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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FGFR1-TACC1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FGFR1-TACC1
FusionPDB ID: 30266
FusionGDB2.0 ID: 30266
HgeneTgene
Gene symbol

FGFR1

TACC1

Gene ID

2260

6867

Gene namefibroblast growth factor receptor 1transforming acidic coiled-coil containing protein 1
SynonymsBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1Ga55
Cytomap

8p11.23

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgrtransforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
Modification date2020032920200320
UniProtAcc

Q9NVK5

O75410

Ensembl transtripts involved in fusion geneENST idsENST00000326324, ENST00000335922, 
ENST00000341462, ENST00000356207, 
ENST00000397091, ENST00000397103, 
ENST00000397108, ENST00000397113, 
ENST00000425967, ENST00000447712, 
ENST00000532791, ENST00000496629, 
ENST00000276520, ENST00000317827, 
ENST00000330691, ENST00000348567, 
ENST00000379931, ENST00000520611, 
ENST00000520973, ENST00000522752, 
ENST00000443286, ENST00000518415, 
ENST00000519416, ENST00000520340, 
ENST00000520615, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 24 X 9=367218 X 21 X 10=3780
# samples 2023
** MAII scorelog2(20/3672*10)=-4.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3780*10)=-4.03868046816406
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FGFR1 [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FGFR1(38275746)-TACC1(38646222), # samples:2
Anticipated loss of major functional domain due to fusion event.FGFR1-TACC1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR1-TACC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR1-TACC1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

HgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

HgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

HgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

HgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851


check buttonFusion gene breakpoints across FGFR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TACC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HO-01AFGFR1chr8

38275746

-TACC1chr8

38585871

+
ChimerDB4BRCATCGA-C8-A1HO-01AFGFR1chr8

38275746

-TACC1chr8

38599869

+
ChimerDB4BRCATCGA-C8-A1HO-01AFGFR1chr8

38275746

-TACC1chr8

38646222

+
ChimerDB4BRCATCGA-C8-A1HOFGFR1chr8

38275745

-TACC1chr8

38646221

+
ChimerDB4UCECTCGA-AP-A5FX-01AFGFR1chr8

38314873

-TACC1chr8

38630161

-
ChimerKB3..FGFR1chr8

38271669

-TACC1chr8

38697741

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397091FGFR1chr838271669-ENST00000519416TACC1chr838697741+6201292936834301020
ENST00000397091FGFR1chr838271669-ENST00000520615TACC1chr838697741+6201292936834301020
ENST00000397091FGFR1chr838271669-ENST00000443286TACC1chr838697741+3523292936834301020
ENST00000447712FGFR1chr838271669-ENST00000519416TACC1chr838697741+6400312856136291022
ENST00000447712FGFR1chr838271669-ENST00000520615TACC1chr838697741+6400312856136291022
ENST00000447712FGFR1chr838271669-ENST00000443286TACC1chr838697741+3722312856136291022
ENST00000341462FGFR1chr838271669-ENST00000519416TACC1chr838697741+6400312856136291022
ENST00000341462FGFR1chr838271669-ENST00000520615TACC1chr838697741+6400312856136291022
ENST00000341462FGFR1chr838271669-ENST00000443286TACC1chr838697741+3722312856136291022
ENST00000532791FGFR1chr838271669-ENST00000519416TACC1chr838697741+6182291034934111020
ENST00000532791FGFR1chr838271669-ENST00000520615TACC1chr838697741+6182291034934111020
ENST00000532791FGFR1chr838271669-ENST00000443286TACC1chr838697741+3504291034934111020
ENST00000397113FGFR1chr838271669-ENST00000519416TACC1chr838697741+576924971312998955
ENST00000397113FGFR1chr838271669-ENST00000520615TACC1chr838697741+576924971312998955
ENST00000397113FGFR1chr838271669-ENST00000443286TACC1chr838697741+309124971312998955
ENST00000356207FGFR1chr838271669-ENST00000519416TACC1chr838697741+591526433433144933
ENST00000356207FGFR1chr838271669-ENST00000520615TACC1chr838697741+591526433433144933
ENST00000356207FGFR1chr838271669-ENST00000443286TACC1chr838697741+323726433433144933
ENST00000326324FGFR1chr838271669-ENST00000519416TACC1chr838697741+590926373433138931
ENST00000326324FGFR1chr838271669-ENST00000520615TACC1chr838697741+590926373433138931
ENST00000326324FGFR1chr838271669-ENST00000443286TACC1chr838697741+323126373433138931
ENST00000397103FGFR1chr838271669-ENST00000519416TACC1chr838697741+52481976272477816
ENST00000397103FGFR1chr838271669-ENST00000520615TACC1chr838697741+52481976272477816
ENST00000397103FGFR1chr838271669-ENST00000443286TACC1chr838697741+25701976272477816

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30266_30266_1_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000326324_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=931AA_BP=765
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN
EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEME
VLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV
HKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK
PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ
LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW
SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSV
ERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE

--------------------------------------------------------------

>30266_30266_2_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000326324_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=931AA_BP=765
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN
EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEME
VLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV
HKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK
PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ
LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW
SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSV
ERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE

--------------------------------------------------------------

>30266_30266_3_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000326324_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=931AA_BP=765
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN
EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEME
VLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV
HKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK
PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ
LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW
SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSV
ERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE

--------------------------------------------------------------

>30266_30266_4_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000341462_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=1022AA_BP=856
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSVPIDALPSSEDDDDDDDSSSEEKE
TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAE
VLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRPVLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD
KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE
QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKV

--------------------------------------------------------------

>30266_30266_5_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000341462_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=1022AA_BP=856
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSVPIDALPSSEDDDDDDDSSSEEKE
TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAE
VLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRPVLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD
KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE
QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKV

--------------------------------------------------------------

>30266_30266_6_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000341462_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=1022AA_BP=856
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSVPIDALPSSEDDDDDDDSSSEEKE
TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAE
VLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRPVLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD
KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE
QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKV

--------------------------------------------------------------

>30266_30266_7_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000356207_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=933AA_BP=767
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKE
MEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM
AVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK
DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE
EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD
VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN
SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMK

--------------------------------------------------------------

>30266_30266_8_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000356207_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=933AA_BP=767
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKE
MEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM
AVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK
DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE
EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD
VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN
SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMK

--------------------------------------------------------------

>30266_30266_9_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000356207_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=933AA_BP=767
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKE
MEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM
AVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK
DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE
EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD
VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN
SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMK

--------------------------------------------------------------

>30266_30266_10_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397091_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=1020AA_BP=854
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE
YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV
LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH
KLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL
SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS
FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVES

--------------------------------------------------------------

>30266_30266_11_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397091_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=1020AA_BP=854
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE
YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV
LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH
KLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL
SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS
FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVES

--------------------------------------------------------------

>30266_30266_12_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397091_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=1020AA_BP=854
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE
YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV
LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH
KLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL
SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS
FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVES

--------------------------------------------------------------

>30266_30266_13_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397103_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=816AA_BP=650
MSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAA
KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGL
PANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQS
AWLTVTRPVAKALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNS
GVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI
SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC
IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
FKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNE
EALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIA

--------------------------------------------------------------

>30266_30266_14_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397103_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=816AA_BP=650
MSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAA
KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGL
PANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQS
AWLTVTRPVAKALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNS
GVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI
SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC
IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
FKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNE
EALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIA

--------------------------------------------------------------

>30266_30266_15_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397103_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=816AA_BP=650
MSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAA
KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGL
PANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQS
AWLTVTRPVAKALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNS
GVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI
SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC
IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
FKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNE
EALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIA

--------------------------------------------------------------

>30266_30266_16_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397113_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=955AA_BP=789
MRPLPALVPPLFPPPNFSSNSRSGAGEAAAAPQVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLP
EQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV
SDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY
ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM
VGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTS
MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQ

--------------------------------------------------------------

>30266_30266_17_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397113_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=955AA_BP=789
MRPLPALVPPLFPPPNFSSNSRSGAGEAAAAPQVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLP
EQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV
SDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY
ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM
VGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTS
MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQ

--------------------------------------------------------------

>30266_30266_18_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000397113_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=955AA_BP=789
MRPLPALVPPLFPPPNFSSNSRSGAGEAAAAPQVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLP
EQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV
SDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY
ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM
VGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTS
MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQ

--------------------------------------------------------------

>30266_30266_19_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000447712_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=1022AA_BP=856
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD
KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE
QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKV

--------------------------------------------------------------

>30266_30266_20_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000447712_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=1022AA_BP=856
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD
KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE
QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKV

--------------------------------------------------------------

>30266_30266_21_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000447712_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=1022AA_BP=856
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD
KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE
QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKV

--------------------------------------------------------------

>30266_30266_22_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000532791_TACC1_chr8_38697741_ENST00000443286_length(amino acids)=1020AA_BP=854
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL
SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS
FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVES

--------------------------------------------------------------

>30266_30266_23_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000532791_TACC1_chr8_38697741_ENST00000519416_length(amino acids)=1020AA_BP=854
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL
SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS
FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVES

--------------------------------------------------------------

>30266_30266_24_FGFR1-TACC1_FGFR1_chr8_38271669_ENST00000532791_TACC1_chr8_38697741_ENST00000520615_length(amino acids)=1020AA_BP=854
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL
SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS
FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVES

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38275746/chr8:38646222)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR1

Q9NVK5

TACC1

O75410

FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (661) >>>661.pdbFusion protein BP residue: 650
CIF file (661) >>>661.cif		FGFR1chr838271669-TACC1chr838697741+
MSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDD
DDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS
GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCI
VENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS
DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAEVLTLFNVTE
AQSGEYVCKVSNYIGEANQSAWLTVTRPVAKALEERPAVMTSPLYLEIII
YCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTV
SADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI
SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP
GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV
LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTH
QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNEL
KIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLS
DLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEE
KLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEE
816
3D view using mol* of 661 (AA BP:650)
PDB file (713) >>>713.pdbFusion protein BP residue: 765
CIF file (713) >>>713.cif		FGFR1chr838271669-TACC1chr838697741+
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSR
APAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPEAEPPRRARVS
LKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARP
SPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKK
LHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWS
IIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPAN
KTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTA
GVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE
RPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV
HKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYE
LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVK
MLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
SKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYL
ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPV
KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK
EGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEK
EQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVK
QEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE
931
3D view using mol* of 713 (AA BP:765)
PDB file (714) >>>714.pdbFusion protein BP residue: 767
CIF file (714) >>>714.cif		FGFR1chr838271669-TACC1chr838697741+
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSR
APAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPEAEPPRRARVS
LKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARP
SPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKME
KKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT
WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLP
ANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK
TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL
EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM
AVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVA
VKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE
YASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGME
YLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL
PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKL
LKEGHRMDKPSNCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTM
EKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLAR
VKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMK
933
3D view using mol* of 714 (AA BP:767)
PDB file (730) >>>730.pdbFusion protein BP residue: 789
CIF file (730) >>>730.cif		FGFR1chr838271669-TACC1chr838697741+
MRPLPALVPPLFPPPNFSSNSRSGAGEAAAAPQVSLKRRIELTVEYPWRC
GALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPV
EVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEV
QDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEE
KETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRW
LKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL
KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT
CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM
VGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSG
VLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFG
QVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHN
PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA
DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL
WEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELKIVAEYEKTIA
QMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKG
VLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQ
VRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAK
955
3D view using mol* of 730 (AA BP:789)
PDB file (760) >>>760.pdbFusion protein BP residue: 854
CIF file (760) >>>760.cif		FGFR1chr838271669-TACC1chr838697741+
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSR
APAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPEAEPPRRARVS
LKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARP
SPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQL
AESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP
SSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK
FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK
GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEF
MCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV
LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYL
EIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRR
QVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR
DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL
SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA
RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLA
ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDR
IYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC
TNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI
HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQ
1020
3D view using mol* of 760 (AA BP:854)
PDB file (761) >>>761.pdbFusion protein BP residue: 854
CIF file (761) >>>761.cif		FGFR1chr838271669-TACC1chr838697741+
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSR
APAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPEAEPPRRARVS
LKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARP
SPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQL
AESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP
SSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT
VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPS
DKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNV
EFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPL
YLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPL
RRQVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR
DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL
SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA
RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLA
ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDR
IYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC
TNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI
HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQ
1020
3D view using mol* of 761 (AA BP:854)
PDB file (762) >>>762.pdbFusion protein BP residue: 856
CIF file (762) >>>762.cif		FGFR1chr838271669-TACC1chr838697741+
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSR
APAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPEAEPPRRARVS
LKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARP
SPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQL
AESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP
SSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT
VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPS
DKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNV
EFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPL
YLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPL
RRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWEL
PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK
DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL
QARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD
LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALF
DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS
NCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQAL
KIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQK
1022
3D view using mol* of 762 (AA BP:856)
PDB file (763) >>>763.pdbFusion protein BP residue: 856
CIF file (763) >>>763.cif		FGFR1chr838271669-TACC1chr838697741+
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSR
APAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPEAEPPRRARVS
LKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARP
SPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQL
AESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSVPID
ALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAK
TVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVP
SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN
VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAE
VLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRPVLEERPAVMTSPL
YLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPL
RRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWEL
PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK
DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL
QARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD
LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALF
DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS
NCTNELKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS
VERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQAL
KIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQK
1022
3D view using mol* of 763 (AA BP:856)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FGFR1_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FGFR1_TACC1_661_pLDDT.png (AA BP:650)
all structure
FGFR1_TACC1_661_pLDDT_and_active_sites.png (AA BP:650)
all structure
FGFR1_TACC1_661_violinplot.png (AA BP:650)
all structure
FGFR1_TACC1_713_pLDDT.png (AA BP:765)
all structure
FGFR1_TACC1_713_pLDDT_and_active_sites.png (AA BP:765)
all structure
FGFR1_TACC1_713_violinplot.png (AA BP:765)
all structure
FGFR1_TACC1_714_pLDDT.png (AA BP:767)
all structure
FGFR1_TACC1_714_pLDDT_and_active_sites.png (AA BP:767)
all structure
FGFR1_TACC1_714_violinplot.png (AA BP:767)
all structure
FGFR1_TACC1_730_pLDDT.png (AA BP:789)
all structure
FGFR1_TACC1_730_pLDDT_and_active_sites.png (AA BP:789)
all structure
FGFR1_TACC1_730_violinplot.png (AA BP:789)
all structure
FGFR1_TACC1_760_pLDDT.png (AA BP:854)
all structure
FGFR1_TACC1_760_pLDDT_and_active_sites.png (AA BP:854)
all structure
FGFR1_TACC1_760_violinplot.png (AA BP:854)
all structure
FGFR1_TACC1_761_pLDDT.png (AA BP:854)
all structure
FGFR1_TACC1_761_pLDDT_and_active_sites.png (AA BP:854)
all structure
FGFR1_TACC1_761_violinplot.png (AA BP:854)
all structure
FGFR1_TACC1_762_pLDDT.png (AA BP:856)
all structure
FGFR1_TACC1_762_pLDDT_and_active_sites.png (AA BP:856)
all structure
FGFR1_TACC1_762_violinplot.png (AA BP:856)
all structure
FGFR1_TACC1_763_pLDDT.png (AA BP:856)
all structure
FGFR1_TACC1_763_pLDDT_and_active_sites.png (AA BP:856)
all structure
FGFR1_TACC1_763_violinplot.png (AA BP:856)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
FGFR1_TACC1_661.png
all structure
FGFR1_TACC1_713.png
all structure
FGFR1_TACC1_714.png
all structure
FGFR1_TACC1_730.png
all structure
FGFR1_TACC1_760.png
all structure
FGFR1_TACC1_761.png
all structure
FGFR1_TACC1_762.png
all structure
FGFR1_TACC1_763.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
6611.0832021.122435.2670.4310.7691.0431.340.8581.5621.541Chain A: 17,20,21,22,24,25,26,28,29,31,32,33,34,60
4,605,608,609,611,612,615,622,638,639,640,641,642,
643,646,652,656
7131.0845781.141828.190.530.740.9641.1370.7481.520.943Chain A: 104,105,106,107,108,109,110,111,112,113,1
14,115,116,117,118,119,120,122,123,124,125,126,127
,128,129,133,134,136,137,140,141,143,144,145,701,7
04,705,706,709,710,714,716,717,719,720,722,723,724
,726,727,730,737,749,750,752,754,755,757,758,761,7
62,763,764,765,768,771,772,775,814,817,818,820,821
,824,825,828,831,832,834,835,838,839
7140.9954131.0281153.1660.6530.6660.830.2980.9570.3110.854Chain A: 207,208,209,210,230,233,235,237,238,239,2
40,241,242,243,244,245,254,255,256,257,259,260,261
,262,287,288,290,316,317,318,319,320,321,322,323,3
25,358,362,612,613,615,617,618,619,620,621,622,623
,624,625,627,628,629,693,694,703,729,733,735,736,7
37,738,739,740,741,742,743,744,745,746,749,750,755
,756,757,758,759,760,761,762
7301.1121871.218802.620.690.680.7681.4620.3973.6792.182Chain A: 664,665,668,669,671,672,674,675,679,680,6
81,739,742,743,744,746,747,748,750,751,754,761,778
,779,781,782,788,791,792,795,796,799,800,803,804,8
07,824,827,828,830,831,832,834,835,838,839
7601.0573241.0921009.1060.5490.7430.9721.0510.9021.1650.887Chain A: 609,610,612,613,614,615,616,617,637,639,6
40,641,648,649,652,653,655,656,658,659,660,662,663
,670,686,687,688,689,690,692,693,696,742,743,744,7
47,748,752,753,755,765,766,767,768,769,770,771,772
,775,776,777,778,780,781,782,783,785,786,787,788,7
91,792,800,802,810
7611.0184641.0441198.7850.4790.7070.9490.560.9820.570.689Chain A: 297,298,315,316,317,323,324,325,326,327,3
29,330,331,332,333,334,335,336,337,338,345,346,348
,691,695,696,697,699,700,701,702,703,704,705,706,7
07,708,709,710,711,712,714,715,716,717,790,816,820
,822,823,824,827,828,829,830,831
7621.0623121.112979.2650.5580.720.9361.2320.7971.5460.805Chain A: 611,612,613,614,615,616,617,618,619,639,6
41,642,643,650,651,654,655,657,658,660,661,662,664
,665,672,686,688,689,690,691,694,695,698,744,745,7
46,749,754,755,757,767,768,769,770,771,773,774,775
,776,777,778,779,780,781,782,783,784,787,788,789,7
90,794,801,802,803,804
7631.0348471.0632437.0150.5150.7230.9670.7540.9530.7910.749Chain A: 298,299,315,316,317,318,324,325,326,327,3
28,330,331,332,333,334,335,336,337,338,339,344,345
,346,347,348,349,361,611,612,614,615,616,617,618,6
19,639,641,642,643,650,651,654,655,658,660,661,662
,664,665,672,688,689,690,691,692,693,694,695,697,6
98,699,701,702,703,704,705,706,707,708,709,710,711
,712,713,714,715,716,717,718,719,744,745,746,748,7
49,750,754,755,757,767,768,769,770,771,773,774,776
,777,778,779,780,781,782,784,787,788,789,790,791,7
92,793,794,802,803,804,818,821,822,824,825,826,827
,828,829,830,831,832,833,834,844,846,847,848,849,8
50,851

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FGFR1FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1, RASA1, CDH2, ZMYM2, FGF4, OPCML, SHC1, S100B, AGER, KLB, CDH11, TGFBR3, PTPN1, IL17RD, FBXO7, CRKL, RPN1, STOML2, DDOST, CANX, LMAN2, TMED9, RCN2, HSPA6, CDC37, HSPA2, ACTG1, ACTA1, PARD3, PGRMC1, PHGDH, ATP5B, VDAC1, VDAC2, SLC25A6, RUVBL2, RPA1, PLCG2, RAP1A, PHB, RAB1A, RAB5A, RAB8A, RAB4A, RAB14, RAB15, ARF4, RAB2B, RAB9A, COPA, SEC22B, TMEM109, STX12, CLPTM1, HSPA1L, DNAJC13, DNAJB1, TUBB4A, TUBA4A, AFAP1, TUBA1B, MTCH1, BAX, IMMT, GNB1, RAB7A, RAB11B, GAB1, PTPN11, RXRA, RARA, Nr4a2, H3F3A, Nr4a1, TH, UBC, SHE, Il17rd, PDGFRB, MFHAS1, PDK1, HEXIM1, LARP7, GNAI1, RIN1, ITGB3, KIAA1429, ERBB2, APEX1, ORF3a, ORF3b, CORO1C, HSP90AB3P, HSP90AB1, BAG2, MRPS7, MRPS31, MRPS14, P4HB, CDK1, HPX, ATP5O, LIMA1, TMOD3, CORO1B, ACTB, PLEC, RPL22L1, PPM1B, TBL2, DIMT1, SPATS2L, FARSB, HSD17B10, NUFIP2, TRMT10C, SND1, OBSCN, AIMP2, RARS, SRP19, POLRMT, MRPS2, MRPS26, BOLA2, ARGLU1, PFKFB3, MRPS6, CFL1, MRPS33, RPL22, KCTD5, HSPD1, EGFR, HULC, LDHA, MKRN2, DDX58, MLC1, IL3RA, IL32, AQP9, KCNE3, UGT1A7, GJA8, CLEC4A, AVPR1B, DEFB135, RNF149, C7orf34, EPB41L4A, CRLF2, DEFB109P1B, TBXA2R, NRSN1, OR1M1, IFNAR1, SYT2, CDH16, FBXO2, TSHR, MFI2, BCAN, CSNK1G2, CDHR4, CTSG, C1QTNF9B, PCDHA8, IZUMO1, CD8B, SFTPC, GREM2, DHFRL1, CD83, KCNC3, ANK1, PTPRN2, TMEM59, PCDHB7, P2RX4,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FGFR1all structure
TACC1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FGFR1-TACC1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
FGFR1TACC1Pazopanib/Topotecan TherapyPubMed34749374

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Related Diseases to FGFR1-TACC1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
FGFR1TACC1Low-Grade Neuroepithelial TumorsPubMed34749374
FGFR1TACC1Breast Invasive Ductal CarcinomaMyCancerGenome
FGFR1TACC1Colon AdenocarcinomaMyCancerGenome
FGFR1TACC1Dysembryoplastic Neuroepithelial TumorMyCancerGenome
FGFR1TACC1High Grade Ovarian Serous AdenocarcinomaMyCancerGenome
FGFR1TACC1Invasive Breast CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)18CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate6GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0011570Mental Depression5PSYGENET
HgeneFGFR1C0011581Depressive disorder5CTD_human;PSYGENET
HgeneFGFR1C0220658Pfeiffer Syndrome5GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C0432283Osteoglophonic dwarfism5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0041696Unipolar Depression4CTD_human;PSYGENET
HgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0005586Bipolar Disorder3PSYGENET
HgeneFGFR1C0795998JACKSON-WEISS SYNDROME3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
HgeneFGFR1C0006142Malignant neoplasm of breast2CGI;CTD_human
HgeneFGFR1C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneFGFR1C0007137Squamous cell carcinoma2CTD_human
HgeneFGFR1C0027022Myeloproliferative disease2CTD_human
HgeneFGFR1C0162809Kallmann Syndrome2CTD_human;ORPHANET
HgeneFGFR1C0432122Interfrontal craniofaciosynostosis2GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C0678222Breast Carcinoma2CGI;CTD_human
HgeneFGFR1C1257931Mammary Neoplasms, Human2CTD_human
HgeneFGFR1C1458155Mammary Neoplasms2CTD_human
HgeneFGFR1C4704874Mammary Carcinoma, Human2CTD_human
HgeneFGFR1C0004114Astrocytoma1CTD_human
HgeneFGFR1C0008924Cleft upper lip1CTD_human
HgeneFGFR1C0008925Cleft Palate1CTD_human
HgeneFGFR1C0010278Craniosynostosis1CTD_human;GENOMICS_ENGLAND
HgeneFGFR1C0011573Endogenous depression1CTD_human
HgeneFGFR1C0017638Glioma1CTD_human
HgeneFGFR1C0018824Heart valve disease1CTD_human
HgeneFGFR1C0024121Lung Neoplasms1CTD_human
HgeneFGFR1C0025193Melancholia1CTD_human
HgeneFGFR1C0036341Schizophrenia1CTD_human
HgeneFGFR1C0085682Hypophosphatemia1GENOMICS_ENGLAND
HgeneFGFR1C0086133Depressive Syndrome1CTD_human
HgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
HgeneFGFR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneFGFR1C0206726gliosarcoma1ORPHANET
HgeneFGFR1C0242379Malignant neoplasm of lung1CTD_human
HgeneFGFR1C0259783mixed gliomas1CTD_human
HgeneFGFR1C0265535Trigonocephaly1CTD_human;ORPHANET
HgeneFGFR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneFGFR1C0280785Diffuse Astrocytoma1CTD_human
HgeneFGFR1C0282126Depression, Neurotic1CTD_human
HgeneFGFR1C0334579Anaplastic astrocytoma1CTD_human
HgeneFGFR1C0334580Protoplasmic astrocytoma1CTD_human
HgeneFGFR1C0334581Gemistocytic astrocytoma1CTD_human
HgeneFGFR1C0334582Fibrillary Astrocytoma1CTD_human
HgeneFGFR1C0334583Pilocytic Astrocytoma1CTD_human
HgeneFGFR1C0334588Giant Cell Glioblastoma1ORPHANET
HgeneFGFR1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneFGFR1C0338503Septo-Optic Dysplasia1ORPHANET
HgeneFGFR1C0342384Idiopathic hypogonadotropic hypogonadism1GENOMICS_ENGLAND
HgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
HgeneFGFR1C0431362Lobar Holoprosencephaly1ORPHANET
HgeneFGFR1C0547065Mixed oligoastrocytoma1CTD_human
HgeneFGFR1C0555198Malignant Glioma1CTD_human
HgeneFGFR1C0750935Cerebral Astrocytoma1CTD_human
HgeneFGFR1C0750936Intracranial Astrocytoma1CTD_human
HgeneFGFR1C0751617Semilobar Holoprosencephaly1ORPHANET
HgeneFGFR1C1519086Pilomyxoid astrocytoma1ORPHANET
HgeneFGFR1C1704230Grade I Astrocytoma1CTD_human
HgeneFGFR1C1837218Cleft palate, isolated1CTD_human
HgeneFGFR1C1852406Cutis Gyrata Syndrome of Beare And Stevenson1GENOMICS_ENGLAND
HgeneFGFR1C2931196Craniofacial dysostosis type 11GENOMICS_ENGLAND
HgeneFGFR1C3150773CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME1ORPHANET
TgeneTACC1C0206726gliosarcoma1ORPHANET
TgeneTACC1C0334588Giant Cell Glioblastoma1ORPHANET