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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FLNA-ACTG2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FLNA-ACTG2
FusionPDB ID: 30627
FusionGDB2.0 ID: 30627
HgeneTgene
Gene symbol

FLNA

ACTG2

Gene ID

2316

72

Gene namefilamin Aactin gamma 2, smooth muscle
SynonymsABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVDACT|ACTA3|ACTE|ACTL3|ACTSG|VSCM
Cytomap

Xq28

2p13.1

Type of geneprotein-codingprotein-coding
Descriptionfilamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filaminactin, gamma-enteric smooth muscleactin, gamma 2, smooth muscle, entericactin-like proteinalpha-actin-3
Modification date2020031320200313
UniProtAcc

P21333

P63267

Ensembl transtripts involved in fusion geneENST idsENST00000344736, ENST00000360319, 
ENST00000369850, ENST00000422373, 
ENST00000369856, ENST00000498491, 
ENST00000409624, ENST00000409918, 
ENST00000345517, ENST00000409731, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 29 X 9=626412 X 15 X 8=1440
# samples 3420
** MAII scorelog2(34/6264*10)=-4.20347756115334
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FLNA [Title/Abstract] AND ACTG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ACTG2(74146651)-FLNA(153590628), # samples:1
FLNA(153595765)-ACTG2(74140612), # samples:1
Anticipated loss of major functional domain due to fusion event.FLNA-ACTG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FLNA-ACTG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FLNA-ACTG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FLNA-ACTG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTG2-FLNA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ACTG2-FLNA seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ACTG2-FLNA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ACTG2-FLNA seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFLNA

GO:0016479

negative regulation of transcription by RNA polymerase I

22307607

HgeneFLNA

GO:0030334

regulation of cell migration

16291724

HgeneFLNA

GO:0031532

actin cytoskeleton reorganization

10051605

HgeneFLNA

GO:0034394

protein localization to cell surface

18322202

HgeneFLNA

GO:0043113

receptor clustering

10692483

HgeneFLNA

GO:0043433

negative regulation of DNA-binding transcription factor activity

15684392

HgeneFLNA

GO:0044319

wound healing, spreading of cells

16291724

HgeneFLNA

GO:0045184

establishment of protein localization

18322202

HgeneFLNA

GO:0051764

actin crosslink formation

10051605

HgeneFLNA

GO:0072659

protein localization to plasma membrane

24951510

HgeneFLNA

GO:0090307

mitotic spindle assembly

18548008

HgeneFLNA

GO:1901381

positive regulation of potassium ion transmembrane transport

24951510


check buttonFusion gene breakpoints across FLNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACTG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-H9-A6BX-01AFLNAchrX

153595765

-ACTG2chr2

74140612

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360319FLNAchrX153595765-ENST00000409731ACTG2chr274140612+187690621585527
ENST00000360319FLNAchrX153595765-ENST00000345517ACTG2chr274140612+187690621585527
ENST00000422373FLNAchrX153595765-ENST00000409731ACTG2chr274140612+208711172131796527
ENST00000422373FLNAchrX153595765-ENST00000345517ACTG2chr274140612+208711172131796527
ENST00000369850FLNAchrX153595765-ENST00000409731ACTG2chr274140612+207511052011784527
ENST00000369850FLNAchrX153595765-ENST00000345517ACTG2chr274140612+207511052011784527
ENST00000344736FLNAchrX153595765-ENST00000409731ACTG2chr274140612+188191171590527
ENST00000344736FLNAchrX153595765-ENST00000345517ACTG2chr274140612+188191171590527

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360319ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.0143639020.9856361
ENST00000360319ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.0143639020.9856361
ENST00000422373ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.0162905850.98370945
ENST00000422373ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.0162905850.98370945
ENST00000369850ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.016160690.9838394
ENST00000369850ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.016160690.9838394
ENST00000344736ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.0144328150.9855672
ENST00000344736ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.0144328150.9855672

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30627_30627_1_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000344736_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------

>30627_30627_2_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000344736_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------

>30627_30627_3_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000360319_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
LQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------

>30627_30627_4_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000360319_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
LQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------

>30627_30627_5_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000369850_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------

>30627_30627_6_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000369850_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------

>30627_30627_7_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000422373_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------

>30627_30627_8_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000422373_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:74146651/chr2:153590628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLNA

P21333

ACTG2

P63267

FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446166_269289.33333333333332640.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-44643_149289.33333333333332640.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548166_269289.33333333333332648.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-54843_149289.33333333333332648.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547166_269289.33333333333332640.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-54743_149289.33333333333332640.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462_274289.33333333333332640.0RegionNote=Actin-binding
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482_274289.33333333333332648.0RegionNote=Actin-binding
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472_274289.33333333333332640.0RegionNote=Actin-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461741_1778289.33333333333332640.0RegionNote=Hinge 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462517_2551289.33333333333332640.0RegionNote=Hinge 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462517_2647289.33333333333332640.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481741_1778289.33333333333332648.0RegionNote=Hinge 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482517_2551289.33333333333332648.0RegionNote=Hinge 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482517_2647289.33333333333332648.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471741_1778289.33333333333332640.0RegionNote=Hinge 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472517_2551289.33333333333332640.0RegionNote=Hinge 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472517_2647289.33333333333332640.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461062_1154289.33333333333332640.0RepeatNote=Filamin 9
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461155_1249289.33333333333332640.0RepeatNote=Filamin 10
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461250_1349289.33333333333332640.0RepeatNote=Filamin 11
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461350_1442289.33333333333332640.0RepeatNote=Filamin 12
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461443_1539289.33333333333332640.0RepeatNote=Filamin 13
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461540_1636289.33333333333332640.0RepeatNote=Filamin 14
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461649_1740289.33333333333332640.0RepeatNote=Filamin 15
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461779_1860289.33333333333332640.0RepeatNote=Filamin 16
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461861_1950289.33333333333332640.0RepeatNote=Filamin 17
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461951_2039289.33333333333332640.0RepeatNote=Filamin 18
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462042_2131289.33333333333332640.0RepeatNote=Filamin 19
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462132_2230289.33333333333332640.0RepeatNote=Filamin 20
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462233_2325289.33333333333332640.0RepeatNote=Filamin 21
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462327_2420289.33333333333332640.0RepeatNote=Filamin 22
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462424_2516289.33333333333332640.0RepeatNote=Filamin 23
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462552_2646289.33333333333332640.0RepeatNote=Filamin 24
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446276_374289.33333333333332640.0RepeatNote=Filamin 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446376_474289.33333333333332640.0RepeatNote=Filamin 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446475_570289.33333333333332640.0RepeatNote=Filamin 3
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446571_663289.33333333333332640.0RepeatNote=Filamin 4
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446667_763289.33333333333332640.0RepeatNote=Filamin 5
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446764_866289.33333333333332640.0RepeatNote=Filamin 6
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446867_965289.33333333333332640.0RepeatNote=Filamin 7
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446966_1061289.33333333333332640.0RepeatNote=Filamin 8
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481062_1154289.33333333333332648.0RepeatNote=Filamin 9
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481155_1249289.33333333333332648.0RepeatNote=Filamin 10
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481250_1349289.33333333333332648.0RepeatNote=Filamin 11
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481350_1442289.33333333333332648.0RepeatNote=Filamin 12
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481443_1539289.33333333333332648.0RepeatNote=Filamin 13
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481540_1636289.33333333333332648.0RepeatNote=Filamin 14
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481649_1740289.33333333333332648.0RepeatNote=Filamin 15
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481779_1860289.33333333333332648.0RepeatNote=Filamin 16
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481861_1950289.33333333333332648.0RepeatNote=Filamin 17
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481951_2039289.33333333333332648.0RepeatNote=Filamin 18
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482042_2131289.33333333333332648.0RepeatNote=Filamin 19
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482132_2230289.33333333333332648.0RepeatNote=Filamin 20
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482233_2325289.33333333333332648.0RepeatNote=Filamin 21
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482327_2420289.33333333333332648.0RepeatNote=Filamin 22
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482424_2516289.33333333333332648.0RepeatNote=Filamin 23
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482552_2646289.33333333333332648.0RepeatNote=Filamin 24
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548276_374289.33333333333332648.0RepeatNote=Filamin 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548376_474289.33333333333332648.0RepeatNote=Filamin 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548475_570289.33333333333332648.0RepeatNote=Filamin 3
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548571_663289.33333333333332648.0RepeatNote=Filamin 4
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548667_763289.33333333333332648.0RepeatNote=Filamin 5
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548764_866289.33333333333332648.0RepeatNote=Filamin 6
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548867_965289.33333333333332648.0RepeatNote=Filamin 7
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548966_1061289.33333333333332648.0RepeatNote=Filamin 8
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471062_1154289.33333333333332640.0RepeatNote=Filamin 9
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471155_1249289.33333333333332640.0RepeatNote=Filamin 10
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471250_1349289.33333333333332640.0RepeatNote=Filamin 11
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471350_1442289.33333333333332640.0RepeatNote=Filamin 12
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471443_1539289.33333333333332640.0RepeatNote=Filamin 13
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471540_1636289.33333333333332640.0RepeatNote=Filamin 14
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471649_1740289.33333333333332640.0RepeatNote=Filamin 15
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471779_1860289.33333333333332640.0RepeatNote=Filamin 16
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471861_1950289.33333333333332640.0RepeatNote=Filamin 17
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471951_2039289.33333333333332640.0RepeatNote=Filamin 18
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472042_2131289.33333333333332640.0RepeatNote=Filamin 19
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472132_2230289.33333333333332640.0RepeatNote=Filamin 20
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472233_2325289.33333333333332640.0RepeatNote=Filamin 21
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472327_2420289.33333333333332640.0RepeatNote=Filamin 22
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472424_2516289.33333333333332640.0RepeatNote=Filamin 23
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472552_2646289.33333333333332640.0RepeatNote=Filamin 24
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547276_374289.33333333333332640.0RepeatNote=Filamin 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547376_474289.33333333333332640.0RepeatNote=Filamin 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547475_570289.33333333333332640.0RepeatNote=Filamin 3
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547571_663289.33333333333332640.0RepeatNote=Filamin 4
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547667_763289.33333333333332640.0RepeatNote=Filamin 5
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547764_866289.33333333333332640.0RepeatNote=Filamin 6
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547867_965289.33333333333332640.0RepeatNote=Filamin 7
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547966_1061289.33333333333332640.0RepeatNote=Filamin 8


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FLNA
ACTG2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461490_1607289.33333333333332640.0furin
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481490_1607289.33333333333332648.0furin
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471490_1607289.33333333333332640.0furin


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Related Drugs to FLNA-ACTG2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FLNA-ACTG2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource