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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FGFR3-BAIAP2L1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FGFR3-BAIAP2L1
	FusionPDB ID: 30301
	FusionGDB2.0 ID: 30301
		Hgene	Tgene
	Gene symbol	FGFR3	BAIAP2L1
	Gene ID	2261	55971
	Gene name	fibroblast growth factor receptor 3	BAR/IMD domain containing adaptor protein 2 like 1
	Synonyms	ACH\|CD333\|CEK2\|HSFGFR3EX\|JTK4	IRTKS
	Cytomap	4p16.3	7q21.3-q22.1
	Type of gene	protein-coding	protein-coding
	Description	fibroblast growth factor receptor 3FGFR-3fibroblast growth factor receptor 3 variant 4fibroblast growth factor receptor 3-Shydroxyaryl-protein kinasetyrosine kinase JTK4	brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1BAI1 associated protein 2 like 1BAI1-associated protein 2-like protein 1insulin receptor tyrosine kinase substrate
	Modification date	20200313	20200313
	UniProtAcc	P22607	Q9UHR4
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000260795, ENST00000340107, ENST00000352904, ENST00000412135, ENST00000440486, ENST00000481110, ENST00000474521,	ENST00000462558, ENST00000005260,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 22 X 14=3080	16 X 9 X 7=1008
	# samples	33	16
	** MAII score	log2(33/3080*10)=-3.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1008*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FGFR3 [Title/Abstract] AND BAIAP2L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FGFR3(1808661)-BAIAP2L1(97991744), # samples:2
Anticipated loss of major functional domain due to fusion event.	FGFR3-BAIAP2L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FGFR3-BAIAP2L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FGFR3-BAIAP2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FGFR3-BAIAP2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FGFR3-BAIAP2L1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. FGFR3-BAIAP2L1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FGFR3-BAIAP2L1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FGFR3	GO:0008543	fibroblast growth factor receptor signaling pathway	8663044
Hgene	FGFR3	GO:0018108	peptidyl-tyrosine phosphorylation	11294897
Hgene	FGFR3	GO:0046777	protein autophosphorylation	11294897
Tgene	BAIAP2L1	GO:0009617	response to bacterium	19366662
Tgene	BAIAP2L1	GO:0030838	positive regulation of actin filament polymerization	21098279

Fusion gene breakpoints across FGFR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BAIAP2L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97949610	-
ChimerKB3	.	.	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-
ChiTaRS5.0	N/A	JE837678	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-
ChiTaRS5.0	N/A	JE837684	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000481110	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97949610	-	5659	2467	228	3788	1186
ENST00000440486	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5885	2530	223	4014	1263
ENST00000412135	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5549	2194	223	3678	1151
ENST00000340107	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5891	2536	223	4020	1265
ENST00000260795	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5731	2376	69	3860	1263
ENST00000352904	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5332	1977	6	3461	1151
ENST00000440486	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5885	2530	223	4014	1263
ENST00000412135	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5549	2194	223	3678	1151
ENST00000340107	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5891	2536	223	4020	1265
ENST00000260795	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5731	2376	69	3860	1263
ENST00000352904	FGFR3	chr4	1808661	+	ENST00000005260	BAIAP2L1	chr7	97991744	-	5332	1977	6	3461	1151

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000440486	ENST00000005260	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	0.001116543	0.9988834
ENST00000412135	ENST00000005260	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	0.001734099	0.9982659
ENST00000340107	ENST00000005260	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	0.001075541	0.99892443
ENST00000260795	ENST00000005260	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	0.00091506	0.99908495
ENST00000352904	ENST00000005260	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	0.001339923	0.9986601

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30301_30301_1_FGFR3-BAIAP2L1_FGFR3_chr4_1808661_ENST00000260795_BAIAP2L1_chr7_97991744_ENST00000005260_length(amino acids)=1263AA_BP=769
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKI
GEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQ
GSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEK
IMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQR
SVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPV
RSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRSAP

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>30301_30301_2_FGFR3-BAIAP2L1_FGFR3_chr4_1808661_ENST00000340107_BAIAP2L1_chr7_97991744_ENST00000005260_length(amino acids)=1265AA_BP=771
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVA
KIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRK
SQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVP
EKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSL
QRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPT
PVRSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRS

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>30301_30301_3_FGFR3-BAIAP2L1_FGFR3_chr4_1808661_ENST00000352904_BAIAP2L1_chr7_97991744_ENST00000005260_length(amino acids)=1151AA_BP=657
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISS
THKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSR
QSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQA
SPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPH
TAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYL

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>30301_30301_4_FGFR3-BAIAP2L1_FGFR3_chr4_1808661_ENST00000412135_BAIAP2L1_chr7_97991744_ENST00000005260_length(amino acids)=1151AA_BP=657
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISS
THKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSR
QSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQA
SPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPH
TAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYL

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>30301_30301_5_FGFR3-BAIAP2L1_FGFR3_chr4_1808661_ENST00000440486_BAIAP2L1_chr7_97991744_ENST00000005260_length(amino acids)=1263AA_BP=769
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKI
GEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQ
GSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEK
IMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQR
SVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPV
RSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRSAP

--------------------------------------------------------------

>30301_30301_6_FGFR3-BAIAP2L1_FGFR3_chr4_1808661_ENST00000481110_BAIAP2L1_chr7_97949610_ENST00000005260_length(amino acids)=1186AA_BP=747
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQQVSLESNASMSSNTPLV
RIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEM
MKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDL
AARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNLVLWGPALGDLHAGGLPVPRHPCGGALQAAEGGPPHGQARQLHTRPVHDHAGVLA
CRALPEAHLQAAGGGPGPCPYRDVHRRHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEK
SQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRW
QETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVN
NSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENET
EAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATV

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:1808661/chr7:97991744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FGFR3 P22607	BAIAP2L1 Q9UHR4
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269\|PubMed:10611230, ECO:0000269\|PubMed:11294897, ECO:0000269\|PubMed:11703096, ECO:0000269\|PubMed:14534538, ECO:0000269\|PubMed:16410555, ECO:0000269\|PubMed:16597617, ECO:0000269\|PubMed:17145761, ECO:0000269\|PubMed:17311277, ECO:0000269\|PubMed:17509076, ECO:0000269\|PubMed:17561467, ECO:0000269\|PubMed:19088846, ECO:0000269\|PubMed:19286672, ECO:0000269\|PubMed:8663044}.	FUNCTION: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269\|PubMed:17430976, ECO:0000269\|PubMed:19366662, ECO:0000269\|PubMed:22921828}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

151_244

758.0

807.0

Domain

Note=Ig-like C2-type 2

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

24_126

758.0

807.0

Domain

Note=Ig-like C2-type 1

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

253_355

758.0

807.0

Domain

Note=Ig-like C2-type 3

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

472_761

758.0

807.0

Domain

Protein kinase

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

151_244

760.0

809.0

Domain

Note=Ig-like C2-type 2

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

24_126

760.0

809.0

Domain

Note=Ig-like C2-type 1

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

253_355

760.0

809.0

Domain

Note=Ig-like C2-type 3

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

472_761

760.0

809.0

Domain

Protein kinase

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

151_244

646.0

695.0

Domain

Note=Ig-like C2-type 2

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

24_126

646.0

695.0

Domain

Note=Ig-like C2-type 1

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

253_355

646.0

695.0

Domain

Note=Ig-like C2-type 3

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

151_244

646.0

695.0

Domain

Note=Ig-like C2-type 2

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

24_126

646.0

695.0

Domain

Note=Ig-like C2-type 1

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

253_355

646.0

695.0

Domain

Note=Ig-like C2-type 3

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

151_244

758.0

807.0

Domain

Note=Ig-like C2-type 2

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

24_126

758.0

807.0

Domain

Note=Ig-like C2-type 1

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

253_355

758.0

807.0

Domain

Note=Ig-like C2-type 3

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

472_761

758.0

807.0

Domain

Protein kinase

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

478_486

758.0

807.0

Nucleotide binding

ATP

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

478_486

760.0

809.0

Nucleotide binding

ATP

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

478_486

646.0

695.0

Nucleotide binding

ATP

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

478_486

646.0

695.0

Nucleotide binding

ATP

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

478_486

758.0

807.0

Nucleotide binding

ATP

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

23_375

758.0

807.0

Topological domain

Extracellular

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

23_375

760.0

809.0

Topological domain

Extracellular

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

23_375

646.0

695.0

Topological domain

Extracellular

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

23_375

646.0

695.0

Topological domain

Extracellular

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

23_375

758.0

807.0

Topological domain

Extracellular

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

376_396

758.0

807.0

Transmembrane

Helical

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

376_396

760.0

809.0

Transmembrane

Helical

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

376_396

646.0

695.0

Transmembrane

Helical

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

376_396

646.0

695.0

Transmembrane

Helical

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

376_396

758.0

807.0

Transmembrane

Helical

Tgene

BAIAP2L1

chr4:1808661

chr7:97991744

ENST00000005260

115_154

17.0

512.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BAIAP2L1

chr4:1808661

chr7:97991744

ENST00000005260

339_402

17.0

512.0

Domain

SH3

Tgene

BAIAP2L1

chr4:1808661

chr7:97991744

ENST00000005260

483_511

17.0

512.0

Region

Note=Binds F-actin

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

472_761

646.0

695.0

Domain

Protein kinase

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

472_761

646.0

695.0

Domain

Protein kinase

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000260795

397_806

758.0

807.0

Topological domain

Cytoplasmic

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000340107

397_806

760.0

809.0

Topological domain

Cytoplasmic

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000352904

397_806

646.0

695.0

Topological domain

Cytoplasmic

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000412135

397_806

646.0

695.0

Topological domain

Cytoplasmic

Hgene

FGFR3

chr4:1808661

chr7:97991744

ENST00000440486

397_806

758.0

807.0

Topological domain

Cytoplasmic

Tgene

BAIAP2L1

chr4:1808661

chr7:97991744

ENST00000005260

1_249

17.0

512.0

Domain

IMD

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (829) >>>829.pdbFusion protein BP residue: 657 CIF file (829) >>>829.cif	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVP GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV GPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGED EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL KNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQ TYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLK HVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTL ANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAK PVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQV ARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRV LTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGE IATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIEL DVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKE IEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYY HLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQA SPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPN SQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLS FAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTV PTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTS TFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRSAPII	1151
3D view using mol* of 829 (AA BP:657)


PDB file (843) >>>843.pdbFusion protein BP residue: 747 CIF file (843) >>>843.cif	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97949610	-	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVP GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV GPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGED EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL KNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQ TYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLK HVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC LAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILV VAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQQVSLESNASMSSNTPLV RIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVM AEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQ LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL ARDVHNLDYYKKTTNLVLWGPALGDLHAGGLPVPRHPCGGALQAAEGGPP HGQARQLHTRPVHDHAGVLACRALPEAHLQAAGGGPGPCPYRDVHRRHVL IEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTE HKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQ KFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRW QETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYD TLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPS LQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEK DGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRSISTVN LSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPN	1186
3D view using mol* of 843 (AA BP:747)


PDB file (871)CIF file (871) >>>871.cif	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVP GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV GPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGED EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL KNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQ TYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLK HVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC LAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILV VAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMA EAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNII NLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQL TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLA RDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT LGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP TFKQLVEDLDRVLTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMILAG KAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHK EIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQ GSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVD KHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKT PASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLI DMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIF PHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTK LLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAA ADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLR	1263
3D view using mol* of 871 (AA BP:)


PDB file (872)CIF file (872) >>>872.cif	FGFR3	chr4	1808661	+	BAIAP2L1	chr7	97991744	-	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVP GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV GPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGED EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL KNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQ TYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLK HVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCR ATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFI LVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVV MAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEE QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFG LARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQ RPTFKQLVEDLDRVLTVTSTDNVMEQFNPGLRNLINLGKNYEKAVNAMIL AGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKF HKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRK SQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFL VDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEI KTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSP LIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKT IFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSY TKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMG AAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVK	1265
3D view using mol* of 872 (AA BP:)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FGFR3_pLDDT.png

BAIAP2L1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FGFR3_BAIAP2L1_829_pLDDT.png (AA BP:657)

FGFR3_BAIAP2L1_829_pLDDT_and_active_sites.png (AA BP:657)

FGFR3_BAIAP2L1_829_violinplot.png (AA BP:657)

FGFR3_BAIAP2L1_843_pLDDT.png (AA BP:747)

FGFR3_BAIAP2L1_843_pLDDT_and_active_sites.png (AA BP:747)

FGFR3_BAIAP2L1_843_violinplot.png (AA BP:747)

FGFR3_BAIAP2L1_871_pLDDT_and_active_sites.png (AA BP:)

FGFR3_BAIAP2L1_871_violinplot.png (AA BP:)

FGFR3_BAIAP2L1_872_pLDDT_and_active_sites.png (AA BP:)

FGFR3_BAIAP2L1_872_violinplot.png (AA BP:)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

FGFR3_BAIAP2L1_829.png

FGFR3_BAIAP2L1_843.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
829	1.0228	389	1.039	1003.275	0.482	0.7322	0.9769	1.0116	1.044	0.969	0.8296	Chain A: 319,320,321,322,323,375,377,378,380,381,3 82,383,384,385,405,407,408,409,416,417,420,421,424 ,428,438,454,455,456,457,460,461,515,520,521,523,5 33,534,535,536,537,539,540,543,544,545,546,547,548 ,549,550,551,552,553,554,555,556,560,564,565,566,5 68,569,570
843	1.0671	588	1.1334	1852.886	0.5661	0.6976	0.8934	1.3366	0.6904	1.9359	0.9596	Chain A: 180,182,214,227,228,575,576,578,579,580,5 82,583,584,589,590,597,599,600,601,602,603,604,605 ,606,607,608,609,610,611,612,613,614,617,621,630,6 31,632,635,641,643,712,713,714,715,716,717,718,719 ,720,721,722,724,725,726,727,728,729,730,731,742,7 46,747,749,750,753,754,757,760,761,764,765,767,768 ,770,771,878,881,882,885,886,887,889,890,893,894,8 97,898,900,901,902,903,904,905,906,907,908,1176,11 77,1178,1179,1180,1181
871	1.071	311	1.118	728.875	0.425	0.737	0.971	1.104	0.809	1.364	0.839	Chain A: 770,771,774,775,776,777,778,779,782,859,8 63,866,867,870,871,874,930,933,934,936,937,938,940 ,941,944,945,947,948,1243,1244,1245,1247,1248,1249 ,1250,1251,1261,1262,1263
872	1.091	226	1.14	604.023	0.504	0.761	0.951	1.263	0.787	1.606	1.181	Chain A: 773,776,777,778,779,780,781,784,858,861,8 62,865,868,869,872,873,876,880,932,935,936,938,939 ,940,942,943,946,947,949,950,1244,1245,1246,1247,1 248,1249,1250,1251,1264,1265

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

FGFR3

C6orf47, SMG7, BORA, CCDC17, HBZ, HNRNPL, NDUFS6, RNF130, ATF3, ARAP1, CHGB, CTSK, RADIL, GTF3C1, KRT8, POLA2, KIAA1377, RPL8, SLC25A6, Sh2b1, SH2B1, FGF9, FGF1, GRB2, FGF8, HSP90AA1, HSP90AB1, HSPA1B, HSPA8, CDC37, HSPA4, SOCS1, SOCS3, FGFR3, SNX11, TMEM231, ILKAP, SRPK2, PVRL1, BRD4, VHL, FNTA, CDK6, FGFR2, TMEM30B, ARRDC3, SDC2, EPHA4, KAL1, RPS6KA3, fgf3, KLB, CSPG4, HEXIM1, LARP7, MAP3K4, CDC25A, DCXR, ERBB2, BRD2, OXT, PRKAR1A, POMC, CUL4B, ATG5, MKRN2, ABCA2, CTLA4, POTEI, TNFRSF10A, MPDZ, SDC4, CLEC4A, CRLF2, FBXO2, ALG6, TM2D3, KLK1, PI15, FSTL4, PRG2, TMEM87A, PDGFRA, LY86, MFAP4, FHL3, DNASE1L1, CELA2B, FBXO6, SIRPD, CBLN4, KLK3, EDN3, PRTN3, ELSPBP1, LYPD4, GGH, GPIHBP1, IL5RA, DNAJB9, TCTN1, UQCC1, LIPG, FCGR3B, SDF2L1, EPDR1, ADAMTS12, IGLL5, CFC1, C1QB,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FGFR3
BAIAP2L1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FGFR3-BAIAP2L1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FGFR3-BAIAP2L1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
FGFR3	BAIAP2L1	Adamantinomatous Craniopharyngioma	MyCancerGenome
FGFR3	BAIAP2L1	Breast Invasive Ductal Carcinoma	MyCancerGenome
FGFR3	BAIAP2L1	Gastric Adenocarcinoma	MyCancerGenome
FGFR3	BAIAP2L1	Glioblastoma	MyCancerGenome
FGFR3	BAIAP2L1	Uterine Corpus Leiomyosarcoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FGFR3	C0001080	Achondroplasia	13	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C0410529	Hypochondroplasia (disorder)	10	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C1864436	Muenke Syndrome	9	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C1868678	THANATOPHORIC DYSPLASIA, TYPE I (disorder)	9	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	FGFR3	C2677099	CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS (disorder)	7	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	FGFR3	C0005684	Malignant neoplasm of urinary bladder	6	CGI;CTD_human;UNIPROT
Hgene	FGFR3	C0005695	Bladder Neoplasm	4	CGI;CTD_human
Hgene	FGFR3	C1300257	Thanatophoric dysplasia, type 2	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	FGFR3	C1864852	CATSHL syndrome	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C2674173	Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C0265269	Lacrimoauriculodentodigital syndrome	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Hgene	FGFR3	C0008924	Cleft upper lip	1	CTD_human
Hgene	FGFR3	C0008925	Cleft Palate	1	CTD_human
Hgene	FGFR3	C0014544	Epilepsy	1	GENOMICS_ENGLAND
Hgene	FGFR3	C0014547	Epilepsies, Partial	1	GENOMICS_ENGLAND
Hgene	FGFR3	C0022603	Seborrheic keratosis	1	UNIPROT
Hgene	FGFR3	C0026764	Multiple Myeloma	1	CGI;CTD_human
Hgene	FGFR3	C0036631	Seminoma	1	CTD_human
Hgene	FGFR3	C0039743	Thanatophoric Dysplasia	1	CTD_human
Hgene	FGFR3	C0152423	Congenital small ears	1	GENOMICS_ENGLAND
Hgene	FGFR3	C0206726	gliosarcoma	1	ORPHANET
Hgene	FGFR3	C0221356	Brachycephaly	1	ORPHANET
Hgene	FGFR3	C0265529	Plagiocephaly	1	ORPHANET
Hgene	FGFR3	C0334082	NEVUS, EPIDERMAL (disorder)	1	CTD_human;UNIPROT
Hgene	FGFR3	C0334588	Giant Cell Glioblastoma	1	ORPHANET
Hgene	FGFR3	C0406803	Syringocystadenoma Papilliferum	1	GENOMICS_ENGLAND
Hgene	FGFR3	C1336708	Testicular Germ Cell Tumor	1	CTD_human;UNIPROT
Hgene	FGFR3	C1837218	Cleft palate, isolated	1	CTD_human
Hgene	FGFR3	C4048328	cervical cancer	1	CTD_human;UNIPROT
Tgene	BAIAP2L1	C0003873	Rheumatoid Arthritis	1	CTD_human