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Fusion Protein:FILIP1-KCNQ5 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: FILIP1-KCNQ5 | FusionPDB ID: 30418 | FusionGDB2.0 ID: 30418 | Hgene | Tgene | Gene symbol | FILIP1 | KCNQ5 | Gene ID | 27145 | 56479 |
| Gene name | filamin A interacting protein 1 | potassium voltage-gated channel subfamily Q member 5 | |
| Synonyms | FILIP | Kv7.5|MRD46 | |
| Cytomap | 6q14.1 | 6q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | filamin-A-interacting protein 1 | potassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | Q4L180 | Q9NR82 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000237172, ENST00000393004, ENST00000370020, ENST00000498523, | ENST00000342056, ENST00000355194, ENST00000355635, ENST00000370392, ENST00000370398, ENST00000402622, ENST00000403813, ENST00000414165, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 4 X 4 X 3=48 | 6 X 6 X 3=108 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: FILIP1 [Title/Abstract] AND KCNQ5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FILIP1(76124413)-KCNQ5(73814980), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FILIP1-KCNQ5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FILIP1-KCNQ5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KCNQ5 | GO:0071805 | potassium ion transmembrane transport | 10787416|11159685 |
| Fusion gene breakpoints across FILIP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KCNQ5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UVM | TCGA-VD-A8KJ-01A | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000342056 | KCNQ5 | chr6 | 73814980 | + | 5870 | 498 | 222 | 2435 | 737 |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000355194 | KCNQ5 | chr6 | 73814980 | + | 5799 | 498 | 222 | 2378 | 718 |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000370398 | KCNQ5 | chr6 | 73814980 | + | 5816 | 498 | 222 | 2378 | 718 |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000370392 | KCNQ5 | chr6 | 73814980 | + | 965 | 498 | 222 | 863 | 213 |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000355635 | KCNQ5 | chr6 | 73814980 | + | 2382 | 498 | 222 | 2381 | 719 |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000414165 | KCNQ5 | chr6 | 73814980 | + | 2049 | 498 | 222 | 2048 | 608 |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000402622 | KCNQ5 | chr6 | 73814980 | + | 2409 | 498 | 222 | 2408 | 728 |
| ENST00000393004 | FILIP1 | chr6 | 76124413 | - | ENST00000403813 | KCNQ5 | chr6 | 73814980 | + | 2352 | 498 | 222 | 2351 | 709 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000342056 | KCNQ5 | chr6 | 73814980 | + | 5979 | 607 | 331 | 2544 | 737 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000355194 | KCNQ5 | chr6 | 73814980 | + | 5908 | 607 | 331 | 2487 | 718 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000370398 | KCNQ5 | chr6 | 73814980 | + | 5925 | 607 | 331 | 2487 | 718 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000370392 | KCNQ5 | chr6 | 73814980 | + | 1074 | 607 | 331 | 972 | 213 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000355635 | KCNQ5 | chr6 | 73814980 | + | 2491 | 607 | 331 | 2490 | 720 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000414165 | KCNQ5 | chr6 | 73814980 | + | 2158 | 607 | 331 | 2157 | 609 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000402622 | KCNQ5 | chr6 | 73814980 | + | 2518 | 607 | 331 | 2517 | 729 |
| ENST00000237172 | FILIP1 | chr6 | 76124413 | - | ENST00000403813 | KCNQ5 | chr6 | 73814980 | + | 2461 | 607 | 331 | 2460 | 710 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000393004 | ENST00000342056 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.003119799 | 0.9968802 |
| ENST00000393004 | ENST00000355194 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.002596711 | 0.9974032 |
| ENST00000393004 | ENST00000370398 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.002541909 | 0.99745816 |
| ENST00000393004 | ENST00000370392 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.021487921 | 0.9785121 |
| ENST00000393004 | ENST00000355635 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.011214123 | 0.98878586 |
| ENST00000393004 | ENST00000414165 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.00853875 | 0.9914613 |
| ENST00000393004 | ENST00000402622 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.011710679 | 0.98828936 |
| ENST00000393004 | ENST00000403813 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.011098061 | 0.988902 |
| ENST00000237172 | ENST00000342056 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.003148864 | 0.99685115 |
| ENST00000237172 | ENST00000355194 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.002637469 | 0.99736255 |
| ENST00000237172 | ENST00000370398 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.002569479 | 0.9974305 |
| ENST00000237172 | ENST00000370392 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.016869608 | 0.98313034 |
| ENST00000237172 | ENST00000355635 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.010941481 | 0.98905855 |
| ENST00000237172 | ENST00000414165 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.008273205 | 0.99172676 |
| ENST00000237172 | ENST00000402622 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.01147429 | 0.9885257 |
| ENST00000237172 | ENST00000403813 | FILIP1 | chr6 | 76124413 | - | KCNQ5 | chr6 | 73814980 | + | 0.010857136 | 0.98914284 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >30418_30418_1_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000342056_length(amino acids)=737AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSSKFCSNKQKLFRMYTSRKQSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSW SFNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSA GHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQ IPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQ INTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKD LGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSIC -------------------------------------------------------------- >30418_30418_2_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000355194_length(amino acids)=718AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQP KPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQI LGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSK DLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPL PAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNI -------------------------------------------------------------- >30418_30418_3_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000355635_length(amino acids)=720AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKQNQQGESQSCQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQ PKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQ ILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDS KDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPP LPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELN IQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALSLPHVKLKX -------------------------------------------------------------- >30418_30418_4_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000370392_length(amino acids)=213AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK -------------------------------------------------------------- >30418_30418_5_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000370398_length(amino acids)=718AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQP KPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQI LGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSK DLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPL PAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNI -------------------------------------------------------------- >30418_30418_6_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000402622_length(amino acids)=729AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTNKFCSNKQKLFRMYTSRKQSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFR PSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRI KSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQT SDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAA PTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQN LIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDAL -------------------------------------------------------------- >30418_30418_7_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000403813_length(amino acids)=710AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTNQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTA LGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSD KKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNS GCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRP ETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSG -------------------------------------------------------------- >30418_30418_8_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000237172_KCNQ5_chr6_73814980_ENST00000414165_length(amino acids)=609AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEH ETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANI SRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQ ESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKW -------------------------------------------------------------- >30418_30418_9_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000342056_length(amino acids)=737AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSSKFCSNKQKLFRMYTSRKQSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSW SFNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSA GHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQ IPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQ INTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKD LGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSIC -------------------------------------------------------------- >30418_30418_10_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000355194_length(amino acids)=718AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQP KPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQI LGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSK DLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPL PAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNI -------------------------------------------------------------- >30418_30418_11_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000355635_length(amino acids)=719AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKQNQQGESQSCQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQ PKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQ ILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDS KDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPP LPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELN -------------------------------------------------------------- >30418_30418_12_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000370392_length(amino acids)=213AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK -------------------------------------------------------------- >30418_30418_13_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000370398_length(amino acids)=718AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQP KPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQI LGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSK DLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPL PAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNI -------------------------------------------------------------- >30418_30418_14_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000402622_length(amino acids)=728AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTNKFCSNKQKLFRMYTSRKQSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFR PSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRI KSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQT SDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAA PTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQN LIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDAL -------------------------------------------------------------- >30418_30418_15_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000403813_length(amino acids)=709AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTNQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTA LGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSD KKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNS GCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRP ETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSG -------------------------------------------------------------- >30418_30418_16_FILIP1-KCNQ5_FILIP1_chr6_76124413_ENST00000393004_KCNQ5_chr6_73814980_ENST00000414165_length(amino acids)=608AA_BP=92 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGE LQITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWK PHLKALHTCSPTKKEQGEASSRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEH ETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANI SRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQ ESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKW -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:76124413/chr6:73814980) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FILIP1 | KCNQ5 |
| FUNCTION: Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. | FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:28669405}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FILIP1 | chr6:76124413 | chr6:73814980 | ENST00000237172 | - | 2 | 6 | 37_41 | 92.0 | 1214.0 | Compositional bias | Note=Poly-Lys |
| Hgene | FILIP1 | chr6:76124413 | chr6:73814980 | ENST00000393004 | - | 2 | 7 | 37_41 | 92.0 | 1178.0 | Compositional bias | Note=Poly-Lys |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 311_316 | 306.0 | 428.0 | Motif | Selectivity filter | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 311_316 | 306.0 | 933.0 | Motif | Selectivity filter | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 311_316 | 306.0 | 943.0 | Motif | Selectivity filter | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 311_316 | 306.0 | 924.0 | Motif | Selectivity filter | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 311_316 | 306.0 | 823.0 | Motif | Selectivity filter | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 320_325 | 306.0 | 428.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 347_932 | 306.0 | 428.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 320_325 | 306.0 | 933.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 347_932 | 306.0 | 933.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 320_325 | 306.0 | 943.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 347_932 | 306.0 | 943.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 320_325 | 306.0 | 924.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 347_932 | 306.0 | 924.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 320_325 | 306.0 | 823.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 347_932 | 306.0 | 823.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 326_346 | 306.0 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 326_346 | 306.0 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 326_346 | 306.0 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 326_346 | 306.0 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 326_346 | 306.0 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FILIP1 | chr6:76124413 | chr6:73814980 | ENST00000237172 | - | 2 | 6 | 192_591 | 92.0 | 1214.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | FILIP1 | chr6:76124413 | chr6:73814980 | ENST00000237172 | - | 2 | 6 | 624_781 | 92.0 | 1214.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | FILIP1 | chr6:76124413 | chr6:73814980 | ENST00000393004 | - | 2 | 7 | 192_591 | 92.0 | 1178.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | FILIP1 | chr6:76124413 | chr6:73814980 | ENST00000393004 | - | 2 | 7 | 624_781 | 92.0 | 1178.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 299_319 | 306.0 | 428.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 299_319 | 306.0 | 933.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 299_319 | 306.0 | 943.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 299_319 | 306.0 | 924.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 299_319 | 306.0 | 823.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 147_156 | 306.0 | 428.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 178_200 | 306.0 | 428.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 1_125 | 306.0 | 428.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 222_229 | 306.0 | 428.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 253_266 | 306.0 | 428.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 288_298 | 306.0 | 428.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 147_156 | 306.0 | 933.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 178_200 | 306.0 | 933.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 1_125 | 306.0 | 933.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 222_229 | 306.0 | 933.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 253_266 | 306.0 | 933.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 288_298 | 306.0 | 933.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 147_156 | 306.0 | 943.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 178_200 | 306.0 | 943.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 1_125 | 306.0 | 943.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 222_229 | 306.0 | 943.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 253_266 | 306.0 | 943.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 288_298 | 306.0 | 943.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 147_156 | 306.0 | 924.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 178_200 | 306.0 | 924.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 1_125 | 306.0 | 924.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 222_229 | 306.0 | 924.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 253_266 | 306.0 | 924.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 288_298 | 306.0 | 924.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 147_156 | 306.0 | 823.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 178_200 | 306.0 | 823.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 1_125 | 306.0 | 823.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 222_229 | 306.0 | 823.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 253_266 | 306.0 | 823.0 | Topological domain | Cytoplasmic | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 288_298 | 306.0 | 823.0 | Topological domain | Extracellular | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 126_146 | 306.0 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 157_177 | 306.0 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 201_221 | 306.0 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 230_252 | 306.0 | 428.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370392 | 4 | 9 | 267_287 | 306.0 | 428.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 126_146 | 306.0 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 157_177 | 306.0 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 201_221 | 306.0 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 230_252 | 306.0 | 933.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000370398 | 4 | 14 | 267_287 | 306.0 | 933.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 126_146 | 306.0 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 157_177 | 306.0 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 201_221 | 306.0 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 230_252 | 306.0 | 943.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000402622 | 4 | 14 | 267_287 | 306.0 | 943.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 126_146 | 306.0 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 157_177 | 306.0 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 201_221 | 306.0 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 230_252 | 306.0 | 924.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000403813 | 4 | 13 | 267_287 | 306.0 | 924.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 126_146 | 306.0 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 157_177 | 306.0 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 201_221 | 306.0 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 230_252 | 306.0 | 823.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | KCNQ5 | chr6:76124413 | chr6:73814980 | ENST00000414165 | 4 | 12 | 267_287 | 306.0 | 823.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| FILIP1 | |
| KCNQ5 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to FILIP1-KCNQ5 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to FILIP1-KCNQ5 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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