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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FRMD8-MARK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FRMD8-MARK2
FusionPDB ID: 31380
FusionGDB2.0 ID: 31380
HgeneTgene
Gene symbol

FRMD8

MARK2

Gene ID

83786

2011

Gene nameFERM domain containing 8microtubule affinity regulating kinase 2
SynonymsFKSG44|iTAPEMK-1|EMK1|PAR-1|Par-1b|Par1b
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Proteinserine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117
Modification date2020031320200329
UniProtAcc

Q9BZ67

Q7KZI7

Ensembl transtripts involved in fusion geneENST idsENST00000317568, ENST00000355991, 
ENST00000416776, ENST00000531296, 
ENST00000315032, ENST00000350490, 
ENST00000361128, ENST00000377810, 
ENST00000502399, ENST00000508192, 
ENST00000509502, ENST00000513765, 
ENST00000408948, ENST00000425897, 
ENST00000377809, ENST00000402010, 
ENST00000413835, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 8=7047 X 6 X 3=126
# samples 1610
** MAII scorelog2(16/704*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FRMD8 [Title/Abstract] AND MARK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FRMD8(65154592)-MARK2(63662631), # samples:2
Anticipated loss of major functional domain due to fusion event.FRMD8-MARK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD8-MARK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD8-MARK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD8-MARK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD8-MARK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FRMD8-MARK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFRMD8

GO:1904469

positive regulation of tumor necrosis factor secretion

29897333

TgeneMARK2

GO:0006468

protein phosphorylation

14976552

TgeneMARK2

GO:0010976

positive regulation of neuron projection development

12429843

TgeneMARK2

GO:0018105

peptidyl-serine phosphorylation

10542369|16717194

TgeneMARK2

GO:0030010

establishment of cell polarity

12429843

TgeneMARK2

GO:0035556

intracellular signal transduction

14976552

TgeneMARK2

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

15324659

TgeneMARK2

GO:0070507

regulation of microtubule cytoskeleton organization

10542369


check buttonFusion gene breakpoints across FRMD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A92D-01AFRMD8chr11

65154592

-MARK2chr11

63662631

+
ChimerDB4STADTCGA-VQ-A92D-01AFRMD8chr11

65154592

+MARK2chr11

63662631

+
ChimerDB4STADTCGA-VQ-A92DFRMD8chr11

65154592

+MARK2chr11

63662630

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000531296FRMD8chr1165154592+ENST00000377809MARK2chr1163662631+43312812872548753
ENST00000531296FRMD8chr1165154592+ENST00000402010MARK2chr1163662631+43762812872593768
ENST00000531296FRMD8chr1165154592+ENST00000413835MARK2chr1163662631+42142812872431714
ENST00000531296FRMD8chr1165154592+ENST00000377809MARK2chr1163662630+43312812872548753
ENST00000531296FRMD8chr1165154592+ENST00000402010MARK2chr1163662630+43762812872593768
ENST00000531296FRMD8chr1165154592+ENST00000413835MARK2chr1163662630+42142812872431714

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000531296ENST00000377809FRMD8chr1165154592+MARK2chr1163662631+0.0031839560.9968161
ENST00000531296ENST00000402010FRMD8chr1165154592+MARK2chr1163662631+0.0030160980.99698395
ENST00000531296ENST00000413835FRMD8chr1165154592+MARK2chr1163662631+0.0031039120.996896
ENST00000531296ENST00000377809FRMD8chr1165154592+MARK2chr1163662630+0.0031839560.9968161
ENST00000531296ENST00000402010FRMD8chr1165154592+MARK2chr1163662630+0.0030160980.99698395
ENST00000531296ENST00000413835FRMD8chr1165154592+MARK2chr1163662630+0.0031039120.996896

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31380_31380_1_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000377809_length(amino acids)=753AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKL

--------------------------------------------------------------

>31380_31380_2_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000402010_length(amino acids)=768AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTP

--------------------------------------------------------------

>31380_31380_3_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000413835_length(amino acids)=714AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYG
VTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSS

--------------------------------------------------------------

>31380_31380_4_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000377809_length(amino acids)=753AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKL

--------------------------------------------------------------

>31380_31380_5_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000402010_length(amino acids)=768AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTP

--------------------------------------------------------------

>31380_31380_6_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000413835_length(amino acids)=714AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYG
VTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65154592/chr11:63662631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRMD8

Q9BZ67

MARK2

Q7KZI7

FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}.FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARK2chr11:65154592chr11:63662630ENST00000315032018323_36218.0780.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000031503201853_30418.0780.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000315032018739_78818.0780.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000350490016323_36218.0710.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000035049001653_30418.0710.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000350490016739_78818.0710.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000361128017323_36218.0720.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000036112801753_30418.0720.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000361128017739_78818.0720.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000377809018323_36218.0774.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000037780901853_30418.0774.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000377809018739_78818.0774.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000377810017323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000037781001753_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000377810017739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000402010019323_36218.0789.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000040201001953_30418.0789.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000402010019739_78818.0789.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000408948016323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000040894801653_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000408948016739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000413835018323_36218.0735.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000041383501853_30418.0735.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000413835018739_78818.0735.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000508192017323_36218.0725.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000050819201753_30418.0725.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000508192017739_78818.0725.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000509502018323_3620746.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000050950201853_3040746.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000509502018739_7880746.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-118323_36245.0756.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-11853_30445.0756.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-118739_78845.0756.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000315032018323_36218.0780.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000031503201853_30418.0780.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000315032018739_78818.0780.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000350490016323_36218.0710.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000035049001653_30418.0710.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000350490016739_78818.0710.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000361128017323_36218.0720.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000036112801753_30418.0720.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000361128017739_78818.0720.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000377809018323_36218.0774.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000037780901853_30418.0774.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000377809018739_78818.0774.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000377810017323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000037781001753_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000377810017739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000402010019323_36218.0789.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000040201001953_30418.0789.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000402010019739_78818.0789.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000408948016323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000040894801653_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000408948016739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000413835018323_36218.0735.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000041383501853_30418.0735.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000413835018739_78818.0735.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000508192017323_36218.0725.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000050819201753_30418.0725.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000508192017739_78818.0725.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000509502018323_3620746.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000050950201853_3040746.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000509502018739_7880746.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-118323_36245.0756.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-11853_30445.0756.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-118739_78845.0756.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST0000031503201859_6718.0780.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000035049001659_6718.0710.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000036112801759_6718.0720.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000037780901859_6718.0774.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000037781001759_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000040201001959_6718.0789.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000040894801659_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000041383501859_6718.0735.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000050819201759_6718.0725.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000050950201859_670746.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-11859_6745.0756.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000031503201859_6718.0780.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000035049001659_6718.0710.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000036112801759_6718.0720.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000037780901859_6718.0774.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000037781001759_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000040201001959_6718.0789.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000040894801659_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000041383501859_6718.0735.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000050819201759_6718.0725.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000050950201859_670746.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-11859_6745.0756.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD8chr11:65154592chr11:63662630ENST00000317568+21130_37628.333333333333332465.0DomainFERM
HgeneFRMD8chr11:65154592chr11:63662630ENST00000355991+21030_37628.333333333333332409.0DomainFERM
HgeneFRMD8chr11:65154592chr11:63662631ENST00000317568+21130_37628.333333333333332465.0DomainFERM
HgeneFRMD8chr11:65154592chr11:63662631ENST00000355991+21030_37628.333333333333332409.0DomainFERM


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FRMD8
MARK2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FRMD8-MARK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FRMD8-MARK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource