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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FOXP1-ACTN4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FOXP1-ACTN4
FusionPDB ID: 31187
FusionGDB2.0 ID: 31187
HgeneTgene
Gene symbol

FOXP1

ACTN4

Gene ID

27086

81

Gene nameforkhead box P1actinin alpha 4
Synonyms12CC4|HSPC215|MFH|QRF1|hFKH1BACTININ-4|FSGS|FSGS1
Cytomap

3p13

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkheadalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4
Modification date2020032920200327
UniProtAcc

Q9H334

O43707

Ensembl transtripts involved in fusion geneENST idsENST00000318779, ENST00000318789, 
ENST00000468577, ENST00000475937, 
ENST00000484350, ENST00000493089, 
ENST00000498215, ENST00000472382, 
ENST00000491238, 		ENST00000497637, 
ENST00000252699, ENST00000390009, 
ENST00000424234, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score34 X 30 X 13=1326027 X 38 X 12=12312
# samples 3848
** MAII scorelog2(38/13260*10)=-5.124937546669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/12312*10)=-4.68088692071969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FOXP1 [Title/Abstract] AND ACTN4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FOXP1(71247353)-ACTN4(39217597), # samples:2
Anticipated loss of major functional domain due to fusion event.FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
FOXP1-ACTN4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

HgeneFOXP1

GO:0010629

negative regulation of gene expression

30111844

HgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

HgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

HgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

HgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

HgeneFOXP1

GO:0036035

osteoclast development

18799727

HgeneFOXP1

GO:0042116

macrophage activation

18799727

HgeneFOXP1

GO:0042117

monocyte activation

18799727

HgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

HgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

HgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

HgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

HgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

HgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

HgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

HgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727

TgeneACTN4

GO:0033209

tumor necrosis factor-mediated signaling pathway

25411248

TgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

TgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

TgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771


check buttonFusion gene breakpoints across FOXP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-GS-A9TU-01AFOXP1chr3

71247353

-ACTN4chr19

39217597

+
ChimerDB4DLBCTCGA-GS-A9TUFOXP1chr3

71247353

-ACTN4chr19

39217597

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000475937FOXP1chr371247353-ENST00000252699ACTN4chr1939217597+33086114311156241
ENST00000475937FOXP1chr371247353-ENST00000424234ACTN4chr1939217597+11576114311156242
ENST00000475937FOXP1chr371247353-ENST00000390009ACTN4chr1939217597+11726114311156241
ENST00000498215FOXP1chr371247353-ENST00000252699ACTN4chr1939217597+32005033231048241
ENST00000498215FOXP1chr371247353-ENST00000424234ACTN4chr1939217597+10495033231048242
ENST00000498215FOXP1chr371247353-ENST00000390009ACTN4chr1939217597+10645033231048241
ENST00000468577FOXP1chr371247353-ENST00000252699ACTN4chr1939217597+28771800725241
ENST00000468577FOXP1chr371247353-ENST00000424234ACTN4chr1939217597+7261800725241
ENST00000468577FOXP1chr371247353-ENST00000390009ACTN4chr1939217597+7411800725241

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000475937ENST00000252699FOXP1chr371247353-ACTN4chr1939217597+0.003162520.9968375
ENST00000475937ENST00000424234FOXP1chr371247353-ACTN4chr1939217597+0.0036228970.99637705
ENST00000475937ENST00000390009FOXP1chr371247353-ACTN4chr1939217597+0.0042143090.99578565
ENST00000498215ENST00000252699FOXP1chr371247353-ACTN4chr1939217597+0.003351970.996648
ENST00000498215ENST00000424234FOXP1chr371247353-ACTN4chr1939217597+0.0060222430.9939778
ENST00000498215ENST00000390009FOXP1chr371247353-ACTN4chr1939217597+0.0068568180.9931432
ENST00000468577ENST00000252699FOXP1chr371247353-ACTN4chr1939217597+0.0031097820.99689025
ENST00000468577ENST00000424234FOXP1chr371247353-ACTN4chr1939217597+0.0039119910.996088
ENST00000468577ENST00000390009FOXP1chr371247353-ACTN4chr1939217597+0.004472930.9955271

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31187_31187_1_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000468577_ACTN4_chr19_39217597_ENST00000252699_length(amino acids)=241AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_2_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000468577_ACTN4_chr19_39217597_ENST00000390009_length(amino acids)=241AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_3_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000468577_ACTN4_chr19_39217597_ENST00000424234_length(amino acids)=241AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_4_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000475937_ACTN4_chr19_39217597_ENST00000252699_length(amino acids)=241AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_5_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000475937_ACTN4_chr19_39217597_ENST00000390009_length(amino acids)=241AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_6_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000475937_ACTN4_chr19_39217597_ENST00000424234_length(amino acids)=242AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_7_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000498215_ACTN4_chr19_39217597_ENST00000252699_length(amino acids)=241AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_8_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000498215_ACTN4_chr19_39217597_ENST00000390009_length(amino acids)=241AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

>31187_31187_9_FOXP1-ACTN4_FOXP1_chr3_71247353_ENST00000498215_ACTN4_chr19_39217597_ENST00000424234_length(amino acids)=242AA_BP=59
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQHIRVGWEQLLTTIARTINEVENQILTRDAK
GISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:71247353/chr19:39217597)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXP1

Q9H334

ACTN4

O43707

FUNCTION: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}.FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621778_789730.0912.0Calcium binding1
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621819_830730.0912.0Calcium binding2
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914778_789511.0693.0Calcium binding1
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914819_830511.0693.0Calcium binding2
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621765_800730.0912.0DomainEF-hand 1
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621806_841730.0912.0DomainEF-hand 2
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914765_800511.0693.0DomainEF-hand 1
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914806_841511.0693.0DomainEF-hand 2
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914528_639511.0693.0RepeatSpectrin 3
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914649_752511.0693.0RepeatSpectrin 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318779-6755_23060.0115.0Compositional biasNote=Gln-rich
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318789-62155_23060.0678.0Compositional biasNote=Gln-rich
HgeneFOXP1chr3:71247353chr19:39217597ENST00000475937-52055_23060.0678.0Compositional biasNote=Gln-rich
HgeneFOXP1chr3:71247353chr19:39217597ENST00000484350-31655_23060.0602.0Compositional biasNote=Gln-rich
HgeneFOXP1chr3:71247353chr19:39217597ENST00000493089-62155_23060.0677.0Compositional biasNote=Gln-rich
HgeneFOXP1chr3:71247353chr19:39217597ENST00000498215-21755_23060.0678.0Compositional biasNote=Gln-rich
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318779-67465_55560.0115.0DNA bindingFork-head
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318789-621465_55560.0678.0DNA bindingFork-head
HgeneFOXP1chr3:71247353chr19:39217597ENST00000475937-520465_55560.0678.0DNA bindingFork-head
HgeneFOXP1chr3:71247353chr19:39217597ENST00000484350-316465_55560.0602.0DNA bindingFork-head
HgeneFOXP1chr3:71247353chr19:39217597ENST00000493089-621465_55560.0677.0DNA bindingFork-head
HgeneFOXP1chr3:71247353chr19:39217597ENST00000498215-217465_55560.0678.0DNA bindingFork-head
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318779-67348_36960.0115.0RegionNote=Leucine-zipper
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318779-67382_38660.0115.0RegionCTBP1-binding
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318789-621348_36960.0678.0RegionNote=Leucine-zipper
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318789-621382_38660.0678.0RegionCTBP1-binding
HgeneFOXP1chr3:71247353chr19:39217597ENST00000475937-520348_36960.0678.0RegionNote=Leucine-zipper
HgeneFOXP1chr3:71247353chr19:39217597ENST00000475937-520382_38660.0678.0RegionCTBP1-binding
HgeneFOXP1chr3:71247353chr19:39217597ENST00000484350-316348_36960.0602.0RegionNote=Leucine-zipper
HgeneFOXP1chr3:71247353chr19:39217597ENST00000484350-316382_38660.0602.0RegionCTBP1-binding
HgeneFOXP1chr3:71247353chr19:39217597ENST00000493089-621348_36960.0677.0RegionNote=Leucine-zipper
HgeneFOXP1chr3:71247353chr19:39217597ENST00000493089-621382_38660.0677.0RegionCTBP1-binding
HgeneFOXP1chr3:71247353chr19:39217597ENST00000498215-217348_36960.0678.0RegionNote=Leucine-zipper
HgeneFOXP1chr3:71247353chr19:39217597ENST00000498215-217382_38660.0678.0RegionCTBP1-binding
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318779-67306_33160.0115.0Zinc fingerNote=C2H2-type
HgeneFOXP1chr3:71247353chr19:39217597ENST00000318789-621306_33160.0678.0Zinc fingerNote=C2H2-type
HgeneFOXP1chr3:71247353chr19:39217597ENST00000475937-520306_33160.0678.0Zinc fingerNote=C2H2-type
HgeneFOXP1chr3:71247353chr19:39217597ENST00000484350-316306_33160.0602.0Zinc fingerNote=C2H2-type
HgeneFOXP1chr3:71247353chr19:39217597ENST00000493089-621306_33160.0677.0Zinc fingerNote=C2H2-type
HgeneFOXP1chr3:71247353chr19:39217597ENST00000498215-217306_33160.0678.0Zinc fingerNote=C2H2-type
TgeneACTN4chr3:71247353chr19:39217597ENST00000252699162119_26730.0912.0Compositional biasPoly-Gly
TgeneACTN4chr3:71247353chr19:39217597ENST0000039000991419_26511.0693.0Compositional biasPoly-Gly
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621163_269730.0912.0DomainCalponin-homology (CH) 2
TgeneACTN4chr3:71247353chr19:39217597ENST00000252699162150_154730.0912.0DomainCalponin-homology (CH) 1
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914163_269511.0693.0DomainCalponin-homology (CH) 2
TgeneACTN4chr3:71247353chr19:39217597ENST0000039000991450_154511.0693.0DomainCalponin-homology (CH) 1
TgeneACTN4chr3:71247353chr19:39217597ENST00000252699162184_88730.0912.0MotifLXXLL motif
TgeneACTN4chr3:71247353chr19:39217597ENST0000039000991484_88511.0693.0MotifLXXLL motif
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621177_192730.0912.0RegionPolyphosphoinositide (PIP2)-binding
TgeneACTN4chr3:71247353chr19:39217597ENST0000025269916211_269730.0912.0RegionNote=Actin-binding
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914177_192511.0693.0RegionPolyphosphoinositide (PIP2)-binding
TgeneACTN4chr3:71247353chr19:39217597ENST000003900099141_269511.0693.0RegionNote=Actin-binding
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621293_403730.0912.0RepeatSpectrin 1
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621413_518730.0912.0RepeatSpectrin 2
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621528_639730.0912.0RepeatSpectrin 3
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621649_752730.0912.0RepeatSpectrin 4
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914293_403511.0693.0RepeatSpectrin 1
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914413_518511.0693.0RepeatSpectrin 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FOXP1_pLDDT.png
all structure
all structure
ACTN4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ACTN4MYOZ2, MYOZ1, PDLIM1, USP6NL, P2rx7, SLC9A3R2, COL17A1, TRIM3, MAGI1, GSN, Lrrc7, CAMK2A, CAMK2B, INO80, UBTF, STAT1, HDAC7, MEF2A, UCHL5, TJP1, ATXN7, HDAC5, VDR, ESR1, PSMA3, ELAVL1, SIRT7, SLC2A4, ISG15, COIL, SACS, HGS, UBASH3B, SHC1, NOS3, ACTN2, ACTN1, FMNL1, TRAF3IP1, FN1, VCAM1, Fcho2, CDH1, ITGA4, SVIL, CD81, IGSF8, ICAM1, TXN, RPS27, POT1, KPNA2, MAPK7, CDKN2A, VCP, SF3A3, GNB2, HUWE1, ACTN3, BMP7, ALK, CUL7, OBSL1, CCDC8, EGFR, LUZP4, RARA, HSPB1, AHNAK, ALDOA, ALDOC, IDH3A, MYH15, MYH2, MYH7B, NCAPG2, PSMA6, PSMB5, PUS7, TPM2, TSG101, CKB, CYC1, ECSIT, MCFD2, PSMB8, TPM1, TPM3, TPM4, NTRK1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, SIN3B, MYEF2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, Actb, Flot2, Myh9, Myo1c, Tpm1, Coro1c, Tmod3, Lima1, Ncbp2, Calml3, Myh10, Flnb, CTNNB1, MCM2, NFYA, CDC73, LCMT2, MEOX2, SORBS2, DDIAS, SSH1, act1, SLC9A1, NCL, DLD, DNM1L, PDHA1, SOD1, TRIM25, TES, CFTR, PPM1D, HDAC4, UBE2M, RAD18, PRPF8, TNIP2, RNF4, TRIM23, AGR2, ACTA1, MYC, CDK9, KIAA1429, ATG16L1, ACTC1, USP14, HDAC2, GBF1, AGRN, DYNC1LI1, BMH1, BMH2, ATXN3, BRF1, CYB5B, GBAS, HADHB, SYNJ2BP, VDAC3, RELA, PRMT5, MDP1, GRIN1, RGS9, BIRC3, SOX2, LNX1, MICALL2, C14orf119, PLEKHA4, PINK1, FANCD2, SH2D3C, SRC, TTN, NEK4, CIT, CHMP4B, CHMP4C, PTGER4, ECT2, KIF14, KIF20A, PRC1, PRNP, MKI67, HNRNPH1, NMRAL1, NUPR1, TRIM21, Apc2, RBM39, LGALS9, YWHAE, EIF3F, INSIG1, INSIG2, RIN3, CANX, GGH, ERP44, ACO2, KDM4C, AHCY, SHMT2, IDH2, SMCHD1, AR, TP53, ACTB, ANKFY1, EZR, RDX, VASP, ZYX, TRIM37, HTRA4, NUDCD2, BGLT3, BTF3, SEPT9, UBR5, LHPP, TFRC, CTSB, CTSS, DPP4, ORF3a, ORF8, NRP1, TMPRSS2, TOP3B, CTSL, FURIN, IFITM1, ANPEP, BSG, IFITM3, TMPRSS11B, CLEC4D, ACE2, TMPRSS4, CLEC4E, nsp2, ORF10, FGD5, TMEM106B, PDE4B, PER2, OTUD3, SIK2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FOXP1
ACTN4all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneACTN4chr3:71247353chr19:39217597ENST000002526991621108_126730.0912.0VCL
TgeneACTN4chr3:71247353chr19:39217597ENST00000252699162112_26730.0912.0VCL
TgeneACTN4chr3:71247353chr19:39217597ENST00000252699162140_61730.0912.0VCL
TgeneACTN4chr3:71247353chr19:39217597ENST00000390009914108_126511.0693.0VCL
TgeneACTN4chr3:71247353chr19:39217597ENST0000039000991412_26511.0693.0VCL
TgeneACTN4chr3:71247353chr19:39217597ENST0000039000991440_61511.0693.0VCL


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Related Drugs to FOXP1-ACTN4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FOXP1-ACTN4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACTN4C4551527Focal segmental glomerulosclerosis 19GENOMICS_ENGLAND;UNIPROT
TgeneACTN4C0007097Carcinoma1CTD_human
TgeneACTN4C0019193Hepatitis, Toxic1CTD_human
TgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
TgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneACTN4C0205696Anaplastic carcinoma1CTD_human
TgeneACTN4C0205697Carcinoma, Spindle-Cell1CTD_human
TgeneACTN4C0205698Undifferentiated carcinoma1CTD_human
TgeneACTN4C0205699Carcinomatosis1CTD_human
TgeneACTN4C0860207Drug-Induced Liver Disease1CTD_human
TgeneACTN4C1257925Mammary Carcinoma, Animal1CTD_human
TgeneACTN4C1262760Hepatitis, Drug-Induced1CTD_human
TgeneACTN4C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
TgeneACTN4C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneACTN4C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneACTN4C4279912Chemically-Induced Liver Toxicity1CTD_human