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Fusion Protein:FKBP1A-ACSL1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: FKBP1A-ACSL1 | FusionPDB ID: 30460 | FusionGDB2.0 ID: 30460 | Hgene | Tgene | Gene symbol | FKBP1A | ACSL1 | Gene ID | 2280 | 2180 |
| Gene name | FKBP prolyl isomerase 1A | acyl-CoA synthetase long chain family member 1 | |
| Synonyms | FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE | ACS1|FACL1|FACL2|LACS|LACS1|LACS2 | |
| Cytomap | 20p13 | 4q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peptidyl-prolyl cis-trans isomerase FKBP1A12 kDa FK506-binding protein12 kDa FKBPFK506 binding protein 1A, 12kDaFK506 binding protein12FK506-binding protein 1FK506-binding protein 12FK506-binding protein 1AFK506-binding protein, T-cell, 12-kDFKBP | long-chain-fatty-acid--CoA ligase 1LACS 1LACS 2acyl-CoA synthetase 1arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 1fatty-acid-Coenzyme A ligase, long-chain 2lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 1long-chain acy | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P62942 | P33121 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000381715, ENST00000381719, ENST00000381724, ENST00000400137, ENST00000439640, ENST00000460490, | ENST00000504900, ENST00000281455, ENST00000437665, ENST00000454703, ENST00000504342, ENST00000507295, ENST00000513317, ENST00000515030, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 6 X 5=180 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: FKBP1A [Title/Abstract] AND ACSL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FKBP1A(1356134)-ACSL1(185689604), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FKBP1A-ACSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FKBP1A-ACSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FKBP1A-ACSL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FKBP1A-ACSL1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. FKBP1A-ACSL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FKBP1A | GO:0000413 | protein peptidyl-prolyl isomerization | 1696686 |
| Hgene | FKBP1A | GO:0007183 | SMAD protein complex assembly | 16720724 |
| Hgene | FKBP1A | GO:0031398 | positive regulation of protein ubiquitination | 16720724 |
| Hgene | FKBP1A | GO:0032092 | positive regulation of protein binding | 18346205 |
| Hgene | FKBP1A | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 7592869 |
| Hgene | FKBP1A | GO:0032925 | regulation of activin receptor signaling pathway | 16720724 |
| Hgene | FKBP1A | GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 12443530 |
| Hgene | FKBP1A | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 7592869 |
| Hgene | FKBP1A | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 12443530 |
| Hgene | FKBP1A | GO:0097435 | supramolecular fiber organization | 18346205 |
| Hgene | FKBP1A | GO:1990000 | amyloid fibril formation | 18346205 |
| Tgene | ACSL1 | GO:0001676 | long-chain fatty acid metabolic process | 22022213|24269233 |
| Tgene | ACSL1 | GO:0008610 | lipid biosynthetic process | 21242590 |
| Tgene | ACSL1 | GO:0044539 | long-chain fatty acid import | 22022213 |
| Fusion gene breakpoints across FKBP1A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ACSL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-51-4081 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000400137 | FKBP1A | chr20 | 1356134 | - | ENST00000504900 | ACSL1 | chr4 | 185689604 | - | 783 | 362 | 164 | 535 | 123 |
| ENST00000381724 | FKBP1A | chr20 | 1356134 | - | ENST00000454703 | ACSL1 | chr4 | 185689604 | - | 2952 | 318 | 135 | 1421 | 428 |
| ENST00000381724 | FKBP1A | chr20 | 1356134 | - | ENST00000515030 | ACSL1 | chr4 | 185689604 | - | 2947 | 318 | 135 | 1421 | 428 |
| ENST00000381724 | FKBP1A | chr20 | 1356134 | - | ENST00000281455 | ACSL1 | chr4 | 185689604 | - | 2946 | 318 | 135 | 1421 | 428 |
| ENST00000381724 | FKBP1A | chr20 | 1356134 | - | ENST00000507295 | ACSL1 | chr4 | 185689604 | - | 1766 | 318 | 135 | 1421 | 428 |
| ENST00000381724 | FKBP1A | chr20 | 1356134 | - | ENST00000437665 | ACSL1 | chr4 | 185689604 | - | 1644 | 318 | 135 | 1421 | 428 |
| ENST00000381724 | FKBP1A | chr20 | 1356134 | - | ENST00000504342 | ACSL1 | chr4 | 185689604 | - | 1526 | 318 | 135 | 1421 | 428 |
| ENST00000381724 | FKBP1A | chr20 | 1356134 | - | ENST00000513317 | ACSL1 | chr4 | 185689604 | - | 1500 | 318 | 135 | 1421 | 428 |
| ENST00000381719 | FKBP1A | chr20 | 1356134 | - | ENST00000454703 | ACSL1 | chr4 | 185689604 | - | 2862 | 228 | 30 | 1331 | 433 |
| ENST00000381719 | FKBP1A | chr20 | 1356134 | - | ENST00000515030 | ACSL1 | chr4 | 185689604 | - | 2857 | 228 | 30 | 1331 | 433 |
| ENST00000381719 | FKBP1A | chr20 | 1356134 | - | ENST00000281455 | ACSL1 | chr4 | 185689604 | - | 2856 | 228 | 30 | 1331 | 433 |
| ENST00000381719 | FKBP1A | chr20 | 1356134 | - | ENST00000507295 | ACSL1 | chr4 | 185689604 | - | 1676 | 228 | 30 | 1331 | 433 |
| ENST00000381719 | FKBP1A | chr20 | 1356134 | - | ENST00000437665 | ACSL1 | chr4 | 185689604 | - | 1554 | 228 | 30 | 1331 | 433 |
| ENST00000381719 | FKBP1A | chr20 | 1356134 | - | ENST00000504342 | ACSL1 | chr4 | 185689604 | - | 1436 | 228 | 30 | 1331 | 433 |
| ENST00000381719 | FKBP1A | chr20 | 1356134 | - | ENST00000513317 | ACSL1 | chr4 | 185689604 | - | 1410 | 228 | 30 | 1331 | 433 |
| ENST00000381715 | FKBP1A | chr20 | 1356134 | - | ENST00000454703 | ACSL1 | chr4 | 185689604 | - | 2876 | 242 | 59 | 1345 | 428 |
| ENST00000381715 | FKBP1A | chr20 | 1356134 | - | ENST00000515030 | ACSL1 | chr4 | 185689604 | - | 2871 | 242 | 59 | 1345 | 428 |
| ENST00000381715 | FKBP1A | chr20 | 1356134 | - | ENST00000281455 | ACSL1 | chr4 | 185689604 | - | 2870 | 242 | 59 | 1345 | 428 |
| ENST00000381715 | FKBP1A | chr20 | 1356134 | - | ENST00000507295 | ACSL1 | chr4 | 185689604 | - | 1690 | 242 | 59 | 1345 | 428 |
| ENST00000381715 | FKBP1A | chr20 | 1356134 | - | ENST00000437665 | ACSL1 | chr4 | 185689604 | - | 1568 | 242 | 59 | 1345 | 428 |
| ENST00000381715 | FKBP1A | chr20 | 1356134 | - | ENST00000504342 | ACSL1 | chr4 | 185689604 | - | 1450 | 242 | 59 | 1345 | 428 |
| ENST00000381715 | FKBP1A | chr20 | 1356134 | - | ENST00000513317 | ACSL1 | chr4 | 185689604 | - | 1424 | 242 | 59 | 1345 | 428 |
| ENST00000439640 | FKBP1A | chr20 | 1356134 | - | ENST00000454703 | ACSL1 | chr4 | 185689604 | - | 2784 | 150 | 0 | 1253 | 417 |
| ENST00000439640 | FKBP1A | chr20 | 1356134 | - | ENST00000515030 | ACSL1 | chr4 | 185689604 | - | 2779 | 150 | 0 | 1253 | 417 |
| ENST00000439640 | FKBP1A | chr20 | 1356134 | - | ENST00000281455 | ACSL1 | chr4 | 185689604 | - | 2778 | 150 | 0 | 1253 | 417 |
| ENST00000439640 | FKBP1A | chr20 | 1356134 | - | ENST00000507295 | ACSL1 | chr4 | 185689604 | - | 1598 | 150 | 0 | 1253 | 417 |
| ENST00000439640 | FKBP1A | chr20 | 1356134 | - | ENST00000437665 | ACSL1 | chr4 | 185689604 | - | 1476 | 150 | 0 | 1253 | 417 |
| ENST00000439640 | FKBP1A | chr20 | 1356134 | - | ENST00000504342 | ACSL1 | chr4 | 185689604 | - | 1358 | 150 | 0 | 1253 | 417 |
| ENST00000439640 | FKBP1A | chr20 | 1356134 | - | ENST00000513317 | ACSL1 | chr4 | 185689604 | - | 1332 | 150 | 0 | 1253 | 417 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000400137 | ENST00000504900 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.16051133 | 0.8394886 |
| ENST00000381724 | ENST00000454703 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000476435 | 0.9995235 |
| ENST00000381724 | ENST00000515030 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000475131 | 0.99952483 |
| ENST00000381724 | ENST00000281455 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000474186 | 0.9995258 |
| ENST00000381724 | ENST00000507295 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000945486 | 0.9990545 |
| ENST00000381724 | ENST00000437665 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.001858371 | 0.99814165 |
| ENST00000381724 | ENST00000504342 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.002898927 | 0.997101 |
| ENST00000381724 | ENST00000513317 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.003003014 | 0.996997 |
| ENST00000381719 | ENST00000454703 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.00078223 | 0.99921775 |
| ENST00000381719 | ENST00000515030 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.00077702 | 0.999223 |
| ENST00000381719 | ENST00000281455 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000776197 | 0.9992238 |
| ENST00000381719 | ENST00000507295 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.001288244 | 0.9987117 |
| ENST00000381719 | ENST00000437665 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.00245703 | 0.997543 |
| ENST00000381719 | ENST00000504342 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.003982998 | 0.99601704 |
| ENST00000381719 | ENST00000513317 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.004057061 | 0.9959429 |
| ENST00000381715 | ENST00000454703 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000435894 | 0.9995641 |
| ENST00000381715 | ENST00000515030 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000432922 | 0.9995671 |
| ENST00000381715 | ENST00000281455 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000433179 | 0.99956685 |
| ENST00000381715 | ENST00000507295 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000776009 | 0.99922395 |
| ENST00000381715 | ENST00000437665 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.001489721 | 0.9985103 |
| ENST00000381715 | ENST00000504342 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.002441897 | 0.9975581 |
| ENST00000381715 | ENST00000513317 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.002507042 | 0.997493 |
| ENST00000439640 | ENST00000454703 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000295832 | 0.9997042 |
| ENST00000439640 | ENST00000515030 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000293378 | 0.99970657 |
| ENST00000439640 | ENST00000281455 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.00029378 | 0.9997062 |
| ENST00000439640 | ENST00000507295 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000431419 | 0.9995685 |
| ENST00000439640 | ENST00000437665 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.000857134 | 0.9991429 |
| ENST00000439640 | ENST00000504342 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.001388674 | 0.99861133 |
| ENST00000439640 | ENST00000513317 | FKBP1A | chr20 | 1356134 | - | ACSL1 | chr4 | 185689604 | - | 0.001415875 | 0.99858415 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >30460_30460_1_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381715_ACSL1_chr4_185689604_ENST00000281455_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_2_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381715_ACSL1_chr4_185689604_ENST00000437665_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_3_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381715_ACSL1_chr4_185689604_ENST00000454703_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_4_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381715_ACSL1_chr4_185689604_ENST00000504342_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_5_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381715_ACSL1_chr4_185689604_ENST00000507295_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_6_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381715_ACSL1_chr4_185689604_ENST00000513317_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_7_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381715_ACSL1_chr4_185689604_ENST00000515030_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_8_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381719_ACSL1_chr4_185689604_ENST00000281455_length(amino acids)=433AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL KVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTF LRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGW LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC -------------------------------------------------------------- >30460_30460_9_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381719_ACSL1_chr4_185689604_ENST00000437665_length(amino acids)=433AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL KVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTF LRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGW LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC -------------------------------------------------------------- >30460_30460_10_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381719_ACSL1_chr4_185689604_ENST00000454703_length(amino acids)=433AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL KVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTF LRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGW LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC -------------------------------------------------------------- >30460_30460_11_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381719_ACSL1_chr4_185689604_ENST00000504342_length(amino acids)=433AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL KVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTF LRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGW LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC -------------------------------------------------------------- >30460_30460_12_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381719_ACSL1_chr4_185689604_ENST00000507295_length(amino acids)=433AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL KVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTF LRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGW LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC -------------------------------------------------------------- >30460_30460_13_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381719_ACSL1_chr4_185689604_ENST00000513317_length(amino acids)=433AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL KVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTF LRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGW LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC -------------------------------------------------------------- >30460_30460_14_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381719_ACSL1_chr4_185689604_ENST00000515030_length(amino acids)=433AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL KVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTF LRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGW LHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC -------------------------------------------------------------- >30460_30460_15_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381724_ACSL1_chr4_185689604_ENST00000281455_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_16_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381724_ACSL1_chr4_185689604_ENST00000437665_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_17_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381724_ACSL1_chr4_185689604_ENST00000454703_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_18_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381724_ACSL1_chr4_185689604_ENST00000504342_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_19_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381724_ACSL1_chr4_185689604_ENST00000507295_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_20_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381724_ACSL1_chr4_185689604_ENST00000513317_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_21_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000381724_ACSL1_chr4_185689604_ENST00000515030_length(amino acids)=428AA_BP=61 MPVSVSSGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQP TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAAL GCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDV -------------------------------------------------------------- >30460_30460_22_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000400137_ACSL1_chr4_185689604_ENST00000504900_length(amino acids)=123AA_BP=66 MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDL -------------------------------------------------------------- >30460_30460_23_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000439640_ACSL1_chr4_185689604_ENST00000281455_length(amino acids)=417AA_BP=50 MGVQVETISPGDGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQT ECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLK IIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRL -------------------------------------------------------------- >30460_30460_24_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000439640_ACSL1_chr4_185689604_ENST00000437665_length(amino acids)=417AA_BP=50 MGVQVETISPGDGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQT ECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLK IIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRL -------------------------------------------------------------- >30460_30460_25_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000439640_ACSL1_chr4_185689604_ENST00000454703_length(amino acids)=417AA_BP=50 MGVQVETISPGDGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQT ECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLK IIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRL -------------------------------------------------------------- >30460_30460_26_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000439640_ACSL1_chr4_185689604_ENST00000504342_length(amino acids)=417AA_BP=50 MGVQVETISPGDGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQT ECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLK IIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRL -------------------------------------------------------------- >30460_30460_27_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000439640_ACSL1_chr4_185689604_ENST00000507295_length(amino acids)=417AA_BP=50 MGVQVETISPGDGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQT ECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLK IIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRL -------------------------------------------------------------- >30460_30460_28_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000439640_ACSL1_chr4_185689604_ENST00000513317_length(amino acids)=417AA_BP=50 MGVQVETISPGDGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQT ECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLK IIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRL -------------------------------------------------------------- >30460_30460_29_FKBP1A-ACSL1_FKBP1A_chr20_1356134_ENST00000439640_ACSL1_chr4_185689604_ENST00000515030_length(amino acids)=417AA_BP=50 MGVQVETISPGDGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQCVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLN RMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQT ECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLK IIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:1356134/chr4:185689604) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FKBP1A | ACSL1 |
| FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:16720724, ECO:0000269|PubMed:1696686, ECO:0000269|PubMed:1701173, ECO:0000269|PubMed:9233797}. | FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). {ECO:0000250|UniProtKB:P18163, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FKBP1A | chr20:1356134 | chr4:185689604 | ENST00000381719 | - | 3 | 4 | 20_108 | 66.0 | 109.0 | Domain | PPIase FKBP-type |
| Hgene | FKBP1A | chr20:1356134 | chr4:185689604 | ENST00000400137 | - | 3 | 5 | 20_108 | 66.0 | 446.0 | Domain | PPIase FKBP-type |
| Tgene | ACSL1 | chr20:1356134 | chr4:185689604 | ENST00000281455 | 10 | 21 | 46_698 | 331.0 | 699.0 | Topological domain | Cytoplasmic | |
| Tgene | ACSL1 | chr20:1356134 | chr4:185689604 | ENST00000504342 | 10 | 21 | 46_698 | 331.0 | 699.0 | Topological domain | Cytoplasmic | |
| Tgene | ACSL1 | chr20:1356134 | chr4:185689604 | ENST00000515030 | 10 | 21 | 46_698 | 331.0 | 699.0 | Topological domain | Cytoplasmic | |
| Tgene | ACSL1 | chr20:1356134 | chr4:185689604 | ENST00000281455 | 10 | 21 | 25_45 | 331.0 | 699.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein | |
| Tgene | ACSL1 | chr20:1356134 | chr4:185689604 | ENST00000504342 | 10 | 21 | 25_45 | 331.0 | 699.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein | |
| Tgene | ACSL1 | chr20:1356134 | chr4:185689604 | ENST00000515030 | 10 | 21 | 25_45 | 331.0 | 699.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| FKBP1A | |
| ACSL1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to FKBP1A-ACSL1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to FKBP1A-ACSL1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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