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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FNIP1-ACSL6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FNIP1-ACSL6
	FusionPDB ID: 30944
	FusionGDB2.0 ID: 30944
		Hgene	Tgene
	Gene symbol	FNIP1	ACSL6
	Gene ID	96459	23305
	Gene name	folliculin interacting protein 1	acyl-CoA synthetase long chain family member 6
	Synonyms	-	ACS2\|FACL6\|LACS 6\|LACS2\|LACS5
	Cytomap	5q31.1	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	folliculin-interacting protein 1	long-chain-fatty-acid--CoA ligase 6arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 6long fatty acyl-CoA synthetase 2
	Modification date	20200327	20200313
	UniProtAcc	Q8TF40	Q9UKU0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000307954, ENST00000307968, ENST00000510461, ENST00000511848,	ENST00000296869, ENST00000379240, ENST00000379244, ENST00000379246, ENST00000379249, ENST00000379255, ENST00000379264, ENST00000379272, ENST00000431707, ENST00000477640, ENST00000543479, ENST00000544770, ENST00000357096,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 11 X 10=1650	6 X 8 X 8=384
	# samples	18	10
	** MAII score	log2(18/1650*10)=-3.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FNIP1 [Title/Abstract] AND ACSL6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FNIP1(131080257)-ACSL6(131298371), # samples:2 FNIP1(131034610)-ACSL6(131329944), # samples:2
Anticipated loss of major functional domain due to fusion event.	FNIP1-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FNIP1-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FNIP1	GO:0000122	negative regulation of transcription by RNA polymerase II	21209915
Hgene	FNIP1	GO:0001932	regulation of protein phosphorylation	18663353
Hgene	FNIP1	GO:0031334	positive regulation of protein complex assembly	25126726
Hgene	FNIP1	GO:0033138	positive regulation of peptidyl-serine phosphorylation	19914239
Tgene	ACSL6	GO:0001676	long-chain fatty acid metabolic process	24269233

Fusion gene breakpoints across FNIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACSL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-UY-A78K-01A	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-
ChimerDB4	BRCA	TCGA-BH-A0H7-01A	FNIP1	chr5	131132523	-	ACSL6	chr5	131329944	-
ChimerDB4	OV	TCGA-24-1470-01A	FNIP1	chr5	131034610	-	ACSL6	chr5	131329944	-
ChimerDB4	OV	TCGA-24-2290-01A	FNIP1	chr5	131132523	-	ACSL6	chr5	131154556	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000379249	ACSL6	chr5	131298371	-	585	219	0	584	194
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000379264	ACSL6	chr5	131298371	-	4936	219	0	674	224
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000379272	ACSL6	chr5	131298371	-	3305	219	0	674	224
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000379255	ACSL6	chr5	131298371	-	1011	219	0	674	224
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000296869	ACSL6	chr5	131298371	-	1007	219	0	674	224
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000379246	ACSL6	chr5	131298371	-	1004	219	0	674	224
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000379244	ACSL6	chr5	131298371	-	1002	219	0	674	224
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000544770	ACSL6	chr5	131298371	-	997	219	0	674	224
ENST00000307968	FNIP1	chr5	131080257	-	ENST00000543479	ACSL6	chr5	131298371	-	675	219	0	674	224
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000379249	ACSL6	chr5	131298371	-	614	248	14	613	200
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000379264	ACSL6	chr5	131298371	-	4965	248	14	703	229
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000379272	ACSL6	chr5	131298371	-	3334	248	14	703	229
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000379255	ACSL6	chr5	131298371	-	1040	248	14	703	229
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000296869	ACSL6	chr5	131298371	-	1036	248	14	703	229
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000379246	ACSL6	chr5	131298371	-	1033	248	14	703	229
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000379244	ACSL6	chr5	131298371	-	1031	248	14	703	229
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000544770	ACSL6	chr5	131298371	-	1026	248	14	703	229
ENST00000307954	FNIP1	chr5	131080257	-	ENST00000543479	ACSL6	chr5	131298371	-	704	248	14	703	230
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000379249	ACSL6	chr5	131298371	-	681	315	6	680	224
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000379264	ACSL6	chr5	131298371	-	5032	315	6	770	254
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000379272	ACSL6	chr5	131298371	-	3401	315	6	770	254
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000379255	ACSL6	chr5	131298371	-	1107	315	6	770	254
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000296869	ACSL6	chr5	131298371	-	1103	315	6	770	254
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000379246	ACSL6	chr5	131298371	-	1100	315	6	770	254
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000379244	ACSL6	chr5	131298371	-	1098	315	6	770	254
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000544770	ACSL6	chr5	131298371	-	1093	315	6	770	254
ENST00000510461	FNIP1	chr5	131080257	-	ENST00000543479	ACSL6	chr5	131298371	-	771	315	6	770	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000379249	ACSL6	chr5	131298371	-	680	314	5	679	225
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000379264	ACSL6	chr5	131298371	-	5031	314	5	769	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000379272	ACSL6	chr5	131298371	-	3400	314	5	769	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000379255	ACSL6	chr5	131298371	-	1106	314	5	769	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000296869	ACSL6	chr5	131298371	-	1102	314	5	769	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000379246	ACSL6	chr5	131298371	-	1099	314	5	769	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000379244	ACSL6	chr5	131298371	-	1097	314	5	769	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000544770	ACSL6	chr5	131298371	-	1092	314	5	769	254
ENST00000511848	FNIP1	chr5	131080257	-	ENST00000543479	ACSL6	chr5	131298371	-	770	314	5	769	255

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000307968	ENST00000379249	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002436169	0.99756384
ENST00000307968	ENST00000379264	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001060524	0.99893945
ENST00000307968	ENST00000379272	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001304743	0.9986953
ENST00000307968	ENST00000379255	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001922841	0.99807715
ENST00000307968	ENST00000296869	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001910311	0.9980896
ENST00000307968	ENST00000379246	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001933352	0.9980666
ENST00000307968	ENST00000379244	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001931299	0.99806875
ENST00000307968	ENST00000544770	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001950819	0.99804914
ENST00000307968	ENST00000543479	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002188242	0.99781173
ENST00000307954	ENST00000379249	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.003400351	0.9965996
ENST00000307954	ENST00000379264	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001085866	0.9989141
ENST00000307954	ENST00000379272	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001365702	0.9986343
ENST00000307954	ENST00000379255	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002115997	0.997884
ENST00000307954	ENST00000296869	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002063275	0.9979367
ENST00000307954	ENST00000379246	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002084182	0.9979158
ENST00000307954	ENST00000379244	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.00209383	0.9979062
ENST00000307954	ENST00000544770	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002173684	0.9978263
ENST00000307954	ENST00000543479	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.00269111	0.99730885
ENST00000510461	ENST00000379249	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.003552184	0.9964478
ENST00000510461	ENST00000379264	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001109024	0.99889106
ENST00000510461	ENST00000379272	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001381971	0.998618
ENST00000510461	ENST00000379255	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002107828	0.9978922
ENST00000510461	ENST00000296869	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002111876	0.99788815
ENST00000510461	ENST00000379246	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002132925	0.997867
ENST00000510461	ENST00000379244	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002140908	0.99785906
ENST00000510461	ENST00000544770	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002198091	0.99780184
ENST00000510461	ENST00000543479	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002869944	0.9971301
ENST00000511848	ENST00000379249	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.003430161	0.9965699
ENST00000511848	ENST00000379264	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001108173	0.9988919
ENST00000511848	ENST00000379272	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.001384986	0.998615
ENST00000511848	ENST00000379255	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002104336	0.9978956
ENST00000511848	ENST00000296869	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002095172	0.9979049
ENST00000511848	ENST00000379246	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002112877	0.9978871
ENST00000511848	ENST00000379244	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002127703	0.99787223
ENST00000511848	ENST00000544770	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002189794	0.9978102
ENST00000511848	ENST00000543479	FNIP1	chr5	131080257	-	ACSL6	chr5	131298371	-	0.002853811	0.9971462

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30944_30944_1_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000296869_length(amino acids)=229AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_2_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000379244_length(amino acids)=229AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_3_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000379246_length(amino acids)=229AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_4_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000379249_length(amino acids)=200AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_5_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000379255_length(amino acids)=229AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_6_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000379264_length(amino acids)=229AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_7_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000379272_length(amino acids)=229AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_8_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000543479_length(amino acids)=230AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_9_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307954_ACSL6_chr5_131298371_ENST00000544770_length(amino acids)=229AA_BP=78
MAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKH
IFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLH

--------------------------------------------------------------

>30944_30944_10_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000296869_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_11_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000379244_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_12_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000379246_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_13_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000379249_length(amino acids)=194AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQD

--------------------------------------------------------------

>30944_30944_14_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000379255_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_15_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000379264_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_16_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000379272_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_17_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000543479_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_18_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000307968_ACSL6_chr5_131298371_ENST00000544770_length(amino acids)=224AA_BP=73
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSAGTLKIIDRKKHIFKLA
QGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV

--------------------------------------------------------------

>30944_30944_19_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000296869_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_20_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000379244_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_21_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000379246_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_22_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000379249_length(amino acids)=224AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_23_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000379255_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_24_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000379264_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_25_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000379272_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_26_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000543479_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_27_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000510461_ACSL6_chr5_131298371_ENST00000544770_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_28_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000296869_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_29_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000379244_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_30_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000379246_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_31_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000379249_length(amino acids)=225AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_32_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000379255_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_33_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000379264_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_34_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000379272_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_35_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000543479_length(amino acids)=255AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

>30944_30944_36_FNIP1-ACSL6_FNIP1_chr5_131080257_ENST00000511848_ACSL6_chr5_131298371_ENST00000544770_length(amino acids)=254AA_BP=103
MRRPWGWRGGCRSRGLASAQRSDPCLAVASMAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRRNEDISVSAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYAD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131080257/chr5:131298371)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FNIP1 Q8TF40	ACSL6 Q9UKU0
FUNCTION: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (PubMed:24081491). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Required for B-cell development (By similarity). {ECO:0000250\|UniProtKB:Q68FD7, ECO:0000250\|UniProtKB:Q9P278, ECO:0000269\|PubMed:17028174, ECO:0000269\|PubMed:18663353, ECO:0000269\|PubMed:24081491, ECO:0000269\|PubMed:25126726, ECO:0000269\|PubMed:27353360, ECO:0000269\|PubMed:30699359}.	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. {ECO:0000269\|PubMed:22633490, ECO:0000269\|PubMed:24269233}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000307968

96_99

73.0

1139.0

Compositional bias

Note=Poly-Ser

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000510461

96_99

73.0

1167.0

Compositional bias

Note=Poly-Ser

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000511848

96_99

73.0

509.0

Compositional bias

Note=Poly-Ser

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000307968

1102_1157

73.0

1139.0

Domain

dDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000307968

37_478

73.0

1139.0

Domain

uDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000307968

486_1092

73.0

1139.0

Domain

cDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000510461

1102_1157

73.0

1167.0

Domain

dDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000510461

37_478

73.0

1167.0

Domain

uDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000510461

486_1092

73.0

1167.0

Domain

cDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000511848

1102_1157

73.0

509.0

Domain

dDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000511848

37_478

73.0

509.0

Domain

uDENN FNIP1/2-type

Hgene

FNIP1

chr5:131080257

chr5:131298371

ENST00000511848

486_1092

73.0

509.0

Domain

cDENN FNIP1/2-type

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000296869

46_697

571.0

723.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000357096

46_697

471.0

623.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379240

46_697

546.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379244

46_697

546.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379246

46_697

557.0

709.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379249

46_697

546.0

668.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379255

46_697

471.0

623.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379264

46_697

571.0

723.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379272

46_697

561.0

713.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000543479

46_697

546.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000296869

25_45

571.0

723.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000357096

25_45

471.0

623.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379240

25_45

546.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379244

25_45

546.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379246

25_45

557.0

709.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379249

25_45

546.0

668.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379255

25_45

471.0

623.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379264

25_45

571.0

723.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000379272

25_45

561.0

713.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr5:131080257

chr5:131298371

ENST00000543479

25_45

546.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FNIP1
ACSL6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	FNIP1	chr5:131080257	chr5:131298371	ENST00000307968	-	2	17	929_1166	73.0	1139.0	HSP90AA1
Hgene	FNIP1	chr5:131080257	chr5:131298371	ENST00000510461	-	2	18	929_1166	73.0	1167.0	HSP90AA1
Hgene	FNIP1	chr5:131080257	chr5:131298371	ENST00000511848	-	2	13	929_1166	73.0	509.0	HSP90AA1

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Related Drugs to FNIP1-ACSL6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FNIP1-ACSL6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source