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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FMR1-FIP1L1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FMR1-FIP1L1
FusionPDB ID: 30780
FusionGDB2.0 ID: 30780
HgeneTgene
Gene symbol

FMR1

FIP1L1

Gene ID

106478973

81608

Gene nameFMR1 intronic transcript 1factor interacting with PAPOLA and CPSF1
SynonymsFMR1FIP1|Rhe|hFip1
Cytomap

Xq27.3

4q12

Type of genencRNAprotein-coding
DescriptionFMR1 intronic transcript 1 (non-protein coding)fragile X mental retardation syndrome proteinpre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
Modification date2019032420200313
UniProtAcc

Q8N0W7

Q6UN15

Ensembl transtripts involved in fusion geneENST idsENST00000218200, ENST00000334557, 
ENST00000370470, ENST00000370471, 
ENST00000370475, ENST00000370477, 
ENST00000439526, ENST00000440235, 
ENST00000492846, 		ENST00000510668, 
ENST00000306932, ENST00000337488, 
ENST00000358575, ENST00000507166, 
ENST00000507922, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 3 X 6=12617 X 15 X 11=2805
# samples 723
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2805*10)=-3.60829500455178
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FMR1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FMR1(146993748)-FIP1L1(54265896), # samples:1
Anticipated loss of major functional domain due to fusion event.FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FMR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FIP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-A45UFMR1chrX

146993748

+FIP1L1chr4

54265896

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000218200FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+21252801602124655
ENST00000218200FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+16062801601386408
ENST00000218200FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+15792801601359399
ENST00000218200FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+787280160756198
ENST00000218200FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+14242801601251363
ENST00000370471FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+21252801602124655
ENST00000370471FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+16062801601386408
ENST00000370471FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+15792801601359399
ENST00000370471FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+787280160756198
ENST00000370471FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+14242801601251363
ENST00000370477FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+21132681482112655
ENST00000370477FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+15942681481374408
ENST00000370477FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+15672681481347399
ENST00000370477FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+775268148744198
ENST00000370477FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+14122681481239363
ENST00000334557FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+2024179592023655
ENST00000334557FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+1505179591285408
ENST00000334557FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+1478179591258399
ENST00000334557FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+68617959655198
ENST00000334557FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+1323179591150363
ENST00000439526FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+2024179592023655
ENST00000439526FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+1505179591285408
ENST00000439526FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+1478179591258399
ENST00000439526FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+68617959655198
ENST00000439526FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+1323179591150363
ENST00000370475FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+2024179592023655
ENST00000370475FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+1505179591285408
ENST00000370475FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+1478179591258399
ENST00000370475FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+68617959655198
ENST00000370475FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+1323179591150363
ENST00000370470FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+18965101895631
ENST00000370470FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+13775101157385
ENST00000370470FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+13505101130376
ENST00000370470FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+558510527175
ENST00000370470FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+11955101022340

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000218200ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0034203360.9965797
ENST00000218200ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0162371940.98376274
ENST00000218200ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.010629850.9893701
ENST00000218200ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0104974790.98950255
ENST00000218200ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0144705620.9855295
ENST00000370471ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0034203360.9965797
ENST00000370471ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0162371940.98376274
ENST00000370471ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.010629850.9893701
ENST00000370471ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0104974790.98950255
ENST00000370471ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0144705620.9855295
ENST00000370477ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0036139920.99638605
ENST00000370477ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0171302910.9828697
ENST00000370477ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.011311370.98868865
ENST00000370477ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0097179430.99028206
ENST00000370477ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0154121880.9845878
ENST00000334557ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0035605210.9964394
ENST00000334557ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0191014370.98089856
ENST00000334557ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0127179790.9872821
ENST00000334557ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0096415130.99035853
ENST00000334557ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0178687440.98213124
ENST00000439526ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0035605210.9964394
ENST00000439526ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0191014370.98089856
ENST00000439526ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0127179790.9872821
ENST00000439526ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0096415130.99035853
ENST00000439526ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0178687440.98213124
ENST00000370475ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0035605210.9964394
ENST00000370475ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0191014370.98089856
ENST00000370475ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0127179790.9872821
ENST00000370475ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0096415130.99035853
ENST00000370475ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0178687440.98213124
ENST00000370470ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0024599560.9975401
ENST00000370470ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0198632570.98013675
ENST00000370470ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0119886580.9880114
ENST00000370470ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.026705790.97329426
ENST00000370470ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0155410880.9844589

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30780_30780_1_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000218200_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=363AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTI
TISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESG
HSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD
EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEAT

--------------------------------------------------------------

>30780_30780_2_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000218200_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=399AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRER
DRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE

--------------------------------------------------------------

>30780_30780_3_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000218200_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=408AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYAR
REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS

--------------------------------------------------------------

>30780_30780_4_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000218200_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=655AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL
SRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKEL
DIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDL
LSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL
WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHP
AVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDE

--------------------------------------------------------------

>30780_30780_5_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000218200_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=198AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL

--------------------------------------------------------------

>30780_30780_6_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000334557_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=363AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTI
TISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESG
HSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD
EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEAT

--------------------------------------------------------------

>30780_30780_7_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000334557_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=399AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRER
DRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE

--------------------------------------------------------------

>30780_30780_8_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000334557_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=408AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYAR
REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS

--------------------------------------------------------------

>30780_30780_9_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000334557_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=655AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL
SRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKEL
DIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDL
LSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL
WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHP
AVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDE

--------------------------------------------------------------

>30780_30780_10_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000334557_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=198AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL

--------------------------------------------------------------

>30780_30780_11_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370470_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=340AA_BP=14
MEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSER
SATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHL
PGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREK

--------------------------------------------------------------

>30780_30780_12_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370470_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=376AA_BP=14
MEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLR
RLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPG
APPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERE
RDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAG

--------------------------------------------------------------

>30780_30780_13_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370470_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=385AA_BP=14
MEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLR
RLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVP
PPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRER
ERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSK

--------------------------------------------------------------

>30780_30780_14_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370470_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=631AA_BP=14
MEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLR
RLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK
QALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENN
GDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRD
LAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNK
IKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEED
KLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF

--------------------------------------------------------------

>30780_30780_15_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370470_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=175AA_BP=14
MEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLR

--------------------------------------------------------------

>30780_30780_16_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370471_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=363AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTI
TISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESG
HSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD
EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEAT

--------------------------------------------------------------

>30780_30780_17_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370471_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=399AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRER
DRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE

--------------------------------------------------------------

>30780_30780_18_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370471_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=408AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYAR
REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS

--------------------------------------------------------------

>30780_30780_19_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370471_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=655AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL
SRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKEL
DIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDL
LSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL
WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHP
AVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDE

--------------------------------------------------------------

>30780_30780_20_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370471_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=198AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL

--------------------------------------------------------------

>30780_30780_21_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370475_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=363AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTI
TISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESG
HSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD
EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEAT

--------------------------------------------------------------

>30780_30780_22_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370475_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=399AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRER
DRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE

--------------------------------------------------------------

>30780_30780_23_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370475_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=408AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYAR
REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS

--------------------------------------------------------------

>30780_30780_24_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370475_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=655AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL
SRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKEL
DIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDL
LSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL
WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHP
AVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDE

--------------------------------------------------------------

>30780_30780_25_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370475_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=198AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL

--------------------------------------------------------------

>30780_30780_26_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370477_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=363AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTI
TISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESG
HSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD
EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEAT

--------------------------------------------------------------

>30780_30780_27_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370477_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=399AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRER
DRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE

--------------------------------------------------------------

>30780_30780_28_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370477_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=408AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYAR
REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS

--------------------------------------------------------------

>30780_30780_29_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370477_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=655AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL
SRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKEL
DIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDL
LSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL
WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHP
AVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDE

--------------------------------------------------------------

>30780_30780_30_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000370477_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=198AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL

--------------------------------------------------------------

>30780_30780_31_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000439526_FIP1L1_chr4_54265896_ENST00000306932_length(amino acids)=363AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTI
TISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESG
HSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSD
EERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEAT

--------------------------------------------------------------

>30780_30780_32_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000439526_FIP1L1_chr4_54265896_ENST00000337488_length(amino acids)=399AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRER
DRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESE

--------------------------------------------------------------

>30780_30780_33_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000439526_FIP1L1_chr4_54265896_ENST00000358575_length(amino acids)=408AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL
PPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYAR
REKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRS

--------------------------------------------------------------

>30780_30780_34_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000439526_FIP1L1_chr4_54265896_ENST00000507166_length(amino acids)=655AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL
SRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKEL
DIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDL
LSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL
WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHP
AVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDE

--------------------------------------------------------------

>30780_30780_35_FMR1-FIP1L1_FMR1_chrX_146993748_ENST00000439526_FIP1L1_chr4_54265896_ENST00000507922_length(amino acids)=198AA_BP=37
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTAS
RKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:146993748/chr4:54265896)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FMR1

Q8N0W7

FIP1L1

Q6UN15

FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000306932615356_406197.0521.0Compositional biasNote=Pro-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000306932615456_562197.0521.0Compositional biasNote=Arg-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000306932615478_594197.0521.0Compositional biasNote=Glu-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000337488818356_406235.0595.0Compositional biasNote=Pro-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000337488818456_562235.0595.0Compositional biasNote=Arg-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000337488818478_594235.0595.0Compositional biasNote=Glu-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000358575718356_406220.0589.0Compositional biasNote=Pro-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000358575718456_562220.0589.0Compositional biasNote=Arg-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000358575718478_594220.0589.0Compositional biasNote=Glu-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507166824356_406235.0850.0Compositional biasNote=Pro-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507166824456_562235.0850.0Compositional biasNote=Arg-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507166824478_594235.0850.0Compositional biasNote=Glu-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507922712356_406220.0379.0Compositional biasNote=Pro-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507922712456_562220.0379.0Compositional biasNote=Arg-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507922712478_594220.0379.0Compositional biasNote=Glu-rich
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000306932615457_490197.0521.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000337488818457_490235.0595.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000358575718457_490220.0589.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507166824457_490235.0850.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chrX:146993748chr4:54265896ENST00000507922712457_490220.0379.0RegionArg/Asp/Glu-rich domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+117222_25117.0591.0DomainKH 1
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+117285_31417.0591.0DomainKH 2
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+1174_5017.0591.0DomainAgenet-like 1
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+11763_11517.0591.0DomainAgenet-like 2
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+117222_25117.0633.0DomainKH 1
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+117285_31417.0633.0DomainKH 2
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+1174_5017.0633.0DomainAgenet-like 1
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+11763_11517.0633.0DomainAgenet-like 2
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+117424_44317.0591.0MotifNuclear export signal
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+117424_44317.0633.0MotifNuclear export signal
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+1171_18417.0591.0RegionRequired for nuclear localization
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+117397_49117.0591.0RegionRequired for nuclear export
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+117534_54817.0591.0RegionNote=RNA-binding RGG-box
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+1171_18417.0633.0RegionRequired for nuclear localization
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+117397_49117.0633.0RegionRequired for nuclear export
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+117534_54817.0633.0RegionNote=RNA-binding RGG-box
TgeneFIP1L1chrX:146993748chr4:54265896ENST000003069326151_356197.0521.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chrX:146993748chr4:54265896ENST000003374888181_356235.0595.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chrX:146993748chr4:54265896ENST000003585757181_356220.0589.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chrX:146993748chr4:54265896ENST000005071668241_356235.0850.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chrX:146993748chr4:54265896ENST000005079227121_356220.0379.0RegionNote=Necessary for stimulating PAPOLA activity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FMR1
FIP1L1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFMR1chrX:146993748chr4:54265896ENST00000370470+117419_63217.0591.0RANBP9
HgeneFMR1chrX:146993748chr4:54265896ENST00000370475+117419_63217.0633.0RANBP9


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Related Drugs to FMR1-FIP1L1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FMR1-FIP1L1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource