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113401_44015.01283.6666666666667RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113442_47815.01283.6666666666667RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113490_52715.01283.6666666666667RepeatNote=WD 7
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112238_27515.0592.0RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112278_31515.0592.0RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112318_35515.0592.0RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112361_39815.0592.0RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112401_44015.0592.0RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112442_47815.0592.0RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112490_52715.0592.0RepeatNote=WD 7
TgeneSTK10chr5:171433462chr5:171554425ENST0000017676311936_294107.0969.0DomainProtein kinase
TgeneSTK10chr5:171433462chr5:171554425ENST0000017676311942_50107.0969.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FBXW11
STK10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FBXW11-STK10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FBXW11-STK10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource