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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FRYL-CNGA1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FRYL-CNGA1
	FusionPDB ID: 31483
	FusionGDB2.0 ID: 31483
		Hgene	Tgene
	Gene symbol	FRYL	CNGA1
	Gene ID	285527	1259
	Gene name	FRY like transcription coactivator	cyclic nucleotide gated channel subunit alpha 1
	Synonyms	AF4p12\|KIAA0826\|MOR2	CNCG\|CNCG1\|CNG-1\|CNG1\|RCNC1\|RCNCa\|RCNCalpha\|RP49
	Cytomap	4p11	4p12
	Type of gene	protein-coding	protein-coding
	Description	protein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homolog	cGMP-gated cation channel alpha-1CNG channel alpha-1cyclic nucleotide gated channel alpha 1cyclic nucleotide-gated cation channel 1cyclic nucleotide-gated channel, photoreceptorinterleukin-1 homologuerod photoreceptor cGMP-gated channel subunit alph
	Modification date	20200313	20200329
	UniProtAcc	O94915	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264319, ENST00000358350, ENST00000507711, ENST00000514783, ENST00000537810, ENST00000503238, ENST00000506685, ENST00000507873,	ENST00000358519, ENST00000402813, ENST00000420489, ENST00000514170, ENST00000544810,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 23 X 13=6279	6 X 6 X 4=144
	# samples	36	7
	** MAII score	log2(36/6279*10)=-4.12446600064719 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FRYL [Title/Abstract] AND CNGA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FRYL(48611004)-CNGA1(47945429), # samples:1 FRYL(48686690)-CNGA1(48012910), # samples:1
Anticipated loss of major functional domain due to fusion event.	FRYL-CNGA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FRYL-CNGA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FRYL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CNGA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A1BC-01A	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-
ChimerDB4	PRAD	TCGA-EJ-8470-01A	FRYL	chr4	48686690	-	CNGA1	chr4	48012910	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000503238	FRYL	chr4	48611004	-	ENST00000402813	CNGA1	chr4	47945429	-	2790	572	0	2345	781
ENST00000503238	FRYL	chr4	48611004	-	ENST00000514170	CNGA1	chr4	47945429	-	2790	572	0	2345	781
ENST00000503238	FRYL	chr4	48611004	-	ENST00000358519	CNGA1	chr4	47945429	-	2788	572	0	2345	781
ENST00000503238	FRYL	chr4	48611004	-	ENST00000544810	CNGA1	chr4	47945429	-	2788	572	0	2345	781
ENST00000503238	FRYL	chr4	48611004	-	ENST00000420489	CNGA1	chr4	47945429	-	2753	572	0	2345	781
ENST00000358350	FRYL	chr4	48611004	-	ENST00000402813	CNGA1	chr4	47945429	-	3395	1177	605	2950	781
ENST00000358350	FRYL	chr4	48611004	-	ENST00000514170	CNGA1	chr4	47945429	-	3395	1177	605	2950	781
ENST00000358350	FRYL	chr4	48611004	-	ENST00000358519	CNGA1	chr4	47945429	-	3393	1177	605	2950	781
ENST00000358350	FRYL	chr4	48611004	-	ENST00000544810	CNGA1	chr4	47945429	-	3393	1177	605	2950	781
ENST00000358350	FRYL	chr4	48611004	-	ENST00000420489	CNGA1	chr4	47945429	-	3358	1177	605	2950	781
ENST00000537810	FRYL	chr4	48611004	-	ENST00000402813	CNGA1	chr4	47945429	-	3395	1177	605	2950	781
ENST00000537810	FRYL	chr4	48611004	-	ENST00000514170	CNGA1	chr4	47945429	-	3395	1177	605	2950	781
ENST00000537810	FRYL	chr4	48611004	-	ENST00000358519	CNGA1	chr4	47945429	-	3393	1177	605	2950	781
ENST00000537810	FRYL	chr4	48611004	-	ENST00000544810	CNGA1	chr4	47945429	-	3393	1177	605	2950	781
ENST00000537810	FRYL	chr4	48611004	-	ENST00000420489	CNGA1	chr4	47945429	-	3358	1177	605	2950	781
ENST00000507711	FRYL	chr4	48611004	-	ENST00000402813	CNGA1	chr4	47945429	-	3344	1126	554	2899	781
ENST00000507711	FRYL	chr4	48611004	-	ENST00000514170	CNGA1	chr4	47945429	-	3344	1126	554	2899	781
ENST00000507711	FRYL	chr4	48611004	-	ENST00000358519	CNGA1	chr4	47945429	-	3342	1126	554	2899	781
ENST00000507711	FRYL	chr4	48611004	-	ENST00000544810	CNGA1	chr4	47945429	-	3342	1126	554	2899	781
ENST00000507711	FRYL	chr4	48611004	-	ENST00000420489	CNGA1	chr4	47945429	-	3307	1126	554	2899	781

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000503238	ENST00000402813	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000392091	0.999608
ENST00000503238	ENST00000514170	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000392091	0.999608
ENST00000503238	ENST00000358519	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000388543	0.99961144
ENST00000503238	ENST00000544810	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000388543	0.99961144
ENST00000503238	ENST00000420489	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000397754	0.99960226
ENST00000358350	ENST00000402813	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000371624	0.9996283
ENST00000358350	ENST00000514170	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000371624	0.9996283
ENST00000358350	ENST00000358519	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.00036787	0.9996321
ENST00000358350	ENST00000544810	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.00036787	0.9996321
ENST00000358350	ENST00000420489	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000374267	0.9996257
ENST00000537810	ENST00000402813	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000371624	0.9996283
ENST00000537810	ENST00000514170	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000371624	0.9996283
ENST00000537810	ENST00000358519	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.00036787	0.9996321
ENST00000537810	ENST00000544810	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.00036787	0.9996321
ENST00000537810	ENST00000420489	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000374267	0.9996257
ENST00000507711	ENST00000402813	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000364298	0.9996357
ENST00000507711	ENST00000514170	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000364298	0.9996357
ENST00000507711	ENST00000358519	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000360593	0.9996394
ENST00000507711	ENST00000544810	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000360593	0.9996394
ENST00000507711	ENST00000420489	FRYL	chr4	48611004	-	CNGA1	chr4	47945429	-	0.000366235	0.9996338

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31483_31483_1_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000358350_CNGA1_chr4_47945429_ENST00000358519_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_2_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000358350_CNGA1_chr4_47945429_ENST00000402813_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_3_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000358350_CNGA1_chr4_47945429_ENST00000420489_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_4_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000358350_CNGA1_chr4_47945429_ENST00000514170_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_5_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000358350_CNGA1_chr4_47945429_ENST00000544810_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_6_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000503238_CNGA1_chr4_47945429_ENST00000358519_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_7_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000503238_CNGA1_chr4_47945429_ENST00000402813_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_8_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000503238_CNGA1_chr4_47945429_ENST00000420489_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_9_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000503238_CNGA1_chr4_47945429_ENST00000514170_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_10_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000503238_CNGA1_chr4_47945429_ENST00000544810_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_11_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000507711_CNGA1_chr4_47945429_ENST00000358519_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_12_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000507711_CNGA1_chr4_47945429_ENST00000402813_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_13_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000507711_CNGA1_chr4_47945429_ENST00000420489_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_14_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000507711_CNGA1_chr4_47945429_ENST00000514170_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_15_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000507711_CNGA1_chr4_47945429_ENST00000544810_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_16_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000537810_CNGA1_chr4_47945429_ENST00000358519_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_17_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000537810_CNGA1_chr4_47945429_ENST00000402813_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_18_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000537810_CNGA1_chr4_47945429_ENST00000420489_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_19_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000537810_CNGA1_chr4_47945429_ENST00000514170_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

>31483_31483_20_FRYL-CNGA1_FRYL_chr4_48611004_ENST00000537810_CNGA1_chr4_47945429_ENST00000544810_length(amino acids)=781AA_BP=0
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTED
ESYEYRPRSSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYN
WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE
IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLT
LTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD
EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS
DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTR

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:48611004/chr4:47945429)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FRYL O94915	.
FUNCTION: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269\|PubMed:16061630}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

623_666

99.66666666666667

691.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

623_666

168.66666666666666

760.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

623_666

99.66666666666667

691.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

623_666

99.66666666666667

691.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

623_666

99.66666666666667

691.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

487_609

99.66666666666667

691.0

Nucleotide binding

3'%2C5'-cGMP

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

487_609

168.66666666666666

760.0

Nucleotide binding

3'%2C5'-cGMP

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

487_609

99.66666666666667

691.0

Nucleotide binding

3'%2C5'-cGMP

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

487_609

99.66666666666667

691.0

Nucleotide binding

3'%2C5'-cGMP

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

487_609

99.66666666666667

691.0

Nucleotide binding

3'%2C5'-cGMP

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

350_360

99.66666666666667

691.0

Region

P-helix

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

361_369

99.66666666666667

691.0

Region

Selectivity filter

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

402_484

99.66666666666667

691.0

Region

C-linker

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

485_612

99.66666666666667

691.0

Region

Cyclic nucleotide-binding domain (CNBD)

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

350_360

168.66666666666666

760.0

Region

P-helix

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

361_369

168.66666666666666

760.0

Region

Selectivity filter

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

402_484

168.66666666666666

760.0

Region

C-linker

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

485_612

168.66666666666666

760.0

Region

Cyclic nucleotide-binding domain (CNBD)

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

350_360

99.66666666666667

691.0

Region

P-helix

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

361_369

99.66666666666667

691.0

Region

Selectivity filter

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

402_484

99.66666666666667

691.0

Region

C-linker

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

485_612

99.66666666666667

691.0

Region

Cyclic nucleotide-binding domain (CNBD)

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

350_360

99.66666666666667

691.0

Region

P-helix

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

361_369

99.66666666666667

691.0

Region

Selectivity filter

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

402_484

99.66666666666667

691.0

Region

C-linker

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

485_612

99.66666666666667

691.0

Region

Cyclic nucleotide-binding domain (CNBD)

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

350_360

99.66666666666667

691.0

Region

P-helix

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

361_369

99.66666666666667

691.0

Region

Selectivity filter

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

402_484

99.66666666666667

691.0

Region

C-linker

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

485_612

99.66666666666667

691.0

Region

Cyclic nucleotide-binding domain (CNBD)

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

186_198

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

218_239

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

260_266

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

289_299

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

327_369

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

402_690

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

186_198

168.66666666666666

760.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

218_239

168.66666666666666

760.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

260_266

168.66666666666666

760.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

289_299

168.66666666666666

760.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

327_369

168.66666666666666

760.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

402_690

168.66666666666666

760.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

186_198

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

218_239

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

260_266

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

289_299

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

327_369

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

402_690

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

186_198

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

218_239

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

260_266

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

289_299

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

327_369

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

402_690

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

186_198

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

218_239

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

260_266

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

289_299

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

327_369

99.66666666666667

691.0

Topological domain

Extracellular

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

402_690

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

165_185

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS1

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

199_217

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS2

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

240_259

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS3

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

267_288

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS4

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

300_326

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS5

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

370_401

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS6

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

199_217

168.66666666666666

760.0

Transmembrane

Helical%3B Name%3DS2

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

240_259

168.66666666666666

760.0

Transmembrane

Helical%3B Name%3DS3

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

267_288

168.66666666666666

760.0

Transmembrane

Helical%3B Name%3DS4

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

300_326

168.66666666666666

760.0

Transmembrane

Helical%3B Name%3DS5

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

370_401

168.66666666666666

760.0

Transmembrane

Helical%3B Name%3DS6

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

165_185

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS1

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

199_217

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS2

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

240_259

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS3

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

267_288

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS4

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

300_326

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS5

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

370_401

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS6

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

165_185

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS1

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

199_217

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS2

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

240_259

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS3

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

267_288

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS4

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

300_326

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS5

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

370_401

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS6

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

165_185

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS1

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

199_217

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS2

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

240_259

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS3

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

267_288

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS4

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

300_326

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS5

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

370_401

99.66666666666667

691.0

Transmembrane

Helical%3B Name%3DS6

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000358519

1_164

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

1_164

168.66666666666666

760.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000420489

1_164

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000514170

1_164

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000544810

1_164

99.66666666666667

691.0

Topological domain

Cytoplasmic

Tgene

CNGA1

chr4:48611004

chr4:47945429

ENST00000402813

165_185

168.66666666666666

760.0

Transmembrane

Helical%3B Name%3DS1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
FRYL	HOMER3, YWHAG, BAK1, YWHAB, DISC1, SIRT7, GRK5, NOTCH1, MMS19, PELI2, SLMAP, ABCF1, KIAA0930, MARK2, POLH, YWHAH, TACC3, Csk, Homer1, Mad2l1bp, Cep44, PDZK1, FRY, HOMER1, FLNC, RNF138, FAM78B, HNRNPL, ZUFSP, KIAA1429, NHLRC2, PPP1CA, SQSTM1, PDCD10, PRR35, MGC50722, LRRC31, KIF23, UFL1, UBQLN1, SHANK3, YWHAZ, YWHAQ, CCDC71, PIP5K1A, SLC9A3R2, ARID4A, SLU7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FRYL
CNGA1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to FRYL-CNGA1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FRYL-CNGA1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source