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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FKBP9-CEP72

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FKBP9-CEP72
FusionPDB ID: 30539
FusionGDB2.0 ID: 30539
HgeneTgene
Gene symbol

FKBP9

CEP72

Gene ID

11328

55722

Gene nameFKBP prolyl isomerase 9centrosomal protein 72
SynonymsFKBP60|FKBP63|PPIase-
Cytomap

7p14.3

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP963 kDa FK506-binding protein63 kDa FKBPFK506 binding protein 9, 63 kDaFK506-binding protein 9FKBP-63FKBP-9PPIase FKBP9rotamasecentrosomal protein of 72 kDacentrosomal protein 72kDa
Modification date2020031320200327
UniProtAcc

Q75LS8

Q9P209

Ensembl transtripts involved in fusion geneENST idsENST00000489038, ENST00000242209, 
ENST00000490776, ENST00000538336, 
ENST00000538443, 		ENST00000264935, 
ENST00000444221, ENST00000514507, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 4=1962 X 4 X 2=16
# samples 73
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/16*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FKBP9 [Title/Abstract] AND CEP72 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FKBP9(33028264)-CEP72(635487), # samples:1
Anticipated loss of major functional domain due to fusion event.FKBP9-CEP72 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FKBP9-CEP72 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FKBP9-CEP72 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FKBP9-CEP72 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FKBP9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP72 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0HX-01AFKBP9chr7

33028264

+CEP72chr5

635487

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242209FKBP9chr733028264+ENST00000264935CEP72chr5635487+286112081692460763
ENST00000242209FKBP9chr733028264+ENST00000444221CEP72chr5635487+285712081692460763
ENST00000538336FKBP9chr733028264+ENST00000264935CEP72chr5635487+298413311332583816
ENST00000538336FKBP9chr733028264+ENST00000444221CEP72chr5635487+298013311332583816
ENST00000538443FKBP9chr733028264+ENST00000264935CEP72chr5635487+26469933652245626
ENST00000538443FKBP9chr733028264+ENST00000444221CEP72chr5635487+26429933652245626
ENST00000490776FKBP9chr733028264+ENST00000264935CEP72chr5635487+2074421781673531
ENST00000490776FKBP9chr733028264+ENST00000444221CEP72chr5635487+2070421781673531

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242209ENST00000264935FKBP9chr733028264+CEP72chr5635487+0.0050501580.9949498
ENST00000242209ENST00000444221FKBP9chr733028264+CEP72chr5635487+0.0050931750.99490684
ENST00000538336ENST00000264935FKBP9chr733028264+CEP72chr5635487+0.0028899880.99711007
ENST00000538336ENST00000444221FKBP9chr733028264+CEP72chr5635487+0.0029235570.9970765
ENST00000538443ENST00000264935FKBP9chr733028264+CEP72chr5635487+0.0119900080.98801
ENST00000538443ENST00000444221FKBP9chr733028264+CEP72chr5635487+0.01210590.9878941
ENST00000490776ENST00000264935FKBP9chr733028264+CEP72chr5635487+0.0226488620.9773512
ENST00000490776ENST00000444221FKBP9chr733028264+CEP72chr5635487+0.0229937530.97700626

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30539_30539_1_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000242209_CEP72_chr5_635487_ENST00000264935_length(amino acids)=763AA_BP=346
MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQL
ITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDG
TLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPEN
CERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQ
CGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRK
RRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLE
TLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELD
DLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQ

--------------------------------------------------------------

>30539_30539_2_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000242209_CEP72_chr5_635487_ENST00000444221_length(amino acids)=763AA_BP=346
MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQL
ITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDG
TLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPEN
CERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQ
CGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRK
RRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLE
TLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELD
DLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQ

--------------------------------------------------------------

>30539_30539_3_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000490776_CEP72_chr5_635487_ENST00000264935_length(amino acids)=531AA_BP=114
MAGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGL
LGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTY
FTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEA
SETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGS
LALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCG

--------------------------------------------------------------

>30539_30539_4_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000490776_CEP72_chr5_635487_ENST00000444221_length(amino acids)=531AA_BP=114
MAGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGL
LGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTY
FTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEA
SETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGS
LALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCG

--------------------------------------------------------------

>30539_30539_5_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000538336_CEP72_chr5_635487_ENST00000264935_length(amino acids)=816AA_BP=399
MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSRYWDTAEDKADKSPCPQ
VRVGVNTSPSCRLKQKGVGIYWKDLQFLVRVQNHGLSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIP
PNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGE
KRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDT
YIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLY
GAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQD
SSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFT
AAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLN
LQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQELSQVRAQHRAEVEQMHWSYQELKKTMALFPHSSASH

--------------------------------------------------------------

>30539_30539_6_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000538336_CEP72_chr5_635487_ENST00000444221_length(amino acids)=816AA_BP=399
MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSRYWDTAEDKADKSPCPQ
VRVGVNTSPSCRLKQKGVGIYWKDLQFLVRVQNHGLSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIP
PNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGE
KRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDT
YIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLY
GAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQD
SSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFT
AAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLN
LQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQELSQVRAQHRAEVEQMHWSYQELKKTMALFPHSSASH

--------------------------------------------------------------

>30539_30539_7_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000538443_CEP72_chr5_635487_ENST00000264935_length(amino acids)=626AA_BP=209
MMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFL
AYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPG
MDEGLLGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAP
RPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTL
SQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVG
EDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSV

--------------------------------------------------------------

>30539_30539_8_FKBP9-CEP72_FKBP9_chr7_33028264_ENST00000538443_CEP72_chr5_635487_ENST00000444221_length(amino acids)=626AA_BP=209
MMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFL
AYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPG
MDEGLLGVCIGEKRRIVVPPHLGYGEEGRESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAP
RPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTL
SQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVG
EDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:33028264/chr5:635487)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP9

Q75LS8

CEP72

Q9P209

FUNCTION: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610166_254346.3333333333333571.0DomainPPIase FKBP-type 2
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+61054_142346.3333333333333571.0DomainPPIase FKBP-type 1
TgeneCEP72chr7:33028264chr5:635487ENST00000264935412476_620230.33333333333334648.0Coiled coilOntology_term=ECO:0000255
TgeneCEP72chr7:33028264chr5:635487ENST00000444221311476_620170.66666666666666306.3333333333333Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610501_513346.3333333333333571.0Calcium binding1
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610546_557346.3333333333333571.0Calcium binding2
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610278_365346.3333333333333571.0DomainPPIase FKBP-type 3
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610389_477346.3333333333333571.0DomainPPIase FKBP-type 4
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610488_523346.3333333333333571.0DomainEF-hand 1
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610533_568346.3333333333333571.0DomainEF-hand 2
HgeneFKBP9chr7:33028264chr5:635487ENST00000242209+610567_570346.3333333333333571.0MotifPrevents secretion from ER
TgeneCEP72chr7:33028264chr5:635487ENST00000264935412111_150230.33333333333334648.0DomainNote=LRRCT
TgeneCEP72chr7:33028264chr5:635487ENST00000444221311111_150170.66666666666666306.3333333333333DomainNote=LRRCT
TgeneCEP72chr7:33028264chr5:635487ENST0000026493541229_50230.33333333333334648.0RepeatNote=LRR 1
TgeneCEP72chr7:33028264chr5:635487ENST0000026493541255_76230.33333333333334648.0RepeatNote=LRR 2
TgeneCEP72chr7:33028264chr5:635487ENST0000026493541277_98230.33333333333334648.0RepeatNote=LRR 3
TgeneCEP72chr7:33028264chr5:635487ENST0000044422131129_50170.66666666666666306.3333333333333RepeatNote=LRR 1
TgeneCEP72chr7:33028264chr5:635487ENST0000044422131155_76170.66666666666666306.3333333333333RepeatNote=LRR 2
TgeneCEP72chr7:33028264chr5:635487ENST0000044422131177_98170.66666666666666306.3333333333333RepeatNote=LRR 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FKBP9
CEP72


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FKBP9-CEP72


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FKBP9-CEP72


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource