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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FRAS1-MRPL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FRAS1-MRPL1
FusionPDB ID: 31285
FusionGDB2.0 ID: 31285
HgeneTgene
Gene symbol

FRAS1

MRPL1

Gene ID

80144

65008

Gene nameFraser extracellular matrix complex subunit 1mitochondrial ribosomal protein L1
SynonymsFRASRS1BM022|L1MT|MRP-L1
Cytomap

4q21.21

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionextracellular matrix protein FRAS1Fraser syndrome 139S ribosomal protein L1, mitochondrialmitochondrial large ribosomal subunit protein uL1m
Modification date2020031320200313
UniProtAcc

Q86XX4

P49406

Ensembl transtripts involved in fusion geneENST idsENST00000264895, ENST00000264899, 
ENST00000325942, 		ENST00000506674, 
ENST00000315567, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 8 X 8=7686 X 4 X 6=144
# samples 137
** MAII scorelog2(13/768*10)=-2.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FRAS1 [Title/Abstract] AND MRPL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FRAS1(78987170)-MRPL1(78870951), # samples:3
Anticipated loss of major functional domain due to fusion event.FRAS1-MRPL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRAS1-MRPL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FRAS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2756-01AFRAS1chr4

78987170

-MRPL1chr4

78870951

+
ChimerDB4LUSCTCGA-66-2756FRAS1chr4

78987170

+MRPL1chr4

78870951

+
ChimerDB4OVTCGA-24-1426-01AFRAS1chr4

78987170

+MRPL1chr4

78870951

+
ChimerDB4PRADTCGA-CH-5794-01AFRAS1chr4

78979239

-MRPL1chr4

78792898

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264899FRAS1chr478987170+ENST00000315567MRPL1chr478870951+932548407748113
ENST00000325942FRAS1chr478987170+ENST00000315567MRPL1chr478870951+932548407748113
ENST00000264895FRAS1chr478987170+ENST00000315567MRPL1chr478870951+932548407748113
ENST00000264899FRAS1chr478979239-ENST00000315567MRPL1chr478792898+16465164071462351
ENST00000325942FRAS1chr478979239-ENST00000315567MRPL1chr478792898+16465164071462351
ENST00000264895FRAS1chr478979239-ENST00000315567MRPL1chr478792898+16465164071462351

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264899ENST00000315567FRAS1chr478987170+MRPL1chr478870951+0.0358134020.96418667
ENST00000325942ENST00000315567FRAS1chr478987170+MRPL1chr478870951+0.0358134020.96418667
ENST00000264895ENST00000315567FRAS1chr478987170+MRPL1chr478870951+0.0358134020.96418667
ENST00000264899ENST00000315567FRAS1chr478979239-MRPL1chr478792898+0.0001970760.9998029
ENST00000325942ENST00000315567FRAS1chr478979239-MRPL1chr478792898+0.0001970760.9998029
ENST00000264895ENST00000315567FRAS1chr478979239-MRPL1chr478792898+0.0001970760.9998029

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31285_31285_1_FRAS1-MRPL1_FRAS1_chr4_78979239_ENST00000264895_MRPL1_chr4_78792898_ENST00000315567_length(amino acids)=351AA_BP=36
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEALIHHQRHSLSKMVYQTSLCSCSVNIRVPNRHFAAATKSAKKTKKGAKEKTPDE
KKDEIEKIKAYPYMEGEPEDDVYLKRLYPRQIYEVEKAVHLLKKFQILDFTSPKQSVYLDLTLDMALGKKKNVEPFTSVLSLPYPFASEI
NKVAVFTENASEVKIAEENGAAFAGGTSLIQKIWDDEIVADFYVAVPEIMPELNRLRKKLNKKYPKLSRNSIGRDIPKMLELFKNGHEIK

--------------------------------------------------------------

>31285_31285_2_FRAS1-MRPL1_FRAS1_chr4_78979239_ENST00000264899_MRPL1_chr4_78792898_ENST00000315567_length(amino acids)=351AA_BP=36
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEALIHHQRHSLSKMVYQTSLCSCSVNIRVPNRHFAAATKSAKKTKKGAKEKTPDE
KKDEIEKIKAYPYMEGEPEDDVYLKRLYPRQIYEVEKAVHLLKKFQILDFTSPKQSVYLDLTLDMALGKKKNVEPFTSVLSLPYPFASEI
NKVAVFTENASEVKIAEENGAAFAGGTSLIQKIWDDEIVADFYVAVPEIMPELNRLRKKLNKKYPKLSRNSIGRDIPKMLELFKNGHEIK

--------------------------------------------------------------

>31285_31285_3_FRAS1-MRPL1_FRAS1_chr4_78979239_ENST00000325942_MRPL1_chr4_78792898_ENST00000315567_length(amino acids)=351AA_BP=36
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEALIHHQRHSLSKMVYQTSLCSCSVNIRVPNRHFAAATKSAKKTKKGAKEKTPDE
KKDEIEKIKAYPYMEGEPEDDVYLKRLYPRQIYEVEKAVHLLKKFQILDFTSPKQSVYLDLTLDMALGKKKNVEPFTSVLSLPYPFASEI
NKVAVFTENASEVKIAEENGAAFAGGTSLIQKIWDDEIVADFYVAVPEIMPELNRLRKKLNKKYPKLSRNSIGRDIPKMLELFKNGHEIK

--------------------------------------------------------------

>31285_31285_4_FRAS1-MRPL1_FRAS1_chr4_78987170_ENST00000264895_MRPL1_chr4_78870951_ENST00000315567_length(amino acids)=113AA_BP=47
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLALDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRAFLRSSTSEG

--------------------------------------------------------------

>31285_31285_5_FRAS1-MRPL1_FRAS1_chr4_78987170_ENST00000264899_MRPL1_chr4_78870951_ENST00000315567_length(amino acids)=113AA_BP=47
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLALDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRAFLRSSTSEG

--------------------------------------------------------------

>31285_31285_6_FRAS1-MRPL1_FRAS1_chr4_78987170_ENST00000325942_MRPL1_chr4_78870951_ENST00000315567_length(amino acids)=113AA_BP=47
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLALDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRAFLRSSTSEG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:78987170/chr4:78870951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRAS1

Q86XX4

MRPL1

P49406

FUNCTION: Involved in extracellular matrix organization (By similarity). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (By similarity). Involved in brain organization and function (By similarity). {ECO:0000250|UniProtKB:Q80T14}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174157_21725.3333333333333324013.0DomainVWFC 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174219_27925.3333333333333324013.0DomainVWFC 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742543_264625.3333333333333324013.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742659_277025.3333333333333324013.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742784_289025.3333333333333324013.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-17427_8825.3333333333333324013.0DomainVWFC 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174283_34325.3333333333333324013.0DomainVWFC 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742905_300725.3333333333333324013.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1743025_312925.3333333333333324013.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174347_41725.3333333333333324013.0DomainVWFC 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-17493_15325.3333333333333324013.0DomainVWFC 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119157_21725.333333333333332738.0DomainVWFC 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119219_27925.333333333333332738.0DomainVWFC 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192543_264625.333333333333332738.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192659_277025.333333333333332738.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192784_289025.333333333333332738.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-11927_8825.333333333333332738.0DomainVWFC 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119283_34325.333333333333332738.0DomainVWFC 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192905_300725.333333333333332738.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1193025_312925.333333333333332738.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119347_41725.333333333333332738.0DomainVWFC 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-11993_15325.333333333333332738.0DomainVWFC 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142157_21725.3333333333333321977.0DomainVWFC 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142219_27925.3333333333333321977.0DomainVWFC 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422543_264625.3333333333333321977.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422659_277025.3333333333333321977.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422784_289025.3333333333333321977.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-14227_8825.3333333333333321977.0DomainVWFC 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142283_34325.3333333333333321977.0DomainVWFC 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422905_300725.3333333333333321977.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1423025_312925.3333333333333321977.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142347_41725.3333333333333321977.0DomainVWFC 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-14293_15325.3333333333333321977.0DomainVWFC 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274157_21736.04013.0DomainVWFC 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274219_27936.04013.0DomainVWFC 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742543_264636.04013.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742659_277036.04013.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742784_289036.04013.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+27427_8836.04013.0DomainVWFC 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274283_34336.04013.0DomainVWFC 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742905_300736.04013.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2743025_312936.04013.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274347_41736.04013.0DomainVWFC 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+27493_15336.04013.0DomainVWFC 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219157_21736.0738.0DomainVWFC 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219219_27936.0738.0DomainVWFC 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192543_264636.0738.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192659_277036.0738.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192784_289036.0738.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+21927_8836.0738.0DomainVWFC 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219283_34336.0738.0DomainVWFC 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192905_300736.0738.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2193025_312936.0738.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219347_41736.0738.0DomainVWFC 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+21993_15336.0738.0DomainVWFC 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242157_21736.01977.0DomainVWFC 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242219_27936.01977.0DomainVWFC 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422543_264636.01977.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422659_277036.01977.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422784_289036.01977.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+24227_8836.01977.0DomainVWFC 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242283_34336.01977.0DomainVWFC 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422905_300736.01977.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2423025_312936.01977.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242347_41736.01977.0DomainVWFC 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+24293_15336.01977.0DomainVWFC 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741046_108925.3333333333333324013.0RepeatNote=FU 14
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741102_119725.3333333333333324013.0RepeatCSPG 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741217_130825.3333333333333324013.0RepeatCSPG 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741329_143825.3333333333333324013.0RepeatCSPG 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741463_155925.3333333333333324013.0RepeatCSPG 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741595_168925.3333333333333324013.0RepeatCSPG 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741710_181025.3333333333333324013.0RepeatCSPG 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741833_193625.3333333333333324013.0RepeatCSPG 7
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1741957_205725.3333333333333324013.0RepeatCSPG 8
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742078_217725.3333333333333324013.0RepeatCSPG 9
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742199_229125.3333333333333324013.0RepeatCSPG 10
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742311_240425.3333333333333324013.0RepeatCSPG 11
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1742439_253625.3333333333333324013.0RepeatCSPG 12
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174409_46025.3333333333333324013.0RepeatNote=FU 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174462_50525.3333333333333324013.0RepeatNote=FU 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174507_55325.3333333333333324013.0RepeatNote=FU 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174555_59925.3333333333333324013.0RepeatNote=FU 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174602_64725.3333333333333324013.0RepeatNote=FU 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174649_70525.3333333333333324013.0RepeatNote=FU 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174708_75325.3333333333333324013.0RepeatNote=FU 7
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174755_80025.3333333333333324013.0RepeatNote=FU 8
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174803_85225.3333333333333324013.0RepeatNote=FU 9
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174854_90025.3333333333333324013.0RepeatNote=FU 10
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174903_94825.3333333333333324013.0RepeatNote=FU 11
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174952_99725.3333333333333324013.0RepeatNote=FU 12
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-174999_104225.3333333333333324013.0RepeatNote=FU 13
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191046_108925.333333333333332738.0RepeatNote=FU 14
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191102_119725.333333333333332738.0RepeatCSPG 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191217_130825.333333333333332738.0RepeatCSPG 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191329_143825.333333333333332738.0RepeatCSPG 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191463_155925.333333333333332738.0RepeatCSPG 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191595_168925.333333333333332738.0RepeatCSPG 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191710_181025.333333333333332738.0RepeatCSPG 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191833_193625.333333333333332738.0RepeatCSPG 7
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1191957_205725.333333333333332738.0RepeatCSPG 8
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192078_217725.333333333333332738.0RepeatCSPG 9
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192199_229125.333333333333332738.0RepeatCSPG 10
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192311_240425.333333333333332738.0RepeatCSPG 11
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1192439_253625.333333333333332738.0RepeatCSPG 12
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119409_46025.333333333333332738.0RepeatNote=FU 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119462_50525.333333333333332738.0RepeatNote=FU 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119507_55325.333333333333332738.0RepeatNote=FU 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119555_59925.333333333333332738.0RepeatNote=FU 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119602_64725.333333333333332738.0RepeatNote=FU 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119649_70525.333333333333332738.0RepeatNote=FU 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119708_75325.333333333333332738.0RepeatNote=FU 7
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119755_80025.333333333333332738.0RepeatNote=FU 8
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119803_85225.333333333333332738.0RepeatNote=FU 9
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119854_90025.333333333333332738.0RepeatNote=FU 10
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119903_94825.333333333333332738.0RepeatNote=FU 11
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119952_99725.333333333333332738.0RepeatNote=FU 12
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-119999_104225.333333333333332738.0RepeatNote=FU 13
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421046_108925.3333333333333321977.0RepeatNote=FU 14
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421102_119725.3333333333333321977.0RepeatCSPG 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421217_130825.3333333333333321977.0RepeatCSPG 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421329_143825.3333333333333321977.0RepeatCSPG 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421463_155925.3333333333333321977.0RepeatCSPG 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421595_168925.3333333333333321977.0RepeatCSPG 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421710_181025.3333333333333321977.0RepeatCSPG 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421833_193625.3333333333333321977.0RepeatCSPG 7
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1421957_205725.3333333333333321977.0RepeatCSPG 8
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422078_217725.3333333333333321977.0RepeatCSPG 9
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422199_229125.3333333333333321977.0RepeatCSPG 10
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422311_240425.3333333333333321977.0RepeatCSPG 11
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1422439_253625.3333333333333321977.0RepeatCSPG 12
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142409_46025.3333333333333321977.0RepeatNote=FU 1
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142462_50525.3333333333333321977.0RepeatNote=FU 2
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142507_55325.3333333333333321977.0RepeatNote=FU 3
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142555_59925.3333333333333321977.0RepeatNote=FU 4
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142602_64725.3333333333333321977.0RepeatNote=FU 5
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142649_70525.3333333333333321977.0RepeatNote=FU 6
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142708_75325.3333333333333321977.0RepeatNote=FU 7
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142755_80025.3333333333333321977.0RepeatNote=FU 8
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142803_85225.3333333333333321977.0RepeatNote=FU 9
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142854_90025.3333333333333321977.0RepeatNote=FU 10
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142903_94825.3333333333333321977.0RepeatNote=FU 11
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142952_99725.3333333333333321977.0RepeatNote=FU 12
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-142999_104225.3333333333333321977.0RepeatNote=FU 13
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741046_108936.04013.0RepeatNote=FU 14
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741102_119736.04013.0RepeatCSPG 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741217_130836.04013.0RepeatCSPG 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741329_143836.04013.0RepeatCSPG 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741463_155936.04013.0RepeatCSPG 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741595_168936.04013.0RepeatCSPG 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741710_181036.04013.0RepeatCSPG 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741833_193636.04013.0RepeatCSPG 7
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2741957_205736.04013.0RepeatCSPG 8
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742078_217736.04013.0RepeatCSPG 9
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742199_229136.04013.0RepeatCSPG 10
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742311_240436.04013.0RepeatCSPG 11
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2742439_253636.04013.0RepeatCSPG 12
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274409_46036.04013.0RepeatNote=FU 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274462_50536.04013.0RepeatNote=FU 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274507_55336.04013.0RepeatNote=FU 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274555_59936.04013.0RepeatNote=FU 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274602_64736.04013.0RepeatNote=FU 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274649_70536.04013.0RepeatNote=FU 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274708_75336.04013.0RepeatNote=FU 7
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274755_80036.04013.0RepeatNote=FU 8
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274803_85236.04013.0RepeatNote=FU 9
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274854_90036.04013.0RepeatNote=FU 10
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274903_94836.04013.0RepeatNote=FU 11
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274952_99736.04013.0RepeatNote=FU 12
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+274999_104236.04013.0RepeatNote=FU 13
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191046_108936.0738.0RepeatNote=FU 14
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191102_119736.0738.0RepeatCSPG 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191217_130836.0738.0RepeatCSPG 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191329_143836.0738.0RepeatCSPG 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191463_155936.0738.0RepeatCSPG 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191595_168936.0738.0RepeatCSPG 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191710_181036.0738.0RepeatCSPG 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191833_193636.0738.0RepeatCSPG 7
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2191957_205736.0738.0RepeatCSPG 8
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192078_217736.0738.0RepeatCSPG 9
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192199_229136.0738.0RepeatCSPG 10
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192311_240436.0738.0RepeatCSPG 11
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2192439_253636.0738.0RepeatCSPG 12
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219409_46036.0738.0RepeatNote=FU 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219462_50536.0738.0RepeatNote=FU 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219507_55336.0738.0RepeatNote=FU 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219555_59936.0738.0RepeatNote=FU 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219602_64736.0738.0RepeatNote=FU 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219649_70536.0738.0RepeatNote=FU 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219708_75336.0738.0RepeatNote=FU 7
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219755_80036.0738.0RepeatNote=FU 8
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219803_85236.0738.0RepeatNote=FU 9
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219854_90036.0738.0RepeatNote=FU 10
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219903_94836.0738.0RepeatNote=FU 11
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219952_99736.0738.0RepeatNote=FU 12
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+219999_104236.0738.0RepeatNote=FU 13
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421046_108936.01977.0RepeatNote=FU 14
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421102_119736.01977.0RepeatCSPG 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421217_130836.01977.0RepeatCSPG 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421329_143836.01977.0RepeatCSPG 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421463_155936.01977.0RepeatCSPG 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421595_168936.01977.0RepeatCSPG 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421710_181036.01977.0RepeatCSPG 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421833_193636.01977.0RepeatCSPG 7
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2421957_205736.01977.0RepeatCSPG 8
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422078_217736.01977.0RepeatCSPG 9
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422199_229136.01977.0RepeatCSPG 10
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422311_240436.01977.0RepeatCSPG 11
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2422439_253636.01977.0RepeatCSPG 12
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242409_46036.01977.0RepeatNote=FU 1
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242462_50536.01977.0RepeatNote=FU 2
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242507_55336.01977.0RepeatNote=FU 3
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242555_59936.01977.0RepeatNote=FU 4
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242602_64736.01977.0RepeatNote=FU 5
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242649_70536.01977.0RepeatNote=FU 6
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242708_75336.01977.0RepeatNote=FU 7
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242755_80036.01977.0RepeatNote=FU 8
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242803_85236.01977.0RepeatNote=FU 9
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242854_90036.01977.0RepeatNote=FU 10
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242903_94836.01977.0RepeatNote=FU 11
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242952_99736.01977.0RepeatNote=FU 12
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+242999_104236.01977.0RepeatNote=FU 13
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-17427_390125.3333333333333324013.0Topological domainExtracellular
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1743923_400825.3333333333333324013.0Topological domainCytoplasmic
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-11927_390125.333333333333332738.0Topological domainExtracellular
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1193923_400825.333333333333332738.0Topological domainCytoplasmic
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-14227_390125.3333333333333321977.0Topological domainExtracellular
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1423923_400825.3333333333333321977.0Topological domainCytoplasmic
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+27427_390136.04013.0Topological domainExtracellular
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2743923_400836.04013.0Topological domainCytoplasmic
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+21927_390136.0738.0Topological domainExtracellular
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2193923_400836.0738.0Topological domainCytoplasmic
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+24227_390136.01977.0Topological domainExtracellular
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2423923_400836.01977.0Topological domainCytoplasmic
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264895-1743902_392225.3333333333333324013.0TransmembraneHelical
HgeneFRAS1chr4:78979239chr4:78792898ENST00000264899-1193902_392225.333333333333332738.0TransmembraneHelical
HgeneFRAS1chr4:78979239chr4:78792898ENST00000325942-1423902_392225.3333333333333321977.0TransmembraneHelical
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264895+2743902_392236.04013.0TransmembraneHelical
HgeneFRAS1chr4:78987170chr4:78870951ENST00000264899+2193902_392236.0738.0TransmembraneHelical
HgeneFRAS1chr4:78987170chr4:78870951ENST00000325942+2423902_392236.01977.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>42_FRAS1_78987170_MRPL1_78870951_ranked_0.pdbFRAS17897923978987170ENST00000315567MRPL1chr478870951+
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLALDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRAFLRSSTSEG
113


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FRAS1_pLDDT.png
all structure
all structure
MRPL1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FRAS1
MRPL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FRAS1-MRPL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FRAS1-MRPL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource