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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCC6-LTA4H

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCC6-LTA4H
FusionPDB ID: 312
FusionGDB2.0 ID: 312
HgeneTgene
Gene symbol

ABCC6

LTA4H

Gene ID

368

4048

Gene nameATP binding cassette subfamily C member 6leukotriene A4 hydrolase
SynonymsABC34|ARA|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|URG7-
Cytomap

16p13.11

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 6URG7 proteinATP-binding cassette, sub-family C (CFTR/MRP), member 6anthracycline resistance-associated proteinmulti-specific organic anion transporter Eleukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27
Modification date2020031320200313
UniProtAcc

O95255

P09960

Ensembl transtripts involved in fusion geneENST idsENST00000205557, ENST00000574094, 
ENST00000575728, 		ENST00000413268, 
ENST00000548375, ENST00000228740, 
ENST00000552789, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 5 X 3=759 X 9 X 6=486
# samples 58
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/486*10)=-2.60288440871842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCC6 [Title/Abstract] AND LTA4H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCC6(16276269)-LTA4H(96397698), # samples:2
Anticipated loss of major functional domain due to fusion event.ABCC6-LTA4H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC6-LTA4H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC6-LTA4H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC6-LTA4H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLTA4H

GO:0019370

leukotriene biosynthetic process

9774412|15078870

TgeneLTA4H

GO:0043171

peptide catabolic process

9774412|15078870|18804029


check buttonFusion gene breakpoints across ABCC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LTA4H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-7672-01AABCC6chr16

16276269

-LTA4Hchr12

96397698

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000205557ABCC6chr1616276269-ENST00000228740LTA4Hchr1296397698-27442277302582850
ENST00000205557ABCC6chr1616276269-ENST00000552789LTA4Hchr1296397698-27422277302582850

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000205557ENST00000228740ABCC6chr1616276269-LTA4Hchr1296397698-0.0033696750.9966304
ENST00000205557ENST00000552789ABCC6chr1616276269-LTA4Hchr1296397698-0.0033680730.9966319

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>312_312_1_ABCC6-LTA4H_ABCC6_chr16_16276269_ENST00000205557_LTA4H_chr12_96397698_ENST00000228740_length(amino acids)=850AA_BP=749
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVA
LWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAI
AFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCIT
IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
WLERVLEACALQPDVDSFPEGIHTSIGEQAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPL

--------------------------------------------------------------

>312_312_2_ABCC6-LTA4H_ABCC6_chr16_16276269_ENST00000205557_LTA4H_chr12_96397698_ENST00000552789_length(amino acids)=850AA_BP=749
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVA
LWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAI
AFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCIT
IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
WLERVLEACALQPDVDSFPEGIHTSIGEQAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:16276269/chr12:96397698)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC6

O95255

LTA4H

P09960

FUNCTION: [Isoform 1]: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644). {ECO:0000269|PubMed:11880368, ECO:0000269|PubMed:12414644}.; FUNCTION: [Isoform 1]: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. {ECO:0000269|PubMed:24277820, ECO:0000269|PubMed:24969777}.; FUNCTION: [Isoform 2]: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. {ECO:0000269|PubMed:23912081}.FUNCTION: Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731311_593749.01504.0DomainABC transmembrane type-1 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731663_670749.01504.0Nucleotide bindingATP 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731120_131749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731150_167749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731189_302749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311_31749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731324_349749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731371_426749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731448_450749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731472_533749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173153_72749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731555_575749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173194_98749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731132_149749.01504.0TransmembraneHelical%3B Name%3D4
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731168_188749.01504.0TransmembraneHelical%3B Name%3D5
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731303_323749.01504.0TransmembraneHelical%3B Name%3D6
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173132_52749.01504.0TransmembraneHelical%3B Name%3D1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731350_370749.01504.0TransmembraneHelical%3B Name%3D7
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731427_447749.01504.0TransmembraneHelical%3B Name%3D8
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731451_471749.01504.0TransmembraneHelical%3B Name%3D9
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731534_554749.01504.0TransmembraneHelical%3B Name%3D10
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731576_596749.01504.0TransmembraneHelical%3B Name%3D11
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173173_93749.01504.0TransmembraneHelical%3B Name%3D2
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-173199_119749.01504.0TransmembraneHelical%3B Name%3D3
TgeneLTA4Hchr16:16276269chr12:96397698ENST000002287401519564_566510.0612.0RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000413268018135_1370489.6666666666667RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000413268018267_2720489.6666666666667RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000413268018362_3650489.6666666666667RegionInhibitor ARM1 binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST00000413268018564_5660489.6666666666667RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST000005527891519564_566486.0588.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311265_1499749.01504.0DomainABC transporter 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731629_853749.01504.0DomainABC transporter 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731947_1228749.01504.0DomainABC transmembrane type-1 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121265_14990100.0DomainABC transporter 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12311_5930100.0DomainABC transmembrane type-1 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12629_8530100.0DomainABC transporter 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12947_12280100.0DomainABC transmembrane type-1 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311299_1306749.01504.0Nucleotide bindingATP 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121299_13060100.0Nucleotide bindingATP 2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12663_6700100.0Nucleotide bindingATP 1
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311019_1061749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311083_1083749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311105_1175749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311197_1198749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311220_1503749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731597_939749.01504.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731961_997749.01504.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121019_10610100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121083_10830100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121105_11750100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121197_11980100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12120_1310100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121220_15030100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12150_1670100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12189_3020100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121_310100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12324_3490100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12371_4260100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12448_4500100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12472_5330100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1253_720100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12555_5750100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12597_9390100.0Topological domainCytoplasmic
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1294_980100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12961_9970100.0Topological domainExtracellular
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311062_1082749.01504.0TransmembraneHelical%3B Name%3D14
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311084_1104749.01504.0TransmembraneHelical%3B Name%3D15
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311176_1196749.01504.0TransmembraneHelical%3B Name%3D16
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-17311199_1219749.01504.0TransmembraneHelical%3B Name%3D17
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731940_960749.01504.0TransmembraneHelical%3B Name%3D12
HgeneABCC6chr16:16276269chr12:96397698ENST00000205557-1731998_1018749.01504.0TransmembraneHelical%3B Name%3D13
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121062_10820100.0TransmembraneHelical%3B Name%3D14
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121084_11040100.0TransmembraneHelical%3B Name%3D15
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121176_11960100.0TransmembraneHelical%3B Name%3D16
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-121199_12190100.0TransmembraneHelical%3B Name%3D17
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12132_1490100.0TransmembraneHelical%3B Name%3D4
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12168_1880100.0TransmembraneHelical%3B Name%3D5
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12303_3230100.0TransmembraneHelical%3B Name%3D6
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1232_520100.0TransmembraneHelical%3B Name%3D1
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12350_3700100.0TransmembraneHelical%3B Name%3D7
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12427_4470100.0TransmembraneHelical%3B Name%3D8
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12451_4710100.0TransmembraneHelical%3B Name%3D9
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12534_5540100.0TransmembraneHelical%3B Name%3D10
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12576_5960100.0TransmembraneHelical%3B Name%3D11
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1273_930100.0TransmembraneHelical%3B Name%3D2
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12940_9600100.0TransmembraneHelical%3B Name%3D12
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-12998_10180100.0TransmembraneHelical%3B Name%3D13
HgeneABCC6chr16:16276269chr12:96397698ENST00000575728-1299_1190100.0TransmembraneHelical%3B Name%3D3
TgeneLTA4Hchr16:16276269chr12:96397698ENST000002287401519135_137510.0612.0RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST000002287401519267_272510.0612.0RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST000002287401519362_365510.0612.0RegionInhibitor ARM1 binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST000005527891519135_137486.0588.0RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST000005527891519267_272486.0588.0RegionSubstrate binding
TgeneLTA4Hchr16:16276269chr12:96397698ENST000005527891519362_365486.0588.0RegionInhibitor ARM1 binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCC6
LTA4H


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCC6-LTA4H


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCC6-LTA4H


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource