UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:FOXP4-CCND3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FOXP4-CCND3
FusionPDB ID: 31237
FusionGDB2.0 ID: 31237
HgeneTgene
Gene symbol

FOXP4

CCND3

Gene ID

116113

896

Gene nameforkhead box P4cyclin D3
SynonymshFKHLA-
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein P4fork head-related protein like Awinged-helix repressor FOXP4G1/S-specific cyclin-D3D3-type cyclin
Modification date2020031320200313
UniProtAcc

Q8IVH2

P30281

Ensembl transtripts involved in fusion geneENST idsENST00000307972, ENST00000373057, 
ENST00000373060, ENST00000373063, 
ENST00000409208, 		ENST00000372987, 
ENST00000372988, ENST00000372991, 
ENST00000414200, ENST00000415497, 
ENST00000510503, ENST00000511642, 
ENST00000511686, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 4=1969 X 3 X 7=189
# samples 1011
** MAII scorelog2(10/196*10)=-0.970853654340483
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/189*10)=-0.780882710696413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FOXP4 [Title/Abstract] AND CCND3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FOXP4(41545819)-CCND3(41908323), # samples:3
Anticipated loss of major functional domain due to fusion event.FOXP4-CCND3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXP4-CCND3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXP4-CCND3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXP4-CCND3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCND3

GO:0001934

positive regulation of protein phosphorylation

8114739

TgeneCCND3

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

8114739


check buttonFusion gene breakpoints across FOXP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCND3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-46-3769-01AFOXP4chr6

41545819

+CCND3chr6

41908323

-
ChimerDB4LUSCTCGA-46-3769FOXP4chr6

41533702

+CCND3chr6

41905132

-
ChimerDB4LUSCTCGA-46-3769FOXP4chr6

41545819

+CCND3chr6

41905132

-
ChimerDB4LUSCTCGA-46-3769FOXP4chr6

41545819

+CCND3chr6

41908323

-
ChimerDB4LUSCTCGA-46-3769FOXP4chr6

41552629

+CCND3chr6

41905132

-
ChimerDB4LUSCTCGA-46-3769FOXP4chr6

41552629

+CCND3chr6

41908323

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373060FOXP4chr641545819+ENST00000511642CCND3chr641905132-22297584581222254
ENST00000373063FOXP4chr641545819+ENST00000511642CCND3chr641905132-22297584581222254
ENST00000409208FOXP4chr641545819+ENST00000511642CCND3chr641905132-20826113111075254
ENST00000373057FOXP4chr641545819+ENST00000511642CCND3chr641905132-20075362361000254
ENST00000307972FOXP4chr641545819+ENST00000511642CCND3chr641905132-178331212776254
ENST00000373060FOXP4chr641552629+ENST00000511642CCND3chr641905132-23528814581345295
ENST00000373063FOXP4chr641552629+ENST00000511642CCND3chr641905132-23528814581345295
ENST00000409208FOXP4chr641552629+ENST00000511642CCND3chr641905132-22057343111198295
ENST00000373057FOXP4chr641552629+ENST00000511642CCND3chr641905132-21306592361123295
ENST00000307972FOXP4chr641552629+ENST00000511642CCND3chr641905132-190643512899295
ENST00000373060FOXP4chr641533702+ENST00000511642CCND3chr641905132-21336624581126222
ENST00000373063FOXP4chr641533702+ENST00000511642CCND3chr641905132-21336624581126222
ENST00000409208FOXP4chr641533702+ENST00000511642CCND3chr641905132-1986515311979222
ENST00000373057FOXP4chr641533702+ENST00000511642CCND3chr641905132-1911440236904222
ENST00000307972FOXP4chr641533702+ENST00000511642CCND3chr641905132-168721612680222

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373060ENST00000511642FOXP4chr641545819+CCND3chr641905132-0.060729270.93927073
ENST00000373063ENST00000511642FOXP4chr641545819+CCND3chr641905132-0.060729270.93927073
ENST00000409208ENST00000511642FOXP4chr641545819+CCND3chr641905132-0.070206360.9297937
ENST00000373057ENST00000511642FOXP4chr641545819+CCND3chr641905132-0.068190850.9318091
ENST00000307972ENST00000511642FOXP4chr641545819+CCND3chr641905132-0.084646350.9153536
ENST00000373060ENST00000511642FOXP4chr641552629+CCND3chr641905132-0.0207348340.9792652
ENST00000373063ENST00000511642FOXP4chr641552629+CCND3chr641905132-0.0207348340.9792652
ENST00000409208ENST00000511642FOXP4chr641552629+CCND3chr641905132-0.0240593480.97594064
ENST00000373057ENST00000511642FOXP4chr641552629+CCND3chr641905132-0.0232946370.9767054
ENST00000307972ENST00000511642FOXP4chr641552629+CCND3chr641905132-0.0277719870.97222805
ENST00000373060ENST00000511642FOXP4chr641533702+CCND3chr641905132-0.058180450.94181955
ENST00000373063ENST00000511642FOXP4chr641533702+CCND3chr641905132-0.058180450.94181955
ENST00000409208ENST00000511642FOXP4chr641533702+CCND3chr641905132-0.087769370.9122306
ENST00000373057ENST00000511642FOXP4chr641533702+CCND3chr641905132-0.082964550.9170355
ENST00000307972ENST00000511642FOXP4chr641533702+CCND3chr641905132-0.073585180.9264148

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31237_31237_1_FOXP4-CCND3_FOXP4_chr6_41533702_ENST00000307972_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=222AA_BP=67
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQDWEVLVLGKLKWDLAAVIAHDF
LAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAA

--------------------------------------------------------------

>31237_31237_2_FOXP4-CCND3_FOXP4_chr6_41533702_ENST00000373057_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=222AA_BP=67
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQDWEVLVLGKLKWDLAAVIAHDF
LAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAA

--------------------------------------------------------------

>31237_31237_3_FOXP4-CCND3_FOXP4_chr6_41533702_ENST00000373060_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=222AA_BP=67
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQDWEVLVLGKLKWDLAAVIAHDF
LAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAA

--------------------------------------------------------------

>31237_31237_4_FOXP4-CCND3_FOXP4_chr6_41533702_ENST00000373063_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=222AA_BP=67
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQDWEVLVLGKLKWDLAAVIAHDF
LAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAA

--------------------------------------------------------------

>31237_31237_5_FOXP4-CCND3_FOXP4_chr6_41533702_ENST00000409208_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=222AA_BP=67
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQDWEVLVLGKLKWDLAAVIAHDF
LAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAA

--------------------------------------------------------------

>31237_31237_6_FOXP4-CCND3_FOXP4_chr6_41545819_ENST00000307972_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=254AA_BP=99
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGAC

--------------------------------------------------------------

>31237_31237_7_FOXP4-CCND3_FOXP4_chr6_41545819_ENST00000373057_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=254AA_BP=99
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGAC

--------------------------------------------------------------

>31237_31237_8_FOXP4-CCND3_FOXP4_chr6_41545819_ENST00000373060_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=254AA_BP=99
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGAC

--------------------------------------------------------------

>31237_31237_9_FOXP4-CCND3_FOXP4_chr6_41545819_ENST00000373063_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=254AA_BP=99
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGAC

--------------------------------------------------------------

>31237_31237_10_FOXP4-CCND3_FOXP4_chr6_41545819_ENST00000409208_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=254AA_BP=99
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGAC

--------------------------------------------------------------

>31237_31237_11_FOXP4-CCND3_FOXP4_chr6_41552629_ENST00000307972_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=295AA_BP=138
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQVPVSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQAL
VKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAP

--------------------------------------------------------------

>31237_31237_12_FOXP4-CCND3_FOXP4_chr6_41552629_ENST00000373057_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=295AA_BP=138
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQVPVSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQAL
VKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAP

--------------------------------------------------------------

>31237_31237_13_FOXP4-CCND3_FOXP4_chr6_41552629_ENST00000373060_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=295AA_BP=138
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQVPVSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQAL
VKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAP

--------------------------------------------------------------

>31237_31237_14_FOXP4-CCND3_FOXP4_chr6_41552629_ENST00000373063_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=295AA_BP=138
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQVPVSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQAL
VKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAP

--------------------------------------------------------------

>31237_31237_15_FOXP4-CCND3_FOXP4_chr6_41552629_ENST00000409208_CCND3_chr6_41905132_ENST00000511642_length(amino acids)=295AA_BP=138
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNN
DSKQSASAVQVPVSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQAL
VKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:41545819/chr6:41908323)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXP4

Q8IVH2

CCND3

P30281

FUNCTION: Transcriptional repressor that represses lung-specific expression. {ECO:0000250}.FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCND3chr6:41533702chr6:41905132ENST000004154970427_152097.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41545819chr6:41905132ENST000004154970427_152097.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41552629chr6:41905132ENST000004154970427_152097.0DomainNote=Cyclin N-terminal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXP4chr6:41533702chr6:41905132ENST00000307972+11665_21968.0681.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373057+21765_21968.0679.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373060+21765_21968.0681.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373063+21765_21968.0668.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41545819chr6:41905132ENST00000307972+21665_219100.0681.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373057+31765_219100.0679.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373060+31765_219100.0681.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373063+31765_219100.0668.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41552629chr6:41905132ENST00000307972+31665_219141.0681.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373057+41765_219141.0679.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373060+41765_219141.0681.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373063+41765_219141.0668.0Compositional biasNote=Gln-rich
HgeneFOXP4chr6:41533702chr6:41905132ENST00000307972+116467_55968.0681.0DNA bindingFork-head
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373057+217467_55968.0679.0DNA bindingFork-head
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373060+217467_55968.0681.0DNA bindingFork-head
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373063+217467_55968.0668.0DNA bindingFork-head
HgeneFOXP4chr6:41545819chr6:41905132ENST00000307972+216467_559100.0681.0DNA bindingFork-head
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373057+317467_559100.0679.0DNA bindingFork-head
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373060+317467_559100.0681.0DNA bindingFork-head
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373063+317467_559100.0668.0DNA bindingFork-head
HgeneFOXP4chr6:41552629chr6:41905132ENST00000307972+316467_559141.0681.0DNA bindingFork-head
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373057+417467_559141.0679.0DNA bindingFork-head
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373060+417467_559141.0681.0DNA bindingFork-head
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373063+417467_559141.0668.0DNA bindingFork-head
HgeneFOXP4chr6:41533702chr6:41905132ENST00000307972+116349_37068.0681.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373057+217349_37068.0679.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373060+217349_37068.0681.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373063+217349_37068.0668.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41545819chr6:41905132ENST00000307972+216349_370100.0681.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373057+317349_370100.0679.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373060+317349_370100.0681.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373063+317349_370100.0668.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41552629chr6:41905132ENST00000307972+316349_370141.0681.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373057+417349_370141.0679.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373060+417349_370141.0681.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373063+417349_370141.0668.0RegionNote=Leucine-zipper
HgeneFOXP4chr6:41533702chr6:41905132ENST00000307972+116307_33268.0681.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373057+217307_33268.0679.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373060+217307_33268.0681.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41533702chr6:41905132ENST00000373063+217307_33268.0668.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41545819chr6:41905132ENST00000307972+216307_332100.0681.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373057+317307_332100.0679.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373060+317307_332100.0681.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41545819chr6:41905132ENST00000373063+317307_332100.0668.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41552629chr6:41905132ENST00000307972+316307_332141.0681.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373057+417307_332141.0679.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373060+417307_332141.0681.0Zinc fingerNote=C2H2-type
HgeneFOXP4chr6:41552629chr6:41905132ENST00000373063+417307_332141.0668.0Zinc fingerNote=C2H2-type
TgeneCCND3chr6:41533702chr6:41905132ENST000003729881527_15257.0212.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41533702chr6:41905132ENST000003729911527_152138.0293.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41533702chr6:41905132ENST000004142000427_15266.0221.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41533702chr6:41905132ENST000005116421527_15257.0212.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41545819chr6:41905132ENST000003729881527_15257.0212.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41545819chr6:41905132ENST000003729911527_152138.0293.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41545819chr6:41905132ENST000004142000427_15266.0221.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41545819chr6:41905132ENST000005116421527_15257.0212.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41552629chr6:41905132ENST000003729881527_15257.0212.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41552629chr6:41905132ENST000003729911527_152138.0293.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41552629chr6:41905132ENST000004142000427_15266.0221.0DomainNote=Cyclin N-terminal
TgeneCCND3chr6:41552629chr6:41905132ENST000005116421527_15257.0212.0DomainNote=Cyclin N-terminal


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FOXP4
CCND3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to FOXP4-CCND3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to FOXP4-CCND3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource