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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FCRL1-KATNA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FCRL1-KATNA1
FusionPDB ID: 30031
FusionGDB2.0 ID: 30031
HgeneTgene
Gene symbol

FCRL1

KATNA1

Gene ID

115350

11104

Gene nameFc receptor like 1katanin catalytic subunit A1
SynonymsCD307a|FCRH1|IFGP1|IRTA5-
Cytomap

1q23.1

6q25.1

Type of geneprotein-codingprotein-coding
DescriptionFc receptor-like protein 1IFGP family protein 1fc receptor homolog 1fcR-like protein 1hIFGP1immune receptor translocation-associated protein 5immunoglobulin superfamily Fc receptor, gp42katanin p60 ATPase-containing subunit A1katanin p60 (ATPase containing) subunit A 1katanin p60 subunit A1p60 katanin
Modification date2020032020200315
UniProtAcc

Q96LA6

O75449

Ensembl transtripts involved in fusion geneENST idsENST00000358292, ENST00000368176, 
ENST00000491942, ENST00000489998, 
ENST00000494504, ENST00000335643, 
ENST00000367411, ENST00000335647, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 1=95 X 6 X 4=120
# samples 35
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FCRL1 [Title/Abstract] AND KATNA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FCRL1(157789797)-KATNA1(149925919), # samples:1
Anticipated loss of major functional domain due to fusion event.FCRL1-KATNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FCRL1-KATNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FCRL1-KATNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FCRL1-KATNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFCRL1

GO:0042113

B cell activation

15479727


check buttonFusion gene breakpoints across FCRL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KATNA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA283968FCRL1chr1

157789797

-KATNA1chr6

149925919

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358292FCRL1chr1157789797-ENST00000335647KATNA1chr6149925919-1221831641057297
ENST00000368176FCRL1chr1157789797-ENST00000335647KATNA1chr6149925919-1237991801073297
ENST00000491942FCRL1chr1157789797-ENST00000335647KATNA1chr6149925919-1192541351028297

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358292ENST00000335647FCRL1chr1157789797-KATNA1chr6149925919-0.0014003210.9985997
ENST00000368176ENST00000335647FCRL1chr1157789797-KATNA1chr6149925919-0.0014431610.9985568
ENST00000491942ENST00000335647FCRL1chr1157789797-KATNA1chr6149925919-0.0013861370.99861383

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30031_30031_1_FCRL1-KATNA1_FCRL1_chr1_157789797_ENST00000358292_KATNA1_chr6_149925919_ENST00000335647_length(amino acids)=297AA_BP=
MERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRG
ESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLE
KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEM

--------------------------------------------------------------

>30031_30031_2_FCRL1-KATNA1_FCRL1_chr1_157789797_ENST00000368176_KATNA1_chr6_149925919_ENST00000335647_length(amino acids)=297AA_BP=
MERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRG
ESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLE
KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEM

--------------------------------------------------------------

>30031_30031_3_FCRL1-KATNA1_FCRL1_chr1_157789797_ENST00000491942_KATNA1_chr6_149925919_ENST00000335647_length(amino acids)=297AA_BP=
MERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRG
ESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLE
KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEM

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:157789797/chr6:149925919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCRL1

Q96LA6

KATNA1

O75449

FUNCTION: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. {ECO:0000269|PubMed:15479727}.FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKATNA1chr1:157789797chr6:149925919ENST0000033564308249_2560312.0Nucleotide bindingATP
TgeneKATNA1chr1:157789797chr6:149925919ENST00000335647210249_256167.0492.0Nucleotide bindingATP
TgeneKATNA1chr1:157789797chr6:149925919ENST00000367411311249_256167.0492.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110109_20010.333333333333334367.0DomainNote=Ig-like C2-type 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-11017_10410.333333333333334367.0DomainNote=Ig-like C2-type 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110208_29110.333333333333334367.0DomainNote=Ig-like C2-type 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111109_20010.333333333333334430.0DomainNote=Ig-like C2-type 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-11117_10410.333333333333334430.0DomainNote=Ig-like C2-type 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111208_29110.333333333333334430.0DomainNote=Ig-like C2-type 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111109_20010.333333333333334429.0DomainNote=Ig-like C2-type 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-11117_10410.333333333333334429.0DomainNote=Ig-like C2-type 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111208_29110.333333333333334429.0DomainNote=Ig-like C2-type 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110354_35910.333333333333334367.0MotifNote=ITIM motif 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110367_37210.333333333333334367.0MotifNote=ITIM motif 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110379_38410.333333333333334367.0MotifNote=ITIM motif 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110410_41510.333333333333334367.0MotifNote=ITIM motif 4
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110423_42810.333333333333334367.0MotifNote=ITIM motif 5
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111354_35910.333333333333334430.0MotifNote=ITIM motif 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111367_37210.333333333333334430.0MotifNote=ITIM motif 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111379_38410.333333333333334430.0MotifNote=ITIM motif 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111410_41510.333333333333334430.0MotifNote=ITIM motif 4
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111423_42810.333333333333334430.0MotifNote=ITIM motif 5
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111354_35910.333333333333334429.0MotifNote=ITIM motif 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111367_37210.333333333333334429.0MotifNote=ITIM motif 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111379_38410.333333333333334429.0MotifNote=ITIM motif 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111410_41510.333333333333334429.0MotifNote=ITIM motif 4
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111423_42810.333333333333334429.0MotifNote=ITIM motif 5
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-11017_30710.333333333333334367.0Topological domainExtracellular
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110329_42910.333333333333334367.0Topological domainCytoplasmic
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-11117_30710.333333333333334430.0Topological domainExtracellular
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111329_42910.333333333333334430.0Topological domainCytoplasmic
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-11117_30710.333333333333334429.0Topological domainExtracellular
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111329_42910.333333333333334429.0Topological domainCytoplasmic
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110308_32810.333333333333334367.0TransmembraneHelical
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111308_32810.333333333333334430.0TransmembraneHelical
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111308_32810.333333333333334429.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FCRL1
KATNA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneKATNA1chr1:157789797chr6:149925919ENST000003356472101_75167.0492.0dynein and NDEL1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003674113111_75167.0492.0dynein and NDEL1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003356472101_29167.0492.0KATNB1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003674113111_29167.0492.0KATNB1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003356472101_185167.0492.0microtubules
TgeneKATNA1chr1:157789797chr6:149925919ENST000003674113111_185167.0492.0microtubules


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Related Drugs to FCRL1-KATNA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FCRL1-KATNA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource