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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FMR1-GPC3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FMR1-GPC3
	FusionPDB ID: 30781
	FusionGDB2.0 ID: 30781
		Hgene	Tgene
	Gene symbol	FMR1	GPC3
	Gene ID	106478973	2719
	Gene name	FMR1 intronic transcript 1	glypican 3
	Synonyms	FMR1	DGSX\|GTR2-2\|MXR7\|OCI-5\|SDYS\|SGB\|SGBS\|SGBS1
	Cytomap	Xq27.3	Xq26.2
	Type of gene	ncRNA	protein-coding
	Description	FMR1 intronic transcript 1 (non-protein coding)fragile X mental retardation syndrome protein	glypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3
	Modification date	20190324	20200315
	UniProtAcc	Q8N0W7	P51654
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000218200, ENST00000334557, ENST00000370470, ENST00000370471, ENST00000370475, ENST00000370477, ENST00000439526, ENST00000440235, ENST00000492846,	ENST00000370818, ENST00000394299, ENST00000543339,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 3 X 6=126	12 X 11 X 6=792
	# samples	7	12
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FMR1 [Title/Abstract] AND GPC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FMR1(146993748)-GPC3(132730627), # samples:1
Anticipated loss of major functional domain due to fusion event.	FMR1-GPC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FMR1-GPC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GPC3	GO:0060828	regulation of canonical Wnt signaling pathway	14610063
Tgene	GPC3	GO:0090263	positive regulation of canonical Wnt signaling pathway	24496449
Tgene	GPC3	GO:2000050	regulation of non-canonical Wnt signaling pathway	14610063

Fusion gene breakpoints across FMR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GPC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-37-4133	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000218200	FMR1	chrX	146993748	+	ENST00000370818	GPC3	chrX	132730627	-	989	280	624	1	208
ENST00000218200	FMR1	chrX	146993748	+	ENST00000394299	GPC3	chrX	132730627	-	980	280	624	1	208
ENST00000218200	FMR1	chrX	146993748	+	ENST00000543339	GPC3	chrX	132730627	-	610	280	543	1	181
ENST00000370471	FMR1	chrX	146993748	+	ENST00000370818	GPC3	chrX	132730627	-	989	280	624	1	208
ENST00000370471	FMR1	chrX	146993748	+	ENST00000394299	GPC3	chrX	132730627	-	980	280	624	1	208
ENST00000370471	FMR1	chrX	146993748	+	ENST00000543339	GPC3	chrX	132730627	-	610	280	543	1	181
ENST00000370477	FMR1	chrX	146993748	+	ENST00000370818	GPC3	chrX	132730627	-	977	268	612	1	204
ENST00000370477	FMR1	chrX	146993748	+	ENST00000394299	GPC3	chrX	132730627	-	968	268	612	1	204
ENST00000370477	FMR1	chrX	146993748	+	ENST00000543339	GPC3	chrX	132730627	-	598	268	531	1	177
ENST00000334557	FMR1	chrX	146993748	+	ENST00000370818	GPC3	chrX	132730627	-	888	179	523	2	174
ENST00000334557	FMR1	chrX	146993748	+	ENST00000394299	GPC3	chrX	132730627	-	879	179	523	2	174
ENST00000334557	FMR1	chrX	146993748	+	ENST00000543339	GPC3	chrX	132730627	-	509	179	59	508	150
ENST00000439526	FMR1	chrX	146993748	+	ENST00000370818	GPC3	chrX	132730627	-	888	179	523	2	174
ENST00000439526	FMR1	chrX	146993748	+	ENST00000394299	GPC3	chrX	132730627	-	879	179	523	2	174
ENST00000439526	FMR1	chrX	146993748	+	ENST00000543339	GPC3	chrX	132730627	-	509	179	59	508	150
ENST00000370475	FMR1	chrX	146993748	+	ENST00000370818	GPC3	chrX	132730627	-	888	179	523	2	174
ENST00000370475	FMR1	chrX	146993748	+	ENST00000394299	GPC3	chrX	132730627	-	879	179	523	2	174
ENST00000370475	FMR1	chrX	146993748	+	ENST00000543339	GPC3	chrX	132730627	-	509	179	59	508	150
ENST00000370470	FMR1	chrX	146993748	+	ENST00000370818	GPC3	chrX	132730627	-	760	51	395	0	132
ENST00000370470	FMR1	chrX	146993748	+	ENST00000394299	GPC3	chrX	132730627	-	751	51	395	0	132
ENST00000370470	FMR1	chrX	146993748	+	ENST00000543339	GPC3	chrX	132730627	-	381	51	0	380	126

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000218200	ENST00000370818	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.004297315	0.9957027
ENST00000218200	ENST00000394299	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.003899432	0.99610054
ENST00000218200	ENST00000543339	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.004491399	0.99550855
ENST00000370471	ENST00000370818	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.004297315	0.9957027
ENST00000370471	ENST00000394299	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.003899432	0.99610054
ENST00000370471	ENST00000543339	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.004491399	0.99550855
ENST00000370477	ENST00000370818	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.003772588	0.9962274
ENST00000370477	ENST00000394299	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.003369596	0.9966304
ENST00000370477	ENST00000543339	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.003679192	0.99632084
ENST00000334557	ENST00000370818	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.002796903	0.9972031
ENST00000334557	ENST00000394299	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.002760493	0.9972395
ENST00000334557	ENST00000543339	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.005002076	0.994998
ENST00000439526	ENST00000370818	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.002796903	0.9972031
ENST00000439526	ENST00000394299	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.002760493	0.9972395
ENST00000439526	ENST00000543339	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.005002076	0.994998
ENST00000370475	ENST00000370818	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.002796903	0.9972031
ENST00000370475	ENST00000394299	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.002760493	0.9972395
ENST00000370475	ENST00000543339	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.005002076	0.994998
ENST00000370470	ENST00000370818	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.007425845	0.9925741
ENST00000370470	ENST00000394299	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.00677164	0.9932284
ENST00000370470	ENST00000543339	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-	0.009611748	0.9903882

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30781_30781_1_FMR1-GPC3_FMR1_chrX_146993748_ENST00000218200_GPC3_chrX_132730627_ENST00000370818_length(amino acids)=208AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV
STFKPFLIQVFIQNSTFGHRHGSQELVESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTP

--------------------------------------------------------------

>30781_30781_2_FMR1-GPC3_FMR1_chrX_146993748_ENST00000218200_GPC3_chrX_132730627_ENST00000394299_length(amino acids)=208AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV
STFKPFLIQVFIQNSTFGHRHGSQELVESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTP

--------------------------------------------------------------

>30781_30781_3_FMR1-GPC3_FMR1_chrX_146993748_ENST00000218200_GPC3_chrX_132730627_ENST00000543339_length(amino acids)=181AA_BP=0
MNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAVSTFKPFLIQVFIQNSTFGHRHGSQELV
ESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTPPGSGASVTAAARARRRPAARSEAALHR

--------------------------------------------------------------

>30781_30781_4_FMR1-GPC3_FMR1_chrX_146993748_ENST00000334557_GPC3_chrX_132730627_ENST00000370818_length(amino acids)=174AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_5_FMR1-GPC3_FMR1_chrX_146993748_ENST00000334557_GPC3_chrX_132730627_ENST00000394299_length(amino acids)=174AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_6_FMR1-GPC3_FMR1_chrX_146993748_ENST00000334557_GPC3_chrX_132730627_ENST00000543339_length(amino acids)=150AA_BP=40
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLR

--------------------------------------------------------------

>30781_30781_7_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370470_GPC3_chrX_132730627_ENST00000370818_length(amino acids)=132AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_8_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370470_GPC3_chrX_132730627_ENST00000394299_length(amino acids)=132AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_9_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370470_GPC3_chrX_132730627_ENST00000543339_length(amino acids)=126AA_BP=17
MEELVVEVRGSNGAFYKLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATP

--------------------------------------------------------------

>30781_30781_10_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370471_GPC3_chrX_132730627_ENST00000370818_length(amino acids)=208AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV
STFKPFLIQVFIQNSTFGHRHGSQELVESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTP

--------------------------------------------------------------

>30781_30781_11_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370471_GPC3_chrX_132730627_ENST00000394299_length(amino acids)=208AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV
STFKPFLIQVFIQNSTFGHRHGSQELVESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTP

--------------------------------------------------------------

>30781_30781_12_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370471_GPC3_chrX_132730627_ENST00000543339_length(amino acids)=181AA_BP=0
MNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAVSTFKPFLIQVFIQNSTFGHRHGSQELV
ESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTPPGSGASVTAAARARRRPAARSEAALHR

--------------------------------------------------------------

>30781_30781_13_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370475_GPC3_chrX_132730627_ENST00000370818_length(amino acids)=174AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_14_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370475_GPC3_chrX_132730627_ENST00000394299_length(amino acids)=174AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_15_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370475_GPC3_chrX_132730627_ENST00000543339_length(amino acids)=150AA_BP=40
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLR

--------------------------------------------------------------

>30781_30781_16_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370477_GPC3_chrX_132730627_ENST00000370818_length(amino acids)=204AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV
STFKPFLIQVFIQNSTFGHRHGSQELVESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTP

--------------------------------------------------------------

>30781_30781_17_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370477_GPC3_chrX_132730627_ENST00000394299_length(amino acids)=204AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV
STFKPFLIQVFIQNSTFGHRHGSQELVESAIGAPHFHHQLLHLLFSPASAGSPPPRGGLRALEAQPPPPPPPPPPPPPPPPPPPPRCRTP

--------------------------------------------------------------

>30781_30781_18_FMR1-GPC3_FMR1_chrX_146993748_ENST00000370477_GPC3_chrX_132730627_ENST00000543339_length(amino acids)=177AA_BP=0
MNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAVSTFKPFLIQVFIQNSTFGHRHGSQELV

--------------------------------------------------------------

>30781_30781_19_FMR1-GPC3_FMR1_chrX_146993748_ENST00000439526_GPC3_chrX_132730627_ENST00000370818_length(amino acids)=174AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_20_FMR1-GPC3_FMR1_chrX_146993748_ENST00000439526_GPC3_chrX_132730627_ENST00000394299_length(amino acids)=174AA_BP=1
MGTRQSVHQEEEAHHRDGHAGEKLQRGMNVPEVVKGAYLVVLRSCLLTVSRRIIHIQIIGQFCKEAELILHFYHSITRASNALIFIITAV

--------------------------------------------------------------

>30781_30781_21_FMR1-GPC3_FMR1_chrX_146993748_ENST00000439526_GPC3_chrX_132730627_ENST00000543339_length(amino acids)=150AA_BP=40
MGLERPQPTSRGRAPGASRAEEKMEELVVEVRGSNGAFYKLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:146993748/chrX:132730627)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FMR1 Q8N0W7	GPC3 P51654
	FUNCTION: Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity). {ECO:0000250\|UniProtKB:Q6V9Y8, ECO:0000250\|UniProtKB:Q8CFZ4, ECO:0000269\|PubMed:14610063, ECO:0000269\|PubMed:16227623, ECO:0000269\|PubMed:17549790, ECO:0000269\|PubMed:24496449}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

222_251

17.0

591.0

Domain

KH 1

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

285_314

17.0

591.0

Domain

KH 2

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

4_50

17.0

591.0

Domain

Agenet-like 1

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

63_115

17.0

591.0

Domain

Agenet-like 2

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

222_251

17.0

633.0

Domain

KH 1

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

285_314

17.0

633.0

Domain

KH 2

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

4_50

17.0

633.0

Domain

Agenet-like 1

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

63_115

17.0

633.0

Domain

Agenet-like 2

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

424_443

17.0

591.0

Motif

Nuclear export signal

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

424_443

17.0

633.0

Motif

Nuclear export signal

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

1_184

17.0

591.0

Region

Required for nuclear localization

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

397_491

17.0

591.0

Region

Required for nuclear export

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370470

534_548

17.0

591.0

Region

Note=RNA-binding RGG-box

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

1_184

17.0

633.0

Region

Required for nuclear localization

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

397_491

17.0

633.0

Region

Required for nuclear export

Hgene

FMR1

chrX:146993748

chrX:132730627

ENST00000370475

534_548

17.0

633.0

Region

Note=RNA-binding RGG-box

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FMR1
GPC3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	FMR1	chrX:146993748	chrX:132730627	ENST00000370470	+	1	17	419_632	17.0	591.0	RANBP9
Hgene	FMR1	chrX:146993748	chrX:132730627	ENST00000370475	+	1	17	419_632	17.0	633.0	RANBP9

Top

Related Drugs to FMR1-GPC3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FMR1-GPC3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source