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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FTCD-GSTM2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FTCD-GSTM2
	FusionPDB ID: 31581
	FusionGDB2.0 ID: 31581
		Hgene	Tgene
	Gene symbol	FTCD	GSTM2
	Gene ID	10841	2946
	Gene name	formimidoyltransferase cyclodeaminase	glutathione S-transferase mu 2
	Synonyms	LCHC1	GST4\|GSTM\|GSTM2-2\|GTHMUS
	Cytomap	21q22.3	1p13.3
	Type of gene	protein-coding	protein-coding
	Description	formimidoyltransferase-cyclodeaminaseformiminotransferase-cyclodeaminase	glutathione S-transferase Mu 2GST class-mu 2GST, muscleS-(hydroxyalkyl)glutathione lyase M2epididymis secretory sperm binding proteinglutathione S-alkyltransferase M2glutathione S-aralkyltransferase M2glutathione S-aryltransferase M2glutathione S-
	Modification date	20200320	20200313
	UniProtAcc	E5RQL4	P28161
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000291670, ENST00000355384, ENST00000359679, ENST00000397743, ENST00000397746, ENST00000397748, ENST00000498355,	ENST00000241337, ENST00000369829, ENST00000414179, ENST00000464206, ENST00000369827, ENST00000369831, ENST00000442650, ENST00000460717,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 6 X 5=210	4 X 3 X 3=36
	# samples	6	4
	** MAII score	log2(6/210*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FTCD [Title/Abstract] AND GSTM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FTCD(47565331)-GSTM2(110213909), # samples:2
Anticipated loss of major functional domain due to fusion event.	FTCD-GSTM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FTCD-GSTM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FTCD-GSTM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FTCD-GSTM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FTCD-GSTM2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. FTCD-GSTM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FTCD-GSTM2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GSTM2	GO:0006749	glutathione metabolic process	2034681\|8373352\|16549767
Tgene	GSTM2	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	17023043
Tgene	GSTM2	GO:0018916	nitrobenzene metabolic process	2034681\|8373352
Tgene	GSTM2	GO:0042178	xenobiotic catabolic process	2034681\|8373352\|16549767
Tgene	GSTM2	GO:0043651	linoleic acid metabolic process	16624487
Tgene	GSTM2	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	17023043\|22406107
Tgene	GSTM2	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	17023043
Tgene	GSTM2	GO:0070458	cellular detoxification of nitrogen compound	2034681\|8373352
Tgene	GSTM2	GO:0071313	cellular response to caffeine	22406107

Fusion gene breakpoints across FTCD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GSTM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CHOL	TCGA-ZH-A8Y6-01A	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+
ChimerDB4	LIHC	TCGA-ED-A4XI-01A	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000291670	FTCD	chr21	47565331	-	ENST00000369831	GSTM2	chr1	110213909	+	2580	1304	38	1606	522
ENST00000291670	FTCD	chr21	47565331	-	ENST00000460717	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000291670	FTCD	chr21	47565331	-	ENST00000369827	GSTM2	chr1	110213909	+	1937	1304	38	1489	483
ENST00000291670	FTCD	chr21	47565331	-	ENST00000442650	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000397748	FTCD	chr21	47565331	-	ENST00000369831	GSTM2	chr1	110213909	+	2580	1304	38	1606	522
ENST00000397748	FTCD	chr21	47565331	-	ENST00000460717	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000397748	FTCD	chr21	47565331	-	ENST00000369827	GSTM2	chr1	110213909	+	1937	1304	38	1489	483
ENST00000397748	FTCD	chr21	47565331	-	ENST00000442650	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000359679	FTCD	chr21	47565331	-	ENST00000369831	GSTM2	chr1	110213909	+	2580	1304	38	1606	522
ENST00000359679	FTCD	chr21	47565331	-	ENST00000460717	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000359679	FTCD	chr21	47565331	-	ENST00000369827	GSTM2	chr1	110213909	+	1937	1304	38	1489	483
ENST00000359679	FTCD	chr21	47565331	-	ENST00000442650	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000397743	FTCD	chr21	47565331	-	ENST00000369831	GSTM2	chr1	110213909	+	2580	1304	38	1606	522
ENST00000397743	FTCD	chr21	47565331	-	ENST00000460717	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000397743	FTCD	chr21	47565331	-	ENST00000369827	GSTM2	chr1	110213909	+	1937	1304	38	1489	483
ENST00000397743	FTCD	chr21	47565331	-	ENST00000442650	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000397746	FTCD	chr21	47565331	-	ENST00000369831	GSTM2	chr1	110213909	+	2580	1304	38	1606	522
ENST00000397746	FTCD	chr21	47565331	-	ENST00000460717	GSTM2	chr1	110213909	+	2328	1304	38	1519	493
ENST00000397746	FTCD	chr21	47565331	-	ENST00000369827	GSTM2	chr1	110213909	+	1937	1304	38	1489	483
ENST00000397746	FTCD	chr21	47565331	-	ENST00000442650	GSTM2	chr1	110213909	+	2328	1304	38	1519	493

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000291670	ENST00000369831	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.002646893	0.9973531
ENST00000291670	ENST00000460717	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003819411	0.99618065
ENST00000291670	ENST00000369827	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.010432245	0.9895677
ENST00000291670	ENST00000442650	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003911822	0.99608815
ENST00000397748	ENST00000369831	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.002646893	0.9973531
ENST00000397748	ENST00000460717	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003819411	0.99618065
ENST00000397748	ENST00000369827	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.010432245	0.9895677
ENST00000397748	ENST00000442650	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003911822	0.99608815
ENST00000359679	ENST00000369831	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.002599552	0.9974005
ENST00000359679	ENST00000460717	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003746624	0.9962534
ENST00000359679	ENST00000369827	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.010196785	0.9898032
ENST00000359679	ENST00000442650	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.00383728	0.9961628
ENST00000397743	ENST00000369831	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.002646893	0.9973531
ENST00000397743	ENST00000460717	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003819411	0.99618065
ENST00000397743	ENST00000369827	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.010432245	0.9895677
ENST00000397743	ENST00000442650	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003911822	0.99608815
ENST00000397746	ENST00000369831	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.002646893	0.9973531
ENST00000397746	ENST00000460717	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003819411	0.99618065
ENST00000397746	ENST00000369827	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.010432245	0.9895677
ENST00000397746	ENST00000442650	FTCD	chr21	47565331	-	GSTM2	chr1	110213909	+	0.003911822	0.99608815

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31581_31581_1_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000291670_GSTM2_chr1_110213909_ENST00000369827_length(amino acids)=483AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_2_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000291670_GSTM2_chr1_110213909_ENST00000369831_length(amino acids)=522AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_3_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000291670_GSTM2_chr1_110213909_ENST00000442650_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_4_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000291670_GSTM2_chr1_110213909_ENST00000460717_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_5_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000359679_GSTM2_chr1_110213909_ENST00000369827_length(amino acids)=483AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_6_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000359679_GSTM2_chr1_110213909_ENST00000369831_length(amino acids)=522AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_7_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000359679_GSTM2_chr1_110213909_ENST00000442650_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_8_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000359679_GSTM2_chr1_110213909_ENST00000460717_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_9_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397743_GSTM2_chr1_110213909_ENST00000369827_length(amino acids)=483AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_10_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397743_GSTM2_chr1_110213909_ENST00000369831_length(amino acids)=522AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_11_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397743_GSTM2_chr1_110213909_ENST00000442650_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_12_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397743_GSTM2_chr1_110213909_ENST00000460717_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_13_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397746_GSTM2_chr1_110213909_ENST00000369827_length(amino acids)=483AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_14_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397746_GSTM2_chr1_110213909_ENST00000369831_length(amino acids)=522AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_15_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397746_GSTM2_chr1_110213909_ENST00000442650_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_16_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397746_GSTM2_chr1_110213909_ENST00000460717_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_17_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397748_GSTM2_chr1_110213909_ENST00000369827_length(amino acids)=483AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_18_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397748_GSTM2_chr1_110213909_ENST00000369831_length(amino acids)=522AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_19_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397748_GSTM2_chr1_110213909_ENST00000442650_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

>31581_31581_20_FTCD-GSTM2_FTCD_chr21_47565331_ENST00000397748_GSTM2_chr1_110213909_ENST00000460717_length(amino acids)=493AA_BP=422
MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL
DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA
RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ
LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS
VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:47565331/chr1:110213909)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FTCD E5RQL4	GSTM2 P28161
	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269\|PubMed:16549767, ECO:0000269\|PubMed:21046276}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000291670

182_326

420.0

555.3333333333334

Region

Formiminotransferase C-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000291670

1_181

420.0

555.3333333333334

Region

Formiminotransferase N-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000291670

327_334

420.0

555.3333333333334

Region

Linker

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000359679

182_326

420.0

573.0

Region

Formiminotransferase C-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000359679

1_181

420.0

573.0

Region

Formiminotransferase N-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000359679

327_334

420.0

573.0

Region

Linker

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397746

182_326

420.0

542.0

Region

Formiminotransferase C-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397746

1_181

420.0

542.0

Region

Formiminotransferase N-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397746

327_334

420.0

542.0

Region

Linker

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397748

182_326

420.0

573.0

Region

Formiminotransferase C-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397748

1_181

420.0

573.0

Region

Formiminotransferase N-subdomain

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397748

327_334

420.0

573.0

Region

Linker

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000291670

335_541

420.0

555.3333333333334

Region

Cyclodeaminase/cyclohydrolase

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000359679

335_541

420.0

573.0

Region

Cyclodeaminase/cyclohydrolase

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397746

335_541

420.0

542.0

Region

Cyclodeaminase/cyclohydrolase

Hgene

FTCD

chr21:47565331

chr1:110213909

ENST00000397748

335_541

420.0

573.0

Region

Cyclodeaminase/cyclohydrolase

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000241337

2_88

120.0

219.0

Domain

Note=GST N-terminal

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000241337

90_208

120.0

219.0

Domain

Note=GST C-terminal

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000442650

2_88

120.0

412.3333333333333

Domain

Note=GST N-terminal

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000442650

90_208

120.0

412.3333333333333

Domain

Note=GST C-terminal

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000460717

2_88

120.0

422.0

Domain

Note=GST N-terminal

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000460717

90_208

120.0

422.0

Domain

Note=GST C-terminal

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000241337

43_46

120.0

219.0

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000241337

59_60

120.0

219.0

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000241337

72_73

120.0

219.0

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000241337

7_8

120.0

219.0

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000442650

43_46

120.0

412.3333333333333

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000442650

59_60

120.0

412.3333333333333

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000442650

72_73

120.0

412.3333333333333

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000442650

7_8

120.0

412.3333333333333

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000460717

43_46

120.0

422.0

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000460717

59_60

120.0

422.0

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000460717

72_73

120.0

422.0

Region

Glutathione binding

Tgene

GSTM2

chr21:47565331

chr1:110213909

ENST00000460717

7_8

120.0

422.0

Region

Glutathione binding

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1116_FTCD_47565331_GSTM2_110213909_1116_FTCD_47565331_GSTM2_110213909_ranked_0.pdb	FTCD	47565331	47565331	ENST00000442650	GSTM2	chr1	110213909	+	MAMSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGAL DVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGA RKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQ LVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGS VAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEKLKPEYLQALPEMLKLYSQFLGKQPWF	522

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FTCD_pLDDT.png

GSTM2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FTCD
GSTM2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FTCD-GSTM2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FTCD-GSTM2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source